Hedgehog / Smoothened
La vía de señalización Hedgehog/Smoothened es una vía crucial relacionada con los GPCR, involucrada en el desarrollo embrionario, la regeneración de tejidos y el mantenimiento de células madre. Smoothened (SMO) es una proteína transmembrana clave que transduce señales de los ligandos Hedgehog (Hh) para activar cascadas de señalización aguas abajo. La desregulación de la vía Hedgehog/Smoothened está implicada en varios tipos de cáncer y trastornos del desarrollo, lo que la convierte en un objetivo significativo para la intervención terapéutica. En CymitQuimica, ofrecemos una gama de moduladores de alta calidad para la vía Hedgehog/Smoothened para apoyar su investigación en biología del desarrollo, oncología y medicina regenerativa.
Se han encontrado 44 productos de "Hedgehog / Smoothened"
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Sonidegib
CAS:<p>Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.</p>Fórmula:C26H26F3N3O3Pureza:98% - 99.97%Forma y color:SolidPeso molecular:485.5MRT-10
CAS:<p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>Fórmula:C24H23N3O5SPureza:99.73%Forma y color:SolidPeso molecular:465.52SANT-1
CAS:<p>SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).</p>Fórmula:C23H27N5Pureza:99.98% - >99.99%Forma y color:SolidPeso molecular:373.49Neurodazine
CAS:<p>Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.</p>Fórmula:C27H21ClN2O3Pureza:98.01%Forma y color:SolidPeso molecular:456.92RUSKI-201
CAS:<p>RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.</p>Fórmula:C20H27N3OSForma y color:SolidPeso molecular:357.51SANT-2
CAS:<p>SANT-2 is a potent inhibitor of Shh signaling pathway.</p>Fórmula:C23H20ClN3O4Forma y color:SolidPeso molecular:437.88Hedgehog Antagonist VIII
CAS:<p>Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.</p>Fórmula:C23H15ClF4N4O2Forma y color:SolidPeso molecular:490.84RUSKI-201 dihydrochloride
CAS:<p>RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.</p>Fórmula:C20H29Cl2N3OSForma y color:SolidPeso molecular:430.43SMANT hydrochloride
CAS:<p>SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.</p>Fórmula:C16H24BrClN2OPureza:99.81%Forma y color:SolidPeso molecular:375.733-epi-Vitamin D3
CAS:<p>3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM in</p>Fórmula:C27H44OForma y color:SolidPeso molecular:384.64SMO-IN-3
CAS:<p>SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.</p>Fórmula:C27H25F4N3O2Forma y color:SolidPeso molecular:499.5MS-0022
CAS:<p>MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.</p>Fórmula:C21H16BrN3OForma y color:SolidPeso molecular:406.28Hedgehog IN-3
CAS:<p>Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].</p>Fórmula:C18H13ClF3N5OForma y color:SolidPeso molecular:407.78AZD8542
CAS:<p>AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.</p>Fórmula:C25H24N4O2Pureza:99.96%Forma y color:SolidPeso molecular:412.48SMO-IN-2
CAS:<p>SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.</p>Fórmula:C25H25F4N5O2Pureza:98.64%Forma y color:SolidPeso molecular:503.49GSA-10
CAS:<p>GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.</p>Fórmula:C26H30N2O5Pureza:99.71%Forma y color:SolidPeso molecular:450.53Robotnikinin
CAS:<p>Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.</p>Fórmula:C25H27ClN2O4Pureza:98%Forma y color:SolidPeso molecular:454.95Hh-Ag1.5
CAS:<p>Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.</p>Fórmula:C28H26ClF2N3OSPureza:99.8%Forma y color:SolidPeso molecular:526.04Hedgehog IN-2
CAS:<p>Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].</p>Fórmula:C24H22N4O2Forma y color:SolidPeso molecular:398.46TAK-441
CAS:<p>TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.</p>Fórmula:C28H31F3N4O6Pureza:99.82%Forma y color:SolidPeso molecular:576.56
