SGLT
Los cotransportadores sodio-glucosa (SGLT) son proteínas de membrana que facilitan la reabsorción de glucosa en los riñones al acoplar el transporte de glucosa con los iones de sodio. Los inhibidores de SGLT son una clase importante de medicamentos utilizados en el tratamiento de la diabetes tipo 2, ya que ayudan a reducir los niveles de glucosa en sangre al prevenir la reabsorción de glucosa en los túbulos renales. Estos inhibidores también están siendo investigados por sus posibles beneficios en la protección cardiovascular y renal. En CymitQuimica, ofrecemos una gama de moduladores de SGLT de alta calidad para apoyar su investigación en diabetes, fisiología renal y trastornos metabólicos.
Se han encontrado 34 productos para "SGLT".
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Sergliflozin A
CAS:Sergliflozin A is a selective SGLT2 inhibitor that induces diabetes in a dose-dependent manner. It reduces hyperglycemia.Fórmula:C20H24O7Pureza:99.71%Forma y color:SolidPeso molecular:376.4004KGA-2727
CAS:KGA-2727: potent, selective SGLT1 inhibitor (human Ki 97.4 nM, rat 43.5 nM), with high selectivity over SGLT2 for diabetes treatment.Fórmula:C26H40N4O8Pureza:98.46%Forma y color:SolidPeso molecular:536.6178O-Desethyl Dapagliflozin
CAS:O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM.Fórmula:C19H21ClO6Pureza:98.33%Forma y color:Yellow OilPeso molecular:380.819SGLT2-IN-4
SGLT2-IN-4 (Compound 1) is a selective and orally active inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2). It increases the proportion of α-helices in proteins and enhances the stability of the SGLT2-D201A mutant. SGLT2-IN-4 is applicable in research for type 2 diabetes.Empagliflozin-d8
CAS:Empagliflozin-d8 is the deuterium-labeled form of Empagliflozin. Empagliflozin (BI 10773) acts as a selective inhibitor of the sodium-glucose co-transporter-2 (SGLT-2), exhibiting an IC50 value of 3.1 nM for human SGLT-2.Fórmula:C23H27ClO7Peso molecular:458.96Dapagliflozin (Standard)
CAS:Dapagliflozin (Standard) is the standard for Dapagliflozin (T2389). Dapagliflozin is a competitive sodium-glucose cotransporter 2 (SGLT2) inhibitor that can reduce renal glucose reabsorption and promote urinary glucose excretion. Dapagliflozin can also inhibit renal mesangial cell fibrosis by regulating the HO-1/TGF-β1/Smad2/3 axis, and is related to research on glucose transport, renal cell responses, and fibrosis signaling. Dapagliflozin can also be used in research on SGLT2 pharmacology and mechanisms of renal fibrosis-related pathways.Fórmula:C21H25ClO6Peso molecular:408.87Canagliflozin (Standard)
CAS:Canagliflozin (Standard) is the standard substance of Canagliflozin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor that inhibits CHO cells expressing mSGLT2, rSGLT2, and hSGLT2 (IC50=2/3.7/4.4 nM). Canagliflozin can be used for the treatment of type II diabetes mellitus (T2DM).Fórmula:C24H25FO5SForma y color:SolidPeso molecular:444.52T-1095
CAS:T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).Fórmula:C26H28O11Pureza:99.78%Forma y color:SolidPeso molecular:516.4939Tofogliflozin (hydrate)
CAS:Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(Ki of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2).Fórmula:C22H28O7Pureza:97.03% - 98.78%Forma y color:White SolidPeso molecular:404.4535Phlorizin
CAS:Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .Fórmula:C21H24O10Pureza:99.73% - 99.77%Forma y color:Solid CrystallinePeso molecular:436.41Sotagliflozin
CAS:Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potentialFórmula:C21H25ClO5SPureza:99% - 99.86%Forma y color:SolidPeso molecular:424.938Dapagliflozin ((2S)-1,2-propanediol, hydrate)
CAS:Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-Fórmula:C24H35ClO9Pureza:99.88% - 99.94%Forma y color:SolidPeso molecular:502.98Mizagliflozin
CAS:Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1.Cost-effective and quality-assured.Fórmula:C28H44N4O8Pureza:98.66% - 99.67%Forma y color:SolidPeso molecular:564.671Canagliflozin
CAS:Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor. Canagliflozin is used to treat type II diabetes mellitus. Cost-effective and quality-assured.Fórmula:C24H25FO5SPureza:98.01% - >99.99%Forma y color:White SolidPeso molecular:444.52Ipragliflozin
CAS:Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.Fórmula:C21H21FO5SPureza:99.38% - 99.70%Forma y color:White SolidPeso molecular:404.45Phloretin
CAS:Phloretin (NSC-407292) inhibits eukaryotic urea transporters, has antioxidative properties, and can induce cancer cell apoptosis. Found in apples and apricots.Fórmula:C15H14O5Pureza:98.53% - >99.99%Forma y color:White SolidPeso molecular:274.2687Ertugliflozin
CAS:PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).Fórmula:C22H25ClO7Pureza:99.89% - 99.96%Forma y color:SolidPeso molecular:436.883Bexagliflozin
CAS:Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 2 nM for human SGLT2.Fórmula:C24H29ClO7Pureza:98.99% - 99.89%Forma y color:SolidPeso molecular:464.936Empagliflozin
CAS:Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6.Fórmula:C23H27ClO7Pureza:98% - 99.98%Forma y color:SolidPeso molecular:450.91Trilobatin
CAS:Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentiallyFórmula:C21H24O10Pureza:97.16%Forma y color:SolidPeso molecular:436.4093
