Receptor de OX
Los receptores de orexina (OX1 y OX2) son GPCR que se unen a las orexinas, neuropéptidos involucrados en la regulación de la vigilia, el apetito y la homeostasis energética. La desregulación de la señalización de la orexina está vinculada a trastornos del sueño como la narcolepsia, así como a condiciones metabólicas como la obesidad. Los moduladores de los receptores de orexina están siendo investigados por su potencial terapéutico en el tratamiento de trastornos del sueño, ansiedad y adicción. En CymitQuimica, ofrecemos una gama de moduladores de receptores de orexina de alta calidad para apoyar su investigación en biología del sueño, metabolismo y neurofarmacología.
Se han encontrado 40 productos de "Receptor de OX"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
SB-649868
CAS:<p>SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).</p>Fórmula:C26H24FN3O3SPureza:99.53%Forma y color:SolidPeso molecular:477.55Orexin 2 Receptor Agonist
CAS:<p>Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.</p>Fórmula:C32H34N4O5SPureza:98.26% - 99.43%Forma y color:SolidPeso molecular:586.7MK-1064
CAS:<p>MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).</p>Fórmula:C24H20ClN5O3Pureza:99.19% - 99.82%Forma y color:SolidPeso molecular:461.9DORA-22
CAS:<p>DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory</p>Fórmula:C23H22F2N4O2Pureza:97.67%Forma y color:SolidPeso molecular:424.44IPSU
CAS:<p>IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.</p>Fórmula:C23H27N5O2Pureza:97.05%Forma y color:SolidPeso molecular:405.49PF3274167
CAS:<p>PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.</p>Fórmula:C19H19ClFN5O3Pureza:99.67% - 99.88%Forma y color:SolidPeso molecular:419.84SB-334867 free base
CAS:<p>SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.</p>Fórmula:C17H13N5O2Pureza:99.67% - >99.99%Forma y color:SolidPeso molecular:319.32MK-3697
CAS:<p>MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).</p>Fórmula:C23H21N5O3SPureza:97.69% - 98.15%Forma y color:SolidPeso molecular:447.51TCS-OX2-29
CAS:<p>TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.</p>Fórmula:C23H31N3O3Pureza:99.81%Forma y color:SolidPeso molecular:397.51Orexin B, rat, mouse Acetate
<p>Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.</p>Fórmula:C128H219N45O36SPureza:94.61%Forma y color:SolidPeso molecular:2996.45TCS 1102
CAS:<p>TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).</p>Fórmula:C27H26N4O2SPureza:99.35% - 99.52%Forma y color:SolidPeso molecular:470.59L-368,899 hydrochloride
CAS:<p>L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.</p>Fórmula:C26H43ClN4O5S2Pureza:99.59%Forma y color:SolidPeso molecular:591.23ACT-462206
CAS:<p>ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.</p>Fórmula:C20H24N2O4SPureza:99.45%Forma y color:SolidPeso molecular:388.48Tebideutorexant
CAS:<p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>Fórmula:C23H16D2F4N4O2Pureza:98.89%Forma y color:SolidPeso molecular:460.42Alixorexton
CAS:<p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>Fórmula:C21H30N2O5SForma y color:SolidPeso molecular:422.538YNT-3708
CAS:<p>YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.</p>Fórmula:C35H36N4O6SForma y color:SolidPeso molecular:640.749(S)-YNT-3708
CAS:<p>(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.</p>Fórmula:C35H36N4O6SForma y color:SolidPeso molecular:640.749Rocavorexant
CAS:<p>Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.</p>Fórmula:C18H19F3N8OForma y color:SolidPeso molecular:420.392RTIOXA-43
CAS:<p>RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.</p>Fórmula:C37H37N5O5SPureza:99.17%Forma y color:SolidPeso molecular:663.79CVN766
CAS:<p>CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].</p>Fórmula:C20H21F3N8OForma y color:SolidPeso molecular:446.43
