Receptor de histamina
Los receptores de histamina son GPCR que median los efectos de la histamina, una amina biógena involucrada en las respuestas inmunitarias, la secreción de ácido gástrico y la neurotransmisión. Hay cuatro subtipos de receptores de histamina (H1, H2, H3 y H4), cada uno de los cuales desempeña roles distintos en las reacciones alérgicas, la función gástrica y la actividad del sistema nervioso central. Los antagonistas de los receptores de histamina se utilizan ampliamente en el tratamiento de alergias, úlceras pépticas y mareos por movimiento. En CymitQuimica, ofrecemos una selección integral de moduladores de receptores de histamina de alta calidad para apoyar su investigación en inmunología, gastroenterología y neurofarmacología.
Se han encontrado 358 productos de "Receptor de histamina"
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FR-A 19
CAS:<p>FR-A 19: Histamine H2 agonist, nanomolar inhibition of basophil histamine release; potent anti-allergic.</p>Fórmula:C25H34Cl3F2N5Forma y color:SolidPeso molecular:548.93VUF 8328
CAS:<p>VUF 8328 is an agonist of histamine H(3) receptor.</p>Fórmula:C7H12N4SPureza:98%Forma y color:SolidPeso molecular:184.26Adriforant
CAS:<p>Adriforant (PF-3893787,ZPL-3893797) is a competitive histamine receptor 4 h4 antagonist that antagonizes histamine-induced phosphorylation of ERK, inflammation.</p>Fórmula:C13H22N6Pureza:99.84%Forma y color:SolidPeso molecular:262.35FRG8701
CAS:<p>FRG8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM.</p>Fórmula:C22H30N2O4SPureza:98%Forma y color:SolidPeso molecular:418.55ReN-1869 hydrochloride
CAS:<p>ReN 1869 hydrochloride is a novel, selective antagonist of histamine H1 receptor.</p>Fórmula:C24H28ClNO2Pureza:98%Forma y color:SolidPeso molecular:397.94H4R antagonist 1
CAS:<p>H4R antagonist 1: selective histamine H4R inhibitor, IC50 27 nM, no affinity for H1R, H2R, H3R.</p>Fórmula:C11H11BrN8Forma y color:SolidPeso molecular:335.16(±)-Tazifylline
CAS:<p>(±)-Tazifylline is a selective and long-acting antagonist of histamine H1 receptor.</p>Fórmula:C23H32N6O3SPureza:99.54%Forma y color:SolidPeso molecular:472.6Noberastine
CAS:<p>Noberastine (R 64947) is a novel histamine H1 antagonist with potent and specific peripheral antihistamine activity.</p>Fórmula:C17H21N5OPureza:99.72% - >99.99%Forma y color:SolidPeso molecular:311.38KSK68
CAS:<p>KSK68 is a sigma-1 and histamine H3 receptor antagonist with analgesic activity, inhibits H3 receptors and can be used to study pain.</p>Fórmula:C23H28N2O2Pureza:99.11%Forma y color:SolidPeso molecular:364.48Immethridine dihydrobromide
CAS:<p>Immethridine dihydrobromide is a histamine H3 receptor agonist.</p>Fórmula:C9H11Br2N3Pureza:97.61% - 98.14%Forma y color:SolidPeso molecular:321.01D18024
CAS:<p>D18024 is a phthalazinonderivat with anti-allergic and anti-histamine effect.</p>Fórmula:C29H31ClFN3OPureza:99.86%Forma y color:SolidPeso molecular:492.03Impromidine hydrochloride
CAS:<p>Impromidine hydrochloride is a very potent and specific histamine H2 receptor agonist for conducting cardiovascular studies.</p>Fórmula:C14H26Cl3N7SPureza:99.82%Forma y color:SolidPeso molecular:430.83Enerisant hydrochloride
CAS:<p>Enerisant HCl is a novel potent and selective histamine H3 receptor antagonist, a substrate for P-gp, mediated by cytochrome P450 (CYP) and transporter proteins</p>Fórmula:C22H31ClN4O3Pureza:99.95%Forma y color:SolidPeso molecular:434.96Linetastine
CAS:<p>Linetastine (TMK-688) inhibits 5-LOX, blocks leukotrienes, counters histamine; researched for asthma, atherosclerosis, ulcers.</p>Fórmula:C35H40N2O6Pureza:99.76%Forma y color:SolidPeso molecular:584.7Pitolisant
CAS:<p>Pitolisant is a potent and selective nonimidazole inverse agonist that acts on the recombinant human histamine H3 receptor with Ki of 0.16 nM.</p>Fórmula:C17H26ClNOPureza:99.84%Forma y color:SolidPeso molecular:295.85KSK94
CAS:<p>KSK94 is an H3 receptor antagonist that inhibits sigma-2 receptors , with a Ki value of 75.2 nM, and can be used to study injurious pain.</p>Fórmula:C25H26N4OPureza:99.60%Forma y color:SolidPeso molecular:398.5Irdabisant
CAS:<p>Irdabisant (CEP-26401) is an H3R antagonist/inverse agonist, BBB permeable, with cognition-enhancing effects for schizophrenia/cognitive research.</p>Fórmula:C18H23N3O2Pureza:99.96%Forma y color:SolidPeso molecular:313.39Efletirizine
CAS:<p>Efletirizine (UCB-28754), a histamine blocker and 5-LO inhibitor, aids in topical allergy treatment.</p>Fórmula:C21H24F2N2O3Pureza:99.39%Forma y color:SolidPeso molecular:390.42Antihistamine-1
CAS:<p>Antihistamine-1 是能够渗透血脑屏障的 H1-抗组胺药 (Ki=6.9 nM), 它也是 CYP2D6 和 hERG 通道的抑制剂，其 IC50 值分别为 5.4 和 0.8 μM。</p>Fórmula:C23H24FN5Pureza:99.69%Forma y color:SolidPeso molecular:389.47NP10679
CAS:<p>NP10679 is a N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit that inhibits histamine H1, hERG channels, and CYPase.</p>Fórmula:C23H26F3N3O3Pureza:99.43%Forma y color:SolidPeso molecular:449.47Proxyfan
CAS:<p>Proxyfan is a high-affinity protean antagonist/agonist of H3 receptors from full agonist to full inverse agonist, depending on given tissue or brain region.</p>Fórmula:C13H16N2OPureza:99.68%Forma y color:SolidPeso molecular:216.28ReN-1869
CAS:<p>ReN-1869 is a novel selective histamine H(1) receptor antagonist with anti-neurogenic pain and anti-inflammatory activity for the study of neurological diseases</p>Fórmula:C24H27NO2Pureza:99.83% - 99.98%Forma y color:SolidPeso molecular:361.48DF-1111301
CAS:<p>DF-1111301 is a novel anti-allergic compound with anti-histamine H1 and anti-PAF activity.</p>Fórmula:C15H25Cl2N3OPureza:99.17%Forma y color:SolidPeso molecular:334.29Eclazolast
CAS:<p>Eclazolast (RHC 2871), a lipophilic anti-allergic, inhibits mast cell mediator release by affecting Fc(epsilon)RI-related processes, dose-dependently.</p>Fórmula:C12H12ClNO4Pureza:98.36% - 98.58%Forma y color:SolidPeso molecular:269.68KP136
CAS:<p>KP136 is an orally effective antiallergic compound (IC50: 76.1 μg/mL for histamine release and 63 ug/mL for degranulation).</p>Fórmula:C16H18N4O3Pureza:98.3% - 98.61%Forma y color:SolidPeso molecular:314.34Bavisant
CAS:<p>Bavisant (JNJ-31001074) is a selective and orally active Human H3 receptor antagonist.</p>Fórmula:C19H27N3O2Pureza:99.21% - 99.65%Forma y color:SolidPeso molecular:329.44Abt-288
CAS:<p>ABT-288 is a selective and potent H3 antagonist for the treatment of mild to moderate Alzheimer's dementia.</p>Fórmula:C23H24N4OPureza:98.17% - 98.49%Forma y color:SolidPeso molecular:372.46Clemastine
CAS:<p>Clemastine (Meclastin) is an antagonist of the H1 receptor and exhibits anti-inflammatory effects.</p>Fórmula:C21H26ClNOPureza:99.21%Forma y color:SolidPeso molecular:343.89JZP-361
CAS:<p>JZP-361: selective MAGL inhibitor (IC50 = 46 nM); weaker on FAAH, hABHD6; anti-histamine; for asthma research.</p>Fórmula:C22H20ClN5OPureza:99.82%Forma y color:SolidPeso molecular:405.88JNJ-28583867
CAS:<p>JNJ-28583867 is an inhibitor of histamine H(3) receptor antagonist and serotonin reuptake.</p>Fórmula:C24H32N2O2SForma y color:SolidPeso molecular:412.59Cipralisant maleate
CAS:<p>Cipralisant maleate is a potent, selective Histamine H3 receptor antagonist.</p>Fórmula:C18H24N2O4Forma y color:SolidPeso molecular:332.39CI-949
CAS:<p>CI-949 inhibits LTC4/D4, histamine, TXB2 release (IC50: 0.5, 11.4, 0.1 μM).</p>Fórmula:C20H20N6O3Pureza:98%Forma y color:SolidPeso molecular:392.41Ebrotidine
CAS:<p>Ebrotidine (FI3542) is a competitive H2-receptor antagonist with Ki of 127.5 nM. Ebrotidine has a potent antisecretory activity and evidenced gastroprotection.</p>Fórmula:C14H17BrN6O2S3Pureza:97.519%Forma y color:SolidPeso molecular:477.42GSK-1004723
CAS:<p>GSK-1004723 is a novel antagonist of histamine H(1) and H(3) receptor. It represents a potential novel therapy for allergic rhinitis.</p>Fórmula:C39H49ClN4O2Forma y color:SolidPeso molecular:641.28Quinotolast sodium
CAS:<p>Quinotolast sodium inhibits histamine, LTC4 and PGD2 release in a concentration-dependent manner in the concentration range of 1-100 μg/mL.</p>Fórmula:C17H12N6NaO3Pureza:98%Forma y color:SolidPeso molecular:371.312UCB-35440
CAS:<p>UCB-35440, a 5-lipoxygenase inhibitor and a histamine H1 receptor antagonist, is used potentially for the treatment of dermatitis.</p>Fórmula:C31H34ClN5O4Forma y color:SolidPeso molecular:576.09Minocromil
CAS:<p>Minocromil is a new agent of Anti-asthmatic.</p>Fórmula:C18H16N2O6Pureza:98%Forma y color:SolidPeso molecular:356.33A-349821
CAS:<p>A-349821 is an H3 receptor agonist radioligand.</p>Fórmula:C28H35F3N2O5Forma y color:SolidPeso molecular:536.59GT-2331
CAS:<p>GT-2331 is a histamine H3 receptor antagonist.</p>Fórmula:C14H20N2Forma y color:SolidPeso molecular:216.32Levocabastine
CAS:<p>Levocarbastine: 2nd-gen H1 antagonist, treats allergic conjunctivitis, selective NTS2 neurotensin inhibitor.</p>Fórmula:C26H29FN2O2Forma y color:SolidPeso molecular:420.52H3 receptor antagonist 1
CAS:<p>H3 receptor antagonist 1 is used in the study of neurological diseases, histamine H3 receptor antagonist.</p>Fórmula:C20H28F2N2OPureza:98%Forma y color:SolidPeso molecular:350.45H4R antagonist 2
CAS:<p>H4R Antagonist 2, a potent Furo[3,2-d]pyrimidine derivative, serves as a histamine H4 receptor antagonist and holds potential for research into rheumatoid</p>Fórmula:C13H17N5OPureza:98%Forma y color:SolidPeso molecular:259.31Cipralisant
CAS:<p>Cipralisant: H3 receptor antagonist (in vivo), agonist (in vitro, pKi 9.9), Ki 0.47 nM in rats, may treat ADHD.</p>Fórmula:C14H20N2Pureza:98%Forma y color:SolidPeso molecular:216.32Levocabastine hydrochloride
CAS:<p>Levocabastine HCl is an agent with antihistaminic activity.</p>Fórmula:C26H30ClFN2O2Forma y color:SolidPeso molecular:456.98ST-1006
CAS:<p>ST-1006: histamine H4 agonist, pKi 7.94, anti-inflammatory, anti-pruritic, promotes basophil migration.</p>Fórmula:C16H20Cl2N6Pureza:98.87% - 99.96%Forma y color:SolidPeso molecular:367.28Enerisant
CAS:<p>Enerisant (TS-091) is a histamine H3 receptor antagonist that promotes pro-cognitive effects and reverses scopolamine-induced cognitive deficits.</p>Fórmula:C22H30N4O3Pureza:99.7%Forma y color:SoildPeso molecular:398.50Tixanox sodium
CAS:<p>Tixanox sodium effectively blocks histamine release in the lungs triggered by anti-IgE. It has also been demonstrated that when administered orally, Tixanox sodium can successfully counteract exercise-induced asthma.</p>Fórmula:C15H9NaO5SForma y color:SolidPeso molecular:324.28CI-624
CAS:<p>CI-624 reduces the secretion and output of hydrogen ions, sodium ions, potassium ions, and pepsin. This compound may be utilized in research focusing on cancer and autoimmune diseases.</p>Fórmula:C8H8N2SForma y color:SolidPeso molecular:164.228H3R antagonist 5
CAS:<p>H3R antagonist 5 (Compound 1b) is a selective inverse agonist of the histamine H3 receptor that can penetrate the blood-brain barrier, with an IC50 of 0.54 nM. It is applicable for research related to the central nervous system.</p>Fórmula:C23H32N2O4Forma y color:SolidPeso molecular:400.511Arpromidine
CAS:<p>Arpromidine (BU-E-50) acts as an agonist for the histamine H2 receptor and an antagonist for the histamine H1 receptor. It demonstrates positive inotropic effects with a lower risk of inducing arrhythmias. Arpromidine can be utilized in studies related to congestive heart failure.</p>Fórmula:C21H25FN6Forma y color:SolidPeso molecular:380.462H1R ligand-1
CAS:<p>H1R ligand-1 (Compound fragment 1) is a high-affinity ligand for the human histamine H1 receptor (H1R). It can serve as a scaffold for synthesizing a series of derivatives to investigate H1R binding kinetics.</p>Fórmula:C19H23NOForma y color:SolidPeso molecular:281.392Nedocromil sodium
CAS:<p>Nedocromil sodium is a pharmacologic stabilizer of mast cells, has been shown to normalize cytokine levels and attenuate cardiac remodeling.</p>Fórmula:C19H17NNaO7Pureza:98%Forma y color:SolidPeso molecular:394.335UR-AK49
CAS:<p>UR-AK49 (compound 11) is an agonist for the human histamine H1 and H2 receptors. It exhibits an EC50 of 23 nM in the GTPase assay involving hH2R-Gsalpha fusion protein expressed in Sf9 insect cells. UR-AK49 is applicable in neurologically related research.</p>Fórmula:C16H27N5OForma y color:SolidPeso molecular:305.42FR-145715
CAS:<p>FR-145715 is a histamine H2 receptor antagonist characterized by its specific anti-Helicobacter pylori activity. This compound is utilized in the study of gastric lesions.</p>Fórmula:C16H21N5O2SForma y color:SolidPeso molecular:347.44Histamine H3 antagonist-1
CAS:<p>Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].</p>Fórmula:C24H28F3N3O2Forma y color:SolidPeso molecular:447.49H3R antagonist 1
CAS:<p>H3R-IN-1 is an effective inverse agonist of the histamine receptor 3 (H3R).</p>Fórmula:C19H23N3O3Forma y color:SolidPeso molecular:341.4(R)-(-)-α-Methylhistamine dihydrochloride
CAS:<p>R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.</p>Fórmula:C6H13Cl2N3Forma y color:SolidPeso molecular:198.09Imetit dihydrobromide
CAS:<p>Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).</p>Fórmula:C6H12Br2N4SPureza:98%Forma y color:SolidPeso molecular:332.06
