Tirosina quinasas
Los inhibidores de tirosina quinasa son una amplia clase de compuestos que inhiben las tirosina quinasas, enzimas responsables de la transferencia de un grupo fosfato a los residuos de tirosina en las proteínas, un paso crítico en la señalización celular. La desregulación de las tirosina quinasas está implicada en muchos tipos de cáncer y otras enfermedades. Estos inhibidores son herramientas esenciales en el estudio de las vías de señalización celular, la investigación del cáncer y el desarrollo de terapias dirigidas. En CymitQuimica, ofrecemos una amplia gama de inhibidores de tirosina quinasa para apoyar su investigación en oncología, biología celular y desarrollo terapéutico.
Se han encontrado 13 productos de "Tirosina quinasas"
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Ilginatinib maleate
CAS:Ilginatinib maleate (NS-018 maleate) is a highly active and orally bioavailable inhibitor of JAK2.
Fórmula:C25H24FN7O4Pureza:99.74% - 99.82%Forma y color:SolidPeso molecular:505.5Delgocitinib
CAS:Delgocitinib is a potent JAK inhibitor (IC50: 2.8-58 nM), treats inflammatory diseases, and is the first topical drug for atopic dermatitis.Fórmula:C16H18N6OPureza:99.95%Forma y color:SolidPeso molecular:310.35Ref: TM-T15096
1mg169,00€5mg311,00€10mg487,00€25mg929,00€50mg1.415,00€100mg2.062,00€200mg2.775,00€1mL*10mM (DMSO)349,00€Ilginatinib
CAS:Ilginatinib (NS-018) is a highly active and orally bioavailable inhibitor of JAK2.Fórmula:C21H20FN7Pureza:98.4% - 99.01%Forma y color:SolidPeso molecular:389.43Ref: TM-T12266
1mg64,00€5mg138,00€10mg187,00€25mg273,00€50mg393,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)133,00€SU 4981
CAS:SU 4981 is an inhibitor of VEGFR and a modulator of tyrosine kinase activity.Fórmula:C19H18N2O2Pureza:95.4%Forma y color:SoildPeso molecular:306.36Ref: TM-T60094
1mg85,00€5mg170,00€10mg245,00€25mg371,00€50mg522,00€100mg700,00€200mg928,00€1mL*10mM (DMSO)169,00€SAR-20347
CAS:SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).Fórmula:C21H18ClFN4O4Pureza:98.99% - 99.77%Forma y color:SolidPeso molecular:444.84Ref: TM-T4210
1mg35,00€5mg80,00€10mg116,00€25mg227,00€50mg354,00€100mg588,00€200mg818,00€1mL*10mM (DMSO)88,00€CZC-8004
CAS:CZC-8004 (CZC-00008004) is a pan-kinase(ABL kinase) inhibitor and binds a range of tyrosine kinases.
Fórmula:C17H16FN5Pureza:99.29%Forma y color:SolidPeso molecular:309.34BMS-911543
CAS:BMS-911543 is a potent and selective inhibitor of JAK2 with IC50 of 1.1 nM, ~350-, 75- and 65-fold selective to JAK1, JAK3 and TYK2, respectively. Phase 1/2.Fórmula:C23H28N8OPureza:97.69% - 99.98%Forma y color:SolidPeso molecular:432.52ZAP-180013
CAS:ZAP-180013 is an inhibitor of zeta-chain-associated protein kinase 70 (ZAP70,IC50 : 1.8 μM).
Fórmula:C19H17Cl2N3O4SPureza:98.89%Forma y color:SolidPeso molecular:454.33GSK-2250665A
CAS:GSK-2250665A is an (Itk) inhibitor (pKi 9.2) with selectivity over Aurora B and Btk, inhibiting IFNγ in PBMCs for T-cell signaling studies.Fórmula:C26H29N5OSPureza:99.38%Forma y color:SolidPeso molecular:459.61Ropsacitinib
CAS:Ropsacitinib (PF-06826647) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain (IC50: 17 nM).Fórmula:C20H17N9Pureza:99.87%Forma y color:SolidPeso molecular:383.41ITK inhibitor 2
CAS:ITK inhibitor 2 (compound 4) is a potent and selective ITK inhibitor with an IC50= 2 nM.Fórmula:C25H33N5O2Pureza:99.67%Forma y color:SolidPeso molecular:435.56TTK inhibitor 3
CAS:TTK inhibitor 3, Selective TTK inhibitor (IC50=3.0 nM), inhibits tumor growth in CAL-51 xenografts and TNBC PDX models.Fórmula:C42H49N9O3Pureza:99.44%Forma y color:SolidPeso molecular:727.9Vecabrutinib
CAS:Vecabrutinib (SNS-062) is a potent and noncovalent BTK and ITK inhibitor (Kd: 0.3 nM and 2.2 nM, respectively). Vecabrutinib displays an IC50 of 24 nM for ITK.
Fórmula:C22H24ClF4N7O2Pureza:99.74%Forma y color:SolidPeso molecular:529.92
