Aurora quinasa
Los inhibidores de las quinasas Aurora se dirigen a las quinasas Aurora, una familia de quinasas de serina/treonina que desempeñan un papel crucial en la regulación de la mitosis. Estas quinasas son esenciales para la correcta alineación, segregación y citocinesis de los cromosomas durante la división celular. La actividad anormal de las quinasas Aurora puede llevar a una proliferación celular descontrolada y al cáncer. Al inhibir las quinasas Aurora, estos compuestos pueden inducir la detención del ciclo celular y la apoptosis en células cancerosas, lo que los convierte en herramientas valiosas en la investigación y terapia del cáncer. En CymitQuimica, ofrecemos una amplia gama de inhibidores de quinasas Aurora de alta calidad para apoyar su investigación en la regulación del ciclo celular, mitosis y oncología.
Se han encontrado 117 productos para "Aurora quinasa".
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CCT241736
CAS:CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3Fórmula:C22H23Cl2N7Pureza:96.2% - 99.81%Forma y color:SolidPeso molecular:456.37CCT 137690
CAS:CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM).Fórmula:C26H31BrN8OPureza:98.51% - 99.89%Forma y color:White SolidPeso molecular:551.48PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Fórmula:C22H25N7O2Pureza:97.58% - 99.94%Forma y color:Yellow SolidPeso molecular:419.48AMG 900
CAS:AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.Fórmula:C28H21N7OSPureza:98.4% - 99.51%Forma y color:SolidPeso molecular:503.58Ref: TM-T6380
1mg49,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg158,00€25mg286,00€50mg442,00€100mg645,00€500mg1.341,00€SNS-314 Mesylate
CAS:SNS-314 Mesylate (SNS-314) is an effective and specific Aurora A/B/C inhibitor. SNS-314 is less inhibition of Trk A/B, Fms, Flt4, c-Raf, Axl, and DDR2.Fórmula:C18H15ClN6OS2·CH4O3SPureza:99.44% - 99.92%Forma y color:SolidPeso molecular:527.04GW779439X
CAS:GW779439X is an inhibitor of CDK.Fórmula:C22H21F3N8Pureza:97.87%Forma y color:SolidPeso molecular:454.45Ref: TM-T8866
1mg58,00€2mg82,00€5mg113,00€1mL*10mM (DMSO)124,00€10mg178,00€25mg404,00€50mg592,00€100mg845,00€PHA-680632
CAS:PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.Fórmula:C28H35N7O2Pureza:98.2%Forma y color:SolidPeso molecular:501.627BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.Fórmula:C16H10BrN3O2Pureza:99.67%Forma y color:SolidPeso molecular:356.17Ref: TM-T22012
5mg43,00€1mL*10mM (DMSO)49,00€10mg60,00€25mg110,00€50mg170,00€100mg269,00€200mg380,00€Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Fórmula:C23H28N8OSPureza:99.99%Forma y color:White SolidPeso molecular:464.59XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Fórmula:C22H31N9OPureza:99.07%Forma y color:SolidPeso molecular:437.54Ref: TM-T17267
1mg52,00€2mg73,00€5mg94,00€1mL*10mM (DMSO)104,00€10mg141,00€25mg244,00€50mg371,00€100mg552,00€AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Forma y color:White SolidPeso molecular:381.43Ref: TM-T3068
2mg39,00€5mg75,00€1mL*10mM (DMSO)84,00€10mg111,00€25mg231,00€50mg371,00€100mg595,00€200mg833,00€Palmatine
CAS:Palmatine, also known as Burasaine, inhibits dopamine production and may treat flavivirus, jaundice, dysentery, hypertension, and liver issues.Fórmula:C21H22NO4Pureza:96.28% - 99.89%Forma y color:Yellow SolidPeso molecular:352.4Palmatine chloride
CAS:Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Fórmula:C21H22ClNO4Pureza:97.9% - 99.89%Forma y color:Yellow SolidPeso molecular:387.86SC-514
CAS:SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.Fórmula:C9H8N2OS2Pureza:99.88% - >99.99%Forma y color:SolidPeso molecular:224.3SNS-314
CAS:SNS-314 inhibits Aurora kinases A and B, blocking cell division in AK-overexpressing tumors.Fórmula:C18H15ClN6OS2Pureza:98%Forma y color:SolidPeso molecular:430.93JNJ-7706621
CAS:JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Fórmula:C15H12F2N6O3SPureza:99.1% - 99.85%Forma y color:SolidPeso molecular:394.36Ref: TM-T6126
1mg48,00€1mL*10mM (DMSO)94,00€5mg100,00€10mg155,00€25mg268,00€50mg432,00€100mg595,00€200mg833,00€KW-2449
CAS:KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.Fórmula:C20H20N4OPureza:98.43% - 99.69%Forma y color:SolidPeso molecular:332.4PF-03814735
CAS:PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.Fórmula:C23H25F3N6O2Pureza:98%Forma y color:White SolidPeso molecular:474.48MK-5108
CAS:MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Fórmula:C22H21ClFN3O3SPureza:98.77%Forma y color:SolidPeso molecular:461.94SCH-1473759 hydrochloride
CAS:SCH-1473759 hydrochloride is an inhibitor of aurora(aurora A and B with IC50s of 4 and 13 nM, respectively).Fórmula:C20H27ClN8OSPureza:98.29%Forma y color:SolidPeso molecular:463TAK-285
CAS:TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.Fórmula:C26H25ClF3N5O3Pureza:99.73%Forma y color:SolidPeso molecular:547.96Ref: TM-T6039
1mg35,00€5mg75,00€1mL*10mM (DMSO)92,00€10mg114,00€25mg205,00€50mg334,00€100mg485,00€200mg690,00€GW843682X
CAS:GW843682X (GW843682) is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).Fórmula:C22H18F3N3O4SPureza:99.92%Forma y color:SolidPeso molecular:477.46Tripolin A
CAS:Tripolin A is a specific non-ATP competitive inhibitor of Aurora A kinase(Aurora A and Aurora B with IC50 values of 1.5 μM and 7 μM, respectively)Fórmula:C15H11NO3Pureza:98%Forma y color:SolidPeso molecular:253.25RET-IN-19
CAS:RET-IN-19, a potent RET inhibitor, anticancer: IC50 6.8 nM (RET-wt), 13.51 nM (RET V804M); for NSCLC research.Fórmula:C28H28N6O4SForma y color:SolidPeso molecular:544.62Ilorasertib hydrochloride
CAS:Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s:Fórmula:C25H22ClFN6O2SPureza:98.45%Forma y color:SolidPeso molecular:525VE-465
CAS:VE-465 is an inhibitor of Aurora kinase, which involves in multiple mitotic events.Fórmula:C22H28N8OSForma y color:SolidPeso molecular:452.58Aurora Kinases-IN-3
CAS:Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Fórmula:C20H16F3N3O4Forma y color:SolidPeso molecular:419.35L 888607 Racemate
CAS:L 888607 Racemate blocks DP1 and TP receptors with 132 nM and 17 nM affinity.Fórmula:C19H15ClFNO2SForma y color:SolidPeso molecular:375.84SAR156497
CAS:SAR156497: selective Aurora A/B/C inhibitor; IC50: 0.5 nM (A), 1 nM (B), 3 nM (C); good metabolic stability; anti-tumoral without genetic specificity.Fórmula:C27H24N4O4Forma y color:SolidPeso molecular:468.5SD-6
CAS:SD-6 is a dual Jak2/Aurora A inhibitor; blocks STAT3 signaling; mitosis inhibitor; hematological cancer research.Fórmula:C20H22N4OSPureza:99.85%Forma y color:SolidPeso molecular:366.48Ref: TM-T73575
1mgA consultar5mgA consultar10mgA consultar1mL*10mM (DMSO)A consultar25mg264,00€50mg432,00€XMD-12
CAS:XMD-12 is a selective pan-Aurora Kinase inhibitor, with an IC50 of 5.6/18.4/24.6 nM for Aurora A/B/C, anti-tumor, promote the apoptosis of cancer cells.Fórmula:C24H26N6O2Pureza:99.94%Forma y color:Yellow SolidPeso molecular:430.5BI-831266
CAS:BI-831266 is a potent and selective Aurora kinase B inhibitor.Fórmula:C27H38ClN7O2Forma y color:SolidPeso molecular:528.09FAK/aurora kinase-IN-1
CAS:FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].Fórmula:C23H24ClN7O3Forma y color:SolidPeso molecular:481.93Aurora kinase inhibitor-10
CAS:Aurora kinase inhibitor-10 is an orally active Aurora B inhibitor (IC50: 8 nM) that exhibits antitumour effects.Fórmula:C21H19F5N6O4SForma y color:SolidPeso molecular:546.47Aurora kinase inhibitor-9
CAS:Aurora kinase inhibitor-9 (9d) targets AURKA/B with IC50: 0.093 μM for A and 0.09 μM for B, with wide anti-proliferative effects.Fórmula:C19H17Cl2N3O4SForma y color:SolidPeso molecular:454.33HOI-07
CAS:HOI-07 is a specific Aurora B inhibitor.Fórmula:C19H13NO4Forma y color:SolidPeso molecular:319.31Aurora A/PKC-IN-1
CAS:Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.Fórmula:C16H14N6OSe2Forma y color:SolidPeso molecular:464.24OM-137
CAS:OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Fórmula:C13H14N4O3SForma y color:SolidPeso molecular:306.34Aurora Kinases-IN-2
CAS:Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.Fórmula:C22H18ClN5O3Forma y color:SolidPeso molecular:435.86Binucleine 2
CAS:Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.Fórmula:C13H11ClFN5Forma y color:SolidPeso molecular:291.71GRK6-IN-1
CAS:GRK6-IN-1 (compound 18) is a potent GRK6 blocker, with an IC50 of 120 nM, showing promise for multiple myeloma research.Fórmula:C22H23ClN6O2Pureza:99.37%Forma y color:SolidPeso molecular:438.91Ref: TM-T62518
1mg54,00€5mg114,00€1mL*10mM (DMSO)126,00€10mg178,00€25mg409,00€50mg708,00€100mg1.153,00€CD532
CAS:CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.Fórmula:C26H25F3N8OPureza:99.99%Forma y color:White SolidPeso molecular:522.52Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Fórmula:C27H21N3O3Pureza:99.22%Forma y color:SolidPeso molecular:435.47Ref: TM-T35570
1mg66,00€5mg144,00€1mL*10mM (DMSO)157,00€10mg245,00€25mg492,00€50mg710,00€100mg973,00€GSK2646264
CAS:GSK2646264 (Compound 44) inhibits SYK (pIC50=7.1) and kinases like LCK, LRRK2; penetrates skin.Fórmula:C24H26N2O2Forma y color:SolidPeso molecular:374.48GRK2 Inhibitor 2
CAS:GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293Fórmula:C19H16N4O2Forma y color:SolidPeso molecular:332.36GW814408X
CAS:GW814408X, a kinase chemical genome group (KCGS) compound, inhibits the AURKC kinase, which is involved in cell cycle progression, checkpoint regulation, and cell division. It exhibits cell line-dependent toxicity, such as cytotoxic effects on HeLa cells, and acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases, potentially impacting Fluc reporter assays [1].Fórmula:C19H16N6OForma y color:SolidPeso molecular:344.37Aurora kinase inhibitor-8
CAS:Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.Fórmula:C30H29N7O3Forma y color:SolidPeso molecular:535.6Aurora Kinases-IN-4
CAS:Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM.Fórmula:C26H28N8OPureza:98%Forma y color:SolidPeso molecular:468.55AAPK-25
CAS:AAPK-25, a dual Aurora/PLK inhibitor, disrupts mitosis, induces apoptosis, and has antitumor properties.Fórmula:C21H13Cl2N3O2SPureza:97.05%Forma y color:SolidPeso molecular:442.32Ref: TM-T10215
1mg54,00€5mg118,00€1mL*10mM (DMSO)131,00€10mg172,00€25mg313,00€50mg469,00€100mg680,00€TC-A 2317 hydrochloride
CAS:TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Fórmula:C19H29ClN6OPureza:98%Forma y color:SolidPeso molecular:392.93
