Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1424 productos de "Autofagia"
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Autocamtide 2, amide
<p>Autocamtide-2, an amide, is a selective CaMKII substrate for CAMK family assays at 100 μM.</p>Fórmula:C65H119N23O19Pureza:98%Forma y color:SolidPeso molecular:1526.79Biotin-16-UTP
CAS:<p>Biotin-16-UTP serves as an efficient substrate for RNA polymerase, capable of substituting UTP in vitro transcription reactions to facilitate RNA labeling [1].</p>Fórmula:C32H48Li4N7O19P3SForma y color:SolidPeso molecular:987.51Salinomycin sodium salt
CAS:<p>Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.</p>Fórmula:C42H69NaO11Pureza:98.76% - 99.11%Forma y color:White Or Light Yellow Crystalline Powder With Special SmelPeso molecular:772.98DOTA-CXCR4-L
<p>DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancer</p>Fórmula:C58H78N16O14Pureza:98%Forma y color:SolidPeso molecular:1223.34E70K
<p>E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuate</p>Fórmula:C108H178N34O28Pureza:98%Forma y color:SolidPeso molecular:2400.78Nictide
CAS:<p>Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.</p>Fórmula:C123H193N45O28Forma y color:SolidPeso molecular:2750.13N6-Isopentenyladenosine
CAS:<p>N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.</p>Fórmula:C15H21N5O4Pureza:97.13% - 99.69%Forma y color:SolidPeso molecular:335.36CXM102
<p>CXM102 is an activator of autophagy. This compound induces autophagy in aged BMSCs, rejuvenating them and promoting their preferential differentiation into osteoblasts. CXM102 enhances the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. In middle-aged male mice, it stimulates bone anabolic metabolism, reduces marrow adipocytes, delays bone loss, lowers serum inflammation levels, reduces organ fibrosis, and extends lifespan.</p>Fórmula:C28H27NO3Forma y color:SolidPeso molecular:425.52TRAF6 peptide
CAS:<p>TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.</p>Fórmula:C145H238N34O44Forma y color:SolidPeso molecular:3161.64SQA1
CAS:<p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>Fórmula:C22H26N4O5Forma y color:SolidPeso molecular:426.47Fumagilin-105
CAS:<p>Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.</p>Fórmula:C46H60N2O9Forma y color:SolidPeso molecular:784.98LC3in-C42
<p>LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.</p>Forma y color:Odour SolidVUF-11222
CAS:<p>VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).</p>Fórmula:C25H31BrINPureza:99.82%Forma y color:SolidPeso molecular:552.33Cabergoline
CAS:<p>Cabergoline (FCE-21336), an ergot-derived dopamine D2-like agonist, targets D2/D3/5-HT2B, normalizes prolactin, controls pituitary tumors.</p>Fórmula:C26H37N5O2Pureza:97.69% - 99.86%Forma y color:White Crystalline SolidPeso molecular:451.6PHTPP-1304
CAS:<p>PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.</p>Fórmula:C51H50F6N4O7Forma y color:SolidPeso molecular:944.96Polyphemusin II-Derived Peptide
CAS:<p>T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.</p>Fórmula:C90H141N33O18S2Forma y color:SolidPeso molecular:2037.42MRL828
<p>MRL828 is a compound that combines a Tau pathology-binding ligand with a guanine group modified by ATTEC technology, allowing it to selectively target aggregated tau proteins for clearance via the autophagy-lysosome pathway (ALP). MRL828 reduces intracellular Tau aggregates and facilitates the secretion of Tau.</p>Fórmula:C46H51FN14O5SForma y color:SolidPeso molecular:930.38716SG31
<p>SG31 is a potent activator of autophagy, exerting its effects through the AMPK/ULK1-dependent pathway.</p>Fórmula:C26H37N6O8PForma y color:SolidPeso molecular:592.58cGMP-HTL
<p>cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.</p>Fórmula:C31H51ClN7O14PSForma y color:SolidPeso molecular:844.27Peptide R
CAS:<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Fórmula:C39H59N13O8S2Forma y color:SolidPeso molecular:902.1Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Fórmula:C115H145ClN18O31S2Zn2Forma y color:SolidPeso molecular:2505.83Tigecycline mesylate
CAS:<p>Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>Fórmula:C30H43N5O11SPureza:98%Forma y color:SolidPeso molecular:681.75Fe-TMPyP
CAS:<p>Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.</p>Fórmula:C44H36Cl5FeN8Forma y color:SolidPeso molecular:909.92Microcolin H
CAS:<p>Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].</p>Fórmula:C38H63N5O9Forma y color:SolidPeso molecular:733.93MRT 67307 dihydrochloride
CAS:<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Fórmula:C26H38Cl2N6O2Pureza:99.75%Forma y color:SoildPeso molecular:537.53Hoechst 33342 analog trihydrochloride
CAS:<p>Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating the</p>Fórmula:C32H38Cl3N7Forma y color:SolidPeso molecular:627.05vMIP-II (1-21) TFA
<p>vMIP-II (1-21) (NT21MP) TFA (TFA is a potent inhibitor of CXCR4. This compound interacts broadly with CC and CXC chemokine receptors. Furthermore, vMIP-II (1-21) TFA inhibits CXCR4 by competing for binding sites with 125I-SDF-1R, exhibiting an IC50 value of 190 nM.</p>Forma y color:Odour SolidClionamine B
CAS:<p>Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.</p>Fórmula:C27H45NO3Forma y color:SolidPeso molecular:431.65Acridine homodimer
CAS:<p>Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.</p>Fórmula:C38H42Cl2N6O2Forma y color:SolidPeso molecular:685.69ITIC-4F
CAS:<p>ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.</p>Fórmula:C94H78F4N4O2S4Pureza:98%Forma y color:SolidPeso molecular:1499.92Desethylamiodarone hydrochloride
CAS:<p>Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.</p>Fórmula:C23H26ClI2NO3Pureza:98%Forma y color:SolidPeso molecular:653.72G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Fórmula:C27H31IN2O3Forma y color:SolidPeso molecular:558.45NAMPT degrader-1
<p>Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.</p>Fórmula:C56H68ClN9O5S2Forma y color:SolidPeso molecular:1046.78RK-682 (calcium salt)
CAS:<p>RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.</p>Fórmula:C42H74CaO10Forma y color:SolidPeso molecular:779.122TSPO Ligand-Linker Conjugates 1
<p>TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.</p>Fórmula:C32H55N3O10SForma y color:SolidPeso molecular:673.86p62-ZZ Ligand-Linker Conjugate 1
CAS:<p>p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.</p>Fórmula:C31H42N2O6Forma y color:SolidPeso molecular:538.68Autophagy agonist-1
<p>Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1/S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.</p>Fórmula:C33H41N3O5Forma y color:SolidPeso molecular:559.7Tetramethylrhodamine-dUTP
<p>Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .</p>Fórmula:C43H52N6O19P3Forma y color:SolidPeso molecular:1049.82Balixafortide TFA (1051366-32-5 free base)
<p>Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.</p>Fórmula:C82H113N22F3O23S2Pureza:98%Forma y color:SolidPeso molecular:1896.05LC3B recruiter 2
CAS:<p>LC3B recruiter 2 (34R) is an LC3B recruiting agent incorporated into the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), with a direct binding affinity for LC3B. It connects via a linker to the CDK9 inhibitor SNS-032, creating an ATTEC capable of targeting and degrading the CDK9 and Cyclin T1 complex, while also inhibiting them. Consequently, LC3B recruiter 2 exerts its function through an LC3B-dependent autophagy-lysosome pathway, interfering with the cancer cell cycle progression, thereby demonstrating antitumor activity.</p>Fórmula:C10H9ClN2O2Forma y color:SolidPeso molecular:224.644Cy5.5-SE (DIPEA)
<p>Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.</p>Fórmula:C53H66N4O16S4Forma y color:SolidPeso molecular:1143.37Corydalmine hydrochloride
CAS:<p>Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.</p>Fórmula:C20H24ClNO4Forma y color:SolidPeso molecular:377.86DB1113
CAS:<p>DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.</p>Fórmula:C59H68F3N13O6SForma y color:SolidPeso molecular:1144.31AZD4721
CAS:<p>AZD4721, an oral CXCR2 antagonist, may be researched for treating inflammation.</p>Fórmula:C19H25FN4O5S2Forma y color:SolidPeso molecular:472.55Cy3-dCTP
<p>Cy3-dCTP, a fluorescent cyanine-dye-labeled nucleotide triphosphate, serves as a DNA imaging probe.</p>Fórmula:C43H51Li4N6O20P3S2Forma y color:SolidPeso molecular:1156.71Beclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Forma y color:Odour SolidYTK-105
CAS:<p>YTK-105 is a ligand targeting autophagy that binds to p62.</p>Fórmula:C16H19NO2Pureza:98.31%Forma y color:SoildPeso molecular:257.33Erlotinib-13C6
CAS:<p>Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.</p>Fórmula:C22H23N3O4Forma y color:SolidPeso molecular:399.397AUTAC1
CAS:<p>AUTAC1 is a MetAP2-targeted autophagy-mediated degradator (AUTAC) that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.</p>Fórmula:C44H63FN8O11SPureza:99.45% - 99.45%Forma y color:SolidPeso molecular:931.08Cyanine 5 Tyramide methyl indole
<p>Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.</p>Fórmula:C40H47N3O8S2Forma y color:SolidPeso molecular:761.95
