Tirosina quinasas
Los inhibidores de tirosina quinasa son una amplia clase de compuestos que inhiben las tirosina quinasas, enzimas responsables de la transferencia de un grupo fosfato a los residuos de tirosina en las proteínas, un paso crítico en la señalización celular. La desregulación de las tirosina quinasas está implicada en muchos tipos de cáncer y otras enfermedades. Estos inhibidores son herramientas esenciales en el estudio de las vías de señalización celular, la investigación del cáncer y el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa para apoyar su investigación en oncología, biología celular y desarrollo terapéutico.
Se han encontrado 25 productos de "Tirosina quinasas"
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Ilginatinib maleate
CAS:<p>Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.</p>Fórmula:C25H24FN7O4Pureza:99.74% - 99.82%Forma y color:SolidPeso molecular:505.5Delgocitinib
CAS:Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.Fórmula:C16H18N6OPureza:99.95%Forma y color:SolidPeso molecular:310.35Ref: TM-T15096
1mg169,00€5mg311,00€10mg487,00€25mg929,00€50mg1.415,00€100mg2.062,00€200mg2.775,00€1mL*10mM (DMSO)349,00€Ilginatinib
CAS:Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C21H20FN7Pureza:98.4% - 99.01%Forma y color:SolidPeso molecular:389.43Ref: TM-T12266
1mg64,00€5mg138,00€10mg187,00€25mg273,00€50mg393,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)133,00€SU 4981
CAS:SU 4981 is an inhibitor of VEGFR and a modulator of tyrosine kinase activity.Fórmula:C19H18N2O2Pureza:95.4%Forma y color:SoildPeso molecular:306.36Ref: TM-T60094
1mg89,00€5mg173,00€10mg259,00€25mg393,00€50mg552,00€100mg738,00€200mg979,00€1mL*10mM (DMSO)172,00€NVP-BSK805 2HCl (1092499-93-8(free base))
NVP-BSK805 2HCl (1092499-93-8(free base)) (BSK 805)(IC50=0.5 nM), a specific and effective ATP-competitive JAK2 inhibitor, is more than 20-fold specificity overFórmula:C27H28F2N6O·2HClPureza:99.13%Forma y color:SolidPeso molecular:563.47Ref: TM-T6294
1mg38,00€5mg104,00€10mg144,00€25mg259,00€50mg365,00€100mg523,00€200mg715,00€1mL*10mM (DMSO)227,00€SAR-20347
CAS:SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).Fórmula:C21H18ClFN4O4Pureza:98.99% - 99.77%Forma y color:SolidPeso molecular:444.84Ref: TM-T4210
1mg35,00€5mg80,00€10mg116,00€25mg227,00€50mg354,00€100mg588,00€200mg818,00€1mL*10mM (DMSO)88,00€Decernotinib
CAS:Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.Fórmula:C18H19F3N6OPureza:99.28% - >99.99%Forma y color:SolidPeso molecular:392.38Ref: TM-T2636
1mg35,00€2mg50,00€5mg74,00€10mg104,00€25mg207,00€50mg311,00€100mg472,00€1mL*10mM (DMSO)84,00€Baricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Fórmula:C16H17N7O2SPureza:99% - >99.99%Forma y color:SolidPeso molecular:371.42Ref: TM-T2485
5mg50,00€10mg73,00€25mg90,00€50mg115,00€100mg144,00€200mg188,00€500mg311,00€1mL*10mM (DMSO)69,00€Pyridone 6
CAS:Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).Fórmula:C18H16FN3OPureza:97.1% - 98.74%Forma y color:SolidPeso molecular:309.34Ref: TM-T3080
1mg52,00€2mg74,00€5mg111,00€10mg183,00€25mg378,00€50mg620,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)116,00€Ruxolitinib (S enantiomer)
CAS:Ruxolitinib S enantiomer (INCB18424) is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor.Fórmula:C17H18N6Pureza:99.37% - 99.79%Forma y color:SolidPeso molecular:306.36GLPG0634 analog
CAS:GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.Fórmula:C23H18N6O2Pureza:99.52% - >99.99%Forma y color:SolidPeso molecular:410.43Ref: TM-T3076
1mg40,00€2mg52,00€5mg88,00€10mg144,00€25mg264,00€50mg465,00€100mg658,00€500mg1.378,00€1mL*10mM (DMSO)87,00€Peficitinib
CAS:Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Fórmula:C18H22N4O2Pureza:98.67% - 99.4%Forma y color:SolidPeso molecular:326.39Ref: TM-T6933
2mg40,00€5mg66,00€10mg104,00€25mg182,00€50mg283,00€100mg439,00€200mg645,00€1mL*10mM (DMSO)73,00€BMS-911543
CAS:BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.Fórmula:C23H28N8OPureza:97.69% - 99.98%Forma y color:SolidPeso molecular:432.52RO495
CAS:<p>RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assays</p>Fórmula:C17H14Cl2N6OPureza:97.94%Forma y color:SolidPeso molecular:389.24Baricitinib phosphate
CAS:Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1/JAK2 inhibitor.Fórmula:C16H20N7O6PSPureza:99.4% - 99.91%Forma y color:SolidPeso molecular:469.41Ref: TM-T2360
5mg43,00€10mg56,00€25mg77,00€50mg87,00€100mg111,00€200mg165,00€500mg274,00€1mL*10mM (DMSO)48,00€ZAP-180013
CAS:<p>ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM).</p>Fórmula:C19H17Cl2N3O4SPureza:98.89%Forma y color:SolidPeso molecular:454.33CZC-8004
CAS:<p>CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.</p>Fórmula:C17H16FN5Pureza:99.29%Forma y color:SolidPeso molecular:309.34Oclacitinib maleate
CAS:Oclacitinib maleate is a selective JAK inhibitor (IC50: 10-99 nM; JAK1 cytokines: 36-249 nM), with no effect on 38 non-JAK kinases.Fórmula:C15H23N5O2S·C4H4O4Pureza:99.17% - 99.92%Forma y color:SolidPeso molecular:453.51Ref: TM-T6914
1mg39,00€2mg50,00€5mg79,00€10mg99,00€25mg170,00€50mg271,00€100mg457,00€1mL*10mM (DMSO)86,00€NVP-BSK805
CAS:NVP-BSK805 (BSK 805) is an ATP-competitive JAK2 inhibitor.Fórmula:C27H28F2N6OPureza:98%Forma y color:SolidPeso molecular:490.55JAK-IN-21
CAS:JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.Fórmula:C19H16N8OPureza:99.87%Forma y color:SolidPeso molecular:372.38
