HER

Tannic acid is a novel hERG channel blocker.

Terfenadine is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, …

Pyrotinib dimaleate is a potent and selective dual inhibitor of EGFR/HER2 with IC50s of 13 …

Epertinib hydrochloride shows potent antitumor activity. Epertinib hydrochloride is a potent, orally active, reversible, and …

PRN1008 is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 …

Cisapride is a serotonin type 4 (5-HT4) receptor agonists are potent prokinetic agents that act …

BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or …

AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG …

ARRY-380 is a potent and selective HER2 inhibitor.

TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and …

HER2/neu (654-662) GP2 acetate is derived from the human epidermal growth factor receptor 2 (HER2-Neu, …

Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: …

Tarloxotinib bromide is an irreversible inhibitor of EGFR/HER2.

Varlitinib is a potent, reversible, small molecule pan-EGFR inhibitor with IC50s of 7, 2, 4 …

CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 …

Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation …

AG-1557 is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).

Afatinib is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) …

Irbinitinib(ARRY-380; ONT-380) is a potent and selective HER2 inhibitor (IC50: 8 nM).

O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value …

SU5204, an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 …

AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor.

SNX-5422 is a synthetic, novel, small molecule Hsp90 Inhibitor. As an oral formulation that demonstrates …

Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: …

RG14620 is an epidermal growth factor receptor (EGFR) inhibitor.

AG-1557 is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).

Poziotinib(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).

SYR127063 (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive …

Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor …

Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to …

NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels …

Sophocarpine has anti-cancer, anti-inflammatory, anti-nociceptive, and antivirus activities, it can prevent implant loosening through inhibiting …

ICA-105574 is an activator of hERG that binds to the channel to remove inactivation, thus …

Sulfatinib (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and …

AZD7507 is a CSF-1R inhibitor with an IC50 of 32 nM. AZD7507 has antitumor activity.

Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5/0.4/10/14/1 nM for …

Endoxifen (EDX) is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity …

TAS0728 is a HER2 inhibitor, with antitumor activity

MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) …

Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channels …

BMS-599626 (AC480) is a selective inhibitor of HER1 and HER2 (IC50s: 20 nM and 30 …

PF-04929113 Mesylate, a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) …

NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of …

BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of …

1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting …

DZD9008 is a rationally designed selective, irreversible EGFR/HER2 inhibitor.

BMS-599626 Hydrochloride is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases …

VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 …

BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s …

Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen …

Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: …

BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 …