Receptor de endotelina
Los receptores de endotelina son GPCR que median los efectos de las endotelinas, péptidos vasoconstrictores potentes que desempeñan un papel significativo en la regulación del tono vascular, el control de la presión arterial y la proliferación celular. Los antagonistas de los receptores de endotelina se utilizan en el tratamiento de afecciones como la hipertensión arterial pulmonar y la insuficiencia cardíaca. Estos receptores también son objetivos importantes en la investigación sobre enfermedades cardiovasculares y cáncer. En CymitQuimica, ofrecemos una selección de moduladores de receptores de endotelina de alta calidad para apoyar su investigación en biología cardiovascular, oncología y fisiología vascular.
Se han encontrado 76 productos de "Receptor de endotelina"
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IRL-3630
CAS:<p>IRL 3460 is an enantiomer.</p>Fórmula:C31H40N4O6SPureza:98%Forma y color:SolidPeso molecular:596.74Endothelin 1 (swine, human), Alexa Fluor 488-labeled
<p>Synthetic human/swine Endothelin 1 peptide, tagged with Alexa Fluor 488, acts as a strong vasoconstrictor via ET A/B receptors.</p>Forma y color:SolidPeso molecular:2848.4Sarafotoxin S6a
CAS:<p>Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.</p>Fórmula:C105H156N28O34S5Pureza:98%Forma y color:SolidPeso molecular:2514.85Sarafotoxin S6b
CAS:<p>non-selective endothelin receptor agonist</p>Fórmula:C110H163N27O34S5Pureza:98%Forma y color:SolidPeso molecular:2567.96[Ala2] Endothelin-3, human
CAS:<p>[Ala2] Endothelin-3, a linear ET-3 analog with Ala replacing Cys, stimulates endothelial cell migration.</p>Fórmula:C120H166N26O32S4Forma y color:SolidPeso molecular:2613.02BQ-123 TFA
<p>BQ-123 TFA: Potent ETA antagonist, IC50 = 7.3 nM, Ki = 25 nM, inhibits ET-1 cell proliferation, lowers rat BP.</p>Fórmula:C33H43F3N6O9Forma y color:SolidPeso molecular:724.72Endothelin 1 (swine, human)
CAS:<p>Endothelin 1, a strong vasoconstrictor, targets ETA/ETB receptors, with a synthetic human/swine peptide sequence.</p>Fórmula:C109H159N25O32S5Forma y color:White PowderPeso molecular:2491.9Endothelin-3 (Rat,Human) (TFA)
<p>Endothelin-3 (Rat, Human) (TFA) is a 21-amino acid vasoactive peptide of endothelial origi, an agonist for the endothelin receptor type B (EDNRB).</p>Fórmula:C123H169F3N26O35S4·xC2HF3O2Pureza:98%Forma y color:SolidPeso molecular:2757.07 (free base)Bosentan (hydrate)
CAS:<p>Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.</p>Fórmula:C27H29N5O6S·H2OPureza:99.31% - 99.86%Forma y color:White PowderPeso molecular:569.63Macitentan
CAS:<p>Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).</p>Fórmula:C19H20Br2N6O4SPureza:98% - >99.99%Forma y color:SolidPeso molecular:588.27Darusentan
CAS:<p>Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries</p>Fórmula:C22H22N2O6Pureza:98.72%Forma y color:SolidPeso molecular:410.43Ambrisentan sodium
CAS:<p>Ambrosentan (BSF 208075) sodium is a selective and oral effective antagonist of ET type A receptor ( ETAR ).</p>Fórmula:C22H21N2NaO4Forma y color:SolidPeso molecular:400.41BQ-788 sodium salt
CAS:<p>BQ-788 sodium salt is a potent and selective antagonist of ETB receptor(ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells).</p>Fórmula:C34H51N5NaO7Forma y color:SolidPeso molecular:664.8Atrasentan
CAS:<p>Atrasentan (ABT-627) is an endothelin receptor antagonist that can inhibit the activity of ETA.Cost-effective and quality-assured.</p>Fórmula:C29H38N2O6Pureza:97.65% - 99.08%Forma y color:SolidPeso molecular:510.62Sparsentan
CAS:<p>Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM,</p>Fórmula:C32H40N4O5SPureza:97.94% - 98.69%Forma y color:SolidPeso molecular:592.75BMS 182874 hydrochloride
CAS:<p>BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.</p>Fórmula:C17H20ClN3O3SPureza:97.01%Forma y color:SolidPeso molecular:381.88Endothelin-2 (49-69), human
CAS:<p>Endothelin-2 (49-69), human (Human endothelin-2) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.</p>Fórmula:C115H160N26O32S4Pureza:98.26%Forma y color:SolidPeso molecular:2546.92Sitaxsentan sodium
CAS:<p>Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.</p>Fórmula:C18H14ClN2O6S2·NaPureza:98.39% - 99.01%Forma y color:SolidPeso molecular:476.89Aprocitentan
CAS:<p>Aprocitentan (ACT-132577) is ETA and ETB antagonist .</p>Fórmula:C16H14Br2N6O4SPureza:99.17%Forma y color:SolidPeso molecular:546.19BQ-123
CAS:<p>BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.</p>Fórmula:C31H42N6O7Pureza:99.22% - ≥95%Forma y color:SolidPeso molecular:610.7
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