Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1424 productos de "Autofagia"
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Wogonoside
CAS:<p>Wogonoside (Wogonin 7-O-glucuronide) acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.</p>Fórmula:C22H20O11Pureza:98.24% - >99.99%Forma y color:SolidPeso molecular:460.39Oroxin B
CAS:<p>Oroxin B (Hypocretin-2) has antioxidant activity.</p>Fórmula:C27H30O15Pureza:98.22% - 99.81%Forma y color:SolidPeso molecular:594.52Topotecan
CAS:<p>Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.</p>Fórmula:C23H23N3O5Pureza:96.14% - 98.23%Forma y color:Light Yellow Needle Crystal Or Crystalline PowderPeso molecular:421.45Obatoclax Mesylate
CAS:<p>Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and</p>Fórmula:C20H19N3O·CH4O3SPureza:99.58% - 99.88%Forma y color:SolidPeso molecular:413.49LRRK2-IN-1
CAS:<p>LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.</p>Fórmula:C31H38N8O3Pureza:98% - 98.82%Forma y color:SolidPeso molecular:570.69Cabazitaxel
<p>Cabazitaxel (XRP6258) is a taxane used for castration-resistant metastatic prostate cancer post-docetaxel failure.</p>Fórmula:C45H57NO14Pureza:98% - 99.93%Forma y color:SolidPeso molecular:835.93Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Forma y color:SolidPeso molecular:178.14H-89 dihydrochloride
CAS:<p>H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).</p>Fórmula:C20H20BrN3O2S·2HClPureza:98.22% - >99.99%Forma y color:SolidPeso molecular:519.28PD98059
CAS:<p>PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.</p>Fórmula:C16H13NO3Pureza:98.63% - >99.99%Forma y color:Yellow SolidPeso molecular:267.28ML327
CAS:<p>ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).</p>Fórmula:C19H18N4O4Pureza:98.47%Forma y color:SolidPeso molecular:366.37Chloroquine
CAS:<p>Chloroquine: antimalarial, anti-inflammatory, autophagy/TLRs inhibitor, treats arthritis, effective against COVID-19 in vitro. EC50: 1.13 μM.</p>Fórmula:C18H26ClN3Pureza:99.5% - 99.98%Forma y color:White To Slightly Yellow Crystalline Powder SolidPeso molecular:319.87Samotolisib
CAS:<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Forma y color:SolidPeso molecular:406.48Sitagliptin phosphate
CAS:<p>Sitagliptin phosphate (MK-0431 phosphate) is a dipeptidyl peptidase-4 (DPP4) inhibitor.</p>Fórmula:C16H18F6N5O5PPureza:99.72% - 99.91%Forma y color:White SolidPeso molecular:505.31A-484954
CAS:<p>A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.</p>Fórmula:C13H15N5O3Pureza:97.47% - 99.86%Forma y color:SolidPeso molecular:289.29KN-92 phosphate
CAS:<p>KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93.</p>Fórmula:C24H28ClN2O7PSPureza:99.86%Forma y color:SolidPeso molecular:554.98Autophinib
CAS:<p>Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and</p>Fórmula:C14H11ClN6O3Pureza:99.25% - 99.41%Forma y color:SolidPeso molecular:346.73Salvigenin
CAS:<p>Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects.</p>Fórmula:C18H16O6Pureza:99.17% - 99.78%Forma y color:SolidPeso molecular:328.32Wortmannin
CAS:<p>Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.</p>Fórmula:C23H24O8Pureza:95.84% - 99.76%Forma y color:White SolidPeso molecular:428.43Leonurine
CAS:<p>Leonurine (SCM-198) is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory.</p>Fórmula:C14H21N3O5Pureza:98.55%Forma y color:White Crystalline PowderPeso molecular:311.33GW786034B
CAS:<p>Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.</p>Fórmula:C21H23N7O2S·HClPureza:99.87%Forma y color:SolidPeso molecular:473.98PF-04691502
CAS:<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Fórmula:C22H27N5O4Pureza:96.27% - ≥95%Forma y color:SolidPeso molecular:425.48Losmapimod
CAS:<p>Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).</p>Fórmula:C22H26FN3O2Pureza:98.35% - 99.89%Forma y color:SolidPeso molecular:383.46DC661
CAS:<p>DC661 is a palmitoyl-protein thioesterase 1 (PPT1) inhibitor that acts as an anti-lysosomal agent by inhibiting autophagy, demonstrating anti-cancer activity.</p>Fórmula:C31H39Cl2N5Pureza:99.07%Forma y color:SolidPeso molecular:552.58Linifanib
CAS:<p>Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and</p>Fórmula:C21H18FN5OPureza:98% - 98.24%Forma y color:SolidPeso molecular:375.4Indophagolin
CAS:<p>Indophagolin: autophagy inhibitor, IC50 140 nM; blocks P2X4, P2X1, P2X3 receptors, IC50s 2.71, 2.40, 3.49 μM.</p>Fórmula:C19H15BrClF3N2O3SPureza:99.76%Forma y color:SolidPeso molecular:523.75Saracatinib
CAS:<p>Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.</p>Fórmula:C27H32ClN5O5Pureza:98% - 99.63%Forma y color:SolidPeso molecular:542.03Pamapimod
CAS:<p>Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.</p>Fórmula:C19H20F2N4O4Pureza:99.52% - 99.99%Forma y color:SolidPeso molecular:406.38Crizotinib hydrochloride
CAS:<p>Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)</p>Fórmula:C21H23Cl3FN5OPureza:98.73% - 98.87%Forma y color:SolidPeso molecular:486.8Danusertib
CAS:<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Fórmula:C26H30N6O3Pureza:97.88% - 98.79%Forma y color:White PowderPeso molecular:474.553-Methyladenine
CAS:<p>3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).</p>Fórmula:C6H7N5Pureza:98.02% - 99.65%Forma y color:SolidPeso molecular:149.15WYC-209
CAS:<p>WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).</p>Fórmula:C20H20N2O3SPureza:99.77%Forma y color:SolidPeso molecular:368.45Salirasib
CAS:<p>Salirasib: Competitive PPMTase inhibitor, blocks Ras methylation, potential cancer treatment, Ki=2.6 μM.</p>Fórmula:C22H30O2SPureza:99.45%Forma y color:SolidPeso molecular:358.54Afatinib Dimaleate
CAS:<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Fórmula:C32H33ClFN5O11Pureza:98.11% - 99.87%Forma y color:SolidPeso molecular:718.08PFK-015
CAS:<p>PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).</p>Fórmula:C17H12N2OPureza:99.7% - 99.85%Forma y color:SolidPeso molecular:260.29TA-02
CAS:<p>TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.</p>Fórmula:C20H13F2N3Pureza:99.35% - 99.79%Forma y color:SolidPeso molecular:333.33Sepantronium bromide
CAS:<p>Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.</p>Fórmula:C20H19BrN4O3Pureza:99.68% - 99.85%Forma y color:SolidPeso molecular:443.26LY294002
CAS:<p>LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).</p>Fórmula:C19H17NO3Pureza:98% - 99.96%Forma y color:Pale Yellow SolidPeso molecular:307.34Pogostone
CAS:<p>Pogostone: anti-bacterial/fungal, blocks T-cells, modulates cytokines, protects against gastric ulcers, boosts antioxidants/PGE2/NP-SH.</p>Fórmula:C12H16O4Pureza:98.46% - 99.03%Forma y color:SolidPeso molecular:224.25PFI-1
CAS:<p>PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.</p>Fórmula:C16H17N3O4SPureza:98.74% - 99.19%Forma y color:SolidPeso molecular:347.393'-Hydroxypterostilbene
CAS:<p>3'-Hydroxypterostilbene suppresses colon cancer cell growth (COLO 205, HCT-116, HT-29) by triggering apoptosis and autophagy, affecting key pathways.</p>Fórmula:C16H16O4Pureza:98.25% - 99.19%Forma y color:SolidPeso molecular:272.3BIIB021
CAS:<p>BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).</p>Fórmula:C14H15ClN6OPureza:98% - 99.82%Forma y color:SolidPeso molecular:318.76Andrographolide
CAS:<p>Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential</p>Fórmula:C20H30O5Pureza:99.39% - 99.97%Forma y color:PowderPeso molecular:350.45Sapanisertib
CAS:<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Fórmula:C15H15N7OPureza:99.19% - >99.99%Forma y color:SolidPeso molecular:309.33BIX-01294 trihydrochloride
CAS:<p>BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.</p>Fórmula:C28H38N6O2·3HClPureza:99.41% - 99.95%Forma y color:SolidPeso molecular:600.02yangonin
CAS:<p>Yangonin (Y100550) is a novel CB1 receptor ligand with affinity for human recombinant CB1 receptors.</p>Fórmula:C15H14O4Pureza:98.82% - 99.55%Forma y color:Pale Yellow PowderPeso molecular:258.27Torkinib
CAS:<p>Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).</p>Fórmula:C16H16N6OPureza:99.11%Forma y color:SolidPeso molecular:308.34CCT007093
CAS:<p>CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 μM).</p>Fórmula:C15H12OS2Pureza:98% - 99.88%Forma y color:SolidPeso molecular:272.39Resatorvid
CAS:<p>Resatorvid (TAK-242) inhibits TLR4, with IC50s for IL-6, TNF-R, NO at 1.3, 1.9, 1.8 nM respectively.</p>Fórmula:C15H17ClFNO4SPureza:99.31% - >99.99%Forma y color:SolidPeso molecular:361.82Fulvestrant
CAS:<p>Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30.</p>Fórmula:C32H47F5O3SPureza:99.1% - >99.99%Forma y color:White PowderPeso molecular:606.77Flavopiridol hydrochloride
CAS:<p>Flavopiridol hydrochloride (MDL 107826A), an inhibitor of cyclin-dependent kinase, is a synthetic N-methylpiperidinyl chlorophenyl flavone compound.</p>Fórmula:C21H21Cl2NO5Pureza:98.87% - 99.88%Forma y color:SolidPeso molecular:438.3
