IGF-1R
Los inhibidores de IGF-1R son compuestos que se dirigen específicamente al receptor de factor de crecimiento similar a la insulina tipo 1 (IGF-1R), una tirosina quinasa receptora involucrada en el crecimiento, desarrollo y supervivencia celular. La señalización de IGF-1R juega un papel significativo en la progresión del cáncer, lo que hace que estos inhibidores sean valiosos en la investigación oncológica. En CymitQuimica, ofrecemos inhibidores de IGF-1R para apoyar su investigación en biología del cáncer, endocrinología y desarrollo de terapias dirigidas.
Se han encontrado 86 productos de "IGF-1R"
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NVP-TAE 226
CAS:<p>NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.</p>Fórmula:C23H25ClN6O3Pureza:98.07% - 98.78%Forma y color:SolidPeso molecular:468.94MAZ51
CAS:<p>MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.</p>Fórmula:C21H18N2OPureza:98.53%Forma y color:SolidPeso molecular:314.38XL228
CAS:<p>XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).</p>Fórmula:C22H31N9OPureza:99.07%Forma y color:SolidPeso molecular:437.54Ceritinib dihydrochloride
CAS:<p>Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.</p>Fórmula:C28H38Cl3N5O3SPureza:99.85% - 99.99%Forma y color:SolidPeso molecular:631.06NT157
CAS:<p>NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.</p>Fórmula:C16H14BrNO5SPureza:99.64%Forma y color:SolidPeso molecular:412.26Ginsenoside Rg5
CAS:<p>Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.</p>Fórmula:C42H70O12Pureza:98% - 99.65%Forma y color:SolidPeso molecular:767Insulin(cattle)
CAS:<p>Insulin(cattle) is a peptide hormone that promotes glycogen synthesis. Insulin) has hypoglycemic activity. Cost-effective and quality-assured.</p>Fórmula:C254H377N65O75S6Pureza:98%Forma y color:SolidPeso molecular:5733.49GSK1838705A
CAS:<p>GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.</p>Fórmula:C27H29FN8O3Pureza:98.89% - >99.99%Forma y color:SolidPeso molecular:532.57AZ7550
CAS:<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Fórmula:C27H31N7O2Pureza:97.07% - 99.75%Forma y color:SolidPeso molecular:485.58NVP-ADW742
CAS:<p>NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl</p>Fórmula:C28H31N5OPureza:96.14% - 98.70%Forma y color:SolidPeso molecular:453.58NBI-31772 hydrate
<p>NBI-31772 hydrate blocks IGF and IGFBPs binding, freeing IGF-I with Ki 1-24 nM; it has anxiolytic and antidepressant effects.</p>Fórmula:C17H13NO8Forma y color:SolidPeso molecular:372.82Linsitinib
CAS:<p>OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.</p>Fórmula:C26H23N5OPureza:99.71% - ≥95%Forma y color:SolidPeso molecular:421.49AZD-3463
CAS:<p>AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.</p>Fórmula:C24H25ClN6OPureza:99.13%Forma y color:SolidPeso molecular:448.95BRD7552
CAS:<p>BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.</p>Fórmula:C33H33N3O15Pureza:>99.99% - ≥98%Forma y color:SolidPeso molecular:711.63PQ401 hydrochloride (196868-63-0(free base))
<p>PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.</p>Fórmula:C18H17Cl2N3O2Pureza:99.86%Forma y color:SolidPeso molecular:378.25MSDC 0160
CAS:<p>MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.</p>Fórmula:C19H18N2O4SPureza:98.11% - 99.53%Forma y color:SolidPeso molecular:370.42Indirubin Derivative E804
CAS:<p>Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.</p>Fórmula:C20H19N3O4Pureza:98.54%Forma y color:SolidPeso molecular:365.38GSK1904529A
CAS:<p>GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .</p>Fórmula:C44H47F2N9O5SPureza:98.2% - 99.38%Forma y color:SolidPeso molecular:851.96Dusigitumab
CAS:<p>Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.</p>Pureza:95% - 95%Forma y color:LiquidFigitumumab
CAS:<p>Figitumumab is a potent anti-IGF1R mAb (IC50=1.8 nM) showing promise in advanced lung squamous cell carcinoma.</p>Pureza:95%Forma y color:LiquidVeligrotug
CAS:<p>Veligrotug is an IV anti-IGF-1R antibody for thyroid eye disease, reducing diplopia and orbital inflammation, supporting autoimmune ophthalmopathy research.</p>Pureza:95% - 95%Forma y color:LiquidAnti-IGFBP2 Antibody (M14)
<p>Anti-IGFBP2 Antibody (M14) is a human monoclonal antibody inhibitor that binds with high affinity to IGFBP2 and prevents its interaction with IGF1. Additionally, Anti-IGFBP2 Antibody (M14) can inhibit the recruitment of human endothelial cells, thereby obstructing tumor progression in human metastatic cancers.</p>Forma y color:Odour LiquidS961
CAS:<p>S961: High-affinity IR antagonist; IC50: HIR-A 0.048 nM, HIR-B 0.027 nM, HIGF-IR 630 nM.</p>Fórmula:C211H297N55O71S2Pureza:98%Forma y color:SolidPeso molecular:4804.13BMS-754807
CAS:<p>BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.</p>Fórmula:C23H24FN9OPureza:99.69% - 99.94%Forma y color:SolidPeso molecular:461.49D-(+)-Sorbose
CAS:<p>D-(+)-Sorbose, an enantiomer inhibiting disaccharidase, lowers glucose and insulin post-meal in rats, possibly preventing diabetes.</p>Fórmula:C6H12O6Forma y color:SolidPeso molecular:180.16BM-131246
CAS:<p>BM-131246 is an orally available and antidiabetic active thiazolidinedione derivative for the study of diabetes.</p>Fórmula:C22H20N2O4SPureza:>99.99%Forma y color:SolidPeso molecular:408.47AZ12253801
CAS:<p>AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.</p>Fórmula:C21H22N8OPureza:98%Forma y color:SolidPeso molecular:402.45KU14R
CAS:<p>KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.</p>Fórmula:C13H14N2OPureza:98%Forma y color:White SolidPeso molecular:214.26I-OMe-Tyrphostin AG 538
CAS:<p>I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.</p>Fórmula:C17H12INO5Pureza:98.23%Forma y color:SolidPeso molecular:437.19Protonstatin-1
CAS:<p>Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.</p>Fórmula:C8H5NO2S2Pureza:99.77%Forma y color:SolidPeso molecular:211.26NT219
CAS:<p>NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.</p>Fórmula:C16H14BrNO5SPureza:98.06% - 99.72%Forma y color:SolidPeso molecular:412.26BMS-695735
CAS:<p>BMS-695735: benzimidazole, inhibits IGF-1 receptor, broad antitumor effects, affects CYP3A4, low solubility, binds plasma proteins.</p>Fórmula:C26H31ClFN7OForma y color:SolidPeso molecular:512.02Tyrphostin AG 538
CAS:<p>Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.</p>Fórmula:C16H11NO5Pureza:98.75%Forma y color:SoildPeso molecular:297.26CL-A3-7
CAS:<p>CL-A3-7 is a viral-cell fusion inhibitor targeting the RSVF protein. It functions by blocking the interaction between the virus and the host's IGF1R, effectively inhibiting the infection of both wild-type and K394R mutant strains of RSV. This compound is suitable for use in antiviral drug development and resistance studies related to RSV.</p>Fórmula:C24H22Br2F2N2O3Forma y color:SolidPeso molecular:584.25IGF-1R inhibitor-4
CAS:<p>IGF-1Rinhibitor-4 (compound 22) is a potent inhibitor of IGF-1R, demonstrating an inhibition rate of 63% at a concentration of 10 μM. This compound plays a significant role in cancer research.</p>Fórmula:C13H15ClN4OForma y color:SolidPeso molecular:278.737AGL-2263
CAS:<p>AGL-2263 is a blocker of insulin receptor (IR)</p>Fórmula:C17H10N2O5Forma y color:SolidPeso molecular:322.27
