Hedgehog / Smoothened
La vía de señalización Hedgehog/Smoothened es una vía crucial relacionada con los GPCR, involucrada en el desarrollo embrionario, la regeneración de tejidos y el mantenimiento de células madre. Smoothened (SMO) es una proteína transmembrana clave que transduce señales de los ligandos Hedgehog (Hh) para activar cascadas de señalización aguas abajo. La desregulación de la vía Hedgehog/Smoothened está implicada en varios tipos de cáncer y trastornos del desarrollo, lo que la convierte en un objetivo significativo para la intervención terapéutica. En CymitQuimica, ofrecemos una gama de moduladores de alta calidad para la vía Hedgehog/Smoothened para apoyar su investigación en biología del desarrollo, oncología y medicina regenerativa.
Se han encontrado 49 productos para "Hedgehog / Smoothened".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
SAG hydrochloride (912545-86-9(free base))
CAS:SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.Fórmula:C28H29Cl2N3OSPureza:99.19% - 99.97%Forma y color:White SolidPeso molecular:526.52Ref: TM-T4211
1mg49,00€2mg65,00€5mg90,00€1mL*10mM (DMSO)105,00€10mg114,00€25mg222,00€50mg334,00€100mg502,00€200mg717,00€MRT-81
CAS:MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Fórmula:C31H29N3O5SPureza:99.72%Forma y color:SolidPeso molecular:555.64HPI 1
CAS:HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Fórmula:C27H29NO6Pureza:97.6%Forma y color:SolidPeso molecular:463.52Ref: TM-T22089
1mg44,00€2mg57,00€1mL*10mM (DMSO)88,00€5mg96,00€10mg128,00€25mg207,00€50mg308,00€100mg447,00€500mg973,00€SAG
CAS:SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.Fórmula:C28H28ClN3OSPureza:97.37% - 98.88%Forma y color:SolidPeso molecular:490.06Ref: TM-T1779
1mg46,00€2mg58,00€5mg86,00€1mL*10mM (DMSO)87,00€10mg114,00€25mg221,00€50mg305,00€100mg452,00€200mg647,00€Neurodazine
CAS:Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Fórmula:C27H21ClN2O3Pureza:98.03%Forma y color:SolidPeso molecular:456.925-LOX inhibitor
CAS:5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is an itraconazole impurity, a LOX-5 inhibitor.Fórmula:C22H27N5O2Pureza:98.52%Forma y color:SolidPeso molecular:393.48Hedgehog Antagonist VIII
CAS:Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.Fórmula:C23H15ClF4N4O2Forma y color:SolidPeso molecular:490.84SMO-IN-3
CAS:SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.Fórmula:C27H25F4N3O2Forma y color:SolidPeso molecular:499.53-epi-Vitamin D3
CAS:3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM inFórmula:C27H44OForma y color:SolidPeso molecular:384.64RUSKI-201
CAS:RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.Fórmula:C20H27N3OSForma y color:SolidPeso molecular:357.51Hedgehog IN-3
CAS:Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].Fórmula:C18H13ClF3N5OForma y color:SolidPeso molecular:407.78SMANT hydrochloride
CAS:SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Fórmula:C16H24BrClN2OPureza:99.81%Forma y color:White SolidPeso molecular:375.73MS-0022
CAS:MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.Fórmula:C21H16BrN3OForma y color:SolidPeso molecular:406.28RUSKI-201 dihydrochloride
CAS:RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.Fórmula:C20H29Cl2N3OSForma y color:SolidPeso molecular:430.43M-25
CAS:M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.Fórmula:C23H29N3O2Forma y color:SolidPeso molecular:379.5LEQ-506
CAS:LEQ506, an oral Smoothened antagonist, may inhibit cancer growth by blocking the Hedgehog signaling pathway.Fórmula:C27H29N5OForma y color:SolidPeso molecular:439.55SANT-2
CAS:SANT-2 is a potent inhibitor of Shh signaling pathway.Fórmula:C23H20ClN3O4Forma y color:SolidPeso molecular:437.88SMO-IN-2
CAS:SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.Fórmula:C25H25F4N5O2Pureza:98.76%Forma y color:White SolidPeso molecular:503.49AZD8542
CAS:AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Fórmula:C25H24N4O2Pureza:99.96%Forma y color:SolidPeso molecular:412.48Hh-Ag1.5
CAS:Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.Fórmula:C28H26ClF2N3OSPureza:99.8%Forma y color:White SolidPeso molecular:526.04Ref: TM-T24754
1mg120,00€5mg289,00€1mL*10mM (DMSO)334,00€10mg447,00€25mg740,00€50mg1.044,00€100mg1.459,00€
