Receptor de opioides
Los receptores opioides son un grupo de receptores acoplados a proteínas G que median los efectos de los opioides endógenos y exógenos. Estos receptores desempeñan un papel central en la modulación del dolor, la regulación del estado de ánimo y los comportamientos adictivos. Los agonistas y antagonistas de los receptores opioides se utilizan ampliamente en el manejo del dolor y el tratamiento de adicciones, así como en la investigación de trastornos neurológicos y psiquiátricos. En CymitQuimica, ofrecemos una selección integral de moduladores de receptores opioides de alta calidad para apoyar su investigación en neurobiología, manejo del dolor y terapia de adicciones.
Se han encontrado 296 productos de "Receptor de opioides"
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Dynorphin B (1-13) (TFA)
<p>Dynorphin B (1-13) TFA acts as an agonist on opioid κ-receptor .</p>Fórmula:C76H116N21F3O19Forma y color:SolidPeso molecular:1684.86Dynorphin B (1-9)
CAS:<p>Dynorphin B (1-9), a neuropeptide and the N-terminal cleavage product of dynorphin B, has its formation inhibited by N-ethylmaleimide (NEM), a non-selective</p>Fórmula:C54H78N16O12Pureza:98%Forma y color:SolidPeso molecular:1143.3Ac-RYYRWK-NH2 TFA
CAS:<p>Ac-RYYRWK-NH2: potent, specific NOP receptor partial agonist with 0.071 nM affinity; no affinity for μ/κ/δ-opioid receptors.</p>Fórmula:C51H70F3N15O11Forma y color:SolidPeso molecular:1126.21KOR agonist 4
<p>KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.</p>Fórmula:C21H25N3Forma y color:SolidPeso molecular:319.44β-Endorphin, equine TFA
<p>β-Endorphin, equine TFA, an endogenous opioid peptide, demonstrates high affinity binding to μ/δ opioid receptors and possesses analgesic properties [1] [2] [3</p>Fórmula:C156H249F3N42O46SForma y color:SolidPeso molecular:3537.96Akuammicine
CAS:<p>Akuammicine, as an indole alkaloid from Catharanthus roseus, can be used in cancer cell eradication.</p>Fórmula:C20H22N2O2Forma y color:SolidPeso molecular:322.408Nociceptin(1-7)
CAS:<p>Bioactive metabolite of nociceptin, antagonist of nociceptin-induced hyperalgesia</p>Fórmula:C31H41N7O9Pureza:98%Forma y color:SolidPeso molecular:655.709[(pF)Phe4]Nociceptin(1-13)NH2
CAS:<p>Potent, selective OP4 agonist; pKi=10.68, pEC50=9.80. >8000x selectivity vs other opioid receptors; long-lasting in vivo effects.</p>Fórmula:C61H99FN22O15Pureza:98%Forma y color:SolidPeso molecular:1399.6ICI 174,864
CAS:<p>Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.</p>Fórmula:C38H53N5O7Pureza:98%Forma y color:White SolidPeso molecular:691.87Dermorphin Analog
<p>Dermorphin Analog, a heptapeptide from amphibian skin, binds μ-opioid receptors selectively and strongly.</p>Fórmula:C44H59N11O10Pureza:98%Forma y color:SolidPeso molecular:901.43PL-017
CAS:<p>μ opioid receptor agonist; IC50: 5.5 nM (μ), >10,000 nM (δ). Induces reversible analgesia, catalepsy, hyperthermia in rats.</p>Fórmula:C29H37N5O5Pureza:98%Forma y color:SolidPeso molecular:535.64[Met5]-Enkephalin, amide
CAS:<p>[Met5]-Enkephalin, amide activates δ and ζ opioid receptors; has multiple forms and varying plasma levels.</p>Fórmula:C27H36N6O6SPureza:98%Forma y color:SolidPeso molecular:572.68MT-7716 hydrochloride
CAS:<p>MT-7716 hydrochloride is a selective agonist of non-peptide nociceptin receptor (NOP)</p>Fórmula:C27H29ClN4O2Pureza:98%Forma y color:SolidPeso molecular:477Opioid receptor agonist 1
<p>Opioid receptor agonist1 (Compound 2638-28) is an orally active opioid receptor agonist that shows strong affinity for MOR, DOR, and KOR, with Ki values of 5, 24, and 212 nM, respectively. It exhibits analgesic activity in both the mouse warm water tail-flick model and the acetic acid writhing model.</p>Fórmula:C32H45N5OForma y color:SolidPeso molecular:515.73PIPE-3297
<p>PIPE-3297 (compound 25) is a selective kappa opioid receptor (KOR) agonist that activates the G protein signaling pathway with an EC50 of 1.1 nM and exhibits low β-arrestin-2 recruitment activity (10%). Additionally, PIPE-3297 promotes myelination and has anti-inflammatory properties.</p>Fórmula:C23H30N2OPeso molecular:350.23581[Nphe1]Nociceptin(1-13)NH2
CAS:<p>Competitive nociceptin receptor antagonist with pKi=8.4; no agonist activity; blocks nociceptin effects in vitro/in vivo.</p>Fórmula:C61H100N22O15Pureza:98%Forma y color:SolidPeso molecular:1381.6SNC 80
CAS:<p>SNC 80, a non-peptide δ-opioid agonist (Ki=1.78 nM, IC50=2.73 nM), also targets μ-δ heteromers (EC50=52.8 nM), with analgesic and antidepressant potential.</p>Fórmula:C28H39N3O2Pureza:99.65%Forma y color:SolidPeso molecular:449.63[DAla2, DArg6] Dynorphin A, (1-13) (porcine)
CAS:<p>'[DAla2, DArg6] Dynorphin A (1-13) porcine is a potent opioid peptide resistant to enzymatic degradation.'</p>Fórmula:C76H128N24O15Forma y color:SolidPeso molecular:1617.98CJ-15208
CAS:<p>CJ-15208: κ-opioid antagonist, IC50: 47 nM kappa, 260 nM mu, 2600 nM delta, reverses asimadoline effects in rabbits (ED50 1.3 µM).</p>Fórmula:C34H35N5O4Forma y color:SolidPeso molecular:577.67U-54494A hydrochloride
CAS:<p>U-54494A hydrochloride is a benzamide derivative related to kappa opioid receptor agonists. U-54494A hydrochloride has anticonvulsant activity.</p>Fórmula:C18H25Cl3N2OForma y color:SolidPeso molecular:391.76Ac-RYYRWK-NH2
CAS:<p>Selective NOP receptor partial agonist peptide; Ki=0.71 nM; >4000 nM for μ, δ, κ receptors; boosts food intake in vivo.</p>Fórmula:C49H69N15O9Pureza:98%Forma y color:SolidPeso molecular:1012.17Gluten Exorphin B5
CAS:<p>Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten.</p>Fórmula:C30H38N6O7Pureza:98%Forma y color:SolidPeso molecular:594.66Herkinorin
CAS:<p>Herkinorin: μ-opioid agonist with 100x μ-affinity, 50x less κ-affinity than Salvinorin A, from Salvia divinorum. Semi-synthetic from Salvinorin B.</p>Fórmula:C28H30O8Forma y color:SolidPeso molecular:494.53Dermorphin
CAS:<p>Dermorphin is agonist of μ-opioid receptor (MOR) agonist.</p>Fórmula:C40H50N8O10Pureza:98.82%Forma y color:SolidPeso molecular:802.87[Nphe1]Nociceptin(1-13)NH2 TFA
<p>[Nphe1]Nociceptin(1-13)NH2 is a selective nociceptin receptor antagonist with potential analgesic properties, pKi=8.4, pA2=6.0.</p>Fórmula:C63H101F3N22O17Forma y color:SolidPeso molecular:1495.61Dynorphin B (1-13)
CAS:<p>Dynorphin B (1-13) acts as an agonist on opioid κ-receptor.</p>Fórmula:C74H115N21O17Pureza:98%Forma y color:SolidPeso molecular:1570.84β-Endorphin (rat)
CAS:<p>β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities.</p>Fórmula:C157H254N42O44SForma y color:SolidPeso molecular:3466.07CTAP
CAS:<p>Potent μ opioid antagonist, IC50 3.5 nM, 1200x selectivity over δ and somatostatin, brain-penetrant, active in vivo.</p>Fórmula:C51H69N13O11S2Pureza:98%Forma y color:White Solid/PowderPeso molecular:1104.32Orphanin FQ(1-11)
CAS:<p>Nociceptin peptide fragment (1-11) with potent ORL1/KOR-3 receptor agonism (Ki = 55 nM), no opioid receptor affinity, and analgesic in mice.</p>Fórmula:C49H75N15O14Pureza:98%Forma y color:SolidPeso molecular:1098.2(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8)
CAS:<p>E-2078, known chemically as (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8), is a stable analog of Dynorphin A (1–8) and functions as a kappa opioid</p>Fórmula:C50H81N15O9Forma y color:SolidPeso molecular:1036.27β-Naltrexamine dihydrochloride
CAS:<p>β-Naltrexamine dihydrochloride is an orally administered, irreversible opioid receptor antagonist. Its derivatives exhibit optimised subtype selectivity and can be used for pain research.</p>Fórmula:C20H28Cl2N2O3Pureza:95.98%Forma y color:SoildPeso molecular:415.35Biphalin TFA
CAS:<p>Biphalin TFA is an opioid peptide analog that penetrates the blood-brain barrier (BBB) and encompasses two active enkephalin pharmacophores.</p>Fórmula:C46H56N10O10·xC2HF3O2Pureza:98%Forma y color:SolidPeso molecular:909.00 (free base)CTOP
CAS:<p>Potent μ-receptor antagonist, Ki=0.96nM, ineffective at δ (>10,000nM). Alters behavior in vivo, boosts K+ currents in rat neurons in vitro, μ-independent.</p>Fórmula:C50H67N11O11S2Pureza:98%Forma y color:SolidPeso molecular:1062.28Cebranopadol hemicitrate
CAS:<p>Cebranopadol hemicitrate is a NOP and opioid receptor agonist that targets human NOP, MOP, KOP, and δ-opioid peptide (DOP) receptors, with Ki/EC50 values of 0.9 nM/13 nM, 0.7 nM/1.2 nM, 2.6 nM/17 nM, and 18 nM/110 nM, respectively. It is used in studies of acute and chronic pain.</p>Forma y color:Solid[DPro10] Dynorphin A (1-11)acetate,porcine
<p>[DPro10] Dynorphin A (1-11)acetate,porcine is a highly potent κ-opioid receptor agonist with a Ki value of 0.13 nM.</p>Fórmula:C65H107N21O15Pureza:99.05%Forma y color:SoildPeso molecular:1422.7Nociceptin (1-13), amide
CAS:<p>Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain</p>Fórmula:C61H100N22O15Pureza:98%Forma y color:SolidPeso molecular:1381.59Ro 64-6198
CAS:<p>Ro 64-6198: Nonpeptide, selective NOP agonist, high brain uptake, EC50=25.6 nM, 100x NOP>opioid affinity.</p>Fórmula:C26H31N3OPureza:98%Forma y color:SolidPeso molecular:401.54[Arg14,Lys15]Nociceptin
CAS:<p>Potent NOP agonist (EC50 = 1 nM), >875x selective vs opioid receptors; outperforms nociceptin in vivo, increases pain perception, reduces movement.</p>Fórmula:C82H137N31O22Pureza:98%Forma y color:SolidPeso molecular:1909.18N-Desmethyl Loperamide
CAS:<p>N-Desmethyl Loperamide is the major metabolite of loperamide. It is also used as the precusor for radiolabelled loperamide.</p>Fórmula:C28H31ClN2O2Forma y color:SolidPeso molecular:463.01MT-7716 free base
CAS:<p>MT-7716: selective NOP agonist, potential in preventing alcohol abuse/relapse.</p>Fórmula:C27H28N4O2Pureza:98%Forma y color:SolidPeso molecular:440.54Neurotransmitter Receptor Compound Library
<p>A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；</p>Forma y color:Odour SolidBAM-22P
CAS:<p>Bovine adrenal medulla docosapeptide (BAM-22P) is a potent opioid agonist, derived from the proenkephalin A gene, which is present in the adrenal medulla.</p>Fórmula:C130H184N38O31S2Pureza:98%Forma y color:SolidPeso molecular:2839.22TAN67
CAS:<p>TAN67 is the first effective selective non-peptide delta1 opioid receptor.</p>Fórmula:C23H26Br2N2OForma y color:SolidPeso molecular:506.282Boc-ypgflt(O-tbu)
CAS:<p>Boc-ypgflt(O-tbu) is a delta-receptor-selective opioid antagonist.</p>Fórmula:C44H64N6O11Forma y color:SolidPeso molecular:853.01UFP-101
CAS:<p>Strong, selective NOP receptor antagonist with pKi=10.24; >3000x selectivity over δ, μ, κ receptors; blocks nociceptin effects.</p>Fórmula:C82H138N32O21Pureza:98%Forma y color:SolidPeso molecular:1908.19N-terminally acetylated Endomorphin-1
<p>N-terminally acetylated Endomorphin-1 is a modified Endomorphin-1.</p>Fórmula:C36H40N6O6Pureza:98%Forma y color:SolidPeso molecular:652.74(Rac)-SNC80
CAS:<p>(Rac)-SNC80, a racemic δ-opioid agonist (K i 1.78 nM), shows potential for treating various headache disorders.</p>Fórmula:C28H39N3O2Forma y color:SolidPeso molecular:449.63DAMGO (TFA)
CAS:<p>DAMGO is a selective peptide agonist of the µ-opioid receptor .</p>Fórmula:C28H36F3N5O8Pureza:98%Forma y color:SolidPeso molecular:627.61Deltorphin acetate
<p>Deltorphin acetate is a substance obtained from the skin secretions of a frog, Phyllomedusa bicolor and shows high selectivity and affinity for δ-opioid</p>Fórmula:C46H66N10O12S2Pureza:98.93%Forma y color:SolidPeso molecular:1015.21N-Phenethylnoroxymorphone
CAS:<p>N-Phenethylnoroxymorphone is an opioid compound that can enhance morphine-induced analgesia in rats. It is used in the research of neurological disorders.</p>Fórmula:C24H25NO4Forma y color:SolidPeso molecular:391.46
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