CaSR
El receptor sensible al calcio (CaSR) es un GPCR que juega un papel vital en el mantenimiento de la homeostasis del calcio al regular la secreción de la hormona paratiroidea y la reabsorción de calcio en los riñones. El CaSR también está involucrado en varios otros procesos fisiológicos, incluido el metabolismo óseo y la función vascular. Los moduladores de CaSR se utilizan en el tratamiento de afecciones como el hiperparatiroidismo, la osteoporosis y las enfermedades cardiovasculares. En CymitQuimica, ofrecemos una selección de moduladores de CaSR de alta calidad para apoyar su investigación en el metabolismo del calcio, endocrinología y salud ósea.
Se han encontrado 32 productos de "CaSR"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Calhex 231 hydrochloride
CAS:Calhex 231 hydrochloride a potent CaSR negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits mir-208a-mediated .Fórmula:C25H28Cl2N2OPureza:99.36%Forma y color:SolidPeso molecular:443.41Tecalcet Hydrochloride
CAS:<p>Tecalcet Hydrochloride, an allosteric CaSR modulator, enhances extracellular Ca2+ sensitivity.</p>Fórmula:C18H23Cl2NOPureza:99.97%Forma y color:SolidPeso molecular:340.29GSK3004774
CAS:<p>GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR.</p>Fórmula:C32H40N4O3Pureza:98%Forma y color:SolidPeso molecular:528.68(Rac)-Upacicalcet
CAS:<p>(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.</p>Fórmula:C11H14ClN3O6SForma y color:SolidPeso molecular:351.76NPS-2143
CAS:NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.Fórmula:C24H25ClN2O2Pureza:99.56%Forma y color:SolidPeso molecular:408.92Ronacaleret HCl
CAS:<p>Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.</p>Fórmula:C25H32ClF2NO4Pureza:99.97%Forma y color:SolidPeso molecular:483.98Encaleret
CAS:<p>Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.</p>Fórmula:C29H33ClFNO4Forma y color:SolidPeso molecular:514.03CaSR antagonist-1
CAS:<p>CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigation</p>Fórmula:C29H24FN3O2SPureza:98%Forma y color:SolidPeso molecular:497.58Calindol hydrochloride
CAS:<p>Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.</p>Fórmula:C21H21ClN2Pureza:99.47%Forma y color:SolidPeso molecular:336.86H-Glu-Thr-OH
CAS:<p>H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).</p>Fórmula:C9H16N2O6Forma y color:SolidPeso molecular:248.23TAK-075
CAS:<p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>Fórmula:C36H46N4O4SForma y color:SolidPeso molecular:630.84SB-423562
CAS:<p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>Fórmula:C26H32N2O4Pureza:99.22%Forma y color:SolidPeso molecular:436.54
