Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1424 productos de "Autofagia"
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Corydalmine hydrochloride
CAS:<p>Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.</p>Fórmula:C20H24ClNO4Forma y color:SolidPeso molecular:377.86NAMPT degrader-1
<p>Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.</p>Fórmula:C56H68ClN9O5S2Forma y color:SolidPeso molecular:1046.78Acridine homodimer
CAS:<p>Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.</p>Fórmula:C38H42Cl2N6O2Forma y color:SolidPeso molecular:685.69Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Fórmula:C115H145ClN18O31S2Zn2Forma y color:SolidPeso molecular:2505.83XL01126
<p>XL01126 degrades LRRK2 (DC50: 14 nM G2019S, 32 nM WT), crosses the blood-brain barrier, aiding Parkinson's studies.</p>Fórmula:C50H64ClFN10O6S2Forma y color:SolidPeso molecular:1019.69p62-ZZ Ligand-Linker Conjugate 1
CAS:<p>p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.</p>Fórmula:C31H42N2O6Forma y color:SolidPeso molecular:538.68Polyphemusin II-Derived Peptide
CAS:<p>T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.</p>Fórmula:C90H141N33O18S2Forma y color:SolidPeso molecular:2037.42TSPO Ligand-Linker Conjugates 1
<p>TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.</p>Fórmula:C32H55N3O10SForma y color:SolidPeso molecular:673.86RK-682 (calcium salt)
CAS:<p>RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.</p>Fórmula:C42H74CaO10Forma y color:SolidPeso molecular:779.122Tetramethylrhodamine-dUTP
<p>Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .</p>Fórmula:C43H52N6O19P3Forma y color:SolidPeso molecular:1049.82AZD4721
CAS:<p>AZD4721, an oral CXCR2 antagonist, may be researched for treating inflammation.</p>Fórmula:C19H25FN4O5S2Forma y color:SolidPeso molecular:472.55G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Fórmula:C27H31IN2O3Forma y color:SolidPeso molecular:558.45Cyanine 5 Tyramide methyl indole
<p>Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.</p>Fórmula:C40H47N3O8S2Forma y color:SolidPeso molecular:761.95Microcolin H
CAS:<p>Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].</p>Fórmula:C38H63N5O9Forma y color:SolidPeso molecular:733.93Cy3-dCTP
<p>Cy3-dCTP, a fluorescent cyanine-dye-labeled nucleotide triphosphate, serves as a DNA imaging probe.</p>Fórmula:C43H51Li4N6O20P3S2Forma y color:SolidPeso molecular:1156.71Fasudil
CAS:<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Fórmula:C14H17N3O2SPureza:99.79% - 99.84%Forma y color:SolidPeso molecular:291.37DMTr-4'-CF3-5-Me-U-CED phosphoramidite
<p>DMTr-4'-CF3-5-Me-U-CED is a dye for oligonucleotide labeling in RNA research.</p>Fórmula:C42H50F3N4O8PForma y color:SolidPeso molecular:826.84PI3K-AKT-mTOR Compound Library
<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>Forma y color:Odour SolidCXCR4 antagonist 1
CAS:<p>CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.</p>Fórmula:C27H43N7Forma y color:SolidPeso molecular:465.69(3R,5S)-Fluvastatin
CAS:<p>(3R,5S)-Fluvastatin, a synthetic HMG-CoA reductase inhibitor (IC50: 8 nM), activates Nrf2 for antioxidant defense.</p>Fórmula:C24H26FNO4Forma y color:SolidPeso molecular:411.47KRH-3955 hydrochloride
CAS:<p>KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.</p>Fórmula:C28H48Cl3N7Forma y color:SolidPeso molecular:589.09MW-150 hydrochloride
CAS:<p>MW-150 hydrochloride is a selective p38α MAPK inhibitor with a 101 nM Ki, offering good CNS penetration and oral bioavailability.</p>Fórmula:C24H24ClN5Forma y color:SolidPeso molecular:417.93Chlorotris(triphenylphosphine)copper
CAS:<p>Chlorotris (triphenylphosphine) copper (CuCl(TPP)₃) is a metal complex that targets DNA. Through non-covalent interactions of its copper (I) center, such as groove-binding, it affects DNA function and exhibits inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris (triphenylphosphine) copper holds potential for research as an antimicrobial, antitumor, and antioxidant agent.</p>Fórmula:C54H45ClCuP3Forma y color:SolidPeso molecular:885.86MeCY5-NHS ester triethylamine
<p>MeCY5-NHS ester (potassium) is a reactive dye optimized for labeling proteins and nucleic acids [1].</p>Fórmula:C42H56N4O10S2Forma y color:SolidPeso molecular:841.04Desethylamiodarone hydrochloride
CAS:<p>Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.</p>Fórmula:C23H26ClI2NO3Pureza:98%Forma y color:SolidPeso molecular:653.72E70K
<p>E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuate</p>Fórmula:C108H178N34O28Pureza:98%Forma y color:SolidPeso molecular:2400.78Rapalink-1
CAS:<p>Rapalink-1 is an mTOR inhibitor that inhibits the mTORC1-4E-BP1 pathway in mice.</p>Fórmula:C91H138N12O24Pureza:98%Forma y color:SolidPeso molecular:1784.14LY2510924
CAS:<p>LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).</p>Fórmula:C62H88N14O10Forma y color:SolidPeso molecular:1189.45Erlotinib-d6 hydrochloride
CAS:<p>Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib D6 hydrochloride a deuterium labeled Erlotinib Hydrochloride.</p>Fórmula:C22H24ClN3O4Pureza:98%Forma y color:SolidPeso molecular:435.93Silibinin-d3
<p>Silibinin-d3 is the deuterium-labelled compound of silibinin, used for isotope tracing. Silibinin inhibit cancer cell proliferation and migration.</p>Fórmula:C25H22O10Forma y color:SolidPeso molecular:485.46Ponatinib-d8
CAS:<p>Ponatinib D8 is a deuterium-enriched, oral multi-kinase inhibitor (Abl, PDGFRα, VEGFR2, FGFR1, Src; IC50s: 0.37-5.4 nM).</p>Fórmula:C29H27F3N6OPureza:98%Forma y color:SolidPeso molecular:540.61ACT-1004-1239
CAS:<p>ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.</p>Fórmula:C27H28F2N6O3Pureza:98.31%Forma y color:SolidPeso molecular:522.55Levomepromazine
CAS:<p>Levomepromazine (Methotrimeprazine) is a Ca2+ release inducer with antiviral, anti-inflammatory, neuroprotective, sedative, and anti-nociceptive activities.</p>Fórmula:C19H24N2OSPureza:99.15%Forma y color:SolidPeso molecular:328.47Regorafenib-d3
CAS:<p>Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase.</p>Fórmula:C21H15ClF4N4O3Pureza:98%Forma y color:SolidPeso molecular:485.83Anti-LRRK2 Antibody (1C773)
<p>Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.</p>Forma y color:Odour LiquidMotixafortide
CAS:<p>Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).</p>Fórmula:C97H144FN33O19S2Pureza:98%Forma y color:SolidPeso molecular:2159.52ATI-2341
CAS:<p>ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.</p>Fórmula:C104H178N26O25S2Forma y color:SolidPeso molecular:2256.82Gefitinib-d8
CAS:<p>Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib.</p>Fórmula:C22H24ClFN4O3Pureza:98%Forma y color:SolidPeso molecular:454.95Metformin-d6 hydrochloride
CAS:<p>Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.</p>Fórmula:C4H12ClN5Pureza:98.1%Forma y color:SolidPeso molecular:171.66CXCR2 antagonist 8
CAS:<p>CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.</p>Fórmula:C14H13N3O5Forma y color:SolidPeso molecular:303.27Tetrahydrocurcumin D6
CAS:<p>Tetrahydrocurcumin D6 is a deuterium labeled Tetrahydrocurcumin. Tetrahydrocurcumin displays inhibitory activity for CYP2C9 and CYP3A4.</p>Fórmula:C21H24O6Pureza:98%Forma y color:SolidPeso molecular:378.45Manzamine A
CAS:<p>Manzamine A, from marine sponges, blocks GSK-3, halts cancer growth, prevents bacterial infections, and reduces tau phosphorylation.</p>Fórmula:C36H44N4OPureza:98%Forma y color:SolidPeso molecular:548.775PS372424 hydrochloride
CAS:<p>PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.</p>Fórmula:C33H45ClN6O4Pureza:95.03%Forma y color:SolidPeso molecular:625.2Idelalisib D5
CAS:<p>Idelalisib D5, a version of Idelalisib marked with deuterium, is an orally bioavailable and highly selective inhibitor of p110δ.</p>Fórmula:C22H18FN7OPureza:98%Forma y color:SolidPeso molecular:420.45Ladarixin
CAS:<p>Ladarixin (DF 2156A free base) is an orally active, non-competitive CXCR1/CXCR2 allosteric inhibitor that suppresses AKT, NF-κB, and angiogenesis.</p>Fórmula:C11H12F3NO6S2Pureza:99.36%Forma y color:SolidPeso molecular:375.34Isoniazid-d4
CAS:<p>Isoniazid-d4 is a deuterium isotope marker for Isoniazid.Isoniazid is a prodrug that must be activated by the bacterial peroxidase KatG, and is bactericidal.</p>Fórmula:C6H3D4N3OForma y color:SolidPeso molecular:141.16Curcumin-d6
CAS:<p>Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-a</p>Fórmula:C21H20O6Pureza:98%Forma y color:SolidPeso molecular:374.422Loperamide-d6 hydrochloride
CAS:<p>Loperamide D6 HCl: Deuterium-enriched opioid for diarrhea.</p>Fórmula:C29H34Cl2N2O2Pureza:98%Forma y color:SolidPeso molecular:519.54THZ-P1-2
CAS:<p>THZ-P1-2 is a PI5P4K inhibitor with anti-leukemic activity and can be used in the study of leukemia.</p>Fórmula:C31H29N7O2Forma y color:SolidPeso molecular:531.61Br-DAPI
CAS:<p>IST5-002 (N6-Benzyladenosine-5'-phosphate) is a Stat5a/b inhibitor with anticancer activity and is used in cancer research.</p>Fórmula:C16H14BrN5Pureza:100%Forma y color:SolidPeso molecular:356.22
