Receptor de efrina
Los inhibidores de los receptores de efrinas (Eph) están dirigidos a los receptores Eph, una familia de tirosina quinasas receptoras que interactúan con ligandos de efrinas unidos a la membrana. La señalización de efrinas es crucial para la posición celular, el patrón de los tejidos y la angiogénesis. La desregulación de esta vía está implicada en el cáncer, enfermedades neurodegenerativas y trastornos del desarrollo. En CymitQuimica, ofrecemos inhibidores de los receptores de efrinas para apoyar su investigación en biología del desarrollo, oncología y neurobiología.
Se han encontrado 23 productos de "Receptor de efrina"
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AWL-II-38.3
CAS:AWL-II-38.3 is a highly potent EphA3 inhibitor with potent kinase inhibitory activity against EphA3.Cost-effective and quality-assured.Fórmula:C23H18F3N5O3Pureza:99.03% - 99.57%Forma y color:SolidPeso molecular:469.42EphA2 agonist 1
CAS:<p>Compound 7bg is a potent, selective EphA2 agonist targeting overexpressed glioblastoma cells.</p>Fórmula:C50H58N12O12Forma y color:SolidPeso molecular:1019.07ALW-II-49-7
CAS:<p>ALW-II-49-7 is a selective and potent inhibitor of EphB2 kinase with an EC50 value of 40 nM in cell.</p>Fórmula:C21H17F3N4O2Pureza:99.72%Forma y color:SoildPeso molecular:414.38Nuzefatide
CAS:<p>Nuzefatide is a peptide that binds to liver protein receptors.</p>Fórmula:C105H162N32O27S3Forma y color:SolidPeso molecular:2400.80SA-PA
<p>SA-PA, a self-assembled intracellular PROTAC leveraging azide-alkyne click chemistry, selectively degrades VEGFR-2, PDGFR-β, and EphB4 proteins within U87 cells</p>Fórmula:C40H32ClF3N10O8Pureza:98%Forma y color:SolidPeso molecular:873.19PKMYT1-IN-8
<p>PKMYT1-IN-8 (Compound 137) is an inhibitor of PKMYT1, with an IC50 value of 9 nM. It also inhibits EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2, exhibiting IC50 values of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10, and 10.9 μM, respectively. Additionally, PKMYT1-IN-8 suppresses the proliferation of cancer cells OVCAR3 with a GI50 of 2.02 μM.</p>Fórmula:C17H16F3N5O2Forma y color:SolidPeso molecular:379.336AZ12672857
CAS:<p>AZ12672857 is an inhibitor of EphB4 with IC50 of 1.3 nM.</p>Fórmula:C26H30N8O2Pureza:98.99%Forma y color:SolidPeso molecular:486.57UniPR1449
<p>UniPR1449 is an EphA2 receptor antagonist with a KD of 3.8±2.4 μM, which is significant in cancer pathophysiology [1].</p>Pureza:98%Forma y color:Odour SolidKYL peptide
CAS:<p>EphA4 inhibitor, Kd 0.8 μM, blocks EphA4-EphrinA5; avoids AβO damage, preserves spines & LTP; long half-life (8-12h), neuroprotective.</p>Fórmula:C74H108N14O17Pureza:98%Forma y color:SolidPeso molecular:1465.75Ehp-inhibitor-2
CAS:<p>Ehp-inhibitor-2 is an Eph family tyrosine kinase inhibitor targeting Eph receptors.</p>Fórmula:C17H13N5OPureza:97.88%Forma y color:SolidPeso molecular:303.32NVP-BHG712 isomer
CAS:<p>NVP-BHG712 isomer shows conserved non-bonded binding to EPHA2 and EPHB4.</p>Fórmula:C26H20F3N7OPureza:99.14%Forma y color:SolidPeso molecular:503.48JI-101
CAS:<p>JI-101 (CGI-1842) is an oral multi-kinase inhibitor that targets VEGFR-2, PDGFR-β, and EphB4.</p>Fórmula:C22H20BrN5O2Pureza:99.41% - 99.97%Forma y color:SolidPeso molecular:466.33NVP-BHG712
CAS:<p>NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition; also shows activity against c-Raf, c-Src and</p>Fórmula:C26H20F3N7OPureza:97.32% - 98.63%Forma y color:SolidPeso molecular:503.48Eph inhibitor 2
CAS:<p>Eph inhibitor 2 is an Eph family tyrosine kinase inhibitor targeting Eph receptors.</p>Fórmula:C18H15N5OPureza:99.01%Forma y color:SolidPeso molecular:317.34Tesevatinib
CAS:<p>Tesevatinib (XL-647) is an oral, multi-targeted tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Fórmula:C24H25Cl2FN4O2Pureza:97.89% - 98.66%Forma y color:SolidPeso molecular:491.39ALW-II-41-27
CAS:<p>ALW-II-41-27 (Eph receptor tyrosine kinase inhibitor), an Eph receptor tyrosine kinase inhibitor, is used for cancer therapy.</p>Fórmula:C32H32F3N5O2SPureza:97.01% - 99.52%Forma y color:SolidPeso molecular:607.69123C4
CAS:<p>123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4 (Ki=0.65 μM)[1].</p>Fórmula:C43H47ClN8O6Pureza:98.94%Forma y color:SolidPeso molecular:807.34EphA2 agonist 2
CAS:<p>EphA2 agonist 2 (Lead compound) is a selective agonist targeting the EphA2 receptor, exhibiting antitumor properties and the ability to cross the blood-brain</p>Fórmula:C40H56N10O6Forma y color:SolidPeso molecular:772.94UniPR129
CAS:<p>UniPR129 is a competitive Eph-ephrin antagonist agent that acts by blocking in vitro angiogenesis at low micromolar concentrations.</p>Fórmula:C36H52N2O4Pureza:98%Forma y color:SolidPeso molecular:576.81LDN-211904 oxalate
CAS:<p>LDN-211904 oxalate (LDN211904 oxalate) is a selective and efficient EphB3 inhibitor with antitumor activity, useful in neurodegenerative disease research.</p>Fórmula:C21H21ClN4O5Pureza:99.87%Forma y color:SolidPeso molecular:444.87UniPR505
CAS:<p>UniPR505 is a potent EphA2 antagonist (IC50: 0.95 µM), a novel 3α-carbamoyloxy derivative with antiangiogenic properties.</p>Fórmula:C39H57N3O5Pureza:98.23%Forma y color:SolidPeso molecular:647.89UniPR1447
CAS:<p>UniPR1447 is a dual antagonist for both EphA2 and EphB2 receptors, exhibiting an IC50 value of 6.6 μM against EphA2-ephrin-A1 binding [1].</p>Fórmula:C36H50N2O4Pureza:98%Forma y color:SolidPeso molecular:574.79UniPR500
CAS:<p>UniPR500, a derivative of UniPR129, is a competitive antagonist for the EphA2 receptor, with a Ki of 0.78 μM. It reduces the binding of biotinylated Ephrin-A1 to EphA2 in a dose-dependent manner, exhibiting an IC50 value of 1.1 μM.</p>Fórmula:C36H51N3O4Forma y color:SolidPeso molecular:589.808
