Síntesis de ADN / ARN
Los inhibidores de la síntesis de ADN y ARN son compuestos que interfieren con los procesos de replicación y transcripción en las células, impidiendo así la producción de material genético esencial. Estos inhibidores pueden dirigirse a diversas enzimas y proteínas involucradas en la síntesis de ácidos nucleicos, lo que los convierte en herramientas valiosas para estudiar los mecanismos de replicación, transcripción y traducción. También se utilizan en el desarrollo de tratamientos para infecciones y cáncer. En CymitQuimica, ofrecemos un amplio espectro de inhibidores de la síntesis de ADN/ARN para apoyar su investigación en biología molecular, virología y desarrollo terapéutico.
Se han encontrado 674 productos para "Síntesis de ADN / ARN".
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Demycarosyl-3D-β-D-digitoxosylmithramycin SK
CAS:Demycarosyl-3D-β-D-digitoxosylmithramycin SK, an analog of Mithramycin, exhibits potent anti-tumor activity.Fórmula:C50H72O23Forma y color:SolidPeso molecular:1041.09Thymidine-D3
CAS:Thymidine-D3 is the deuterated form of Thymidine. It is a specific precursor of deoxyribonucleic acid (DNA) and functions as a cell synchronizing agent. Thymidine (TWP2911) acts as a DNA synthesis inhibitor, blocking cells at the G1/S boundary before DNA replication.Fórmula:C10H14N2O5Forma y color:SolidPeso molecular:245.25Uridine triphosphate-15N2 dilithium
Uridine triphosphate-15N2 dilithium is the 15N-labeled version of uridine triphosphate. Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a nucleotide that regulates functions related to pancreatic endocrine and exocrine behavior, proliferation, channels, transporters, and intracellular signaling under both normal and pathological conditions.Forma y color:Odour SolidAdenine-13C5,15C5
Adenine-13C5,15C5 is the isotopically labeled form of adenine. This purine is one of the four nucleotide bases in DNA and is also a component of RNA. Adenine (T0064) is crucial in cellular respiration, the formation of ATP, coenzymes NAD and FAD, and protein synthesis.Forma y color:Odour SolidRibonuclease T1
CAS:Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.Forma y color:SolidSuricapavir
CAS:Suricapavir is an effective viral replication inhibitor with antiviral activity.Fórmula:C41H29ClF9N9O4SForma y color:SolidPeso molecular:950.23DIZ-3
CAS:DIZ-3: Selective G4 ligand, stabilizes structure, inhibits ALT cancer cell growth by inducing cell cycle arrest and apoptosis.Fórmula:C46H44F2N8Forma y color:SolidPeso molecular:746.89DHODH-IN-16
CAS:DHODH-IN-16 is an effective inhibitor of dihydroorotate dehydrogenase (DHODH, IC50 = 0.396 nM for human).Fórmula:C24H25FN4O3Pureza:99.64%Forma y color:White SolidPeso molecular:436.48Ref: TM-T40168
10mgA consultar25mgA consultar50mgA consultar1mg72,00€5mg160,00€1mL*10mM (DMSO)170,00€SD49-7
CAS:SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.Fórmula:C18H14N2O3Pureza:99.91%Forma y color:Yellow SolidPeso molecular:306.32Ref: TM-T67781
1mg57,00€5mg124,00€1mL*10mM (DMSO)141,00€10mg178,00€25mg359,00€50mg520,00€100mg745,00€500mg1.485,00€7-Deazaxanthine
CAS:7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase) and reduces TPase activity in a concentration-dependent manner, with an IC50 value of 40 μM. Additionally, 7-Deazaxanthine exhibits significant anti-angiogenic properties.Fórmula:C6H5N3O2Forma y color:SolidPeso molecular:151.12Phen-DC3 Trifluoromethanesulfonate
CAS:Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.Fórmula:C36H26F6N6O8S2Pureza:98%Forma y color:SolidPeso molecular:848.75Nitrosofolic acid
CAS:Nitrosofolic acid is a folic acid derivaive.Fórmula:C19H18N8O7Forma y color:SolidPeso molecular:470.4016,16-dimethyl Prostaglandin A1
CAS:16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.Fórmula:C22H36O4Forma y color:SolidPeso molecular:364.526Lorutengitide
CAS:Lorutengitide is a transcription-regulating peptide with antiproliferative activity.Fórmula:C30H50N8O12Forma y color:SolidPeso molecular:714.764KC12
KC12 acts as an inhibitor of the FOXM1 transcription factor. In cancer cells of the MDA-MB-231 line, KC12 exhibits cytotoxicity with an IC50 of 6.13 µM.Fórmula:C23H17F3N2O3SForma y color:SolidPeso molecular:458.453UCK2 Inhibitor-3
CAS:UCK2 Inhibitor-3 blocks UCK2 (IC50: 16.6μM) and DNA polymerases eta/kappa (IC50s: 56μM/16μM), aiding uridine salvage in certain cells.Fórmula:C19H13BrFN5O2SForma y color:SolidPeso molecular:474.31CW-2
CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).Fórmula:C43H42Cl2FN11O10PtForma y color:SolidPeso molecular:1156.21251Emicoron
CAS:Importazole is an inhibitor of the transport receptor importin-β. It specifically inhibits importin-β likely by altering its interaction with RanGTP.Fórmula:C52H58N6O4Pureza:98%Forma y color:SolidPeso molecular:831.05RNA splicing modulator 1
CAS:RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].Fórmula:C19H20N6OSForma y color:SolidPeso molecular:380.47MRK-952
MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.Fórmula:C20H20ClF3N6Forma y color:SolidPeso molecular:436.861Tubercidin 5'-triphosphate tetrasodium
Tubercidin5'-triphosphate (7-Deazaadenosine 5'-triphosphate) tetrasodium is a nucleoside analogue and serves as an active metabolite of Tubercidin.Forma y color:Odour SolidFF-10502
CAS:FF-10502, a pyrimidine analog of Gemcitabine, inhibits DNA polymerases α/β, targeting dormant cancer cells.Fórmula:C9H12FN3O3SForma y color:SolidPeso molecular:261.275-Methylcytidine 5′-triphosphate trisodium
5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium), a modified nucleoside triphosphate, enhances translational properties and stability, whileFórmula:C10H15N3Na3O14P3Forma y color:SolidPeso molecular:563.13Clofarabine-5'-diphosphate trisodium
Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Fórmula:C10H10ClFN5Na3O9P2Forma y color:SolidPeso molecular:529.58ddATP tetrasodium
ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) tetrasodium is an active metabolite of 2',3'-dideoxyinosine and functions as a chain elongation inhibitor for DNA polymerase. It is utilized in DNA sequencing using the Sanger method and in research related to viral infections.Fórmula:C10H12N5Na4O11P3Forma y color:SolidPeso molecular:563.11HDAC-IN-85
HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.Fórmula:C24H27FN4O5Forma y color:SolidPeso molecular:470.49Bromochloroacetonitrile
CAS:Bromochloroacetonitrile, a water disinfection by-product, is mutagenic and can break DNA strands.Fórmula:C2HBrClNForma y color:SolidPeso molecular:154.39DNA31
CAS:DNA31 is a potent RNA polymerase inhibitor.Fórmula:C48H58N4O13Pureza:98%Forma y color:SolidPeso molecular:898.99PIF1-IN-1
PIF1-IN-1 (Compound 48) is an inhibitor of the hPIF1 helicase, with an IC50 value of 320 μM.Forma y color:Odour SolidRNA splicing modulator 3
CAS:RNA Splicing Modulator 3 (Compound 236) is an effective RNA splicing modulator, exhibiting an AC50 value of less than 100 nM [1].Fórmula:C19H20N6OSForma y color:SolidPeso molecular:380.47Adeninobananin
CAS:Adeninobananin, a negative control tool, exhibits no inhibitory activity against the SARS Coronavirus helicase.Fórmula:C19H19ClN6O9Forma y color:SolidPeso molecular:510.8413-TP
13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.Fórmula:C12H19F2N6O12P3Forma y color:SolidPeso molecular:570.23N1-Methylpseudouridine-5′-triphosphate tetralithium
N1-Methylpseudouridine-5′-triphosphate tetralithium, also known as 1-Methylpseudouridine-5′-triphosphate tetralithium, is a nucleobase-modified nucleotide.Fórmula:C10H13Li4N2O15P3Forma y color:SolidPeso molecular:521.9M7G(3'-OMe-5')pppA(2'-OMe)
M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.Fórmula:C23H33N10O17P3Forma y color:SolidPeso molecular:814.496PGD-IN-2
6PGD-IN-2 is a non-competitive inhibitor of 6-phosphogluconate dehydrogenase (6PGD) with an IC50 value of 5.1 μM. It disrupts 6PGD oligomerization in a substrate-dependent manner and induces the production of NADPH and Ru-5-P while reducing DNA synthesis in A549 cells. 6PGD-IN-2 is applicable in research on non-small cell cancer and liver cancer.Forma y color:Odour Solid5-Iminodaunorubicin
CAS:5-Iminodaunorubicin: a quinone-altered anthracycline with antitumor effects, causing DNA breaks in cancer.Fórmula:C27H30N2O9Forma y color:SolidPeso molecular:526.54Pseudorabies virus-IN-1
Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.Fórmula:C27H23ClF2N4O2Forma y color:SolidPeso molecular:508.9472'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium
2'-Deoxy-2'-fluoroadenosine 5'-triphosphate tetralithium, an ATP analog, exhibits robust mixed-type inhibition of poly(AU) synthesis.Fórmula:C10H11FLi4N5O12P3Forma y color:SolidPeso molecular:532.9AF-615
CAS:AF-615 is an innovative inhibitor of the CDT1/Geminin protein complex, capable of inducing DNA damage and cell death in cancer cells.Fórmula:C10H13N5O2SForma y color:SolidPeso molecular:267.31DG1
DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressingFórmula:C19H17N5O5SForma y color:SolidPeso molecular:427.43Antipain
CAS:Antipain, from Actinomycetes, blocks proteases and combats MNNG-induced genetic changes.Fórmula:C27H44N10O6Pureza:98%Forma y color:SolidPeso molecular:604.713F3 peptide
CAS:F3 peptide is a fragment of human high mobility group protein 2 (HMGB2) that specifically binds to nucleolin, expressed on the membranes of cancer cells, neovasculature, and endothelial cells. Serving as an effective ligand, F3 peptide enhances the druggability of macromolecular drugs or nanoparticles.Fórmula:C152H263N49O41Forma y color:SolidPeso molecular:3433.02RNA binder 1
RNA binder 1 (Compound 4b) is an RNA-binding agent capable of crossing the blood-brain barrier. It selectively binds to the G-quadruplex structure of the G4C2 repeat sequence RNA of the C9orf72 gene. This compound significantly reduces levels of the toxic polypeptides poly(GA) and poly(GP) in cells derived from amyotrophic lateral sclerosis (ALS) patients, while it has no significant impact on the antisense polypeptide poly(PR), demonstrating selectivity for sense RNA. RNA binder 1 is useful for studying ALS and frontotemporal dementia (FTD).Fórmula:C22H20N10S2Forma y color:SolidPeso molecular:488.13138(+)-Glaucarubinone
(+)-Glaucarubinone is a natural product that can be used as a reference standard.Fórmula:C25H34O10Forma y color:SolidPeso molecular:494.537N6-Methyladenine
CAS:N6-Methyladenine (6-(Methylamino)Purine) is a modified purine commonly found in genomes of prokaryotes, protists, and plants.Fórmula:C6H7N5Pureza:99.78%Forma y color:SolidPeso molecular:149.15Pyrindamycin A
CAS:Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia.Fórmula:C26H26ClN3O8Pureza:98%Forma y color:SolidPeso molecular:543.95ONX 0801 trisodium
CAS:ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.Fórmula:C32H30N5Na3O10Forma y color:SolidPeso molecular:713.583'-Deoxyuridine-5'-triphosphate trisodium
3'-dUTP trisodium, a nucleotide analogue, inhibits RNA polymerases I/II and UTP integration into RNA (Ki=2.0 μM).Fórmula:C9H12N2Na3O14P3Forma y color:SolidPeso molecular:534.08ddGTP trisodium
ddGTP trisodium, a ddNTP, inhibits or serves as a substrate for DNA polymerase α, halting DNA chain elongation.Fórmula:C10H13N5Na3O12P3Forma y color:SolidPeso molecular:557.13DMT-dG(ib) Phosphoramidite
CAS:DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.Fórmula:C44H54N7O8PPureza:99.21%Forma y color:SolidPeso molecular:839.92
