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PAFR

PAFR

El receptor del factor activador de plaquetas (PAFR) es un GPCR que se une al factor activador de plaquetas (PAF), un potente mediador fosfolipídico involucrado en la inflamación, la trombosis y las respuestas alérgicas. La señalización del PAFR juega un papel crucial en las respuestas inmunitarias, la salud cardiovascular y la patogénesis de enfermedades inflamatorias. La modulación de la actividad del PAFR es de interés en el desarrollo de terapias antiinflamatorias y antitrombóticas. En CymitQuimica, ofrecemos una variedad de moduladores de PAFR de alta calidad para apoyar su investigación en inmunología, biología cardiovascular e inflamación.

Se han encontrado 10 productos para "PAFR".

  • 2-Acetylbenzoic acid
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    2-Acetylbenzoic acid

    CAS:
    2-Acetylbenzoic acid outperforms 2-propionyloxybenzoic in hindering platelet function and PG synthesis; both similar in blocking PGI2 creation.
    Fórmula:C9H8O3
    Pureza:99.62%
    Forma y color:Off-White Solid
    Peso molecular:164.158

    Ref: TM-TMA0536

  • Tulopafant
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    Tulopafant

    CAS:
    Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival.
    Fórmula:C25H19N3O2S
    Pureza:99.38%
    Forma y color:Yellow Solid
    Peso molecular:425.5

    Ref: TM-T17178

  • PAF-AN-1
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    PAF-AN-1

    CAS:
    PAF-AN-1 is a novel potent platelet-activating factor receptor (PAF) antagonist involved in the study of anaphylactic death.
    Fórmula:C28H28N2O3
    Pureza:98.06%
    Forma y color:Solid
    Peso molecular:440.53

    Ref: TM-T14007

  • Rocepafant
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    Rocepafant

    CAS:
    Rocepafant (LAU8080), a PAF antagonist, reduces neonatal rat brain damage and inhibits TNF-α toxicity in L929 cells.
    Fórmula:C26H23ClN6OS2
    Pureza:97.31% - 98.95%
    Forma y color:Solid
    Peso molecular:535.083

    Ref: TM-T28607

  • SDZ-62-434
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    SDZ-62-434

    CAS:
    SDZ-62-434 is a platelet-activating factor inhibitor with antitumor activity and may be used in the study of leukemia.
    Fórmula:C23H27Cl2N3
    Pureza:99.90%
    Forma y color:Solid
    Peso molecular:416.39

    Ref: TM-T28740

  • 48740 RP
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    48740 RP

    CAS:
    48740 RP (RP 55779) is an antagonist of platelet-activating factor.
    Fórmula:C12H11N3OS
    Pureza:99.79%
    Forma y color:Yellow Solid
    Peso molecular:245.3

    Ref: TM-T10159

  • Foropafant
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    Foropafant

    CAS:
    Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM).
    Fórmula:C28H40N4S
    Pureza:99.67%
    Forma y color:Yellow Solid
    Peso molecular:464.709

    Ref: TM-T15338

  • ST-899
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    ST-899

    CAS:
    ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS). The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.
    Fórmula:C22H29BrClNO6
    Forma y color:Solid
    Peso molecular:518.83

    Ref: TM-T211047

  • Logo de CymitQuimica
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    SDZ-62-434 free base

    CAS:
    SDZ-62-434 (free base) is a platelet-activating factor (PAF) antagonist with antiproliferative properties against human solid tumors and hematological malignancies.
    Fórmula:C23H25N3
    Peso molecular:343.47

    Ref: TM-T213709

  • Apafant
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    Apafant

    CAS:
    Apafant (WEB 2086) is a PAF antagonist that blocks eosinophil activation and can be used to study experimental allergic conjunctivitis in guinea pigs.
    Fórmula:C22H22ClN5O2S
    Pureza:99.56%
    Forma y color:White Solid
    Peso molecular:455.96

    Ref: TM-T14300