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ALK

ALK

Los inhibidores de ALK son compuestos que específicamente atacan e inhiben la quinasa del linfoma anaplásico (ALK), una tirosina quinasa receptora involucrada en el desarrollo y progresión de ciertos tipos de cáncer, incluyendo el cáncer de pulmón de células no pequeñas y el neuroblastoma. Al inhibir ALK, estos compuestos bloquean las vías de señalización que promueven el crecimiento y la supervivencia de las células tumorales. En CymitQuimica, ofrecemos inhibidores de ALK para apoyar su investigación en oncología, terapias dirigidas contra el cáncer y transducción de señales.

Se han encontrado 112 productos de "ALK"

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  • IN-1130
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    IN-1130

    CAS:
    <p>IN-1130: ALK5 inhibitor, IC50 - 5.3 nM (Smad3), 36 nM (casein), 4.3 μM (p38α MAPK).</p>
    Fórmula:C25H20N6O
    Pureza:99.79%
    Forma y color:Solid
    Peso molecular:420.47

    Ref: TM-T15572

  • TGF-βRI inhibitor 3
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    TGF-βRI inhibitor 3

    CAS:
    <p>TGF-βRI inhibitor 3 (Compound 9ac) is a selective inhibitor of TGF-β that effectively suppresses the TGF-β signaling pathway. It exhibits IC50 values of 13 μM for c-Src kinase and 0.63 μM for ALK5 kinase.</p>
    Fórmula:C21H21NO4
    Forma y color:Solid
    Peso molecular:351.396

    Ref: TM-T205215

  • CEP-14083
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    CEP-14083

    CAS:
    <p>CEP-14083: potent ALK inhibitor, effective in NPM/ALK T-cell lymphoma, binds ATP site; IC50=11 nmol/L, also inhibits insulin receptor, preclinical efficacy.</p>
    Fórmula:C31H30N6O2
    Forma y color:Solid
    Peso molecular:518.61

    Ref: TM-T68538

  • Logo de CymitQuimica
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    ALK-IN-23

    <p>ALK-IN-23 inhibits ALK (IC50: 1.6-0.71 nM), hinders cancer cell spread, forms colonies in vitro, and reduces tumors in mice with low toxicity.</p>
    Fórmula:C26H29ClN8O3S
    Forma y color:Solid
    Peso molecular:569.08

    Ref: TM-T64027

  • DDO-02267
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    DDO-02267

    CAS:
    <p>DDO-02267 is a selective lysine-targeted covalent inhibitor of ALKBH5, with an IC50 value of 0.49 μM. It increases levels of N6-methyladenosine (m6A) and targets the ALKBH5-AXL signaling axis. DDO-02267 serves as a probe for studying the biological function of mRNA demethylases.</p>
    Fórmula:C18H12N2O7S
    Forma y color:Solid
    Peso molecular:400.362

    Ref: TM-T204967

  • W23-1006
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    W23-1006

    CAS:
    <p>W23-1006 is a selective covalent ALKBH5 inhibitor. It binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. The inhibitory activity of W23-1006 is approximately 30 times stronger than that of FTO and 8 times greater than that of ALKBH3. W23-1006 is applicable for research in triple-negative breast cancer (TNBC).</p>
    Fórmula:C17H12BrN3O5
    Forma y color:Solid
    Peso molecular:418.198

    Ref: TM-T205034

  • PF-06463922 acetate
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    PF-06463922 acetate

    CAS:
    <p>PF-06463922 acetate: ALK/ROS1 inhibitor, brain- penetrable, active vs crizotinib-resistant mutants, in NSCLC trials.</p>
    Fórmula:C23H23FN6O4
    Forma y color:Solid
    Peso molecular:466.46

    Ref: TM-T70060

  • DA-0157
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    DA-0157

    CAS:
    <p>DA-0157 is an orally active inhibitor targeting EGFR and ALK, designed to overcome resistance mutations in non-small cell lung cancer (NSCLC). It effectively inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S (IC50= 6.9 nM), Ba/F3-EGFR WT (IC50= 0.83 μM), Ba/F3-EML4-ALK-L1196M (IC50= 5.5 nM), and Ba/F3-EML4-ALK (IC50= 7.4 nM). Additionally, DA-0157 inhibits CYP2D6 with an IC50 of 5.26 μM and demonstrates antitumor activity in mouse models.</p>
    Fórmula:C31H43BrN7O2P
    Forma y color:Solid
    Peso molecular:656.597

    Ref: TM-T205118

  • ALKBH5-IN-3
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    ALKBH5-IN-3

    CAS:
    <p>ALKBH5-IN-3 (Compound 20m) is an efficacious and selective inhibitor of ALKBH5, exhibiting an IC50 value of 21 nM. It effectively stabilizes ALKBH5 in HepG2 cells and enhances m6A levels in intact cells.</p>
    Fórmula:C11H7F3N2O3
    Forma y color:Solid
    Peso molecular:272.18

    Ref: TM-T201322

  • CDD-1115
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    CDD-1115

    CAS:
    <p>CDD-1115 is a potent and selective BMPR2 inhibitor, with an IC50 of 1.8 nM and a Kiapp of 6.2 nM. It effectively suppresses gene expression mediated by bone morphogenetic proteins (BMPs). BMPs regulate cellular processes in various tissue types, such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.</p>
    Fórmula:C32H30N6O3
    Forma y color:Solid
    Peso molecular:546.619

    Ref: TM-T205172

  • Zotizalkib
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    Zotizalkib

    CAS:
    <p>TPX-0131: potent, selective, CNS-ready, oral ALK inhibitor (WT IC50: 1.4nM, G1202R/L1196M IC50: 0.3nM) with robust antitumor effects.</p>
    Fórmula:C21H20F3N5O3
    Pureza:98.7%
    Forma y color:Solid
    Peso molecular:447.41

    Ref: TM-T9414

  • AZ12601011
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    AZ12601011

    CAS:
    <p>AZ12601011 is a TGFBR1 kinase inhibitor that inhibits the growth of breast tumors.</p>
    Fórmula:C19H15N5
    Pureza:98.81%
    Forma y color:Solid
    Peso molecular:313.36

    Ref: TM-T10426