Síntesis de ADN / ARN
Los inhibidores de la síntesis de ADN y ARN son compuestos que interfieren con los procesos de replicación y transcripción en las células, impidiendo así la producción de material genético esencial. Estos inhibidores pueden dirigirse a diversas enzimas y proteínas involucradas en la síntesis de ácidos nucleicos, lo que los convierte en herramientas valiosas para estudiar los mecanismos de replicación, transcripción y traducción. También se utilizan en el desarrollo de tratamientos para infecciones y cáncer. En CymitQuimica, ofrecemos un amplio espectro de inhibidores de la síntesis de ADN/ARN para apoyar su investigación en biología molecular, virología y desarrollo terapéutico.
Se han encontrado 673 productos para "Síntesis de ADN / ARN".
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ddATP tetrasodium
ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) tetrasodium is an active metabolite of 2',3'-dideoxyinosine and functions as a chain elongation inhibitor for DNA polymerase. It is utilized in DNA sequencing using the Sanger method and in research related to viral infections.Fórmula:C10H12N5Na4O11P3Forma y color:SolidPeso molecular:563.11cis-Lomibuvir
CAS:cis-Lomibuvir (cis-VX-222) is a selective HCV NS5B RdRp inhibitor with a Kd of 17 nM and an EC50 of 5.2 nM, targeting thumb pocket 2.Fórmula:C25H35NO4SForma y color:SolidPeso molecular:445.61N1-Methylpseudouridine-5′-triphosphate tetralithium
N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.Fórmula:C10H13Li4N2O15P3Forma y color:SolidPeso molecular:521.9Mulnitorsen
CAS:Mulnitorsen acts as an inhibitor of antisense non-coding mitochondrial RNA (ASncmtRNA) synthesis and serves as an antitumor agent [1].Fórmula:C172H217N74O82P17S17Forma y color:SolidPeso molecular:5704.66ddGTP trisodium
ddGTP trisodium, a ddNTP, inhibits or serves as a substrate for DNA polymerase α, halting DNA chain elongation.Fórmula:C10H13N5Na3O12P3Forma y color:SolidPeso molecular:557.13Phen-DC3 Trifluoromethanesulfonate
CAS:Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.Fórmula:C36H26F6N6O8S2Pureza:98%Forma y color:SolidPeso molecular:848.75M7G(3'-OMe-5')pppA(2'-OMe)
M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.Fórmula:C23H33N10O17P3Forma y color:SolidPeso molecular:814.49CW-2
CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).Fórmula:C43H42Cl2FN11O10PtForma y color:SolidPeso molecular:1156.21251Antipain
CAS:Antipain, from Actinomycetes, blocks proteases and combats MNNG-induced genetic changes.Fórmula:C27H44N10O6Pureza:98%Forma y color:SolidPeso molecular:604.713Tubercidin 5'-triphosphate tetrasodium
Tubercidin5'-triphosphate (7-Deazaadenosine 5'-triphosphate) tetrasodium is a nucleoside analogue and serves as an active metabolite of Tubercidin.Forma y color:Odour SolidDemycarosyl-3D-β-D-digitoxosylmithramycin SK
CAS:Demycarosyl-3D-β-D-digitoxosylmithramycin SK, an analog of Mithramycin, exhibits potent anti-tumor activity.Fórmula:C50H72O23Forma y color:SolidPeso molecular:1041.09T-2513
CAS:T-2513 inhibits topoisomerase I by covalently bonding to its DNA complex, blocking DNA replication and causing cell death.Fórmula:C25H27N3O5Forma y color:SolidPeso molecular:449.507CSN5-IN-2
CSN5-IN-2 (Compound 31) is a CSN5 inhibitor with an IC50 of 0.36 μM. It increases Cullin 1 neddylation levels in cancer cells and downregulates the expression of RAD51 and PD-L1. CSN5-IN-2 exhibits antitumor activity, which is enhanced when used in combination with Talazoparib.Forma y color:Odour SolidAV-153
CAS:AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.Fórmula:C14H19NNaO6Forma y color:SolidPeso molecular:320.297LB80317
CAS:LB-80317, a DNA polymerase inhibitor, is used potentially for the potential treatment of hepatitis B virus infection.Fórmula:C10H14N5O5PForma y color:SolidPeso molecular:315.22RNA splicing modulator 2
CAS:RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .Fórmula:C20H21N5OSForma y color:SolidPeso molecular:379.48RNA splicing modulator 1
CAS:RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].Fórmula:C19H20N6OSForma y color:SolidPeso molecular:380.47SD49-7
CAS:SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.Fórmula:C18H14N2O3Pureza:99.91%Forma y color:Yellow SolidPeso molecular:306.32Ref: TM-T67781
1mg57,00€5mg124,00€1mL*10mM (DMSO)141,00€10mg178,00€25mg359,00€50mg520,00€100mg745,00€500mg1.485,00€2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium
2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium, an ATP analog, exhibits robust mixed-type inhibition of poly(AU) synthesis.Fórmula:C10H11FLi4N5O12P3Forma y color:SolidPeso molecular:532.9(+)-Glaucarubinone
(+)-Glaucarubinone is a natural product that can be used as a reference standard.Fórmula:C25H34O10Forma y color:SolidPeso molecular:494.537FF-10502
CAS:FF-10502, a pyrimidine analog of Gemcitabine, inhibits DNA polymerases α/β, targeting dormant cancer cells.Fórmula:C9H12FN3O3SForma y color:SolidPeso molecular:261.272'-(2-Nitrobenzyl)-ATP trisodium
2'-(2-Nitrobenzyl)-ATP trisodium is an rATP analogue that acts as a transcription terminator. It inhibits T7 RNA polymerase from continuing RNA chain extension.Fórmula:C17H18N6Na3O15P3Forma y color:SolidPeso molecular:707.97361Nuclease S1
CAS:Nuclease S1 breaks down ssDNA and RNA, trims protruding ends of dsDNA.Forma y color:SolidRAD51-IN-3
CAS:RAD51-IN-3 is a Rad51 inhibitor.Fórmula:C31H41N5O5S2Forma y color:SolidPeso molecular:627.82DIZ-3
CAS:DIZ-3: Selective G4 ligand, stabilizes structure, inhibits ALT cancer cell growth by inducing cell cycle arrest and apoptosis.Fórmula:C46H44F2N8Forma y color:SolidPeso molecular:746.89Ribonuclease T1
CAS:Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.Forma y color:SolidLorutengitide
CAS:Lorutengitide is a transcription-regulating peptide with antiproliferative activity.Fórmula:C30H50N8O12Forma y color:SolidPeso molecular:714.764RNA polymerase II-IN-2
RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.Fórmula:C41H58N10O12SForma y color:SolidPeso molecular:915.02wrwycr-NH2 TFA
wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.Forma y color:Odour SolidKWR137
KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.Fórmula:C33H31ClF3N9O4Forma y color:SolidPeso molecular:710.105Bromochloroacetonitrile
CAS:Bromochloroacetonitrile, a water disinfection by-product, is mutagenic and can break DNA strands.Fórmula:C2HBrClNForma y color:SolidPeso molecular:154.39DNA31
CAS:DNA31 is a potent RNA polymerase inhibitor.Fórmula:C48H58N4O13Pureza:98%Forma y color:SolidPeso molecular:898.99SR15006
CAS:SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).Fórmula:C16H20ClN3O4SPureza:99.87%Forma y color:SolidPeso molecular:385.87WRN inhibitor 17
CAS:WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.Fórmula:C33H34F4N4O6SForma y color:SolidPeso molecular:690.715-Iminodaunorubicin
CAS:5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.Fórmula:C27H30N2O9Forma y color:SolidPeso molecular:526.54Uridine 5'-O-thiodiphosphate trisodium
Uridine 5'-O-thiodiphosphate (trisodium) (UDP-β-S (trisodium)) acts as an agonist for the purinergic P2Y6 receptor. This compound selectively induces the accumulation of inositol phosphate in 1321N1 cells expressing P2Y6 receptors, with an EC50 value of 28 nM. Additionally, it stimulates DNA synthesis in rat aortic smooth muscle cells.Thymidine-D3
CAS:Thymidine-D3 is the deuterated form of Thymidine. It is a specific precursor of deoxyribonucleic acid (DNA) and functions as a cell synchronizing agent. Thymidine (TWP2911) acts as a DNA synthesis inhibitor, blocking cells at the G1/S boundary before DNA replication.Fórmula:C10H14N2O5Forma y color:SolidPeso molecular:245.25AO-022
AO-022 is a potent conformational inhibitor of TALDO1. It reduces the protein expression of vimentin and snail, exhibiting antiproliferative and antitumor activities. AO-022 holds potential for use in breast cancer research.Forma y color:Odour SolidONX 0801 trisodium
CAS:ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Fórmula:C32H30N5Na3O10Forma y color:SolidPeso molecular:713.58Uridine triphosphate-15N2 dilithium
Uridine triphosphate-15N2 dilithium is the 15N-labeled version of uridine triphosphate. Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a nucleotide that regulates functions related to pancreatic endocrine and exocrine behavior, proliferation, channels, transporters, and intracellular signaling under both normal and pathological conditions.Forma y color:Odour SolidAdenine-13C5,15C5
Adenine-13C5,15C5 is the isotopically labeled form of adenine. This purine is one of the four nucleotide bases in DNA and is also a component of RNA. Adenine (T0064) is crucial in cellular respiration, the formation of ATP, coenzymes NAD and FAD, and protein synthesis.Forma y color:Odour SolidML-60218
CAS:ML-60218 inhibits RNA pol III in yeast/humans with IC50s of 32/27 μM; disrupts and prevents viroplasms.Fórmula:C19H15Cl2N3O2S2Pureza:98.1%Forma y color:SolidPeso molecular:452.38Ref: TM-T40661
1mg50,00€5mg108,00€1mL*10mM (DMSO)117,00€10mg168,00€25mg369,00€50mg575,00€100mg817,00€200mg1.099,00€Carbazole
CAS:Carbazole belongs to the class of carbazole-based organic compounds. Carbazole can form novel DNA small groove complexes, inhibiting the synthesis of new DNA or RNA.Fórmula:C12H9NPureza:99.82%Forma y color:SolidPeso molecular:167.2113'-Deoxyuridine-5'-triphosphate trisodium
3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).Fórmula:C9H12N2Na3O14P3Forma y color:SolidPeso molecular:534.08MRK-952
MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.Fórmula:C20H20ClF3N6Forma y color:SolidPeso molecular:436.861CTP Synthetase-IN-1 Ammonium salt
CTP Synthetase-IN-1 Ammonium salt is a CTPS inhibitor with potential antibacterial, anti-inflammatory, and antitumor activity for the study of SARS-CoV-2 viral infectionsFórmula:C20H22F3N7O3S2Pureza:99.97%Forma y color:SolidPeso molecular:529.56DG1
DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressingFórmula:C19H17N5O5SForma y color:SolidPeso molecular:427.43Ac-rC Phosphoramidite
CAS:Ac-rC Phosphoramidite can modify phosphodisulfide oligonucleotides.Fórmula:C47H64N5O9PSiPureza:98.29%Forma y color:White SolidPeso molecular:902.1Pseudorabies virus-IN-1
Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.Fórmula:C27H23ClF2N4O2Forma y color:SolidPeso molecular:508.947
