Receptor S1P
Los receptores de esfingosina-1-fosfato (S1P) son una familia de GPCR que se unen a la molécula de señalización lipídica esfingosina-1-fosfato. Estos receptores desempeñan roles críticos en el tráfico de células inmunitarias, el desarrollo vascular y el mantenimiento de la integridad de las barreras endoteliales. Los moduladores de los receptores S1P se están desarrollando para el tratamiento de la esclerosis múltiple, el cáncer y las enfermedades cardiovasculares debido a su capacidad para influir en las respuestas inmunitarias y la migración celular. En CymitQuimica, ofrecemos una variedad de moduladores de receptores S1P de alta calidad para apoyar su investigación en inmunología, oncología y biología vascular.
Se han encontrado 17 productos de "Receptor S1P"
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MP-A08
CAS:MP-A08 selectively inhibits SPHK1; targets SphK1 & SphK2 with Ki of 6.9 μM & 27 μM, respectively.Fórmula:C27H25N3O4S2Pureza:97.44%Forma y color:SolidPeso molecular:519.64Azido-FTY720
CAS:Azido-FTY720 (azido-Fingolimod) is an analogue of FTY720, with an azido group for click chemistry reactions. FTY720 is an orally available S1P1R modulator .Fórmula:C19H32N4O2Forma y color:SolidPeso molecular:348.49SphK1&2-IN-1
CAS:SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.
Fórmula:C14H14N2O3SPureza:99.59%Forma y color:SolidPeso molecular:290.34Biotin Sphingosine
CAS:Cimbuterol-d9 is deuterium-labeled Cimbuterol, a 12 β(2)-adrenergic agonist.Fórmula:C28H52N4O4SForma y color:SolidPeso molecular:540.8MHP
CAS:MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.Fórmula:C16H23NO4Pureza:98.58%Forma y color:SolidPeso molecular:293.36Ref: TM-T4658
1mg34,00€2mg46,00€5mg66,00€10mg101,00€25mg207,00€50mg334,00€100mg537,00€200mg762,00€1mL*10mM (DMSO)73,00€Siponimod
CAS:Siponimod (BAF312) modulates S1P1/S1P5 with EC50s of 0.39/0.98 nM; >1000x selectivity over S1P2-4.Fórmula:C29H35F3N2O3Pureza:99.13% - 99.8%Forma y color:SolidPeso molecular:516.59Opaganib
CAS:Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).Fórmula:C23H25ClN2OPureza:98.86% - 99.85%Forma y color:SolidPeso molecular:380.91Ref: TM-T6750
1mg38,00€2mg50,00€5mg80,00€10mg117,00€25mg227,00€50mg394,00€100mg583,00€1mL*10mM (DMSO)82,00€4-Deoxypyridoxine hydrochloride
CAS:4-Deoxypyridoxine HCl halts S1P breakdown by blocking SPL, reducing apoptosis in insulinoma cells like S1P.Fórmula:C8H12ClNO2Pureza:99.90%Forma y color:White To Off White Crystalline PowderPeso molecular:189.64SK1-IN-1
CAS:SK1-IN-1 is a SPHK1 inhibitor (IC50: 58 nM), with potential anticancer activity, and can be used to study cancer and neurodegenerative diseases.Fórmula:C22H30N4O3Pureza:98.72%Forma y color:SolidPeso molecular:398.5SK1-I hydrochloride
CAS:SK1-I hydrochloride is a selective and competitive SphK1 inhibitor and sphingosine analog ,anti-leukemic to inhibit tumor cell growth and promote apoptosis.Fórmula:C17H28ClNO2Pureza:99.80%Forma y color:SolidPeso molecular:313.86N,N-Dimethylsphingosine
CAS:N,N-Dimethylsphingosine,is a potent competitive SphK phosphorylation inhibitor.DMS is elevated in models of neuropathic pain by increasing IL-1β and MCP-1.Fórmula:C20H41NO2Pureza:98%Forma y color:Clear Colorless To Faint Yellow Liquid/White To Off-White PowderPeso molecular:327.55SLM6031434 HCl
CAS:SLM6031434 HCl (SLM-6031434 HCl) is a SphK2 inhibitor that reduces LPS-induced TNF伪 and IL-1尾 production.Fórmula:C22H31ClF3N5O2Pureza:98%Forma y color:SolidPeso molecular:489.96Iso-SLR 080811
CAS:Iso-SLR 080811 is an isomer of SLR 080811, suitable for relevant research in the life sciences. SLR080811 is a selective SphK2 inhibitor (Ki=1.3 μM).Fórmula:C21H32ClN5OPureza:98.34%Forma y color:SolidPeso molecular:405.97S1P1 Agonist III
CAS:S1P1 Agonist III is an orally active S1P1 receptor agonist (EC₅₀ = 18 nM) with applications in inflammation, immunology, and receptor signaling studies.Fórmula:C21H16F3N3O3Pureza:99.08%Forma y color:SolidPeso molecular:415.37Amgen-23
CAS:Amgen-23 is a selective and highly potent sphingosine kinase 1 (SPHK1) inhibitor that inhibits SPHK2 and can be used in anticancer research.Fórmula:C23H25Cl2N3O2SPureza:97.31%Forma y color:SolidPeso molecular:478.44K6PC-5
CAS:K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels.Fórmula:C19H37NO4Pureza:99.9%Forma y color:SolidPeso molecular:343.5AMG-369
CAS:AMG-369 (AMG 247) is an S1P1/S1P5 dual agonist that delays the development of experimental autoimmune encephalomyelitis in rats.Fórmula:C26H22FN3O2SPureza:98.04% - 98.92%Forma y color:SolidPeso molecular:459.54
