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GRK

GRK

Las quinasas de receptores acoplados a proteínas G (GRK) son una familia de enzimas que fosforilan GPCR activados, lo que lleva a la desensibilización de los receptores y a la regulación de la señalización de los receptores. Las GRK desempeñan un papel crucial en el control de la intensidad y la duración de la señalización de los GPCR, lo que las hace importantes en la regulación de varios procesos fisiológicos, incluida la función cardiovascular, la respuesta inmunitaria y la neurotransmisión. Los inhibidores y activadores de GRK se estudian por su potencial en aplicaciones terapéuticas en insuficiencia cardíaca, cáncer y trastornos neurológicos. En CymitQuimica, ofrecemos una gama de moduladores de GRK de alta calidad para apoyar su investigación en transducción de señales, regulación de receptores y desarrollo terapéutico.

Se han encontrado 31 productos de "GRK"

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  • CCG-224406
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    CCG-224406

    CAS:
    <p>CCG-22440 is a Highly Selective and Potent Inhibitor of G Protein-Coupled Receptor Kinase 2.</p>
    Fórmula:C29H27FN6O5
    Forma y color:Solid
    Peso molecular:558.56

    Ref: TM-T30777

  • CCG-273463
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    CCG-273463

    CAS:
    <p>CCG-273463: Potent GRK5 inhibitor (IC50: 9 nM), used for researching heart failure, hypertrophy, cancer.</p>
    Fórmula:C26H25BrN4O3
    Forma y color:Solid
    Peso molecular:521.41

    Ref: TM-T63640

  • CCG-273220
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    CCG-273220

    CAS:
    <p>CCG-273220 covalently inhibits GRK5 at Cys474 with 220 nM IC50; more selective over GRK2.</p>
    Fórmula:C26H24ClFN4O3
    Forma y color:Solid
    Peso molecular:494.95

    Ref: TM-T63340

  • GSK466317A
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    GSK466317A

    CAS:
    <p>GSK466317A is a GRK2 inhibitor.</p>
    Fórmula:C21H16ClF3N4O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:448.83

    Ref: TM-T27479

  • GSK299115A
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    GSK299115A

    CAS:
    <p>GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.</p>
    Fórmula:C20H16Cl2N4O2
    Pureza:99.81%
    Forma y color:Solid
    Peso molecular:415.27

    Ref: TM-T27471

  • GSK2163632A
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    GSK2163632A

    CAS:
    <p>GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.</p>
    Fórmula:C27H32N8O3S
    Forma y color:Solid
    Peso molecular:548.66

    Ref: TM-T24106

  • GRK2 Inhibitor 2
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    GRK2 Inhibitor 2

    CAS:
    <p>GRK2 Inhibitor 2 (Compound 8h), with an IC50 of 19 nM for GRK2 and 137 nM for Aurora-A, enhances β-AR-mediated cAMP accumulation in GRK2-overexpressing HEK293</p>
    Fórmula:C19H16N4O2
    Forma y color:Solid
    Peso molecular:332.36

    Ref: TM-T79913

  • Ro 32-0432 hydrochloride
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    Ro 32-0432 hydrochloride

    CAS:
    <p>Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.</p>
    Fórmula:C28H28N4O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:452.55

    Ref: TM-T23244

  • CCG258208
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    CCG258208

    CAS:
    <p>GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).</p>
    Fórmula:C24H25FN4O4
    Pureza:98%
    Forma y color:Solid
    Peso molecular:452.48

    Ref: TM-T13714

  • GRK6-IN-5
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    GRK6-IN-5

    CAS:
    <p>GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>
    Fórmula:C23H21N3O2
    Forma y color:Solid
    Peso molecular:371.432

    Ref: TM-T205394

  • GRK6-IN-4
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    GRK6-IN-4

    CAS:
    <p>GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>
    Fórmula:C15H15N5
    Forma y color:Solid
    Peso molecular:265.313

    Ref: TM-T204959