Hedgehog / Smoothened

Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata …

Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum …

Itraconazole is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.

Tolnaftate is a synthetic antifungal agent.

GANT 58 is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).

Dynarrestin is a cytoplasmic dynein 1 and 2 aminothiazole inhibitor that reversibly inhibits dynein 1-driven …

Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) …

ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in …

CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds …

Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing …

CUR61414 is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). …

TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor …

Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is …

Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 …

HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced …

GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM. It …

The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane …

SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects …

HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the …

SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway.

Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group …

GANT 61 is an inhibitor for Gli1 and Gli2.

Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 …

BMS-833923, an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent …

SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist.

LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 …

MK-4101, an effective inhibitor of the Hedgehog pathway, has anti-tumor activity through the induction of …

MRT 10 is a smoothened (Smo) receptor antagonist (an IC50 = 0.5 μM in HEK293 …

JK184 is a potent Hedgehog (Hh) pathway inhibitor.

Taladegib is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor …

Ciliobrevin A is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.