c-Fms

CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.

CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and …

Edicotinib is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: …

cFMS Receptor Inhibitor IV is an inhibitor of c-Fms tyrosine kinase.

Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently …

c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an …

c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).

Cerdulatinib (PRT-062070) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 …

PLX-5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.

OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), …

Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain …

AEE788 has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain …

Pexidartinib is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, …

Linifanib (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R …

Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an …

cFMS Receptor Inhibitor II is a CSF1R kinase inhibitor

Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 …

DCC-3014 is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM) …

Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, …

PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 …

Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, …

AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.

CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity …

AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and …

BLZ945 is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective …

GW2580 is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.

PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also …

PLX647 is a highly selective dual FMS/KIT kinase inhibitor (IC50: 28/16 nM).

K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.

c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1 (Example 7). It inhibits unphosphorylated c-FMS …

c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also …

PLX5622 hemifumarate is a highly selective brain penetrant and orally active CSF1R inhibitor with an …