Receptor de OX
Los receptores de orexina (OX1 y OX2) son GPCR que se unen a las orexinas, neuropéptidos involucrados en la regulación de la vigilia, el apetito y la homeostasis energética. La desregulación de la señalización de la orexina está vinculada a trastornos del sueño como la narcolepsia, así como a condiciones metabólicas como la obesidad. Los moduladores de los receptores de orexina están siendo investigados por su potencial terapéutico en el tratamiento de trastornos del sueño, ansiedad y adicción. En CymitQuimica, ofrecemos una gama de moduladores de receptores de orexina de alta calidad para apoyar su investigación en biología del sueño, metabolismo y neurofarmacología.
Se han encontrado 41 productos de "Receptor de OX"
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PF3274167
CAS:PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.Fórmula:C19H19ClFN5O3Pureza:99.67% - 99.88%Forma y color:SolidPeso molecular:419.84MK-3697
CAS:MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).Fórmula:C23H21N5O3SPureza:97.69% - 98.15%Forma y color:SolidPeso molecular:447.51Ref: TM-T1913
1mg49,00€2mg65,00€5mg90,00€10mg113,00€25mg200,00€50mg333,00€100mg477,00€1mL*10mM (DMSO)100,00€TCS-OX2-29
CAS:TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.Fórmula:C23H31N3O3Pureza:99.81%Forma y color:SolidPeso molecular:397.51Ref: TM-T4965
1mg34,00€5mg66,00€10mg90,00€25mg147,00€50mg203,00€100mg286,00€200mg425,00€1mL*10mM (DMSO)73,00€Orexin B, rat, mouse Acetate
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.Fórmula:C128H219N45O36SPureza:94.61%Forma y color:SolidPeso molecular:2996.45OXA (17-33) acetate
OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).Fórmula:C79H125N23O22Pureza:98.52%Forma y color:SolidPeso molecular:1748.98TCS 1102
CAS:TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).Fórmula:C27H26N4O2SPureza:99.35% - 99.52%Forma y color:SolidPeso molecular:470.59SB-334867 free base
CAS:SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.Fórmula:C17H13N5O2Pureza:99.67% - >99.99%Forma y color:SolidPeso molecular:319.32Ref: TM-T6140
2mg39,00€5mg66,00€10mg94,00€25mg152,00€50mg215,00€100mg319,00€200mg475,00€1mL*10mM (DMSO)73,00€IPSU
CAS:IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.Fórmula:C23H27N5O2Pureza:97.05%Forma y color:SolidPeso molecular:405.49Ref: TM-T5503
2mg51,00€5mg86,00€10mg97,00€25mg200,00€50mg299,00€100mg432,00€200mg662,00€1mL*10mM (DMSO)92,00€DORA-22
CAS:DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryFórmula:C23H22F2N4O2Pureza:97.67%Forma y color:SolidPeso molecular:424.44Ref: TM-T5500
1mg131,00€2mg188,00€5mg284,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)331,00€MK-1064
CAS:MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).Fórmula:C24H20ClN5O3Pureza:99.19% - 99.82%Forma y color:SolidPeso molecular:461.9L-368,899 hydrochloride
CAS:L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.Fórmula:C26H43ClN4O5S2Pureza:99.59%Forma y color:SolidPeso molecular:591.23Ref: TM-T11794
2mg105,00€5mg147,00€10mg230,00€25mg439,00€50mg685,00€100mg964,00€1mL*10mM (DMSO)200,00€ACT-462206
CAS:ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.Fórmula:C20H24N2O4SPureza:99.45%Forma y color:SolidPeso molecular:388.48Ref: TM-T26559
1mg42,00€5mg88,00€10mg130,00€25mg264,00€50mg423,00€100mg670,00€500mg1.341,00€1mL*10mM (DMSO)87,00€Rocatinlimab
CAS:Rocatinlimab (AMG 451) (KHK4083) is a fully human, non-fucosylated IgG1 anti-OX40 monoclonal antibody indicated for atopic dermatitis (AD) research [1].Forma y color:LiquidAlixorexton
CAS:Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.Fórmula:C21H30N2O5SForma y color:SolidPeso molecular:422.538Rocavorexant
CAS:Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.Fórmula:C18H19F3N8OForma y color:SolidPeso molecular:420.392OX2R agonist 1
CAS:OX2R agonist 1 is an OX2R activator with an EC50 of less than 100 nM. It is utilized in research related to narcolepsy and cataplexy.Fórmula:C21H28F2N2O5SForma y color:SolidPeso molecular:458.52YNT-3708
CAS:YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.Fórmula:C35H36N4O6SForma y color:SolidPeso molecular:640.749RTIOXA-43
CAS:RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.Fórmula:C37H37N5O5SPureza:99.17%Forma y color:SolidPeso molecular:663.79Ref: TM-T87345
1mg221,00€5mg545,00€10mg879,00€25mg1.696,00€50mg2.725,00€100mg3.686,00€1mL*10mM (DMSO)795,00€(S)-YNT-3708
CAS:(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.Fórmula:C35H36N4O6SForma y color:SolidPeso molecular:640.749CVN766
CAS:CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].Fórmula:C20H21F3N8OForma y color:SolidPeso molecular:446.43
