IGF-1R
Los inhibidores de IGF-1R son compuestos que se dirigen específicamente al receptor de factor de crecimiento similar a la insulina tipo 1 (IGF-1R), una tirosina quinasa receptora involucrada en el crecimiento, desarrollo y supervivencia celular. La señalización de IGF-1R juega un papel significativo en la progresión del cáncer, lo que hace que estos inhibidores sean valiosos en la investigación oncológica. En CymitQuimica, ofrecemos inhibidores de IGF-1R para apoyar su investigación en biología del cáncer, endocrinología y desarrollo de terapias dirigidas.
Se han encontrado 103 productos de "IGF-1R"
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GIP (1-30) amide, porcine TFA
GIP (1-30) amide, porcine TFA: a full GIP receptor agonist, similar to natural GIP(1-42), stimulates insulin, mildly inhibits gastric acid.Forma y color:LiquidOI338
OI338 is an orally available, ultralong-acting insulin analogue.Fórmula:C260H403N65O84S6Forma y color:SolidPeso molecular:5971.76Gastric Inhibitory Peptide (1-42) (porcine) TFA
Gastric Inhibitory Peptide (1-42) (porcine) TFA is a glucose-dependent insulinotropic polypeptide released by intestinal K-cells.Fórmula:C225H342N60O66S·XCF3COOHForma y color:SolidPeso molecular:4975.55LDD39
LDD39, a PROTAC targeting the degradation of RET protein, effectively and persistently degrades total RET (tRET) protein in vivo and inhibits phosphorylated RET (pRET) signaling.Fórmula:C55H59F2N11O6Forma y color:SolidPeso molecular:1008.12[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)
CAS:Insulin Receptor (1142-1153) binds insulin, is a substrate for its kinase, and has research/medical potential.Fórmula:C72H110N19O33P3Pureza:98%Forma y color:SolidPeso molecular:1862.67IGF-I (24-41)
CAS:IGF-I (24-41) is a fragment of IGF-I, affecting GH activities with anabolic, antioxidant, anti-inflammatory, and cytoprotective properties.Fórmula:C88H133N27O28Pureza:98%Forma y color:SolidPeso molecular:2017.16[D-Ala2]-GIP (human)
CAS:Potent GIP receptor agonist with 630 pM EC50; enhances cAMP, glucose control, insulin, cognition in diabetic/obese animals; neuroprotective in PD model.Fórmula:C226H338N60O66SPureza:98%Forma y color:SolidPeso molecular:4983.58Teprotumumab
CAS:Teprotumumab: human antibody, inhibits IGF-1R, used for thyroid eye diseases.
Pureza:SDS-PAGE:95.2%;SEC-HPLC:99.6%Forma y color:LiquidPeso molecular:145.62 kDacis-NVP-ADW742
CAS:NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.Fórmula:C28H31N5OForma y color:SolidPeso molecular:453.59DA-JC4
CAS:DA-JC4: dual GLP-1/GIP agonist, for neurological disease research and insulin pathway studies.Fórmula:C225H346N56O65Forma y color:SolidPeso molecular:4875.49TLK19781
CAS:TLK19781 is an insulin receptor modulator.Fórmula:C33H24Cl2N4O13S4Pureza:98%Forma y color:SolidPeso molecular:883.73GIP, human
CAS:Insulinotropic hormone from K-cells, binds GIP receptors, boosts insulin, affects lipids, and has antiapoptotic properties.
Fórmula:C226H338N60O66SPureza:98%Forma y color:SolidPeso molecular:4983.6WAY-270250
CAS:WAY-270250 is an IGF-1R/SRC inhibitor.Fórmula:C18H16N2O2Pureza:99.97%Forma y color:SoildPeso molecular:292.33NBI-31772
CAS:NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).Fórmula:C17H11NO7Pureza:99.79%Forma y color:SolidPeso molecular:341.27Macupatide
CAS:Macupatide is a gastric inhibitory polypeptide (GIP) receptor agonist, utilized in research related to antidiabetic applications.Forma y color:SolidZIGIR
ZIGIR enables insulin-based sorting of pure alpha and beta cells, revealing zinc(II) in human delta cell granules.Fórmula:C39H40N6O3Pureza:98.34% - 99.32%Forma y color:SolidPeso molecular:640.77TAK-778
CAS:TAK-778, a derivative of ipriflavone, demonstrates the ability to stimulate bone growth in both in vitro and in vivo models.Fórmula:C24H28NO7PSPureza:98%Forma y color:SolidPeso molecular:505.52Acetyl Gastric Inhibitory Peptide (human)
CAS:Acetyl Gastric Inhibitory Peptide: improved insulinotropic, antihyperglycemic, for diabetes/obesity research.Fórmula:C228H340N60O67SForma y color:SolidPeso molecular:5025.6GIP (1-30) amide,human
CAS:GIP (1-30) amide (Human) is a glucose-dependent insulinotropic polypeptide that stimulates insulin secretion, reducing postprandial glycemic issues.Fórmula:C162H240N40O47SPureza:98%Forma y color:SolidPeso molecular:3531.94IGF-1R inhibitor-2
CAS:IGF-1R inhibitor-2 blocks the insulin-like growth factor-1 receptor, potentially reversing tumor cell transformation and increasing apoptosis susceptibility.Fórmula:C24H24FN7O2Forma y color:SolidPeso molecular:461.501
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