c-Kit
Los inhibidores de c-Kit son compuestos que bloquean la actividad del Receptor del Factor de Células Madre (c-Kit), una tirosina quinasa que desempeña un papel crucial en la supervivencia, proliferación y diferenciación celular, particularmente en células hematopoyéticas. Las mutaciones en c-Kit están vinculadas a varios tipos de cáncer, incluidos los tumores del estroma gastrointestinal (GIST) y la leucemia. En CymitQuimica, ofrecemos inhibidores de c-Kit para apoyar su investigación en oncología, hematología y biología de células madre.
Se han encontrado 117 productos de "c-Kit"
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Tandutinib
CAS:Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3Fórmula:C31H42N6O4Pureza:99.45% - ≥98%Forma y color:White SolidPeso molecular:562.7Vimseltinib
CAS:Vimseltinib (DCC-3014) is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM).Fórmula:C23H25N7O2Pureza:99.05% - 99.57%Forma y color:SolidPeso molecular:431.49Ref: TM-T10652
1mg87,00€5mg178,00€10mg295,00€25mg505,00€50mg690,00€100mg888,00€1mL*10mM (DMSO)203,00€SKLB4771
CAS:SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor.Fórmula:C25H27N7O3S2Pureza:98% - >99.99%Forma y color:SolidPeso molecular:537.66Ref: TM-T2051
1mg63,00€2mg93,00€5mg124,00€10mg177,00€25mg371,00€50mg557,00€100mg792,00€500mg1.611,00€1mL*10mM (DMSO)148,00€AZD3229
CAS:AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors.Fórmula:C24H26FN7O3Pureza:98.83%Forma y color:SolidPeso molecular:479.51Ref: TM-T5409
1mg44,00€5mg87,00€10mg140,00€25mg248,00€50mg364,00€100mg509,00€200mg698,00€1mL*10mM (DMSO)99,00€c-Kit-IN-1
CAS:c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).Fórmula:C26H21F2N5O3Pureza:98.72% - 98.73%Forma y color:SolidPeso molecular:489.47Ref: TM-T4332
1mg39,00€5mg81,00€10mg120,00€25mg235,00€50mg373,00€100mg610,00€200mg840,00€1mL*10mM (DMSO)88,00€Imatinib
CAS:Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kitFórmula:C29H31N7OPureza:99.42% - 99.94%Forma y color:Off White PowderPeso molecular:493.6Telatinib
CAS:Telatinib (Bay 57-9352) inhibits VEGFR2/3, c-Kit, PDGFRα with IC50s: 6 nM, 4 nM, 1 nM, 15 nM.Fórmula:C20H16ClN5O3Pureza:97.61% - 99.81%Forma y color:SolidPeso molecular:409.83Linifanib
CAS:Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) andFórmula:C21H18FN5OPureza:98% - 98.24%Forma y color:SolidPeso molecular:375.4Ref: TM-T2514
5mg48,00€10mg80,00€25mg119,00€50mg178,00€100mg259,00€200mg477,00€500mg772,00€1mL*10mM (DMSO)50,00€GW786034B
CAS:Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.Fórmula:C21H23N7O2S·HClPureza:99.87%Forma y color:SolidPeso molecular:473.98N-Desethylsunitinib hydrochloride
CAS:N-Desethylsunitinib HCl, active sunitinib metabolite, inhibits VEGFR, PDGFRβ, KIT.Fórmula:C20H24ClFN4O2Pureza:99.42%Forma y color:SolidPeso molecular:406.88JNK-IN-8
CAS:JNK-IN-8 (JNK Inhibitor XVI) is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM).Fórmula:C29H29N7O2Pureza:99.24% - >99.99%Forma y color:SolidPeso molecular:507.59Ref: TM-T2668
2mg47,00€5mg77,00€10mg119,00€25mg207,00€50mg344,00€100mg510,00€200mg722,00€1mL*10mM (DMSO)87,00€CP-673451
CAS:CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than otherFórmula:C24H27N5O2Pureza:99.62% - 99.88%Forma y color:SolidPeso molecular:417.5Ref: TM-T6091
1mg49,00€2mg63,00€5mg90,00€10mg170,00€25mg334,00€50mg512,00€100mg737,00€500mg1.521,00€1mL*10mM (DMSO)108,00€KI8751
CAS:KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.Fórmula:C24H18F3N3O4Pureza:99.22% - 99.9%Forma y color:SolidPeso molecular:469.41Ref: TM-T2446
2mg34,00€5mg50,00€10mg81,00€25mg147,00€50mg279,00€100mg447,00€200mg635,00€1mL*10mM (DMSO)52,00€GNF-5837
CAS:GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).Fórmula:C28H21F4N5O2Pureza:97.26% - 98.08%Forma y color:SolidPeso molecular:535.49Ref: TM-T6097
5mg48,00€10mg80,00€25mg117,00€50mg178,00€100mg295,00€200mg384,00€500mg622,00€1mL*10mM (DMSO)52,00€Motesanib
CAS:Motesanib (AMG 706) orally blocks VEGFR, PDGFR, Kit, Ret; curbing angiogenesis and cancer cell growth.Fórmula:C22H23N5OPureza:98% - 99.09%Forma y color:SolidPeso molecular:373.45Ref: TM-T2288
5mg34,00€10mg49,00€25mg81,00€50mg114,00€100mg160,00€200mg230,00€500mg389,00€1mL*10mM (DMSO)39,00€Gilteritinib
CAS:Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM,Fórmula:C29H44N8O3Pureza:97.75% - 99.90%Forma y color:SolidPeso molecular:552.71Ref: TM-T4409
1g1.288,00€1mg38,00€2mg52,00€5mg85,00€10mg114,00€25mg177,00€50mg261,00€100mg411,00€500mg954,00€Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFórmula:C21H15ClF4N4O3Pureza:98% - 99.95%Forma y color:SolidPeso molecular:482.82Ref: TM-T1792
5mg34,00€10mg49,00€25mg75,00€50mg90,00€100mg137,00€200mg175,00€500mg294,00€1mL*10mM (DMSO)54,00€Lenvatinib mesylate
CAS:Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.Fórmula:C22H23ClN4O7SPureza:99.03% - 99.79%Forma y color:SolidPeso molecular:522.96Tyrphostin AG1296
CAS:Tyrphostin AG1296 (Tyrphostin AG 1296) is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR.Fórmula:C16H14N2O2Pureza:99.94% - >99.99%Forma y color:SolidPeso molecular:266.29Ref: TM-T6711
2mg40,00€5mg58,00€10mg90,00€25mg180,00€50mg279,00€100mg411,00€200mg585,00€1mL*10mM (DMSO)81,00€Dovitinib lactate hydrate
CAS:Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).Fórmula:C24H27FN6O4Pureza:99.82%Forma y color:SolidPeso molecular:482.51
