Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Se han encontrado 107 productos de "Ubiquitinación"
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CB-5083
CAS:<p>CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).</p>Fórmula:C24H23N5O2Pureza:95.95% - 99.92%Forma y color:SolidPeso molecular:413.47Skp2 Inhibitor C1
CAS:<p>Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.</p>Fórmula:C18H13BrN2O4S2Pureza:97.36%Forma y color:SolidPeso molecular:465.34ML364
CAS:<p>ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.</p>Fórmula:C24H18F3N3O3S2Pureza:99.35% - >99.99%Forma y color:SolidPeso molecular:517.54BC-1382
CAS:<p>BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).</p>Fórmula:C23H29N3O5SPureza:99.15% - 99.94%Forma y color:SolidPeso molecular:459.56NSC632839
CAS:<p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>Fórmula:C21H22ClNOPureza:99.74% - 99.88%Forma y color:SolidPeso molecular:339.86SJB2-043
CAS:<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Fórmula:C17H9NO3Pureza:98.44%Forma y color:SolidPeso molecular:275.26DUB-IN-2
CAS:<p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>Fórmula:C15H9N5OPureza:98.96%Forma y color:SolidPeso molecular:275.26GNE-6640
CAS:<p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>Fórmula:C20H18N4OPureza:98.64%Forma y color:SolidPeso molecular:330.38USP7-IN-8
CAS:<p>Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.</p>Fórmula:C21H21N3O2Pureza:99.31%Forma y color:SolidPeso molecular:347.41Subasumstat
CAS:<p>Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.</p>Fórmula:C25H28ClN5O5S2Pureza:97.02% - 98.22%Forma y color:SolidPeso molecular:578.1CYM5442
CAS:<p>CYM5442 is an S1P agonist, targeting to Sphingosine.</p>Fórmula:C23H27N3O4Pureza:98.02% - 99.48%Forma y color:SolidPeso molecular:409.48IU1-248
CAS:<p>IU1-248 is a derivative of IU1. IU1-248 is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM[1].</p>Fórmula:C20H23N3O2Pureza:99.3%Forma y color:SolidPeso molecular:337.42LANOSTEROL
CAS:<p>Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.</p>Fórmula:C30H50OPureza:97.99% - 99.67%Forma y color:SolidPeso molecular:426.72USP1-IN-2
CAS:<p>USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.</p>Fórmula:C26H22F4N6OPureza:99.69% - 99.88%Forma y color:SolidPeso molecular:510.486BI8626
CAS:<p>BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cells</p>Fórmula:C25H28N8Pureza:98.66%Forma y color:SolidPeso molecular:440.54USP28-IN-4
CAS:<p>USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Fórmula:C22H18Cl2N2O3SPureza:98.48%Forma y color:SolidPeso molecular:461.36FT827
CAS:<p>FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.</p>Fórmula:C27H28N6O5SPureza:98.76%Forma y color:SolidPeso molecular:548.61DT204
CAS:<p>DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.</p>Fórmula:C19H13BrClNO5SPureza:99.17%Forma y color:SolidPeso molecular:482.73USP28-IN-3
CAS:<p>USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Fórmula:C23H20Cl2N2O3SPureza:99.92%Forma y color:SolidPeso molecular:475.39I-138
CAS:<p>I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.</p>Fórmula:C26H23F3N6OPureza:99.41%Forma y color:SolidPeso molecular:492.5Smurf1-IN-1
CAS:<p>Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy</p>Fórmula:C24H29ClN6O2Pureza:98%Forma y color:SolidPeso molecular:468.98OTUB1/USP8-IN-1
CAS:<p>OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.</p>Fórmula:C22H16ClFN2O4Pureza:98.59%Forma y color:SoildPeso molecular:426.83CB-5339
CAS:<p>p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].</p>Fórmula:C24H24N6OPureza:97.66%Forma y color:SoildPeso molecular:412.49GSK2643943A
CAS:<p>GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.</p>Fórmula:C17H12FN3Pureza:97.09%Forma y color:SolidPeso molecular:277.3SJB3-019A
CAS:<p>SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times</p>Fórmula:C16H8N2O3Pureza:99.72%Forma y color:SolidPeso molecular:276.25NAcM-OPT
CAS:<p>NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).</p>Fórmula:C23H29Cl2N3OPureza:99.93%Forma y color:SolidPeso molecular:434.4USP30 inhibitor 11
CAS:<p>USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.</p>Fórmula:C17H16N6O2SPureza:98.84% - 99.59%Forma y color:SolidPeso molecular:368.41P22074
CAS:<p>P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.</p>Fórmula:C12H9NO3S2Pureza:>99.99%Forma y color:SolidPeso molecular:279.33USP22-IN-1
CAS:<p>USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.</p>Fórmula:C22H18N4Pureza:98.2%Forma y color:SolidPeso molecular:338.41Ubiquitination-IN-1
CAS:<p>Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).</p>Fórmula:C21H14F3N3O2SPureza:98.396% - 99.88%Forma y color:SolidPeso molecular:429.42USP30 inhibitor 18
CAS:<p>USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.</p>Fórmula:C26H28FN3O4SPureza:99.85%Forma y color:SolidPeso molecular:497.58Cbl-b-IN-13
CAS:<p>Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].</p>Fórmula:C29H30F3N5O2Pureza:98%Forma y color:SolidPeso molecular:537.58Cbl-b-IN-6
CAS:<p>Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (</p>Fórmula:C30H32F5N5OPureza:98%Forma y color:SolidPeso molecular:573.6Cbl-b-IN-10
CAS:<p>Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (</p>Fórmula:C31H37F3N6OPureza:98%Forma y color:SolidPeso molecular:566.66Cbl-b-IN-9
CAS:<p>Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximal</p>Fórmula:C30H33F3N6O2Pureza:98%Forma y color:SolidPeso molecular:566.62Cbl-b-IN-12
CAS:<p>Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100</p>Fórmula:C28H29F3N6O2Pureza:98%Forma y color:SolidPeso molecular:538.56Cbl-b-IN-7
CAS:<p>Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50s</p>Fórmula:C29H31F4N5O2Pureza:98%Forma y color:SolidPeso molecular:557.58Skp2 inhibitor 2
CAS:<p>Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.</p>Fórmula:C27H32N4OPureza:98%Forma y color:SolidPeso molecular:428.57Cbl-b-IN-8
CAS:<p>Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5</p>Fórmula:C35H44F3N7O3Pureza:98%Forma y color:SolidPeso molecular:667.76Cbl-b-IN-11
CAS:<p>Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) of</p>Fórmula:C31H35F5N6OPureza:98%Forma y color:SolidPeso molecular:602.64USP7-IN-1
CAS:<p>USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).</p>Fórmula:C23H24ClN3O3Pureza:99.82%Forma y color:SolidPeso molecular:425.91LDN-91946
CAS:<p>LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).</p>Fórmula:C15H10N2O4SPureza:97.12%Forma y color:SolidPeso molecular:314.32UPCDC30766
CAS:<p>UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].</p>Fórmula:C30H32F2N6O3SPureza:98%Forma y color:SolidPeso molecular:594.68FT671
CAS:<p>FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).</p>Fórmula:C24H23F4N7O3Pureza:98%Forma y color:SolidPeso molecular:533.48PYZD-4409
CAS:<p>PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.</p>Fórmula:C14H7ClFN3O5Pureza:99.71%Forma y color:SolidPeso molecular:351.67CC0651
CAS:<p>CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).</p>Fórmula:C20H21Cl2NO6Pureza:99.03%Forma y color:SolidPeso molecular:442.29UC-764864
CAS:<p>UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling in</p>Fórmula:C19H18N2OSPureza:99.3%Forma y color:SolidPeso molecular:322.42IMP-1710
CAS:<p>IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.</p>Fórmula:C23H19N5OPureza:99.3%Forma y color:SolidPeso molecular:381.43BC-1293
CAS:<p>BC-1293 inhibits FBXO24, stabilizes DARS2, and elevates cytokines in mice, showing immunostimulatory potential for immune modulation research.</p>Fórmula:C26H28N4O4SPureza:98.40%Forma y color:SolidPeso molecular:492.59PRC1-IN-1
CAS:<p>PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex 1 (PRC1) with an IC50 of 2.3 μM. It targets RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1, exhibiting IC50 values of 2.8 μM, 2.6 μM, and 1.8 μM, respectively.</p>Fórmula:C24H19ClFN3O2Forma y color:SolidPeso molecular:435.878
