GRK
Las quinasas de receptores acoplados a proteínas G (GRK) son una familia de enzimas que fosforilan GPCR activados, lo que lleva a la desensibilización de los receptores y a la regulación de la señalización de los receptores. Las GRK desempeñan un papel crucial en el control de la intensidad y la duración de la señalización de los GPCR, lo que las hace importantes en la regulación de varios procesos fisiológicos, incluida la función cardiovascular, la respuesta inmunitaria y la neurotransmisión. Los inhibidores y activadores de GRK se estudian por su potencial en aplicaciones terapéuticas en insuficiencia cardíaca, cáncer y trastornos neurológicos. En CymitQuimica, ofrecemos una gama de moduladores de GRK de alta calidad para apoyar su investigación en transducción de señales, regulación de receptores y desarrollo terapéutico.
Se han encontrado 33 productos de "GRK"
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CCG-271423
CAS:CCG-271423: potent GRK5 inhibitor (IC50: 0.0021 μM), less on GRK2 (IC50: 44 μM); lowers Ca2+ events and heart cell contractility.Fórmula:C28H26N4O3Forma y color:SolidPeso molecular:466.53CCG-224406
CAS:CCG-22440 is a Highly Selective and Potent Inhibitor of G Protein-Coupled Receptor Kinase 2.Fórmula:C29H27FN6O5Forma y color:SolidPeso molecular:558.56GRK5-IN-4
CAS:GRK5-IN-4: potent, selective covalent inhibitor of GRK5 (IC50=1.1 μM), 90x more specific than GRK2, useful for heart failure research.Fórmula:C26H25N7O3Forma y color:SolidPeso molecular:483.52CCG-273463
CAS:CCG-273463: Potent GRK5 inhibitor (IC50: 9 nM), used for researching heart failure, hypertrophy, cancer.Fórmula:C26H25BrN4O3Forma y color:SolidPeso molecular:521.41GRK5-IN-3
CAS:GRK5-IN-3 is a covalent inhibitor of G protein-coupled receptor kinase 5 (GRK5).GRK5-IN-3 significantly inhibits GRK5 (IC50: 0.22 μM) and GRK6 (IC50: 0.41 μM).Fórmula:C23H21N7O3Forma y color:SolidPeso molecular:443.46GSK299115A
CAS:GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.Fórmula:C20H16Cl2N4O2Pureza:99.81%Forma y color:SolidPeso molecular:415.27Ref: TM-T27471
1mg303,00€5mg732,00€1mL*10mM (DMSO)895,00€10mg1.018,00€25mg1.513,00€50mg2.035,00€100mg2.673,00€DS-1558
CAS:DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDFFórmula:C21H21F3O4Forma y color:SolidPeso molecular:394.38Ro 32-0432 hydrochloride
CAS:Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.Fórmula:C28H28N4O2Pureza:98%Forma y color:SolidPeso molecular:452.55GSK2163632A
CAS:GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.Fórmula:C27H32N8O3SForma y color:SolidPeso molecular:548.66GRK6-IN-4
CAS:GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.Fórmula:C15H15N5Forma y color:SolidPeso molecular:265.313CCG258208
CAS:GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Fórmula:C24H25FN4O4Pureza:98%Forma y color:SolidPeso molecular:452.48GRK6-IN-5
CAS:GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.Fórmula:C23H21N3O2Forma y color:SolidPeso molecular:371.432LAS195319
CAS:LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.Fórmula:C29H26N10O3SForma y color:SolidPeso molecular:594.65
