c-Fms
Los inhibidores de c-Fms se dirigen al receptor del factor estimulante de colonias-1 (c-Fms), una tirosina quinasa involucrada en la regulación de los macrófagos y otras células inmunitarias. La señalización de c-Fms juega un papel en la proliferación, diferenciación y supervivencia de estas células. La desregulación de c-Fms está asociada con enfermedades como el cáncer, condiciones inflamatorias y osteoporosis. En CymitQuimica, ofrecemos inhibidores de c-Fms para apoyar su investigación en inmunología, oncología y enfermedades inflamatorias.
Se han encontrado 108 productos de "c-Fms"
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Ki20227
CAS:<p>Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM).</p>Fórmula:C24H24N4O5SPureza:98.97% - 99.88%Forma y color:SolidPeso molecular:480.54Vimseltinib
CAS:<p>Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).</p>Fórmula:C23H25N7O2Pureza:99.05% - 99.57%Forma y color:SolidPeso molecular:431.49Sotuletinib
CAS:<p>Sotuletinib (BLZ945) is an orally active, effective and specific CSF-1R inhibitor, >1000-fold selective against its closest receptor tyrosine kinase homologs.</p>Fórmula:C20H22N4O3SPureza:97.43% - 99.82%Forma y color:SolidPeso molecular:398.48AZ304
CAS:<p>AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).</p>Fórmula:C27H25N5O2Pureza:99.82%Forma y color:SolidPeso molecular:451.52GW2580
CAS:<p>GW2580 (SC-203877) is a specific, oral-bioavailable CSF-1R inhibitor for c-FMS.</p>Fórmula:C20H22N4O3Pureza:99.48% - >99.99%Forma y color:SolidPeso molecular:366.41PLX5622
CAS:<p>PLX5622 is a selective, orally active and blood-brain barrier permeable CSF1R inhibitor. PLX5622 induces elimination of microglia. Cost effective and quality assured.</p>Fórmula:C21H19F2N5OPureza:98% - 99.92%Forma y color:SolidPeso molecular:395.41Linifanib
CAS:<p>Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and</p>Fórmula:C21H18FN5OPureza:98% - 98.24%Forma y color:SolidPeso molecular:375.4Nampt-IN-1
CAS:<p>Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.</p>Fórmula:C20H25N3O5SPureza:99.28% - 99.4%Forma y color:SolidPeso molecular:419.49OSI-930
CAS:<p>OSI-930 is an oral c-Kit/VEGFR-2 inhibitor targeting tumor growth and angiogenesis.</p>Fórmula:C22H16F3N3O2SPureza:99.67%Forma y color:SolidPeso molecular:443.44Dovitinib
CAS:<p>Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.</p>Fórmula:C21H21FN6OPureza:99.35% - 99.92%Forma y color:SolidPeso molecular:392.43Anumigilimab
CAS:<p>Anumigilimab (CSL-324) is a fully human therapeutic anti-G-CSFR antibody with potential anti-tumor activity for the study of inflammation.</p>Pureza:95.75% (SEC-HPLC) - 98.43% (SEC-HPLC)Forma y color:LiquidPeso molecular:143.86 kDaLenzilumab
CAS:<p>Lenzilumab (KB 003) is a humanized GM-CSF neutralizing antibody for the study of COVID-19.</p>Pureza:98.9% (SDS-PAGE); 98.5% (SEC-HPLC) - 98.9% (SDS-PAGE); 98.5% (SEC-HPLC)Forma y color:LiquidNamilumab
CAS:<p>Namilumab (AMG203) is a humanised IgG1 monoclonal antibody that neutralises GM-CSF. rheumatoid arthritis and active axial spondyloarthritis.</p>Pureza:95%Forma y color:LiquidTrabikibart
CAS:<p>Trabikibart (CSL311) is a human βc-specific antibody inhibiting IL-3, GM-CSF and IL-5, regulating eosinophil survival in chronic inflammatory disease research.</p>Pureza:95% - 95%Forma y color:LiquidCabiralizumab
CAS:<p>Cabiralizumab is an anti-CSF1R monoclonal antibody that enhances T cell infiltration, inhibits osteoclasts, and is used in RA and immune-oncology research.</p>Pureza:95% - 95%Forma y color:LiquidAnti-Mouse GM-CSF Antibody (MP1-22E9)
<p>Anti-Mouse GM-CSF Antibody is a rat-derived IgG2a isotype inhibitor that targets mouse granulocyte-macrophage colony-stimulating factor (GM-CSF).</p>Pureza:98%Forma y color:Odour LiquidCSF1R-IN-19
CAS:<p>CSF1R-IN-19 is a robust inhibitor of CSF1R that influences the exchange of inflammatory factors between TAMs and glioma cells. It holds potential for cancer research [1].</p>Fórmula:C20H27N7OForma y color:SolidPeso molecular:381.47Sotuletinib dihydrochloride
CAS:<p>Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM.</p>Fórmula:C20H24Cl2N4O3SPureza:98%Forma y color:SolidPeso molecular:471.4c-Fms-IN-9
CAS:<p>c-Fms-IN-9 inhibits c-FMS/uFMS and uKIT with IC50 <0.01μM and 0.1-1μM, from patent WO2014145023A1.</p>Fórmula:C21H23N7O2Pureza:98%Forma y color:SolidPeso molecular:405.45Leustroducsin A
CAS:<p>Leustroducsin A is an inducer of colony-stimulating factors (CSFs) extracted from Streptomyces platensis SANK 60191.</p>Fórmula:C32H52NO10PForma y color:SolidPeso molecular:641.73c-Fms-IN-7
CAS:<p>c-Fms-IN-7 is a cFMS inhibitor (IC50: 18.5 nM).</p>Fórmula:C26H24N6OSPureza:98%Forma y color:SolidPeso molecular:468.57c-Fms-IN-8
CAS:<p>c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.</p>Fórmula:C27H30N2O5Pureza:98%Forma y color:SolidPeso molecular:462.54JNJ-28312141
CAS:<p>JNJ-28312141: oral CSF1R/FLT3 inhibitor, potential for treating acute myeloid leukemia, tumors, and bone events.</p>Fórmula:C26H32N6O2Pureza:98%Forma y color:SolidPeso molecular:460.57CSF1R-IN-4
CAS:<p>CSF1R-IN-4, a potent CSF-1R inhibitor, may impact TAM/glioma cell communication, with cancer research potential. (WO2021197276A1, compound 104)</p>Fórmula:C23H20N6O3Forma y color:SolidPeso molecular:428.44c-Fms-IN-10
CAS:<p>c-Fms-IN-10 is a thieno[3,2-d]pyrimidine derivative, an FMS kinase inhibitor with IC50 of 2 nM, exhibiting anti-tumor properties.</p>Fórmula:C22H19N7OSPureza:98%Forma y color:SolidPeso molecular:429.5CSF1R-IN-13
CAS:<p>CSF1R-IN-13: potent cancer research CSF1R inhibitor impacting cell growth regulation.</p>Fórmula:C21H20N4O3Forma y color:SolidPeso molecular:376.41CSF1R-IN-8
CAS:<p>CSF1R-IN-8 (Compound 22) is a CSF-1R inhibitor (IC50: 0.012 μM).</p>Fórmula:C24H22N4O4Forma y color:SolidPeso molecular:430.46CSF1R-IN-10
CAS:<p>CSF1R-IN-10 (Compound 48) is a CSF-1R inhibitor (IC50: 0.005 μM).</p>Fórmula:C25H22N4O3Forma y color:SolidPeso molecular:426.47Leustroducsin C
CAS:<p>Leustroducsin C is an inducer of colony-stimulating factors CSF extracted from Streptomyces platensis SANK 60191.</p>Fórmula:C34H56NO10PForma y color:SolidPeso molecular:669.78CSF1R-IN-14
CAS:<p>CSF1R-IN-14, an isoindolinone derivative, powerfully inhibits CSF1R, with potential in cancer research. See WO2019134662A1, compound 1.</p>Fórmula:C23H22F3N5OForma y color:SolidPeso molecular:441.45CSF1R-IN-12
CAS:<p>CSF1R-IN-12 is an effective CSF1R inhibitor. CSF1R-IN-12 has research potential in cancer diseases.</p>Fórmula:C21H17F3N4OForma y color:SolidPeso molecular:398.38CSF1R-IN-7
CAS:<p>CSF1R-IN-7 is a highly selective CSF-1R inhibitor with good brain penetration for treatment of diseases associated with microglia-mediated neuroinflammation.</p>Fórmula:C22H22N6O3Pureza:99.41% - 99.93%Forma y color:SolidPeso molecular:418.45CSF1R-IN-9
CAS:<p>CSF1R-IN-9 (Compound 46) is a CSF-1R inhibitor (IC50: 0.028 μM).</p>Fórmula:C26H26N4O2Forma y color:SolidPeso molecular:426.51CSF1R-IN-6
CAS:<p>CSF1R-IN-6, a compound, effectively inhibits macrophage CSF1R essential for survival and differentiation.</p>Fórmula:C20H18N8O3Forma y color:SolidPeso molecular:418.41c-Fms-IN-2
CAS:<p>c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).</p>Fórmula:C19H21N3O3Pureza:99.56%Forma y color:SolidPeso molecular:339.39ABD-295
CAS:<p>ABD-295, a biphenylsulfide derivative, inhibits osteoclasts and prevents bone loss in vitro and in vivo.</p>Fórmula:C17H19F2NO3SPureza:98%Forma y color:SolidPeso molecular:355.4c-Fms-IN-6
CAS:<p>c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).</p>Fórmula:C22H25N7O2Pureza:98%Forma y color:SolidPeso molecular:419.48IACS-9439
CAS:<p>IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM.</p>Fórmula:C23H26ClN7O3SPureza:98%Forma y color:SolidPeso molecular:516.02c-Fms-IN-1
CAS:<p>c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).</p>Fórmula:C22H27N5O2Pureza:99.94%Forma y color:SolidPeso molecular:393.48Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Fórmula:C27H21N3O3Pureza:99.22%Forma y color:SolidPeso molecular:435.47c-Fms-IN-3
CAS:<p>c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.</p>Fórmula:C23H30N6OPureza:99.87%Forma y color:SolidPeso molecular:406.52c-Fms-IN-13
CAS:<p>c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.</p>Fórmula:C22H26N4O2Pureza:99.93% - 99.97%Forma y color:SolidPeso molecular:378.47Pimicotinib
CAS:<p>Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.</p>Fórmula:C22H24N6O3Pureza:99.8%Forma y color:SolidPeso molecular:420.46CSF1R-IN-3
CAS:<p>CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM.</p>Fórmula:C30H38N8O4Pureza:97.31%Forma y color:SolidPeso molecular:574.67c-Fms-IN-14
CAS:<p>c-Fms-IN-14 (Example 76) is a potent inhibitor of the c-Fms kinase with an IC50 of 4 nM, utilized in cancer and autoimmune disease research [1].</p>Fórmula:C26H24N6OPureza:98%Forma y color:SolidPeso molecular:436.51Axl/Mer/CSF1R-IN-2
CAS:<p>Axl/Mer/CSF1R-IN-2 (Comp 4) serves as an inhibitor for Axl, Mer, and CSF1R [1].</p>Fórmula:C24H22F3N5O5Forma y color:SolidPeso molecular:517.46Axl/Mer/CSF1R-IN-1
CAS:<p>Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds)</p>Fórmula:C25H24F3N5O5Forma y color:SolidPeso molecular:531.48Ataquimast
CAS:<p>Ataquimast is used in curing advanced receptor-positive breast cancer.</p>Fórmula:C11H14ClN3OPureza:99.92%Forma y color:SolidPeso molecular:239.7JTE-952
CAS:<p>JTE-952: oral, selective Type II CSF-1R inhibitor, IC50 = 13 nM for CSF1R, 261 nM for TrkA, effective in mouse arthritis model.</p>Fórmula:C30H34N2O6Pureza:98%Forma y color:SolidPeso molecular:518.6CSF1R-IN-5
CAS:<p>CSF1R-IN-5: Potent CSF1R inhibitor, may alter TAM/glioma inflammatory exchanges, potential cancer research tool. (WO2021197276A1, Compound 11)</p>Fórmula:C22H19N7O3Forma y color:SolidPeso molecular:429.43
