Receptor S1P

JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of …

Amiselimod hydrochloride is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.

PF429242 dihydrochloride can reversibly inhibit S1P (IC50 of 175 nM).

CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 …

MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both …

Vibozilimod is S1P receptor-1 (S1PR1) agonist .

PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 …

[(3S)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;hydrobromide is a S1P1 antagonist with Ki of 2.84 μM.

K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient …

WAY-272077 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.

Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. …

Sphingosine-1-phosphate receptor 1 agonist SEW2871 prolongs heterotopic heart allograft survival in mice.

Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in …

PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than …

SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : …

MHP is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein …

Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.

Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.

TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).

SKI II is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while …

GLPG2938 is a potent and selective antagonist of S1P2.

BAF312 (Siponimod), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with …

CS 2100 is an S1P1 agonist.

Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear …

ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.

CYM5442 is an S1P agonist, targeting to Sphingosine.

SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces …

noncompetitive allosteric agonist of S1P2

K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 …

GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).

An S1P receptor agonist.

4-Deoxypyridoxine (hydrochloride) inhibits the degradation of intracellular S1P by inhibiting S1P lyase (SPL) activity, minimized …

Ozanimod (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in …

Etrasimod is a specific and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor (IC50: 1.88 …

ABC294640 is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).

Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and …

CYM-5541 is a selective and allosteric S1P3 receptor agonist.

VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and …

PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).

SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).

ASP-4058 is a selective and oral bioactive agonist for S1P1 and S1P5. It ameliorates rodent …

KD-3010 is a orally, potent active, and selective PPARδ agonist.