Receptor de endotelina
Los receptores de endotelina son GPCR que median los efectos de las endotelinas, péptidos vasoconstrictores potentes que desempeñan un papel significativo en la regulación del tono vascular, el control de la presión arterial y la proliferación celular. Los antagonistas de los receptores de endotelina se utilizan en el tratamiento de afecciones como la hipertensión arterial pulmonar y la insuficiencia cardíaca. Estos receptores también son objetivos importantes en la investigación sobre enfermedades cardiovasculares y cáncer. En CymitQuimica, ofrecemos una selección de moduladores de receptores de endotelina de alta calidad para apoyar su investigación en biología cardiovascular, oncología y fisiología vascular.
Se han encontrado 86 productos de "Receptor de endotelina"
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Macitentan
CAS:Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).Fórmula:C19H20Br2N6O4SPureza:98% - >99.99%Forma y color:SolidPeso molecular:588.27Endothelin-2 (49-69), human
CAS:Endothelin-2 (49-69), human (Human endothelin-2) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.Fórmula:C115H160N26O32S4Pureza:98.26%Forma y color:SolidPeso molecular:2546.92Nebentan potassium
CAS:Nebentan potassium (YM598) is an ETA receptor antagonist that inhibits pulmonary arterial hypertension and is used in the study of neurologic diseases.Fórmula:C24H20KN5O5SPureza:99.05%Forma y color:SolidPeso molecular:529.61Ref: TM-T36008
1mg55,00€2mg81,00€5mg117,00€10mg187,00€25mg329,00€50mg530,00€100mg718,00€200mg938,00€1mL*10mM (DMSO)140,00€Zibotentan
CAS:Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.Fórmula:C19H16N6O4SPureza:97.00% - 97.02%Forma y color:SolidPeso molecular:424.43TBC3711
CAS:TBC3711 is an endothelin receptor modulator. It is used for the research of endothelin-mediated disorders.Fórmula:C20H21N3O5S2Pureza:98%Forma y color:SolidPeso molecular:447.53ZD-1611
CAS:ZD-1611 is an effective and selective ETA receptor antagonist. It is used for the research of ischemic stroke.Fórmula:C22H24N4O5SPureza:98%Forma y color:SolidPeso molecular:456.51CH 141
CAS:CH 141 is a new type of peripheral vasodilator.Fórmula:C19H21N3OForma y color:SolidPeso molecular:307.39ABT-546
CAS:ABT-546 is a potent, selective endothelin ETA receptor antagonist, Ki 0.46 nM for [125I]ET-1 binding.Fórmula:C30H48N2O6Pureza:98%Forma y color:SolidPeso molecular:532.71BMS-193884
CAS:BMS-193884 is an oral endothelin antagonist for the treatment of congestive heart failure (CHF) and pulmonary arterial hypertension.Fórmula:C20H17N3O4SForma y color:SolidPeso molecular:395.43CI 1020
CAS:endothelin-A receptor (ETA) antagonistFórmula:C28H26O9Pureza:98%Forma y color:SolidPeso molecular:506.5PD-156707
CAS:PD-156707 is a selective antagonist of endothelin A receptor.Fórmula:C28H26NaO9Pureza:98%Forma y color:SolidPeso molecular:529.497WS 009B
CAS:WS 009B is an antagonist of the endothelin receptor.Fórmula:C24H25NO11SPureza:98%Forma y color:SolidPeso molecular:535.52Daglutril
CAS:Daglutril is a NEP/ECE inhibitor for treating hypertension, heart failure, and pulmonary issues, blocking big endothelin-1 conversion.Fórmula:C31H38N2O6Forma y color:SolidPeso molecular:534.64Atrasentan hydrochloride
CAS:Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).Fórmula:C29H39ClN2O6Pureza:99.75%Forma y color:SolidPeso molecular:547.08Avosentan
CAS:Avosentan（Ro 67-0565; SPP-301） is a potent endothelin receptor (ETA) antagonist.Cost-effective and quality-assured.Fórmula:C23H21N5O5SPureza:98.31% - 99.47%Forma y color:SolidPeso molecular:479.51PD-159020
CAS:PD-159020 is a non-selective antagonist of ETA/ETB(hETA and hETB with IC50s of 30 and 50 nM , respectively).Fórmula:C32H25NO8Pureza:98%Forma y color:SolidPeso molecular:551.54WS 009A
CAS:WS 009A is an antagonist of the endothelin receptor.Fórmula:C24H25NO10SPureza:98%Forma y color:SolidPeso molecular:519.52ETA antagonist 1
CAS:ETA antagonist 1 is an antagonist of ETA selective (IC50 of 0.08 μM).Fórmula:C20H25N3O3SPureza:98%Forma y color:SolidPeso molecular:387.5Aminaftone
CAS:Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.Fórmula:C18H15NO4Pureza:96.31% - 99.39%Forma y color:SolidPeso molecular:309.32FR 139317
CAS:highly potent and selective ETA endothelin receptor antagonistFórmula:C33H44N6O5Pureza:98%Forma y color:SolidPeso molecular:604.74BMS 182874
CAS:BMS 182874: Oral ETA antagonist, IC50=0.150 μM, Ki=0.055 μM, lowers hypertension in rats.Fórmula:C17H19N3O3SPureza:99.73%Forma y color:SolidPeso molecular:345.42Edonentan
CAS:Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.Fórmula:C28H32N4O5SPureza:98.07% - 99.6%Forma y color:SolidPeso molecular:536.64SB-209670
CAS:SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.Fórmula:C29H28O9Pureza:98.29% - 99.40%Forma y color:SolidPeso molecular:520.53Ref: TM-T34541
1mg333,00€5mg787,00€10mg1.074,00€25mg1.510,00€50mg1.882,00€100mg2.375,00€500mg4.655,00€1mL*10mM (DMSO)797,00€Sitaxsentan
CAS:Sitaxsentan (TBC-11251), a selective ETA receptor antagonist, prevents vasoconstriction by blocking endothelin.Fórmula:C18H15ClN2O6S2Pureza:97.99% - 98.71%Forma y color:SolidPeso molecular:454.9L-749329
CAS:L-749329 is a ligand of ET(A) and ET(B) endothelin receptor.Fórmula:C28H29NO8SPureza:98%Forma y color:SolidPeso molecular:539.6Clazosentan
CAS:Clazosentan (Ro 61-1790) is a selective ET_A receptor antagonist that inhibits ET-1 vasoconstriction and prevents cerebral vasospasm.Fórmula:C25H23N9O6SPureza:95.39% - >99.99%Forma y color:SolidPeso molecular:577.57Ref: TM-T64084
1mg79,00€5mg178,00€10mg279,00€25mg628,00€50mg1.017,00€100mg1.311,00€200mg1.768,00€1mL*10mM (DMSO)230,00€K-8794
CAS:K-8794 is an orally active and selective endothelin receptor ETB antagonist that can be utilized in cardiovascular disease research.Fórmula:C36H38N6O6SForma y color:SolidPeso molecular:682.789Edonentan hydrate
CAS:Edonentan (BMS 207940) hydrate effectively blocks the endothelin A (ETA) receptor as a potent and selective antagonist, featuring a K i of 10 pM. It exhibits complete (100%) oral bioavailability in rats [1].Fórmula:C28H34N4O6SForma y color:SolidPeso molecular:554.66Diosuxentan
CAS:Diosuxentan is an inhibitor of ETA and is utilized in research pertaining to cardiovascular, renal, and neuronal inflammatory diseases.Fórmula:C20H21BrN6O7SForma y color:SolidPeso molecular:569.39BMS-248360
CAS:BMS-248360: Oral dual hAT1/hETA antagonist with Kis of 10nM & 1.9nM, respectively; treats hypertension.Fórmula:C36H45N5O5SPureza:98%Forma y color:SolidPeso molecular:659.84JKC 302
CAS:JKC 302 is an ET-A receptor antagonist that partially inhibits the contraction of tracheal rings in asthmatic rats induced by ET-1.Fórmula:C30H42N6O6Forma y color:SolidPeso molecular:582.69Macitentan (n-butyl analogue)
CAS:Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.Fórmula:C20H21Br2N5O4SPureza:98%Forma y color:SolidPeso molecular:587.29IRL 2500
CAS:IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.Fórmula:C36H35N3O4Pureza:99.36%Forma y color:White Crystalline SolidPeso molecular:573.68Tezosentan
CAS:Tezosentan is an antagonist of the endothelin receptor (pA2s: 9.5, 7.7 for ETA and ETB receptors, respectively).Fórmula:C27H27N9O6SPureza:98%Forma y color:SolidPeso molecular:605.63BQ-788
CAS:BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.Fórmula:C34H51N5O7Pureza:98.81%Forma y color:SolidPeso molecular:641.8Ref: TM-T10595
1mg137,00€2mg188,00€5mg329,00€10mg472,00€25mg753,00€50mg1.017,00€100mg1.378,00€500mg2.737,00€1mL*10mM (DMSO)360,00€Patecibart
CAS:Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).
Pureza:98%Forma y color:LiquidRef: TM-T81538
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