Receptor TAM
Los inhibidores de los receptores TAM están dirigidos a la familia de receptores tirosina quinasa TAM, que incluye Tyro3, Axl y Mer. Estos receptores están involucrados en la regulación de las respuestas inmunitarias, la supervivencia celular y la eliminación de células apoptóticas. La desregulación de los receptores TAM está implicada en el cáncer, enfermedades autoinmunes e inflamación crónica. En CymitQuimica, ofrecemos inhibidores de los receptores TAM para apoyar su investigación en inmunología, oncología e inflamación.
Se han encontrado 32 productos de "Receptor TAM"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
XL092
CAS:<p>XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.</p>Fórmula:C29H25FN4O5Pureza:98.60%Forma y color:SolidPeso molecular:528.53Cabozantinib
CAS:<p>Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).</p>Fórmula:C28H24FN3O5Pureza:99.68% - 99.88%Forma y color:SolidPeso molecular:501.51Cabozantinib hydrochloride
CAS:<p>Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6</p>Fórmula:C28H25ClFN3O5Pureza:99.97%Forma y color:SolidPeso molecular:537.96UNC2250
CAS:<p>UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).</p>Fórmula:C24H36N6O2Pureza:98.57% - 99.87%Forma y color:SolidPeso molecular:440.58DS-1205
CAS:<p>DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.</p>Fórmula:C41H42FN5O7Pureza:99.75%Forma y color:SolidPeso molecular:735.8Dubermatinib
CAS:<p>Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.</p>Fórmula:C24H30ClN7O2SPureza:98.65% - 99.58%Forma y color:SolidPeso molecular:516.06RU-302
CAS:<p>RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain.</p>Fórmula:C24H24F3N3O2SPureza:99.84%Forma y color:SolidPeso molecular:475.53R916562
CAS:<p>R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.</p>Fórmula:C26H30ClN9SPureza:98%Forma y color:SolidPeso molecular:536.09AXL-IN-14
CAS:<p>AXL-IN-14: orally active, potent AXL inhibitor (IC50=0.8 nM); hinders Gas6/AXL migration, invasion; lowers p-AXL, p-AKT; anti-tumor.</p>Fórmula:C32H24F2N4O4Pureza:98%Forma y color:SolidPeso molecular:566.55AXL-IN-15
CAS:<p>AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1</p>Fórmula:C26H32F3N9O3Pureza:98%Forma y color:SolidPeso molecular:575.59MerTK-IN-1
CAS:<p>MerTK-IN-1 (compound 31) serves as an inhibitor of MerTK, with the capability to bind to the target in vivo.</p>Fórmula:C23H26N8O4Forma y color:SolidPeso molecular:478.50MerTK/Axl-IN-1
CAS:<p>MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.</p>Fórmula:C40H47FN6O4Forma y color:SolidPeso molecular:694.84
