GPCR19
GPCR19, también conocido como GPR19, es un miembro de la familia de los receptores acoplados a proteínas G, cuyos roles aún están siendo elucidados en varios procesos fisiológicos. Aunque menos caracterizado que otros GPCR, el GPCR19 es de interés en investigaciones centradas en descubrir nuevos objetivos terapéuticos para enfermedades metabólicas, cáncer y trastornos neurológicos. En CymitQuimica, ofrecemos una selección de herramientas de investigación y reactivos para apoyar sus investigaciones sobre las funciones y las posibles aplicaciones terapéuticas del GPCR19.
Se han encontrado 31 productos de "GPCR19"
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Hyodeoxycholic acid
CAS:<p>Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.</p>Fórmula:C24H40O4Pureza:97.29% - 98.82%Forma y color:SolidPeso molecular:392.57Deoxycholic acid
CAS:<p>Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate.</p>Fórmula:C24H40O4Pureza:99.91% - 99.91%Forma y color:Crystals From Alc SolidPeso molecular:392.57Ursodeoxycholic acid
CAS:<p>Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!</p>Fórmula:C24H40O4Pureza:99.74% - ≥95%Forma y color:White - Almost White Solid PowderPeso molecular:392.57PEN (rat)
CAS:<p>PEN (rat) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.</p>Fórmula:C102H169N27O33Pureza:98%Forma y color:SolidPeso molecular:2301.62TGR5 agonist 1
<p>Compound 18 (TGR5 agonist 1) is a potent agonist of TGR5, exhibiting an EC50 value of 0.31 µM [1].</p>Fórmula:C28H48NNaO6SForma y color:SolidPeso molecular:549.74TGR5 agonist 4
<p>TGR5 agonist 4 (compound 19), a derivative of cholic acid, selectively activates the TGR5 receptor with an effective concentration (EC50) of 4 μM [1].</p>Fórmula:C24H38F2O5Forma y color:SolidPeso molecular:444.555-HT7R antagonist 1 free base
CAS:<p>5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.</p>Fórmula:C14H17ClN4Forma y color:SolidPeso molecular:276.77PEN (human)
CAS:<p>PEN (human) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.</p>Fórmula:C97H159N27O32Pureza:98%Forma y color:SolidPeso molecular:2215.49Cholic Acid 7-sulfate
CAS:<p>Cholic acid 7-sulfate: a cholic acid metabolite with added sulfate at position 7, increased in feces of male mice with specific diets.</p>Fórmula:C24H40O8SForma y color:SolidPeso molecular:488.64TGR5 agonist 2
<p>TGR5 agonist 2 (compound 19) serves as a highly potent agonist of TGR5, demonstrating an EC50 value of 0.27 µM [1].</p>Fórmula:C29H50NNaO6SForma y color:SolidPeso molecular:563.77TGR5 agonist 6
CAS:<p>Compound 22b, also known as TGR5 agonist 6, is a non-systemic, intestine-targeted TGR5 agonist that demonstrates significant and sustained blood glucose-lowering effects with an acceptable safety profile.</p>Fórmula:C42H48Cl2N6O6Forma y color:SolidPeso molecular:803.77TGR5 agonist 7
<p>TGR5 agonist 7 (Compound 22-Na) is an intestine-restricted, orally active agonist of the G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 of less than 1 μM. In mouse models, it demonstrates blood glucose-lowering effects, making it useful for diabetes research.</p>Fórmula:C37H59N2NaO9SForma y color:SolidPeso molecular:730.93Triamterene
CAS:<p>Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.</p>Fórmula:C12H11N7Pureza:99.77%Forma y color:Yellow Yellow SolidPeso molecular:253.26BAR502
CAS:<p>BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).</p>Fórmula:C25H44O3Pureza:99.95%Forma y color:SolidPeso molecular:392.62BAR501
CAS:<p>BAR501是高效选择性的 GPBAR1激动剂(EC50:1 μM)。</p>Fórmula:C26H46O3Pureza:99.29% - 99.68%Forma y color:SolidPeso molecular:406.64TC-G 1005
CAS:<p>TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5).</p>Fórmula:C25H25N3O2Pureza:98.60% - 99.78%Forma y color:SolidPeso molecular:399.48Deoxycholic acid sodium salt
CAS:<p>Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates BAT thermogenic activity.</p>Fórmula:C24H39NaO4Pureza:97.88% - 99.75%Forma y color:Cream Crystalline PowderPeso molecular:414.56SBI-115
CAS:<p>SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5</p>Fórmula:C14H13ClN2O4SPureza:99.53% - 99.78%Forma y color:SolidPeso molecular:340.78TGR5 Receptor Agonist
CAS:<p>TGR5 is a potent TGR5(GPCR19) agonist.</p>Fórmula:C18H14Cl2N2O2Pureza:99.77% - ≥95%Forma y color:SolidPeso molecular:361.22PEN (human) aceate
<p>PEN (human) aceate, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.</p>Fórmula:C99H163N27O34Pureza:99.25%Forma y color:SolidPeso molecular:2275.51SB756050
CAS:<p>SB756050 is a specific TGR5 agonist.</p>Fórmula:C21H28N2O8S2Pureza:98.78% - >99.99%Forma y color:SolidPeso molecular:500.59Ursodeoxycholic acid sodium
CAS:<p>Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.</p>Fórmula:C24H40NaO4Pureza:99.66% - 99.96%Forma y color:SolidPeso molecular:415.56CAY10789
CAS:<p>CAY10789: potent CysLT1R antagonist (IC50 2.8 µM), GPBAR1 agonist (EC50 3 µM), reduces U937 cell adhesion, TNF-α, stable with promising pharmacokinetics.</p>Fórmula:C17H15NO2Forma y color:SolidPeso molecular:265.31WB403
CAS:<p>WB403 activates TGR5, lowers fasting/postprandial glucose and HbA1c, enhances glucose tolerance, and normalizes pancreatic α/β-cells in diabetic mice.</p>Fórmula:C19H19BrN2OSPureza:98%Forma y color:SolidPeso molecular:403.34TGR5 agonist 3
CAS:<p>Compound 8, a cholic acid derivative, functions as a selective TGR5 agonist and exhibits an EC50 value of 5 μM [1].</p>Fórmula:C28H48O5Forma y color:SolidPeso molecular:464.68INT-777 R-enantiomer
CAS:<p>INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5.</p>Fórmula:C27H46O5Pureza:98%Forma y color:SolidPeso molecular:450.65RO5527239
CAS:<p>RO5527239 is a potent, orally available GPBAR1 agonist agent.</p>Fórmula:C28H31N3O3Pureza:98%Forma y color:SolidPeso molecular:457.56INT-777
CAS:<p>INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM.</p>Fórmula:C27H46O5Pureza:99.89%Forma y color:SolidPeso molecular:450.655-HT7R antagonist 1
<p>5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R.</p>Fórmula:C14H18Cl2N4Forma y color:SolidPeso molecular:313.23TGR5 Receptor Agonist 3
CAS:<p>TGR5 Receptor Agonist 3 is a GPBAR1 agonist with EC50 of 16.4 nM (hTGR5) & 209 nM (mTGR5), ensures gallbladder safety and reduces filling.</p>Fórmula:C29H27N3O6Forma y color:SolidPeso molecular:513.54GPBAR1-IN-3
CAS:<p>GPBAR1-IN-3 (Compound 14) is both a selective agonist for GPBAR1, with an EC50 value of 0.17 μM, and an antagonist for CysLT1R [1].</p>Fórmula:C21H23NO2Forma y color:SolidPeso molecular:321.41
