Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1424 productos de "Autofagia"
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sbp-7455
CAS:<p>SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.</p>Fórmula:C16H17F3N4O2Pureza:97.90% - 99.842%Forma y color:SolidPeso molecular:354.33Kaempferol
CAS:<p>Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ.</p>Fórmula:C15H10O6Pureza:98% - 99.41%Forma y color:Yellow Needles From Alcohol And Water SolidPeso molecular:286.24Amsacrine hydrochloride
CAS:<p>Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.</p>Fórmula:C21H20ClN3O3SPureza:99.05% - 99.92%Forma y color:SolidPeso molecular:429.92Typhaneoside
CAS:<p>Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction.</p>Fórmula:C34H42O20Pureza:98.92% - 99.95%Forma y color:SolidPeso molecular:770.69DPN
CAS:<p>DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .</p>Fórmula:C15H13NO2Pureza:99.01%Forma y color:Off-White SolidPeso molecular:239.27Pantoprazole
CAS:<p>Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux</p>Fórmula:C16H15F2N3O4SPureza:99.28% - 99.63%Forma y color:Almost White SolidPeso molecular:383.37AS-605240
CAS:<p>AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).</p>Fórmula:C12H7N3O2SPureza:97% - 99.91%Forma y color:SolidPeso molecular:257.27Nutlin-3a
CAS:<p>Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C30H30Cl2N4O4Pureza:95.62% - 99.71%Forma y color:SolidPeso molecular:581.49FIPI
CAS:<p>FIPI, a halopemide derivative, strongly blocks PLD1 and PLD2 (IC50s: 25 nM, 20 nM) and hinders PLD-mediated cell activity.</p>Fórmula:C23H24FN5O2Pureza:97.21% - 98.68%Forma y color:SolidPeso molecular:421.47Sirtinol
CAS:<p>Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).</p>Fórmula:C26H22N2O2Pureza:97.12% - 99.96%Forma y color:SolidPeso molecular:394.47Quercitrin
CAS:<p>Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities.</p>Fórmula:C21H20O11Pureza:98.89% - 99.66%Forma y color:Yellow Crystals From Dil Methanol Or Ethanol SolidPeso molecular:448.38Embelin
CAS:<p>Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).</p>Fórmula:C17H26O4Pureza:97.07% - 99.88%Forma y color:SolidPeso molecular:294.39GNE-9605
CAS:<p>GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).</p>Fórmula:C17H20ClF4N7OPureza:98.55% - 98.75%Forma y color:SolidPeso molecular:449.83PX-478
CAS:<p>PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.</p>Fórmula:C13H20Cl4N2O3Pureza:97% - 99.79%Forma y color:SolidPeso molecular:394.12Rotenone
CAS:<p>Rotenone, a plant-derived insecticide, inhibits mitochondrial electron transport, found in Leguminosae.</p>Fórmula:C23H22O6Pureza:89.58% - 99.88%Forma y color:Less To Brownish Crystals Or A White To Brownish-White Crystalline Powder Has Neither Odor Nor Taste (Ntp 1992)Peso molecular:394.42Quisinostat dihydrochloride
CAS:<p>Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性，高效的 pan-HDAC 抑制剂，具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。</p>Fórmula:C21H28Cl2N6O2Pureza:97.13%Forma y color:SolidPeso molecular:467.39Mdivi-1
CAS:<p>Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM).</p>Fórmula:C15H10Cl2N2O2SPureza:96.57% - 99.23%Forma y color:SolidPeso molecular:353.22SMER28
CAS:<p>SMER28 triggers autophagy in cells without mTOR, blocking amyloid beta buildup.</p>Fórmula:C11H10BrN3Pureza:99.94% - >99.99%Forma y color:SolidPeso molecular:264.12Rasagiline Mesylate
CAS:<p>Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.</p>Fórmula:C13H17NO3SPureza:99.33%Forma y color:White PowderPeso molecular:267.34LC3-mHTT-IN-AN1
CAS:<p>LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.</p>Fórmula:C15H9Br2NO3Pureza:97.26%Forma y color:SolidPeso molecular:411.04Alisertib
CAS:<p>Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.</p>Fórmula:C27H20ClFN4O4Pureza:98.31% - >99.99%Forma y color:SolidPeso molecular:518.92Afatinib
CAS:<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Fórmula:C24H25ClFN5O3Pureza:98.56% - 99.9%Forma y color:Off-White SolidPeso molecular:485.94Tubastatin A
CAS:<p>Tubastatin A: Selective HDAC6 inhibitor, IC50 of 15 nM, 1000x less effective on other isozymes except HDAC8.</p>Fórmula:C20H21N3O2Pureza:97.22% - 99.51%Forma y color:SolidPeso molecular:335.4Mycro 3
CAS:<p>Mycro 3 is potent and selective for c-Myc in whole cell assays.</p>Fórmula:C24H17ClF2N6O4Pureza:99.51% - 99.61%Forma y color:SolidPeso molecular:526.88Neferine
CAS:<p>Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.</p>Fórmula:C38H44N2O6Pureza:98.81% - 99.65%Forma y color:SolidPeso molecular:624.773-Bromopyruvic acid
CAS:<p>3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition.</p>Fórmula:C3H3BrO3Pureza:95% - 99.644%Forma y color:White To Pale Yellow Crystalline PowderPeso molecular:166.96MK-2206 dihydrochloride
CAS:<p>MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and</p>Fórmula:C25H23Cl2N5OPureza:99.228% - 99.94%Forma y color:SolidPeso molecular:480.39Diosgenin glucoside
CAS:<p>Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis</p>Fórmula:C33H52O8Pureza:97.17% - 99.44%Forma y color:SolidPeso molecular:576.76Fangchinoline
CAS:<p>Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.</p>Fórmula:C37H40N2O6Pureza:99.86% - >99.99%Forma y color:SolidPeso molecular:608.72Schisandrol B
CAS:<p>Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.</p>Fórmula:C23H28O7Pureza:99.14% - 99.95%Forma y color:SolidPeso molecular:416.46AZD 6482
CAS:<p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.</p>Fórmula:C22H24N4O4Pureza:99.79% - 99.95%Forma y color:SolidPeso molecular:408.45Brefeldin A
CAS:<p>Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM).</p>Fórmula:C16H24O4Pureza:96.45% - 99.89%Forma y color:White SolidPeso molecular:280.36Dioscin
CAS:<p>Dioscin (Collettiside III) is a saponin with antitumor activities.</p>Fórmula:C45H72O16Pureza:99.85% - 99.87%Forma y color:SolidPeso molecular:869.04GLPG1837
CAS:<p>GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.</p>Fórmula:C16H20N4O3SPureza:99.64% - 99.91%Forma y color:SolidPeso molecular:348.42ABT-737
CAS:<p>ABT-737 is a BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w. ABT-737 exhibits antitumor activity and anti-aging activity. Cost-effective and quality-assured.</p>Fórmula:C42H45ClN6O5S2Pureza:98.15% - >99.99%Forma y color:SolidPeso molecular:813.43Neflamapimod
CAS:<p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>Fórmula:C19H9Cl2F2N3OSPureza:97.88% - 99.75%Forma y color:SolidPeso molecular:436.26Turofexorate Isopropyl
CAS:<p>Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM</p>Fórmula:C25H24F2N2O3Pureza:98.55% - 99.73%Forma y color:SolidPeso molecular:438.47Calcimycin
CAS:<p>Calcimycin (A-23187) is a polyether antibiotic that transports Ca²⁺, uncouples phosphorylation, and inhibits ATPase in mitochondria.</p>Fórmula:C29H37N3O6Pureza:98%Forma y color:SolidPeso molecular:523.62Vandetanib
CAS:<p>Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 (IC50: 40 nM). It also inhibits VEGFR3 and EGFR.</p>Fórmula:C22H24BrFN4O2Pureza:99.7% - >99.99%Forma y color:White SolidPeso molecular:475.35SGI-1776
CAS:<p>SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.</p>Fórmula:C20H22F3N5OPureza:99.3% - >99.99%Forma y color:SolidPeso molecular:405.42Carbamazepine
CAS:<p>Carbamazepine: a tricyclic with anticonvulsant and analgesic effects, treats trigeminal neuralgia.</p>Fórmula:C15H12N2OPureza:99.78% - 99.79%Forma y color:SolidPeso molecular:236.27Milciclib
CAS:<p>Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.</p>Fórmula:C25H32N8OPureza:99.28%Forma y color:SolidPeso molecular:460.57STF-62247
CAS:<p>STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.</p>Fórmula:C15H13N3SPureza:99.6% - 99.67%Forma y color:SolidPeso molecular:267.35Fenretinide
CAS:<p>Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.</p>Fórmula:C26H33NO2Pureza:98% - 99.68%Forma y color:Yellow PowderPeso molecular:391.55Isoalantolactone
CAS:<p>Isoalantolactone (Isohelenin), isolated from Inula spp., can inhibit the growth of several types of Y cells.</p>Fórmula:C15H20O2Pureza:99.75% - 99.94%Forma y color:SolidPeso molecular:232.32CD437
CAS:<p>CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.</p>Fórmula:C27H26O3Pureza:98.92% - 99.63%Forma y color:SolidPeso molecular:398.49Zoledronic acid monohydrate
CAS:<p>Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.</p>Fórmula:C5H12N2O8P2Pureza:99.91%Forma y color:White To Off-White PowderPeso molecular:290.1Betulinic acid
CAS:<p>Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.</p>Fórmula:C30H48O3Pureza:99.12% - 99.7%Forma y color:White Crystalline PowderPeso molecular:456.7ISOGINKGETIN
CAS:<p>ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.</p>Fórmula:C32H22O10Pureza:98% - 99.72%Forma y color:SolidPeso molecular:566.51FERULIC ACID METHYL ESTER
CAS:<p>FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants. FERULIC ACID METHYL ESTER has antioxidant activities.</p>Fórmula:C11H12O4Pureza:99.66% - 99.95%Forma y color:SolidPeso molecular:208.21
