Hedgehog / Smoothened
La vía de señalización Hedgehog/Smoothened es una vía crucial relacionada con los GPCR, involucrada en el desarrollo embrionario, la regeneración de tejidos y el mantenimiento de células madre. Smoothened (SMO) es una proteína transmembrana clave que transduce señales de los ligandos Hedgehog (Hh) para activar cascadas de señalización aguas abajo. La desregulación de la vía Hedgehog/Smoothened está implicada en varios tipos de cáncer y trastornos del desarrollo, lo que la convierte en un objetivo significativo para la intervención terapéutica. En CymitQuimica, ofrecemos una gama de moduladores de alta calidad para la vía Hedgehog/Smoothened para apoyar su investigación en biología del desarrollo, oncología y medicina regenerativa.
Se han encontrado 44 productos de "Hedgehog / Smoothened"
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GANT 58
CAS:<p>GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).</p>Fórmula:C24H16N4SPureza:99.53%Forma y color:SolidPeso molecular:392.48Dynarrestin
CAS:<p>Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.</p>Fórmula:C22H23F2N3O2SPureza:99.64%Forma y color:SolidPeso molecular:431.5ALLO-2
CAS:<p>ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.</p>Fórmula:C18H12F3N5OPureza:99.19%Forma y color:SolidPeso molecular:371.32HL2-m5
CAS:<p>HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.</p>Fórmula:C70H101N15O24S3Forma y color:SolidPeso molecular:1632.83CUR61414 hydrochloride
<p>CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.</p>Fórmula:C31H43ClN4O5Pureza:94.05%Forma y color:SolidPeso molecular:587.15SAG dihydrochloride
CAS:<p>SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.</p>Fórmula:C28H30Cl3N3OSPureza:>99.99%Forma y color:SoildPeso molecular:562.98HSP70-IN-3
<p>HSP70-IN-3: Strong HSP70 blocker; IC50=1.1μM/1.9μM (ASZ001/C3H10T1/2); hinders Hedgehog signaling and cancer cell growth, lowers GLI1 levels.</p>Fórmula:C48H78N6O7SForma y color:SolidPeso molecular:883.23GI-560192
CAS:<p>GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.</p>Fórmula:C20H16N2O2Pureza:99.53%Forma y color:SoildPeso molecular:316.35GLI1-IN-3
<p>GLI1-IN-3 (Compound 11a) is a triterpenoid-like compound that inhibits Hedgehog signaling in cancer cells with GLI1 overexpression. It suppresses the proliferation of non-small cell lung cancer and prostate cancer cell lines with excessive Hh signaling activation. Additionally, GLI1-IN-3 reduces the expression of GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells.</p>Forma y color:Odour SolidHPP-9
<p>HPP-9, a Proteolysis-Targeting Chimera (PROTAC) derived from Hedgehog Pathway Inhibitor-1 (HPI-1) with a pIC50 value of 6.71, is designed to degrade BET</p>Fórmula:C49H52N6O11Forma y color:SolidPeso molecular:900.97SANT 2
CAS:<p>SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.</p>Fórmula:C26H26ClN3O4Pureza:99.23%Forma y color:SolidPeso molecular:479.96Ciliobrevin A
CAS:<p>Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.</p>Fórmula:C17H9Cl2N3O2Pureza:98.54% - 99.57%Forma y color:SolidPeso molecular:358.18MRT-81
CAS:<p>MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.</p>Fórmula:C31H29N3O5SPureza:99.72%Forma y color:SolidPeso molecular:555.64HPI 1
CAS:<p>HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.</p>Fórmula:C27H29NO6Pureza:97.6%Forma y color:SolidPeso molecular:463.52HhAntag
CAS:<p>HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity</p>Fórmula:C24H23ClN4O3Pureza:95.73%Forma y color:SolidPeso molecular:450.92SAG hydrochloride (912545-86-9(free base))
CAS:<p>SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.</p>Fórmula:C28H29Cl2N3OSPureza:99.19% - 99.77%Forma y color:SolidPeso molecular:526.52Glasdegib
CAS:<p>Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.</p>Fórmula:C21H22N6OPureza:98.72%Forma y color:SolidPeso molecular:374.44Taladegib
CAS:<p>Taladegib (LY2940680), an oral Smo receptor antagonist, targets Hedgehog signaling for cancer treatment.</p>Fórmula:C26H24F4N6OPureza:98.75% - >99.99%Forma y color:SolidPeso molecular:512.5JK184
CAS:<p>JK184 is a potent Hedgehog (Hh) pathway inhibitor.</p>Fórmula:C19H18N4OSPureza:98.93% - 99.89%Forma y color:SolidPeso molecular:350.44SAG
CAS:<p>SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.</p>Fórmula:C28H28ClN3OSPureza:97.37% - 98.88%Forma y color:SolidPeso molecular:490.06Sonidegib
CAS:<p>Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.</p>Fórmula:C26H26F3N3O3Pureza:98% - 99.97%Forma y color:SolidPeso molecular:485.5MRT-10
CAS:<p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>Fórmula:C24H23N3O5SPureza:99.73%Forma y color:SolidPeso molecular:465.52SANT-1
CAS:<p>SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).</p>Fórmula:C23H27N5Pureza:99.98% - >99.99%Forma y color:SolidPeso molecular:373.49Neurodazine
CAS:<p>Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.</p>Fórmula:C27H21ClN2O3Pureza:98.01%Forma y color:SolidPeso molecular:456.92RUSKI-201
CAS:<p>RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.</p>Fórmula:C20H27N3OSForma y color:SolidPeso molecular:357.51SANT-2
CAS:<p>SANT-2 is a potent inhibitor of Shh signaling pathway.</p>Fórmula:C23H20ClN3O4Forma y color:SolidPeso molecular:437.88Hedgehog Antagonist VIII
CAS:<p>Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.</p>Fórmula:C23H15ClF4N4O2Forma y color:SolidPeso molecular:490.84RUSKI-201 dihydrochloride
CAS:<p>RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.</p>Fórmula:C20H29Cl2N3OSForma y color:SolidPeso molecular:430.43SMANT hydrochloride
CAS:<p>SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.</p>Fórmula:C16H24BrClN2OPureza:99.81%Forma y color:SolidPeso molecular:375.733-epi-Vitamin D3
CAS:<p>3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM in</p>Fórmula:C27H44OForma y color:SolidPeso molecular:384.64SMO-IN-3
CAS:<p>SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.</p>Fórmula:C27H25F4N3O2Forma y color:SolidPeso molecular:499.5MS-0022
CAS:<p>MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.</p>Fórmula:C21H16BrN3OForma y color:SolidPeso molecular:406.28Hedgehog IN-3
CAS:<p>Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].</p>Fórmula:C18H13ClF3N5OForma y color:SolidPeso molecular:407.78AZD8542
CAS:<p>AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.</p>Fórmula:C25H24N4O2Pureza:99.96%Forma y color:SolidPeso molecular:412.48SMO-IN-2
CAS:<p>SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.</p>Fórmula:C25H25F4N5O2Pureza:98.64%Forma y color:SolidPeso molecular:503.49GSA-10
CAS:<p>GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.</p>Fórmula:C26H30N2O5Pureza:99.71%Forma y color:SolidPeso molecular:450.53Robotnikinin
CAS:<p>Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.</p>Fórmula:C25H27ClN2O4Pureza:98%Forma y color:SolidPeso molecular:454.95Hh-Ag1.5
CAS:<p>Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.</p>Fórmula:C28H26ClF2N3OSPureza:99.8%Forma y color:SolidPeso molecular:526.04Hedgehog IN-2
CAS:<p>Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].</p>Fórmula:C24H22N4O2Forma y color:SolidPeso molecular:398.46TAK-441
CAS:<p>TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.</p>Fórmula:C28H31F3N4O6Pureza:99.82%Forma y color:SolidPeso molecular:576.56SAG 21k
CAS:<p>SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.</p>Fórmula:C29H28ClF2N3O2SPureza:99.51%Forma y color:SolidPeso molecular:556.07MRT-92
CAS:<p>MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.</p>Fórmula:C33H34N4O5Forma y color:SolidPeso molecular:566.65IMP-1575
CAS:<p>IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.</p>Fórmula:C19H25N3OSPeso molecular:343.49BRD50837
CAS:<p>BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).</p>Fórmula:C26H32ClN3O6SPureza:98%Forma y color:SolidPeso molecular:550.07
