GTPasa
Las GTPasas son una familia de enzimas que hidrolizan el guanosín trifosfato (GTP) a guanosín difosfato (GDP), desempeñando un papel crucial en las vías de transducción de señales, incluidas las mediadas por GPCR. Las GTPasas actúan como interruptores moleculares en varios procesos celulares, como la división, el crecimiento y la diferenciación celular. La desregulación de la actividad de las GTPasas está implicada en numerosas enfermedades, incluido el cáncer y los trastornos genéticos. En CymitQuimica, ofrecemos una selección de moduladores de GTPasa de alta calidad para apoyar su investigación en señalización celular, biología del cáncer y vías relacionadas con GPCR.
Se han encontrado 28 productos para "GTPasa".
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PT-129
PT-129 is a PROTAC degrader targeting the NTF2 domain of G3BP1/2, degrading stress granules in stressed cells, suppressing proliferation.Fórmula:C46H48N8O12SForma y color:Yellow SolidPeso molecular:936.98RGS2-Galpha-q interaction-IN-1
RGS2–Galpha-q interaction-IN-1 (Compound AJ-3) is an inhibitor of the RGS2-Galpha-q interaction. It inhibits the growth of cancer cell lines that express RGS2 and has anti-cell migration properties.Fórmula:C30H30ClN7O3Forma y color:SolidPeso molecular:572.06Myristoylated ARF6 (2-13)
Myristoylated ARF6 (2-13) inhibits the MyD88–ARNO–ARF6 signaling axis by inactivating ARF6.Fórmula:C74H128N16O18Forma y color:SolidPeso molecular:1528.95925ART5537
ART5537 is a selective EXO1 inhibitor with an EC50 of 55 nM, an IC50 of 3.4 nM, and a Kd of 6.8 nM. It inhibits the homologous recombination (HR) process in HAP1 parental cells with an EC50 of 7.2 nM. The selectivity of ART5537 for the broad-spectrum nuclease superfamily members is over 200-fold higher. Its biological effects are entirely driven by EXO1 inhibition. ART5537 enhances sensitivity to ionizing radiation and exhibits synergism with Olaparib. It is applicable in research on breast and colon cancers.ARF6 (2-13)
CAS:ARF6 (2-13), a peptide with the sequence GKVLSKIFGNKE, acts as an inhibitor of ARF6 and can be utilized in endotoxemia research [1].Fórmula:C60H102N16O17Peso molecular:1319.55CID-1067700
CAS:CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM).Fórmula:C18H18N2O4S2Pureza:99.46%Forma y color:SolidPeso molecular:390.477Exo-1
CAS:Exo-1 (Methyl 3-(4-fluorobenzoyl)-6-methyl-2-pyridinecarboxylate) is a synthetic compound that has been shown to affect the metabolism of various nutrients, asFórmula:C15H12FNO3Pureza:99.45%Forma y color:White SolidPeso molecular:273.2591BQU57
CAS:BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.Fórmula:C16H13F3N4OPureza:97.45% - 98.72%Forma y color:SolidPeso molecular:334.2958CCG-50014
CAS:CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.Fórmula:C16H13FN2O2SPureza:98.53%Forma y color:White SolidPeso molecular:316.35Exo1
CAS:Exo1 is an inhibitor of the exocytic pathwayFórmula:C15H12FNO3Pureza:98.75%Forma y color:SolidPeso molecular:273.26MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Fórmula:C21H19N3O2SPureza:98.80%Forma y color:White SolidPeso molecular:377.459NAV-2729
CAS:NAV-2729 inhibits six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF), the strongest effects being against BRAG2, Arf1 and Arf6.Fórmula:C25H17ClN4O3Pureza:98.91% - 99.57%Forma y color:Yellow SolidPeso molecular:456.88RBC8
CAS:RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.Fórmula:C25H20N4O3Pureza:98.44% - 99.81%Forma y color:White SolidPeso molecular:424.4513ML-097
CAS:ML-097 (CID-2160985) is a pan activator of Ras-related GTPasesFórmula:C14H11BrO3Pureza:99.12%Forma y color:SolidPeso molecular:307.139Dynamin inhibitory peptide Acetate
Dynamin inhibitory peptide Acetate is a peptide with the sequence Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro that inhibit the GTPase dynamin.Fórmula:C49H84N18O16Pureza:97.28%Forma y color:SolidPeso molecular:1181.3Arf1-GEFs-IN-1
CAS:Arf1-GEFs-IN-1 is a potent and orally active inhibitor of ADP-ribosylation factor 1-guanine nucleotide exchange factors (Arf1-GEFs), exhibiting an IC50 value of 40 μM in CT26 cells. Primarily, Arf1-GEFs-IN-1 induces tumor regression by triggering anti-tumor immune responses rather than direct cytotoxicity. It effectively enhances CCL5 expression and demonstrates excellent in vivo efficacy. Arf1-GEFs-IN-1 is applicable in colon cancer research.Fórmula:C19H18N6SPeso molecular:362.45QS11
CAS:QS11, a GTPase ARFGAP1, modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation.Fórmula:C36H33N5O2Pureza:98.59%Forma y color:SolidPeso molecular:567.68Bragsin1
CAS:Bragsin1 is a potent and selective and noncompetitive ArfGEF BRAG2 inhibitor, inhibits Arf GTPase activation(IC50 : 3 μM),and with anti-cancer activity.Fórmula:C11H6F3NO4Forma y color:SolidPeso molecular:273.1648CCG-2046
CAS:CCG-2046 is a chemical inhibitor targeting RGS4, demonstrating an inhibition concentration (IC50) of 4.3 μM for the interaction between RGS4 and Gαo signal.Fórmula:C11H10N4Forma y color:SolidPeso molecular:198.2239CCG-4986
CAS:CCG-4986 is the first small molecule RGS inhibitor reported that directly bound to an RGS protein.Fórmula:C13H11ClN2O5S2Forma y color:SolidPeso molecular:374.82
