Receptor de dopamina
Los receptores de dopamina son un grupo de receptores acoplados a proteínas G (GPCR) que responden al neurotransmisor dopamina, jugando un papel clave en la regulación del movimiento, la motivación, la recompensa y varias funciones cognitivas. Estos receptores se dividen en familias similares a D1 y D2, cada una con funciones y perfiles farmacológicos distintos. Los moduladores de los receptores de dopamina se estudian ampliamente por sus aplicaciones en el tratamiento de la enfermedad de Parkinson, la esquizofrenia, la adicción y otros trastornos neuropsiquiátricos. En CymitQuimica, ofrecemos una amplia gama de moduladores de receptores de dopamina de alta calidad para apoyar su investigación en neurociencia, salud mental y señalización GPCR.
Se han encontrado 445 productos de "Receptor de dopamina"
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LY3154885
CAS:LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM) that reduces the risk of drug-drug interactions (DDI).Fórmula:C23H23Cl2N3O2Forma y color:SolidPeso molecular:444.35Sonepiprazole
CAS:Sonepiprazole (PNU-101387G) is a chemical compound known for its selective antagonistic properties toward D4 dopamine receptors, exhibiting dissociationFórmula:C21H27N3O3SPureza:99.81%Forma y color:SolidPeso molecular:401.52Quinpirole dihydrochloride
CAS:Quinpirole dihydrochloride is an agonist of the D2-like dopamine receptor.Fórmula:C13H23Cl2N3Pureza:98%Forma y color:SolidPeso molecular:292.25CP-293019
CAS:CP-293019 is a potent, selective antagonist of dopamine D4 receptor.Fórmula:C19H22F2N4OPureza:98%Forma y color:SolidPeso molecular:360.4LY-368975
CAS:LY-368975 is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. LY-368975 reduces food consumption in rodents.Fórmula:C17H21NOSForma y color:SolidPeso molecular:287.42Naxagolide free base
CAS:Naxagolide is a sustained release formulation. It is a dopamine agonist.Fórmula:C15H21NO2Pureza:98%Forma y color:SolidPeso molecular:247.33PD 128907
CAS:PD 128907 - potent, selective dopamine D2/D3 agonist for researching receptor roles in the brain.Fórmula:C14H19NO3Pureza:98%Forma y color:SolidPeso molecular:249.314-Amino-PPHT Hydrobromide
CAS:4-Amino-PPHT Hydrobromide is a precursor for fluorescent labeled Dopamine D2 receptors agonist.Fórmula:C21H28N2OPureza:98%Forma y color:SolidPeso molecular:324.46PW0464
CAS:PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for neurological disorders.Fórmula:C19H17F2N3O4Pureza:98.78%Forma y color:SolidPeso molecular:389.35Ref: TM-T36946
1mg160,00€5mg386,00€10mg635,00€25mg1.228,00€50mg1.839,00€100mg2.470,00€1mL*10mM (DMSO)425,00€LBT 999
CAS:LBT 999 is used as a dopamine reuptake inhibitor.Fórmula:C20H26FNO2Forma y color:SolidPeso molecular:331.42(+)-Dihydrexidine hydrochloride
CAS:(+)-Dihydrexidine hydrochloride is an agonist of dopamine D1 receptor(EC50 of 72± 21 nM).Fórmula:C17H18ClNO2Pureza:98%Forma y color:SolidPeso molecular:303.78Pentiapine
CAS:Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.Fórmula:C15H17N5SPureza:99.35%Forma y color:SolidPeso molecular:299.39Ref: TM-T12405
1mg487,00€5mg753,00€10mg1.216,00€25mg1.691,00€50mg2.262,00€100mg3.068,00€1mL*10mM (DMSO)938,00€ABT-670
CAS:ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.Fórmula:C19H23N3O2Pureza:98%Forma y color:SolidPeso molecular:325.4SKF 81297
CAS:SKF 81297 is a selective and potent agonist for the dopamine D1 receptor [1].Fórmula:C16H16ClNO2Pureza:98%Forma y color:SolidPeso molecular:289.76SKF 81297 hydrobromide
CAS:SKF 81297 hydrobromide, a selective agonist of the dopamine D1-like receptor，exhibits central activity and is widely used to study the neuromodulatory effects.Fórmula:C16H17BrClNO2Pureza:99.52%Forma y color:SolidPeso molecular:370.67AJ-76 hydrochloride
CAS:AJ-76 hydrochloride ((+)-AJ 76 hydrochloride) serves as a dopamine autoreceptor antagonist, exhibiting pK i values of 6.95 for hD3, 6.67 for hD4, 6.37 for hD2S, 6.21 for hD2L, and 6.07 for rD2 receptors, indicating its binding affinity strength across these receptor types.Fórmula:C15H24ClNOForma y color:SolidPeso molecular:269.81Carbidine dihydrochloride
CAS:Carbidine, a gamma-carboline derivative, is an atypical antipsychotic that modulates dopamine release and tyrosine hydroxylase activity.Fórmula:C13H20Cl2N2Pureza:98.59%Forma y color:SolidPeso molecular:275.217UWA-101 hydrochloride
CAS:UWA-101 hydrochloride is a selective, non-cytotoxic inhibitor of DAT/SERT, demonstrating EC50 values of 3.6 µM for DAT and 2.3 µM for SERT inhibition. It mitigates motor disorders and other side effects associated with dopaminergic agent use (e.g., L-DOPA) without exhibiting psychotropic effects. This compound is utilized in research focused on neurodegenerative conditions like Parkinson's disease [1] [2].Fórmula:C13H18ClNO2Forma y color:SolidPeso molecular:255.74PAOPA
CAS:dopamine D2 receptor modulatorFórmula:C11H18N4O3Pureza:>99.99%Forma y color:SolidPeso molecular:254.29NMI 8739
CAS:NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor.
Fórmula:C30H41NO3Pureza:98.51%Forma y color:SolidPeso molecular:463.65Lumateperone
CAS:Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).
Fórmula:C24H28FN3OPureza:99.68% - 99.91%Forma y color:SolidPeso molecular:393.59-Methyl-β-carboline
CAS:9-Methyl-β-carboline is a cognitive enhancer with neuroprotective, neurorestorative, and anti-inflammatory properties. Its behavioral effects may be linked to hippocampal dopamine levels and the stimulation of dendritic and synaptic proliferation.Fórmula:C12H10N2Forma y color:SolidPeso molecular:182.221RS 12254
CAS:RS 12254 is a dopamine agonist and antihypertensive agent.Fórmula:C28H40N2O4Pureza:98%Forma y color:SolidPeso molecular:468.63Disulergine
CAS:Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.Fórmula:C17H24N4O2SPureza:98%Forma y color:SolidPeso molecular:348.46U91356
CAS:U91356 is an agonist of the dopamine receptors.Fórmula:C13H17N3OPureza:98%Forma y color:SolidPeso molecular:231.29Dopamine D3 receptor antagonist-1
Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor selective or multi-targeting ligand with a Ki value of 1.58 nM that has demonstrated therapeuticFórmula:C31H35Cl2N3O3Forma y color:SolidPeso molecular:568.53D4R antagonist-1
Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.Fórmula:C21H25F2NO2Forma y color:SolidPeso molecular:361.43CM699
CAS:CM699 is an effective dual inhibitor of the dopamine transporter (DAT) and Sigma receptor (σR), with IC50 values of 311 nM and 14.1 nM, respectively.Fórmula:C24H29N3O2Forma y color:SolidPeso molecular:391.51Dopamine D3 receptor ligand-1
Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:Fórmula:C27H29N5OForma y color:SolidPeso molecular:439.55Dopamine D3 receptor antagonist-2
Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor selective (Ki=2.16 nM) or multi-targeting dual ligand that shows potential effects in CNS disorders.Fórmula:C23H27Cl2N3O3Forma y color:SolidPeso molecular:464.38NMDAR antagonist 5
CAS:NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.Fórmula:C17H21N3Forma y color:SolidPeso molecular:267.369D4R antagonis-2
Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.Fórmula:C21H23ClF2N2O2Forma y color:SolidPeso molecular:408.87Lisuride
CAS:Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.Fórmula:C20H26N4OForma y color:SolidPeso molecular:338.45Cendifensine
CAS:Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).Fórmula:C14H17Cl2NOForma y color:SolidPeso molecular:286.197LY3154207
CAS:LY3154207: selective, potent oral human dopamine D1 receptor PAM, low agonist activity, EC50=3 nM.Fórmula:C24H29Cl2NO3Forma y color:SolidPeso molecular:450.4Dopamine D4 receptor ligand 3
CAS:Dopamine D4 receptor ligand 3 (Compound 16) functions as a dopamine D4 receptor (D4R) antagonist with a pKi of 8.86. In HEK-293T cells, it shows pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors, respectively. This compound inhibits the activity of human glioma cell lines U87 MG, T98G, and U251 MG, and it induces ROS production and mitochondrial dysfunction in these glioma cells.Fórmula:C28H31N3O5Forma y color:SolidPeso molecular:489.56D1R antagonist 1
CAS:Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].Fórmula:C22H26BrNO4Pureza:98%Forma y color:SolidPeso molecular:448.35PD-147693
CAS:PD-147693 (compound II) is an active metabolite of the presynaptic dopamine autoreceptor agonist CI-1007, and it exhibits antipsychotic activity similar to CI-1007.Fórmula:C24H27NOForma y color:SolidPeso molecular:345.477Neflumozide
CAS:Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.Fórmula:C22H23FN4O2Forma y color:SolidPeso molecular:394.44Quinagolide Free Base
CAS:Quinagolide Free Base is a non-ergot dopamine D(2)-agonist.Fórmula:C20H33N3O3SForma y color:SolidPeso molecular:395.56RG-15
CAS:RG-15 is an orally active dopamine receptor antagonist with high affinity for the human D2 receptor (pKi of 8.23) and human D3 receptor (pKi of 10.49). It inhibits dopamine-stimulated [35S]GTPγS binding with IC50 values of 21.2 nM in rat striatal membranes, 36.7 nM in mouse A9 cells expressing human D2L receptors, and 7.2 nM in CHO cells expressing human D3 receptors. RG-15 enhances dopamine turnover and synthesis in the striatum and olfactory bulb of mice, exhibiting antipsychotic activity.Fórmula:C25H32Cl2F3N5O2SForma y color:SolidPeso molecular:594.52UNC10099984A
CAS:UNC10099984A (Compound 6) is a functionally selective ligand for the dopamine D2 receptor, exhibiting a Ki value of 4.6 nM and an EC50 of 6.2 nM for β-arrestin. This compound is useful for research into central nervous system diseases related to the D2 receptor.Fórmula:C24H29Cl2N3O2Forma y color:SolidPeso molecular:462.413-Hydroxybenzylamine
CAS:3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.Fórmula:C7H9NOForma y color:SolidPeso molecular:123.1556-Chloro-5-(2-chloroethyl)indolin-2-one
CAS:6-Chloro-5-(2-chloroethyl)indolin-2-one is a useful organic compound for research related to life sciences. The catalog number is T64862 and the CAS number is 118289-55-7.Fórmula:C10H9Cl2NOForma y color:SolidPeso molecular:230.09GR 218,231
CAS:GR 218,231 is a selective antagonist of D3 dopamine receptor.Fórmula:C24H33NO3SPureza:98%Forma y color:SolidPeso molecular:415.59
