Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1424 productos de "Autofagia"
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Pinosylvin
CAS:<p>Pinosylvin (5-Styrylresorcinol) induces autophagy via AMPK activation. Pinosylvin is likely to act as a pro-angiogenic factor.</p>Fórmula:C14H12O2Pureza:99.89% - 99.91%Forma y color:SolidPeso molecular:212.24Berbamine dihydrochloride
CAS:<p>Berbamine dihydrochloride (Berbamine), a natural compound derived from the Berberis amurensis plant, has been shown to exhibit antitumor activity in several Ys.</p>Fórmula:C37H42Cl2N2O6Pureza:95% - 99.99%Forma y color:SolidPeso molecular:681.65Isosorbide Mononitrate
CAS:<p>Isosorbide Mononitrate (Corangin) is a Nitrate Vasodilator, dilating the blood vessels so as to reduce the blood pressure.</p>Fórmula:C6H9NO6Pureza:98.16%Forma y color:Isosorbide-5-Mononitrate Is A Crystalline Solid It Is Very Flammable And May Be Toxic By IngestionPeso molecular:191.14Entinostat
CAS:<p>Entinostat (MS-275) is an HDAC class I with oral activity. Entinostat has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C21H20N4O3Pureza:98% - 99.74%Forma y color:SolidPeso molecular:376.41CCT128930 hydrochloride
CAS:<p>CCT128930 hydrochloride: Potent AKT inhibitor (IC50=6 nM), 28x selective over PKA, 20x over p70S6K, induces cell cycle arrest & DNA damage.</p>Fórmula:C18H21Cl2N5Pureza:98.55%Forma y color:SolidPeso molecular:378.3Gartanin
CAS:<p>Gartanin enhances androgen receptor degradation and has neuroprotective effects by boosting HO-1, AMPK, SIRT1, and PGC-1α pathways.</p>Fórmula:C23H24O6Pureza:99.64% - 99.85%Forma y color:SolidPeso molecular:396.43Lucanthone hydrochloride
CAS:<p>Lucanthone hydrochloride is a novel acridine derivative which supresses autophagic degradation and triggers apoptosis in colon cancer cells.</p>Fórmula:C20H25ClN2OSForma y color:SolidPeso molecular:376.94PTC-209 hydrobromide
CAS:<p>PTC-209 hydrobromide (PTC-209 HBr) is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in</p>Fórmula:C17H13Br2N5OS·HBrPureza:99.91%Forma y color:SolidPeso molecular:576.1Autogramin-1
CAS:<p>Autogramin-1 potently inhibits starvation-induced autophagy with IC50 of 0.17 μM.</p>Fórmula:C23H27N5O5SPureza:97.69% - 99.25%Forma y color:SolidPeso molecular:485.56XL388
CAS:<p>XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.</p>Fórmula:C23H22FN3O4SPureza:99.39% - 99.53%Forma y color:SolidPeso molecular:455.5NSC 185058
CAS:<p>NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.</p>Fórmula:C11H9N3SPureza:99.27%Forma y color:SolidPeso molecular:215.27PF-543 hydrochloride
CAS:<p>PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2</p>Fórmula:C27H32ClNO4SPureza:98.9% - 99.93%Forma y color:SolidPeso molecular:502.1URMC-099
CAS:<p>URMC-099: oral, brain-accessible MLK/LRRK2 inhibitor; IC50 – MLK1/2/3/DLK: 19/42/14/150 nM, LRRK2: 11 nM.</p>Fórmula:C27H27N5Pureza:99.32% - 99.98%Forma y color:SolidPeso molecular:421.54Autocamtide-2-related inhibitory peptide
CAS:<p>Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.</p>Fórmula:C64H116N22O19Pureza:>99.99%Forma y color:SolidPeso molecular:1497.74PF-06447475
CAS:<p>PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.</p>Fórmula:C17H15N5OPureza:98.61% - 99.62%Forma y color:SolidPeso molecular:305.33Onjisaponin B
CAS:<p>Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-</p>Fórmula:C75H112O35Pureza:99.20% - 99.972%Forma y color:SolidPeso molecular:1573.67A-867744
CAS:<p>A-867744 is an effective and selective type II positive allosteric modulator of the α7 nAChR (EC50: 1.0 μM).</p>Fórmula:C20H19ClN2O3SPureza:95.66%Forma y color:SolidPeso molecular:402.89Cucurbitacin E
CAS:<p>Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.</p>Fórmula:C32H44O8Pureza:98.88% - 99.87%Forma y color:SolidPeso molecular:556.69TA-01
CAS:<p>TA-01 is a potent CK1 and p38 MAPK inhibitor, with IC50s of 6.4 nM, 6.8 nM, 6.7 nM for CK1ε, CK1δ and p38 MAPK, respectively.</p>Fórmula:C20H12F3N3Pureza:99.55% - 99.94%Forma y color:SolidPeso molecular:351.32Glucosamine sulfate
CAS:<p>Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.</p>Fórmula:C6H13NO5·H2SO4Pureza:99.64%Forma y color:White CrystalPeso molecular:277.25
