Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Se han encontrado 107 productos de "Ubiquitinación"
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C527
CAS:<p>C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).</p>Fórmula:C17H8FNO3Pureza:97.22%Forma y color:SolidPeso molecular:293.25ML-792
CAS:<p>ML-792 is a specific small ubiquitin-like modifier activating enzyme (SUMO) inhibitor.Cost-effective and quality-assured.</p>Fórmula:C21H23BrN6O5SPureza:99.32% - 99.82%Forma y color:SolidPeso molecular:551.41IU1-47
CAS:<p>IU1-47 是一种特异性 USP14抑制剂，IC50为 0.6 μM。它诱导培养的神经元中 tau 蛋白降解。它抑制 IsoT/USP5， IC50为 20 μM。</p>Fórmula:C19H23ClN2OPureza:98.94%Forma y color:SolidPeso molecular:330.85NSC232003
CAS:<p>NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.</p>Fórmula:C6H7N3O3Pureza:97.72%Forma y color:SolidPeso molecular:169.14WS-383
CAS:<p>WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).</p>Fórmula:C18H21Cl2N9S2Pureza:98.46%Forma y color:SolidPeso molecular:498.46MF-094
CAS:<p>MF-094 is a selective USP30 inhibitor with IC50 of 0.12 μM. MF-094 can increase protein ubiquitination and accelerate mitophagy.Cost-effective and quality-assured.</p>Fórmula:C30H37N3O4SPureza:99.93%Forma y color:SolidPeso molecular:535.7TAS4464 hydrochloride
CAS:<p>TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).</p>Fórmula:C21H24ClFN6O6SPureza:98.61% - 98.96%Forma y color:SolidPeso molecular:542.97HBX 19818
CAS:<p>HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).</p>Fórmula:C25H28ClN3OPureza:97.71%Forma y color:SolidPeso molecular:421.96USP8-IN-2
CAS:<p>USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.</p>Fórmula:C19H20ClF3N4OSPureza:99.92%Forma y color:SolidPeso molecular:444.9USP8-IN-3
CAS:<p>USP8-IN-3 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with IC50 of 4.0 μM against USP8D.</p>Fórmula:C18H18F3N5O2SPureza:99.79%Forma y color:SolidPeso molecular:425.43UP158
CAS:<p>UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.</p>Fórmula:C17H17ClN4O2Forma y color:SolidPeso molecular:344.8OTUB2-IN-1
<p>OTUB2-IN-1 is an OTUB2 inhibitor with antitumor activity and can be used to study skin cancer and non-small cell lung cancer (NSCLC).</p>Fórmula:C19H18N2O6S2Pureza:98.19%Forma y color:SolidPeso molecular:434.49E3 ligase Ligand 36
CAS:<p>E3 ligase Ligand 36 is an E3 ligase ligand that can be utilized for synthesizing PROTACs, such as PROTAC BRM/BRG1 degrader-1.</p>Fórmula:C25H30N4O5SForma y color:SolidPeso molecular:498.6NSC819701
<p>NSC819701 is a triazole-based inhibitor of p97ATPase. It inhibits the activity of p97ATPase by binding to specific sites on p97.</p>Fórmula:C30H32F2N8O3SForma y color:SolidPeso molecular:622.69OTUB1/USP8-IN-1 HCl
<p>OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemia</p>Fórmula:C22H17Cl2FN2O4Pureza:99.92%Forma y color:SolidPeso molecular:463.29Post-Translational Modification Compound Library
<p>Contains xnum active small molecules for research related to post-translational modifications (PTMs);</p>Forma y color:Odour SolidE3 ligase Ligand 41
CAS:<p>E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.</p>Fórmula:C13H12ClF3N2O4Forma y color:SolidPeso molecular:352.69Skp2 inhibitor 3
<p>Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.</p>Forma y color:Odour SolidUP12
CAS:<p>UP12 enhances ATPase activity by activating valosin-containing protein (VCP), with an EC50 of 2.57 μM.</p>Fórmula:C23H16ClN3O3SForma y color:SolidPeso molecular:449.91dCeMM3
CAS:<p>dCeMM3 is a glue degrader that induces ubiquitination and degradation of cyclin K by promoting CDK12-cyclin K interaction with CRL4B ligase.</p>Fórmula:C14H11ClN4OSPureza:98.48% - 99.41%Forma y color:SolidPeso molecular:318.78BIO-2007817
<p>BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. This compound enhances the activity of wild-type Parkin, stimulates Parkin's autoubiquitination, and induces the appearance of mono-ubiquitinated forms of Miro1 (a Parkin substrate) with an EC50 of 0.17 μM.</p>Fórmula:C32H36N6O3Forma y color:SolidPeso molecular:552.67RNF5 agonist 1
CAS:<p>RNF5 agonist 1 (analog-1), a structural analog of the RNF5 inhibitor inh-02, is a potent RNF5 agonist. In CFBE41o- cells expressing F508del-CFTR, RNF5 agonist 1 enhances the ubiquitination of ATG4B.</p>Fórmula:C22H18N4SForma y color:SolidPeso molecular:370.47UP163
CAS:<p>UP163 enhances ATPase activity and activates valosin-containing protein (VCP), with an EC50 of 9.0 μM. It also reduces MG-132-induced TDP-43 aggregation.</p>Fórmula:C20H15ClN2O5SForma y color:SolidPeso molecular:430.86Ubiquitination Compound Library
<p>A unique collection of xnum ubiquitination related small chemicals can be used for high throughput and high content screening；</p>Forma y color:Odour SolidUSP8-IN-1
CAS:<p>USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].</p>Fórmula:C18H21N5O3SPureza:99.07%Forma y color:SoildPeso molecular:387.46STD1T
CAS:<p>STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.</p>Fórmula:C19H19N3O4S2Pureza:98.77%Forma y color:SolidPeso molecular:417.5MSC1094308
CAS:<p>MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.</p>Fórmula:C29H29F3N2Forma y color:SolidPeso molecular:462.55USP25/28 inhibitor AZ1
CAS:<p>USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.</p>Fórmula:C17H16BrF4NO2Pureza:99.79% - 99.79%Forma y color:SolidPeso molecular:422.21IU1-248
CAS:<p>IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].</p>Fórmula:C20H23N3O2Pureza:99.3%Forma y color:SolidPeso molecular:337.42XL177A
CAS:<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>Fórmula:C48H57ClN8O5Pureza:98.75%Forma y color:SolidPeso molecular:861.47DUB-IN-3
CAS:<p>DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.</p>Fórmula:C16H9N5OPureza:99.34%Forma y color:SolidPeso molecular:287.28NSC632839
CAS:<p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>Fórmula:C21H22ClNOPureza:99.74% - 99.88%Forma y color:SolidPeso molecular:339.86ML241
CAS:<p>ML241 is a potent and selective inhibitors of p97 ATPase.</p>Fórmula:C23H24N4OPureza:98%Forma y color:SolidPeso molecular:372.46ML240
CAS:<p>ML240 is a selective, ATP-competitive p97 inhibitor.</p>Fórmula:C23H20N6OPureza:99.73% - >99.99%Forma y color:SolidPeso molecular:396.44BC-1382
CAS:<p>BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).</p>Fórmula:C23H29N3O5SPureza:99.15% - 99.94%Forma y color:SolidPeso molecular:459.56USP7/USP47 inhibitor
CAS:<p>USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,</p>Fórmula:C18H11Cl2N3O3S3Pureza:98.5% - 98.71%Forma y color:SolidPeso molecular:484.4GNE-6640
CAS:<p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>Fórmula:C20H18N4OPureza:98.64%Forma y color:SolidPeso molecular:330.38Skp2 Inhibitor C1
CAS:<p>Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.</p>Fórmula:C18H13BrN2O4S2Pureza:97.36%Forma y color:SolidPeso molecular:465.34SJB2-043
CAS:<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Fórmula:C17H9NO3Pureza:98.44%Forma y color:SolidPeso molecular:275.26PR-619
CAS:<p>PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.</p>Fórmula:C7H5N5S2Pureza:97.25% - >99.99%Forma y color:SolidPeso molecular:223.28NMS-873
CAS:<p>NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.</p>Fórmula:C27H28N4O3S2Pureza:99.05% - 99.85%Forma y color:SolidPeso molecular:520.67USP7-IN-8
CAS:<p>Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.</p>Fórmula:C21H21N3O2Pureza:99.31%Forma y color:SolidPeso molecular:347.41ML-323
CAS:<p>ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay and in orthogonal gel-based assays using K63-linked di-Ub and Ub-PCNA as substrates.</p>Fórmula:C23H24N6Pureza:99.87% - 99.96%Forma y color:SolidPeso molecular:384.48DUB-IN-2
CAS:<p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>Fórmula:C15H9N5OPureza:98.96%Forma y color:SolidPeso molecular:275.26ML364
CAS:<p>ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.</p>Fórmula:C24H18F3N3O3S2Pureza:99.35% - >99.99%Forma y color:SolidPeso molecular:517.54GNE-6776
CAS:<p>GNE-6776 is a selective USP7 inhibitor.</p>Fórmula:C20H20N4O2Pureza:96.59% - 98.2%Forma y color:SolidPeso molecular:348.4VLX1570
CAS:<p>VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.</p>Fórmula:C23H17F2N3O6Pureza:98.53% - 99.91%Forma y color:SolidPeso molecular:469.39P005091
CAS:<p>P005091 (P5091) is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.</p>Fórmula:C12H7Cl2NO3S2Pureza:99.53% - 99.87%Forma y color:SolidPeso molecular:348.22WSB1 Degrader 1
CAS:<p>WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.</p>Fórmula:C21H22N2O2Pureza:98.57%Forma y color:SolidPeso molecular:334.412-D08
CAS:<p>2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.</p>Fórmula:C15H10O5Pureza:98.58% - 98.95%Forma y color:SolidPeso molecular:270.24
