Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Se han encontrado 107 productos de "Ubiquitinación"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
IU1-47
CAS:<p>IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。</p>Fórmula:C19H23ClN2OPureza:98.94%Forma y color:SolidPeso molecular:330.85HBX 19818
CAS:<p>HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).</p>Fórmula:C25H28ClN3OPureza:97.71%Forma y color:SolidPeso molecular:421.96TAS4464 hydrochloride
CAS:<p>TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).</p>Fórmula:C21H24ClFN6O6SPureza:98.61% - 98.96%Forma y color:SolidPeso molecular:542.97ML-792
CAS:<p>ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.</p>Fórmula:C21H23BrN6O5SPureza:99.32% - 99.82%Forma y color:SolidPeso molecular:551.41WS-383
CAS:<p>WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).</p>Fórmula:C18H21Cl2N9S2Pureza:98.46%Forma y color:SolidPeso molecular:498.46C527
CAS:<p>C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).</p>Fórmula:C17H8FNO3Pureza:97.22%Forma y color:SolidPeso molecular:293.25NSC232003
CAS:<p>NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.</p>Fórmula:C6H7N3O3Pureza:97.72%Forma y color:SolidPeso molecular:169.14MF-094
CAS:<p>MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.</p>Fórmula:C30H37N3O4SPureza:99.93%Forma y color:SolidPeso molecular:535.7UP158
CAS:<p>UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.</p>Fórmula:C17H17ClN4O2Forma y color:SolidPeso molecular:344.8NSC819701
<p>NSC819701 is a triazole-based inhibitor of p97ATPase. It inhibits the activity of p97ATPase by binding to specific sites on p97.</p>Fórmula:C30H32F2N8O3SForma y color:SolidPeso molecular:622.69Ubiquitination Compound Library
<p>A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；</p>Forma y color:Odour SoliddCeMM3
CAS:<p>dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.</p>Fórmula:C14H11ClN4OSPureza:98.48% - 99.41%Forma y color:SolidPeso molecular:318.78UP163
CAS:<p>UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.</p>Fórmula:C20H15ClN2O5SForma y color:SolidPeso molecular:430.86Post-Translational Modification Compound Library
<p>Contains xnum active small molecules for research related to post-translational modifications (PTMs);</p>Forma y color:Odour SolidSkp2 inhibitor 3
<p>Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.</p>Forma y color:Odour SolidUP12
CAS:<p>UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.</p>Fórmula:C23H16ClN3O3SForma y color:SolidPeso molecular:449.91USP8-IN-2
CAS:<p>USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.</p>Fórmula:C19H20ClF3N4OSPureza:99.92%Forma y color:SolidPeso molecular:444.9USP8-IN-3
CAS:<p>USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.</p>Fórmula:C18H18F3N5O2SPureza:99.79%Forma y color:SolidPeso molecular:425.43E3 ligase Ligand 36
CAS:<p>E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM/BRG1 degrader-1.</p>Fórmula:C25H30N4O5SForma y color:SolidPeso molecular:498.6BIO-2007817
<p>BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. This compound enhances the activity of wild-type Parkin, stimulates Parkin's autoubiquitination, and induces the appearance of mono-ubiquitinated forms of Miro1 (a Parkin substrate) with an EC50 of 0.17 μM.</p>Fórmula:C32H36N6O3Forma y color:SolidPeso molecular:552.67E3 ligase Ligand 41
CAS:<p>E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.</p>Fórmula:C13H12ClF3N2O4Forma y color:SolidPeso molecular:352.69OTUB1/USP8-IN-1 HCl
<p>OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemia</p>Fórmula:C22H17Cl2FN2O4Pureza:99.92%Forma y color:SolidPeso molecular:463.29OTUB2-IN-1
<p>OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).</p>Fórmula:C19H18N2O6S2Pureza:98.19%Forma y color:SolidPeso molecular:434.49RNF5 agonist 1
CAS:<p>RNF5 agonist 1 (analog-1), a structural analog of the RNF5 inhibitor inh-02, is a potent RNF5 agonist. In CFBE41o- cells expressing F508del-CFTR, RNF5 agonist 1 enhances the ubiquitination of ATG4B.</p>Fórmula:C22H18N4SForma y color:SolidPeso molecular:370.47USP8-IN-1
CAS:<p>USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].</p>Fórmula:C18H21N5O3SPureza:99.07%Forma y color:SoildPeso molecular:387.46STD1T
CAS:<p>STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.</p>Fórmula:C19H19N3O4S2Pureza:98.77%Forma y color:SolidPeso molecular:417.5MSC1094308
CAS:<p>MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.</p>Fórmula:C29H29F3N2Forma y color:SolidPeso molecular:462.55P005091
CAS:<p>P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.</p>Fórmula:C12H7Cl2NO3S2Pureza:99.53% - 99.87%Forma y color:SolidPeso molecular:348.22XL177A
CAS:<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>Fórmula:C48H57ClN8O5Pureza:98.75%Forma y color:SolidPeso molecular:861.47USP25/28 inhibitor AZ1
CAS:<p>USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.</p>Fórmula:C17H16BrF4NO2Pureza:99.79% - 99.79%Forma y color:SolidPeso molecular:422.21ML241
CAS:<p>ML241 is a potent and selective inhibitors of p97 ATPase.</p>Fórmula:C23H24N4OPureza:98%Forma y color:SolidPeso molecular:372.46TCID
CAS:<p>TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.</p>Fórmula:C9H2Cl4O2Pureza:99.34%Forma y color:SolidPeso molecular:283.92GS143
CAS:<p>GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.</p>Fórmula:C28H19FN2O4Pureza:97.67%Forma y color:SolidPeso molecular:466.46COH000
CAS:<p>COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).</p>Fórmula:C25H25NO5Pureza:99.23%Forma y color:SolidPeso molecular:419.47DKM 2-93
CAS:<p>DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).</p>Fórmula:C11H14ClNO3Pureza:98.37%Forma y color:SolidPeso molecular:243.69GNE-6776
CAS:<p>GNE-6776 is a selective USP7 inhibitor.</p>Fórmula:C20H20N4O2Pureza:96.59% - 98.2%Forma y color:SolidPeso molecular:348.4ICCB-19 hydrochloride
CAS:<p>ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.</p>Fórmula:C12H22ClN3OSPureza:99.3%Forma y color:SolidPeso molecular:291.84DUB-IN-3
CAS:<p>DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.</p>Fórmula:C16H9N5OPureza:99.34%Forma y color:SolidPeso molecular:287.28ML241 hydrochloride
CAS:<p>ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-</p>Fórmula:C23H25ClN4OPureza:99.91% - 99.96%Forma y color:SolidPeso molecular:408.92P 22077
CAS:<p>P 22077 (P22077) is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.</p>Fórmula:C12H7F2NO3S2Pureza:97.9% - 99.58%Forma y color:SolidPeso molecular:315.32ML240
CAS:<p>ML240 is a selective, ATP-competitive p97 inhibitor.</p>Fórmula:C23H20N6OPureza:99.73% - >99.99%Forma y color:SolidPeso molecular:396.44MID-1
CAS:<p>MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.</p>Fórmula:C12H11N3O4SPureza:99.39%Forma y color:SolidPeso molecular:293.3USP7/USP47 inhibitor
CAS:<p>USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,</p>Fórmula:C18H11Cl2N3O3S3Pureza:98.5% - 98.71%Forma y color:SolidPeso molecular:484.4WSB1 Degrader 1
CAS:<p>WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.</p>Fórmula:C21H22N2O2Pureza:98.57%Forma y color:SolidPeso molecular:334.41VLX1570
CAS:<p>VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.</p>Fórmula:C23H17F2N3O6Pureza:98.53% - 99.91%Forma y color:SolidPeso molecular:469.39ML-323
CAS:<p>ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.</p>Fórmula:C23H24N6Pureza:99.87% - 99.96%Forma y color:SolidPeso molecular:384.48NMS-873
CAS:<p>NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.</p>Fórmula:C27H28N4O3S2Pureza:99.05% - 99.85%Forma y color:SolidPeso molecular:520.67PR-619
CAS:<p>PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.</p>Fórmula:C7H5N5S2Pureza:97.25% - >99.99%Forma y color:SolidPeso molecular:223.282-D08
CAS:<p>2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.</p>Fórmula:C15H10O5Pureza:98.58% - 98.95%Forma y color:SolidPeso molecular:270.24DUB-IN-1
CAS:<p>DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).</p>Fórmula:C20H11N5OPureza:98.33% - 98.96%Forma y color:SolidPeso molecular:337.33CB-5083
CAS:<p>CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).</p>Fórmula:C24H23N5O2Pureza:95.95% - 99.92%Forma y color:SolidPeso molecular:413.47Skp2 Inhibitor C1
CAS:<p>Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.</p>Fórmula:C18H13BrN2O4S2Pureza:97.36%Forma y color:SolidPeso molecular:465.34ML364
CAS:<p>ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.</p>Fórmula:C24H18F3N3O3S2Pureza:99.35% - >99.99%Forma y color:SolidPeso molecular:517.54BC-1382
CAS:<p>BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).</p>Fórmula:C23H29N3O5SPureza:99.15% - 99.94%Forma y color:SolidPeso molecular:459.56NSC632839
CAS:<p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>Fórmula:C21H22ClNOPureza:99.74% - 99.88%Forma y color:SolidPeso molecular:339.86SJB2-043
CAS:<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Fórmula:C17H9NO3Pureza:98.44%Forma y color:SolidPeso molecular:275.26DUB-IN-2
CAS:<p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>Fórmula:C15H9N5OPureza:98.96%Forma y color:SolidPeso molecular:275.26GNE-6640
CAS:<p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>Fórmula:C20H18N4OPureza:98.64%Forma y color:SolidPeso molecular:330.38USP7-IN-8
CAS:<p>Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.</p>Fórmula:C21H21N3O2Pureza:99.31%Forma y color:SolidPeso molecular:347.41Subasumstat
CAS:<p>Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.</p>Fórmula:C25H28ClN5O5S2Pureza:97.02% - 98.22%Forma y color:SolidPeso molecular:578.1CYM5442
CAS:<p>CYM5442 is an S1P agonist, targeting to Sphingosine.</p>Fórmula:C23H27N3O4Pureza:98.02% - 99.48%Forma y color:SolidPeso molecular:409.48IU1-248
CAS:<p>IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].</p>Fórmula:C20H23N3O2Pureza:99.3%Forma y color:SolidPeso molecular:337.42LANOSTEROL
CAS:<p>Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.</p>Fórmula:C30H50OPureza:97.99% - 99.67%Forma y color:SolidPeso molecular:426.72USP1-IN-2
CAS:<p>USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.</p>Fórmula:C26H22F4N6OPureza:99.69% - 99.88%Forma y color:SolidPeso molecular:510.486BI8626
CAS:<p>BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cells</p>Fórmula:C25H28N8Pureza:98.66%Forma y color:SolidPeso molecular:440.54USP28-IN-4
CAS:<p>USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Fórmula:C22H18Cl2N2O3SPureza:98.48%Forma y color:SolidPeso molecular:461.36FT827
CAS:<p>FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.</p>Fórmula:C27H28N6O5SPureza:98.76%Forma y color:SolidPeso molecular:548.61DT204
CAS:<p>DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.</p>Fórmula:C19H13BrClNO5SPureza:99.17%Forma y color:SolidPeso molecular:482.73USP28-IN-3
CAS:<p>USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Fórmula:C23H20Cl2N2O3SPureza:99.92%Forma y color:SolidPeso molecular:475.39I-138
CAS:<p>I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.</p>Fórmula:C26H23F3N6OPureza:99.41%Forma y color:SolidPeso molecular:492.5Smurf1-IN-1
CAS:<p>Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy</p>Fórmula:C24H29ClN6O2Pureza:98%Forma y color:SolidPeso molecular:468.98OTUB1/USP8-IN-1
CAS:<p>OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.</p>Fórmula:C22H16ClFN2O4Pureza:98.59%Forma y color:SoildPeso molecular:426.83CB-5339
CAS:<p>p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].</p>Fórmula:C24H24N6OPureza:97.66%Forma y color:SoildPeso molecular:412.49GSK2643943A
CAS:<p>GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.</p>Fórmula:C17H12FN3Pureza:97.09%Forma y color:SolidPeso molecular:277.3SJB3-019A
CAS:<p>SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times</p>Fórmula:C16H8N2O3Pureza:99.72%Forma y color:SolidPeso molecular:276.25NAcM-OPT
CAS:<p>NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).</p>Fórmula:C23H29Cl2N3OPureza:99.93%Forma y color:SolidPeso molecular:434.4USP30 inhibitor 11
CAS:<p>USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.</p>Fórmula:C17H16N6O2SPureza:98.84% - 99.59%Forma y color:SolidPeso molecular:368.41P22074
CAS:<p>P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.</p>Fórmula:C12H9NO3S2Pureza:>99.99%Forma y color:SolidPeso molecular:279.33USP22-IN-1
CAS:<p>USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.</p>Fórmula:C22H18N4Pureza:98.2%Forma y color:SolidPeso molecular:338.41Ubiquitination-IN-1
CAS:<p>Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).</p>Fórmula:C21H14F3N3O2SPureza:98.396% - 99.88%Forma y color:SolidPeso molecular:429.42USP30 inhibitor 18
CAS:<p>USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.</p>Fórmula:C26H28FN3O4SPureza:99.85%Forma y color:SolidPeso molecular:497.58Cbl-b-IN-13
CAS:<p>Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].</p>Fórmula:C29H30F3N5O2Pureza:98%Forma y color:SolidPeso molecular:537.58Cbl-b-IN-6
CAS:<p>Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (</p>Fórmula:C30H32F5N5OPureza:98%Forma y color:SolidPeso molecular:573.6Cbl-b-IN-10
CAS:<p>Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (</p>Fórmula:C31H37F3N6OPureza:98%Forma y color:SolidPeso molecular:566.66Cbl-b-IN-9
CAS:<p>Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximal</p>Fórmula:C30H33F3N6O2Pureza:98%Forma y color:SolidPeso molecular:566.62Cbl-b-IN-12
CAS:<p>Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100</p>Fórmula:C28H29F3N6O2Pureza:98%Forma y color:SolidPeso molecular:538.56Cbl-b-IN-7
CAS:<p>Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50s</p>Fórmula:C29H31F4N5O2Pureza:98%Forma y color:SolidPeso molecular:557.58Skp2 inhibitor 2
CAS:<p>Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.</p>Fórmula:C27H32N4OPureza:98%Forma y color:SolidPeso molecular:428.57Cbl-b-IN-8
CAS:<p>Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5</p>Fórmula:C35H44F3N7O3Pureza:98%Forma y color:SolidPeso molecular:667.76Cbl-b-IN-11
CAS:<p>Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) of</p>Fórmula:C31H35F5N6OPureza:98%Forma y color:SolidPeso molecular:602.64USP7-IN-1
CAS:<p>USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).</p>Fórmula:C23H24ClN3O3Pureza:99.82%Forma y color:SolidPeso molecular:425.91LDN-91946
CAS:<p>LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).</p>Fórmula:C15H10N2O4SPureza:97.12%Forma y color:SolidPeso molecular:314.32UPCDC30766
CAS:<p>UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].</p>Fórmula:C30H32F2N6O3SPureza:98%Forma y color:SolidPeso molecular:594.68FT671
CAS:<p>FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).</p>Fórmula:C24H23F4N7O3Pureza:98%Forma y color:SolidPeso molecular:533.48PYZD-4409
CAS:<p>PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.</p>Fórmula:C14H7ClFN3O5Pureza:99.71%Forma y color:SolidPeso molecular:351.67CC0651
CAS:<p>CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).</p>Fórmula:C20H21Cl2NO6Pureza:99.03%Forma y color:SolidPeso molecular:442.29UC-764864
CAS:<p>UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling in</p>Fórmula:C19H18N2OSPureza:99.3%Forma y color:SolidPeso molecular:322.42IMP-1710
CAS:<p>IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.</p>Fórmula:C23H19N5OPureza:99.3%Forma y color:SolidPeso molecular:381.43BC-1293
CAS:<p>BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.</p>Fórmula:C26H28N4O4SPureza:98.40%Forma y color:SolidPeso molecular:492.59PRC1-IN-1
CAS:<p>PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.</p>Fórmula:C24H19ClFN3O2Forma y color:SolidPeso molecular:435.878Cbl-b-IN-26
CAS:<p>Cbl-b-IN-26 (Example A1) is an inhibitor of Cbl-b with a dissociation constant (Kd) of 34.6 nM. It is used in the research of chronic viral infections and cancer.</p>Fórmula:C21H19F3N6Forma y color:SolidPeso molecular:412.41USP7-797
CAS:<p>USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.</p>Fórmula:C27H28ClN3O3SPureza:95.90%Forma y color:SolidPeso molecular:510.05USP7-IN-6
CAS:<p>USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).</p>Fórmula:C41H43N7O4SPureza:98%Forma y color:SolidPeso molecular:729.89DCN1-UBC12-IN-4
CAS:<p>DCN1-UBC12-IN-4 (compound 5p) acts as an inhibitor of DCN1-UBC12, exhibiting an IC50 value greater than 10000 nM and possesses antitumor activity.</p>Fórmula:C8H6ClN3SForma y color:SolidPeso molecular:211.67USP15-IN-1
CAS:<p>USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).</p>Fórmula:C22H23N3O3Pureza:99.509% - 99.81%Forma y color:SolidPeso molecular:377.44USP5-IN-1
<p>USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.</p>Fórmula:C19H20ClN3O5SPureza:99.76%Forma y color:SoildPeso molecular:437.9Cbl-b-IN-3
CAS:<p>Cbl-b-IN-3 is a potent inhibitor of casitas b lineage lymphoma proto-oncogene-b (Cbl-b) (ic50 < 1 nM).Cost-effective and quality-assured.</p>Fórmula:C30H34F3N5OPureza:99%Forma y color:SolidPeso molecular:537.62
