GTPasa
Las GTPasas son una familia de enzimas que hidrolizan el guanosín trifosfato (GTP) a guanosín difosfato (GDP), desempeñando un papel crucial en las vías de transducción de señales, incluidas las mediadas por GPCR. Las GTPasas actúan como interruptores moleculares en varios procesos celulares, como la división, el crecimiento y la diferenciación celular. La desregulación de la actividad de las GTPasas está implicada en numerosas enfermedades, incluido el cáncer y los trastornos genéticos. En CymitQuimica, ofrecemos una selección de moduladores de GTPasa de alta calidad para apoyar su investigación en señalización celular, biología del cáncer y vías relacionadas con GPCR.
Se han encontrado 21 productos de "GTPasa"
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Myristoylated ARF6 (2-13)
<p>Myristoylated ARF6 (2-13) inhibits the MyD88–ARNO–ARF6 signaling axis by inactivating ARF6.</p>Fórmula:C74H128N16O18Peso molecular:1528.95925RGS2-Galpha-q interaction-IN-1
RGS2–Galpha-q interaction-IN-1 (Compound AJ-3) is an inhibitor of the RGS2-Galpha-q interaction. It inhibits the growth of cancer cell lines that express RGS2 and has anti-cell migration properties.Fórmula:C30H30ClN7O3Forma y color:SolidPeso molecular:572.06RBC8
CAS:<p>RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.</p>Fórmula:C25H20N4O3Pureza:98.44% - 99.81%Forma y color:SolidPeso molecular:424.45NAV-2729
CAS:<p>NAV-2729 inhibits six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF), the strongest effects being against BRAG2, Arf1 and Arf6.</p>Fórmula:C25H17ClN4O3Pureza:98.83% - 98.91%Forma y color:SolidPeso molecular:456.88Exo-1
CAS:<p>Exo-1 (Methyl 3-(4-fluorobenzoyl)-6-methyl-2-pyridinecarboxylate) is a synthetic compound that has been shown to affect the metabolism of various nutrients, as</p>Fórmula:C15H12FNO3Pureza:99.45%Forma y color:SolidPeso molecular:273.26BQU57
CAS:<p>BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.</p>Fórmula:C16H13F3N4OPureza:97.45% - 98.72%Forma y color:SolidPeso molecular:334.3ML-097
CAS:<p>ML-097 (CID-2160985) is a pan activator of Ras-related GTPases</p>Fórmula:C14H11BrO3Pureza:99.12%Forma y color:SolidPeso molecular:307.139Dynamin inhibitory peptide Acetate
<p>Dynamin inhibitory peptide Acetate is a peptide with the sequence Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro that inhibit the GTPase dynamin.</p>Fórmula:C49H84N18O16Pureza:97.28%Forma y color:SolidPeso molecular:1181.3CCG-50014
CAS:<p>CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.</p>Fórmula:C16H13FN2O2SPureza:98.53%Forma y color:SolidPeso molecular:316.35CID-1067700
CAS:<p>CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM).</p>Fórmula:C18H18N2O4S2Pureza:99.46%Forma y color:SolidPeso molecular:390.48MLS-573151
CAS:<p>MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).</p>Fórmula:C21H19N3O2SPureza:98.80%Forma y color:SolidPeso molecular:377.46Bragsin1
CAS:<p>Bragsin1 is a potent and selective and noncompetitive ArfGEF BRAG2 inhibitor, inhibits Arf GTPase activation(IC50 : 3 μM),and with anti-cancer activity.</p>Fórmula:C11H6F3NO4Forma y color:SolidPeso molecular:273.16CCG-4986
CAS:<p>CCG-4986 is the first small molecule RGS inhibitor reported that directly bound to an RGS protein.</p>Fórmula:C13H11ClN2O5S2Forma y color:SolidPeso molecular:374.82QS11
CAS:<p>QS11, a GTPase ARFGAP1, modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation.</p>Fórmula:C36H33N5O2Pureza:98.59%Forma y color:SolidPeso molecular:567.68CCG-2046
CAS:<p>CCG-2046 is a chemical inhibitor targeting RGS4, demonstrating an inhibition concentration (IC50) of 4.3 μM for the interaction between RGS4 and Gαo signal.</p>Fórmula:C11H10N4Forma y color:SolidPeso molecular:198.22Compound C108
CAS:<p>Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2).</p>Fórmula:C15H14N2O3Pureza:99.77%Forma y color:SolidPeso molecular:270.28RBC10
CAS:<p>RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-</p>Fórmula:C24H25ClN2O2Pureza:99.71%Forma y color:SolidPeso molecular:408.92CCG-63808
CAS:<p>CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.</p>Fórmula:C25H15FN4O2SPureza:90%Forma y color:SolidPeso molecular:454.48CCG-63802
CAS:<p>CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins.</p>Fórmula:C26H18N4O2SPureza:90%Forma y color:SolidPeso molecular:450.51Anti-inflammatory agent 49
CAS:<p>Compound SC9, an anti-inflammatory agent, serves as a potent and selective inhibitor of the Drp1-Fis1 interaction, mitigating FIS1-mediated mitochondrial</p>Fórmula:C21H22N8O3SPureza:99.56% - 99.74%Forma y color:SolidPeso molecular:466.52
