Hedgehog / Smoothened
La vía de señalización Hedgehog/Smoothened es una vía crucial relacionada con los GPCR, involucrada en el desarrollo embrionario, la regeneración de tejidos y el mantenimiento de células madre. Smoothened (SMO) es una proteína transmembrana clave que transduce señales de los ligandos Hedgehog (Hh) para activar cascadas de señalización aguas abajo. La desregulación de la vía Hedgehog/Smoothened está implicada en varios tipos de cáncer y trastornos del desarrollo, lo que la convierte en un objetivo significativo para la intervención terapéutica. En CymitQuimica, ofrecemos una gama de moduladores de alta calidad para la vía Hedgehog/Smoothened para apoyar su investigación en biología del desarrollo, oncología y medicina regenerativa.
Se han encontrado 49 productos de "Hedgehog / Smoothened"
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MRT-81
CAS:MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Fórmula:C31H29N3O5SPureza:99.72%Forma y color:SolidPeso molecular:555.64Ref: TM-T9532
1mg46,00€5mg92,00€1mL*10mM (DMSO)110,00€10mg138,00€25mg241,00€50mg349,00€100mg479,00€200mg657,00€SAG
CAS:SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.
Fórmula:C28H28ClN3OSPureza:97.37% - 98.88%Forma y color:SolidPeso molecular:490.06Ciliobrevin A
CAS:Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.Fórmula:C17H9Cl2N3O2Pureza:98.54% - 99.57%Forma y color:SolidPeso molecular:358.18Ref: TM-T3156
2mg39,00€5mg56,00€1mL*10mM (DMSO)65,00€10mg80,00€25mg165,00€50mg224,00€100mg314,00€200mg467,00€HPI 1
CAS:HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Fórmula:C27H29NO6Pureza:97.6%Forma y color:SolidPeso molecular:463.52Ref: TM-T22089
1mg44,00€2mg57,00€5mg96,00€1mL*10mM (DMSO)102,00€10mg128,00€25mg207,00€50mg308,00€100mg447,00€500mg973,00€Neurodazine
CAS:Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Fórmula:C27H21ClN2O3Pureza:98.01%Forma y color:SolidPeso molecular:456.925-LOX inhibitor
CAS:5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is an itraconazole impurity, a LOX-5 inhibitor.Fórmula:C22H27N5O2Pureza:98.01%Forma y color:SolidPeso molecular:393.48MS-0022
CAS:MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.Fórmula:C21H16BrN3OForma y color:SolidPeso molecular:406.28SMANT hydrochloride
CAS:SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Fórmula:C16H24BrClN2OPureza:99.81%Forma y color:SolidPeso molecular:375.733-epi-Vitamin D3
CAS:3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM inFórmula:C27H44OForma y color:SolidPeso molecular:384.64RUSKI-201 dihydrochloride
CAS:RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.Fórmula:C20H29Cl2N3OSForma y color:SolidPeso molecular:430.43Hedgehog Antagonist VIII
CAS:Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.Fórmula:C23H15ClF4N4O2Forma y color:SolidPeso molecular:490.84SMO-IN-3
CAS:SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.Fórmula:C27H25F4N3O2Forma y color:SolidPeso molecular:499.5RUSKI-201
CAS:RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.Fórmula:C20H27N3OSForma y color:SolidPeso molecular:357.51SANT-2
CAS:SANT-2 is a potent inhibitor of Shh signaling pathway.Fórmula:C23H20ClN3O4Forma y color:SolidPeso molecular:437.88Hedgehog IN-3
CAS:Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].Fórmula:C18H13ClF3N5OForma y color:SolidPeso molecular:407.78M-25
CAS:M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.Fórmula:C23H29N3O2Forma y color:SolidPeso molecular:379.5LEQ-506
CAS:LEQ506, an oral Smoothened antagonist, may inhibit cancer growth by blocking the Hedgehog signaling pathway.Fórmula:C27H29N5OForma y color:SolidPeso molecular:439.55SMO-IN-2
CAS:SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.Fórmula:C25H25F4N5O2Pureza:98.64%Forma y color:SolidPeso molecular:503.49AZD8542
CAS:AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Fórmula:C25H24N4O2Pureza:99.96%Forma y color:SolidPeso molecular:412.48Hedgehog IN-2
CAS:Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].Fórmula:C24H22N4O2Forma y color:SolidPeso molecular:398.46
