Receptor de dopamina
Los receptores de dopamina son un grupo de receptores acoplados a proteínas G (GPCR) que responden al neurotransmisor dopamina, jugando un papel clave en la regulación del movimiento, la motivación, la recompensa y varias funciones cognitivas. Estos receptores se dividen en familias similares a D1 y D2, cada una con funciones y perfiles farmacológicos distintos. Los moduladores de los receptores de dopamina se estudian ampliamente por sus aplicaciones en el tratamiento de la enfermedad de Parkinson, la esquizofrenia, la adicción y otros trastornos neuropsiquiátricos. En CymitQuimica, ofrecemos una amplia gama de moduladores de receptores de dopamina de alta calidad para apoyar su investigación en neurociencia, salud mental y señalización GPCR.
Se han encontrado 407 productos de "Receptor de dopamina"
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A-437203
CAS:<p>A-437203 (Lu201640), selective D3 antagonist with Ki: D2-71nM, D3-1.6nM, D4-6220nM; based on 1H-pyrimidin-2-one scaffold.</p>Fórmula:C20H27F3N6OSPureza:98.80%Forma y color:SolidPeso molecular:456.53BP14979
CAS:<p>BP14979 is D3R-selective partial agonist.</p>Fórmula:C23H34N4O2Pureza:98.29% - 99.73%Forma y color:SolidPeso molecular:398.54SK609 HCl
CAS:<p>SK609 HCl is a selective dopamine D3 receptor agonist. It also has atypical signaling properties.</p>Fórmula:C10H15Cl2NPureza:99.02%Forma y color:SolidPeso molecular:220.14Remoxipride hydrochloride
CAS:<p>Remoxipride hydrochloride (Roxiam) is a selective antagonist of D2 receptor with IC50s of 1.57 μM, ＞100 μM and 42 μM for D2 receptor, D1 receptor and α1-</p>Fórmula:C16H24BrClN2O3Pureza:99.88%Forma y color:SolidPeso molecular:407.73CyPPA
CAS:<p>CyPPA enhances SK channels, reducing firing rate and extending apamin-sensitive afterhyperpolarization.</p>Fórmula:C16H23N5Pureza:99.88%Forma y color:SolidPeso molecular:285.39Fananserin
CAS:<p>Fananserin: Oral 5-HT2A antagonist (Ki=0.37 nM, rat), blocks human D4 receptor (Ki=2.93 nM).</p>Fórmula:C23H24FN3O2SPureza:99.88%Forma y color:SolidPeso molecular:425.52CCG 203769
CAS:<p>CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.</p>Fórmula:C8H14N2O2SPureza:99.88%Forma y color:SolidPeso molecular:202.27Sonepiprazole
CAS:<p>Sonepiprazole (PNU-101387G) is a chemical compound known for its selective antagonistic properties toward D4 dopamine receptors, exhibiting dissociation</p>Fórmula:C21H27N3O3SPureza:99.81%Forma y color:SolidPeso molecular:401.52CY 208-243
CAS:<p>CY 208-243 is a selective dopamine D1 receptor agonist with anti-Parkinson disease activity.</p>Fórmula:C19H18N2Pureza:98%Forma y color:SolidPeso molecular:274.36Timiperone
CAS:<p>Timiperone exhibits a high affinity for cerebral dopamine D2 receptors, demonstrating antipsychotic activity as it mitigates stereotyped behavior.</p>Fórmula:C22H24FN3OSPureza:98%Forma y color:SolidPeso molecular:397.51ABT-670
CAS:<p>ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.</p>Fórmula:C19H23N3O2Pureza:98%Forma y color:SolidPeso molecular:325.4SKF 81297
CAS:<p>SKF 81297 is a selective and potent agonist for the dopamine D1 receptor [1].</p>Fórmula:C16H16ClNO2Pureza:98%Forma y color:SolidPeso molecular:289.76FAUC-312
CAS:<p>FAUC-312 is a potent and selective agonist of the dopamine D4 receptor.</p>Fórmula:C21H26N4Pureza:98%Forma y color:SolidPeso molecular:334.46LY3154885
CAS:<p>LY3154885 is an orally active dopamine D1 receptor orthosteric modulator (PAM) that reduces the risk of drug-drug interactions (DDI).</p>Fórmula:C23H23Cl2N3O2Forma y color:SolidPeso molecular:444.35Quinpirole dihydrochloride
CAS:<p>Quinpirole dihydrochloride is an agonist of the D2-like dopamine receptor.</p>Fórmula:C13H23Cl2N3Pureza:98%Forma y color:SolidPeso molecular:292.25Pentiapine
CAS:<p>Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.</p>Fórmula:C15H17N5SPureza:99.35%Forma y color:SolidPeso molecular:299.39AJ-76 hydrochloride
CAS:<p>AJ-76 hydrochloride ((+)-AJ 76 hydrochloride) serves as a dopamine autoreceptor antagonist, exhibiting pK i values of 6.95 for hD3, 6.67 for hD4, 6.37 for hD2S, 6.21 for hD2L, and 6.07 for rD2 receptors, indicating its binding affinity strength across these receptor types.</p>Fórmula:C15H24ClNOForma y color:SolidPeso molecular:269.81Carbidine dihydrochloride
CAS:<p>Carbidine, a gamma-carboline derivative, is an atypical antipsychotic that modulates dopamine release and tyrosine hydroxylase activity.</p>Fórmula:C13H20Cl2N2Pureza:98.59%Forma y color:SolidPeso molecular:275.217UWA-101 hydrochloride
CAS:<p>UWA-101 hydrochloride is a selective, non-cytotoxic inhibitor of DAT/SERT, demonstrating EC50 values of 3.6 µM for DAT and 2.3 µM for SERT inhibition. It mitigates motor disorders and other side effects associated with dopaminergic agent use (e.g., L-DOPA) without exhibiting psychotropic effects. This compound is utilized in research focused on neurodegenerative conditions like Parkinson's disease [1] [2].</p>Fórmula:C13H18ClNO2Forma y color:SolidPeso molecular:255.74SB-414796
CAS:<p>SB-414796 is a selective antagonist of the dopamine D3 receptor.</p>Fórmula:C29H36N4O4SPureza:98%Forma y color:SolidPeso molecular:536.69Naxagolide free base
CAS:<p>Naxagolide is a sustained release formulation. It is a dopamine agonist.</p>Fórmula:C15H21NO2Pureza:98%Forma y color:SolidPeso molecular:247.33Dihydrexidine
CAS:<p>Dihydrexidine is a full efficacy D1-like dopamine receptor (D1/D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian activity.</p>Fórmula:C17H17NO2Pureza:98%Forma y color:SolidPeso molecular:267.32Z1078601926
CAS:<p>Z1078601926 is an allosteric inhibitor of the human dopamine transporter (hDAT) and exhibits a synergistic effect when combined with Nomifensine [1].</p>Fórmula:C14H19FN2OForma y color:SolidPeso molecular:250.31Carmoxirole hydrochloride
CAS:<p>Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective dopamine D2 receptor agonist with antihypertensive activity in vivo.</p>Fórmula:C24H27ClN2O2Pureza:99.37% - 99.62%Forma y color:SolidPeso molecular:410.94PW0464
CAS:<p>PW0464 ((Rac)-Razpipadon) is a non-catechol D1R agonist and potent omplete G protein biased ligand with an EC50 (Gs-cAMP)=5.8 nM for neurological disorders.</p>Fórmula:C19H17F2N3O4Pureza:98.78%Forma y color:SolidPeso molecular:389.35LBT 999
CAS:<p>LBT 999 is used as a dopamine reuptake inhibitor.</p>Fórmula:C20H26FNO2Forma y color:SolidPeso molecular:331.42JNJ-37822681 dihydrochloride
CAS:<p>JNJ-37822681 dihydrochloride 是特异性的、有中枢活性的，可快速解离的多巴胺 D2受体拮抗剂，与多巴胺 D2L 受体结合的亲和力适中 (Ki=158 nM)。JNJ-37822681 dihydrochloride 在精神分裂症和躁郁症领域有研究价值。</p>Fórmula:C17H19Cl2F5N4Pureza:99.78%Forma y color:SolidPeso molecular:445.26(+)-Dihydrexidine hydrochloride
CAS:<p>(+)-Dihydrexidine hydrochloride is an agonist of dopamine D1 receptor(EC50 of 72± 21 nM).</p>Fórmula:C17H18ClNO2Pureza:98%Forma y color:SolidPeso molecular:303.78Brilaroxazine
CAS:<p>Brilaroxazine (RP5063): multimodal dopamine/5-HT modulator, partial agonist at D2/D3/D4, 5-HT1A/2A, and antagonist at 5-HT2B/7.</p>Fórmula:C22H25Cl2N3O3Pureza:99.36%Forma y color:SolidPeso molecular:450.36LY-368975
CAS:<p>LY-368975 is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. LY-368975 reduces food consumption in rodents.</p>Fórmula:C17H21NOSForma y color:SolidPeso molecular:287.42SKF 81297 hydrobromide
CAS:<p>SKF 81297 hydrobromide, a selective agonist of the dopamine D1-like receptor，exhibits central activity and is widely used to study the neuromodulatory effects.</p>Fórmula:C16H17BrClNO2Pureza:99.52%Forma y color:SolidPeso molecular:370.67CP-293019
CAS:<p>CP-293019 is a potent, selective antagonist of dopamine D4 receptor.</p>Fórmula:C19H22F2N4OPureza:98%Forma y color:SolidPeso molecular:360.44-Amino-PPHT Hydrobromide
CAS:<p>4-Amino-PPHT Hydrobromide is a precursor for fluorescent labeled Dopamine D2 receptors agonist.</p>Fórmula:C21H28N2OPureza:98%Forma y color:SolidPeso molecular:324.46PAOPA
CAS:<p>dopamine D2 receptor modulator</p>Fórmula:C11H18N4O3Pureza:>99.99%Forma y color:SolidPeso molecular:254.29NMI 8739
CAS:<p>NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor.</p>Fórmula:C30H41NO3Pureza:98.51%Forma y color:SolidPeso molecular:463.65Lumateperone
CAS:<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Fórmula:C24H28FN3OPureza:99.68% - 99.91%Forma y color:SolidPeso molecular:393.5Dopamine D3 receptor antagonist-1
<p>Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor selective or multi-targeting ligand with a Ki value of 1.58 nM that has demonstrated therapeutic</p>Fórmula:C31H35Cl2N3O3Forma y color:SolidPeso molecular:568.53D4R antagonist-1
<p>Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.</p>Fórmula:C21H25F2NO2Forma y color:SolidPeso molecular:361.43CM699
CAS:<p>CM699 is an effective dual inhibitor of the dopamine transporter (DAT) and Sigma receptor (σR), with IC50 values of 311 nM and 14.1 nM, respectively.</p>Fórmula:C24H29N3O2Forma y color:SolidPeso molecular:391.51Dopamine D3 receptor ligand-1
<p>Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:</p>Fórmula:C27H29N5OForma y color:SolidPeso molecular:439.55D1R antagonist 1
CAS:<p>Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].</p>Fórmula:C22H26BrNO4Pureza:98%Forma y color:SolidPeso molecular:448.35Dopamine D3 receptor antagonist-2
<p>Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor selective (Ki=2.16 nM) or multi-targeting dual ligand that shows potential effects in CNS disorders.</p>Fórmula:C23H27Cl2N3O3Forma y color:SolidPeso molecular:464.38UNC10099984A
CAS:<p>UNC10099984A (Compound 6) is a functionally selective ligand for the dopamine D2 receptor, exhibiting a Ki value of 4.6 nM and an EC50 of 6.2 nM for β-arrestin. This compound is useful for research into central nervous system diseases related to the D2 receptor.</p>Fórmula:C24H29Cl2N3O2Forma y color:SolidPeso molecular:462.41Neflumozide
CAS:<p>Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.</p>Fórmula:C22H23FN4O2Forma y color:SolidPeso molecular:394.44NMDAR antagonist 5
CAS:<p>NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.</p>Fórmula:C17H21N3Forma y color:SolidPeso molecular:267.369D4R antagonis-2
<p>Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.</p>Fórmula:C21H23ClF2N2O2Forma y color:SolidPeso molecular:408.87Lisuride
CAS:<p>Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.</p>Fórmula:C20H26N4OForma y color:SolidPeso molecular:338.45Cendifensine
CAS:<p>Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).</p>Fórmula:C14H17Cl2NOForma y color:SolidPeso molecular:286.197Disulergine
CAS:<p>Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.</p>Fórmula:C17H24N4O2SPureza:98%Forma y color:SolidPeso molecular:348.46Dinoxyline
CAS:<p>Dinoxyline is a potent dopamine receptor agonist, with dissociation constants (Ki values) for D1, D2, D3, and D4 receptors being 7 nM, 6 nM, 5 nM, and 43 nM, respectively. It is utilized in neuroscience research.</p>Fórmula:C15H13NO3Forma y color:SolidPeso molecular:255.27
