Síntesis de ADN / ARN
Los inhibidores de la síntesis de ADN y ARN son compuestos que interfieren con los procesos de replicación y transcripción en las células, impidiendo así la producción de material genético esencial. Estos inhibidores pueden dirigirse a diversas enzimas y proteínas involucradas en la síntesis de ácidos nucleicos, lo que los convierte en herramientas valiosas para estudiar los mecanismos de replicación, transcripción y traducción. También se utilizan en el desarrollo de tratamientos para infecciones y cáncer. En CymitQuimica, ofrecemos un amplio espectro de inhibidores de la síntesis de ADN/ARN para apoyar su investigación en biología molecular, virología y desarrollo terapéutico.
Se han encontrado 707 productos de "Síntesis de ADN / ARN"
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2'-OMe-Ac-C Phosphoramidite
CAS:<p>2'-OMe-Ac-C Phosphoramidite, a modified phosphoramidite, is utilized in the synthesis of oligonucleotides.</p>Fórmula:C42H52N5O9PForma y color:SolidPeso molecular:801.86LB80317
CAS:<p>LB-80317, a DNA polymerase inhibitor, is used potentially for the potential treatment of hepatitis B virus infection.</p>Fórmula:C10H14N5O5PForma y color:SolidPeso molecular:315.22Phen-DC3 Trifluoromethanesulfonate
CAS:<p>Phen-DC3 Trifluoromethanesulfonate targets G-quadruplexes and inhibits FANCJ/DinG helicases; IC50s: 65±6/50±10 nM.</p>Fórmula:C36H26F6N6O8S2Pureza:98%Forma y color:SolidPeso molecular:848.75MRK-952
<p>MRK-952 is a NUDIX hydrolase inhibitor. NUDIX enzymes play a role in cellular metabolism, homeostasis, and mRNA processing.</p>Fórmula:C20H20ClF3N6Forma y color:SolidPeso molecular:436.861Pyrindamycin A
CAS:<p>Pyrindamycin A is an antibiotic that inhibits DNA synthesis,and shows antitumor activities against murine leukemia.</p>Fórmula:C26H26ClN3O8Pureza:98%Forma y color:SolidPeso molecular:543.95GS-443902 trisodium
CAS:<p>GS-443902 trisodium, a strong RdRp blocker, inhibits RSV/HCV with IC50 of 1.1/5 μM and is Remdesivir's active form.</p>Fórmula:C12H16N5O13P3·xNaForma y color:SolidGuanosine triphosphate
CAS:<p>Guanosine triphosphate (GTP), a native nucleotide, and its derivatives may serve as specific inhibitors against COVID-19 [1].</p>Fórmula:C10H16N5O14P3Forma y color:SolidPeso molecular:523.18RNA splicing modulator 2
CAS:<p>RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] .</p>Fórmula:C20H21N5OSForma y color:SolidPeso molecular:379.485-BrdUTP sodium salt
CAS:<p>5-BrdUTP sodium salt is a TdT substrate that can be used to label the DNA double-strand breaks.</p>Fórmula:C9H10BrN2Na4O14P3Pureza:98%Forma y color:SolidPeso molecular:634.977-TFA-ap-7-Deaza-ddG
CAS:<p>Compound 19d, a nucleotide derivative, is used to make thiotriphosphate dye terminators for DNA sequencing.</p>Fórmula:C16H16F3N5O4Forma y color:SolidPeso molecular:399.33Clofarabine-5'-triphosphate
CAS:<p>Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.</p>Fórmula:C10H14ClFN5O12P3Forma y color:SolidPeso molecular:543.625'-O-DMT-Bz-rC
CAS:<p>5’-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Fórmula:C37H35N3O8Forma y color:SolidPeso molecular:649.69HDAC-IN-85
<p>HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.</p>Fórmula:C24H27FN4O5Forma y color:SolidPeso molecular:470.495'-O-DMT-PAC-dA
CAS:<p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>Fórmula:C39H37N5O7Forma y color:SolidPeso molecular:687.74CW-2
<p>CW-2 is a PARP1 PROTAC degrader known for its potent antiproliferative effects against MDA-MB-231 cells (IC50 = 0.72 μM) and cisplatin-resistant cells (A549/CDDP: IC50 = 3.52 μM). It exhibits synergistic antitumor activity and enhanced membrane permeability. CW-2 exerts its antitumor effects by inducing DNA damage, disrupting DNA repair, and triggering mitochondrial-dependent apoptosis (apoptosis).</p>Fórmula:C43H42Cl2FN11O10PtForma y color:SolidPeso molecular:1156.21251Thailanstatin C
CAS:<p>Thailanstatin C from Burkholderia thailandensis blocks pre-mRNA splicing, IC50 6.84 μM.</p>Fórmula:C30H46ClNO9Forma y color:SolidPeso molecular:600.15Bz-rC Phosphoramidite
CAS:<p>Bz-rC Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>Fórmula:C52H66N5O9PSiForma y color:SolidPeso molecular:964.185wrwyar-NH2 TFA
<p>wrwyar-NH2 (TFA) serves as the control peptide for wrwycr-NH2.</p>Forma y color:Odour SolidAc-rC Phosphoramidite
CAS:<p>Ac-rC Phosphoramidite can modify phosphodisulfide oligonucleotides.</p>Fórmula:C47H64N5O9PSiPureza:98.29%Forma y color:SolidPeso molecular:902.1Carbazole
CAS:<p>Carbazole belongs to the class of carbazole-based organic compounds. Carbazole can form novel DNA small groove complexes, inhibiting the synthesis of new DNA or RNA.</p>Fórmula:C12H9NPureza:99.82%Forma y color:SolidPeso molecular:167.211KWR137
<p>KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.</p>Fórmula:C33H31ClF3N9O4Forma y color:SolidPeso molecular:710.1055'-O-DMT-rI
CAS:<p>5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1].</p>Fórmula:C31H30N4O7Forma y color:SolidPeso molecular:570.5916,16-dimethyl Prostaglandin A1
CAS:<p>16,16-dimethyl Prostaglandin A1 is a useful organic compound for research related to life sciences.</p>Fórmula:C22H36O4Forma y color:SolidPeso molecular:364.526Diguanosine 5′-triphosphate
CAS:<p>Diguanosine 5′-triphosphate (Gp3G) is a kind of homodinucleotide from by GTP:GTP guanylyltransferase.</p>Fórmula:C20H27N10O18P3Forma y color:SolidPeso molecular:788.409Brr2-IN-2
<p>Brr2-IN-2 (Compound 30) is an inhibitor of Brr2, exhibiting an IC50 of 42 nM against Brr2 ATPase.</p>Fórmula:C21H25FN4O2Forma y color:SolidPeso molecular:384.4513-TP
<p>13-TP is an inhibitor of SARS-CoV-2. It effectively suppresses in vitro RNA synthesis catalyzed by the central replication-transcription complex (C-RTC, nsp12-nsp7-nsp82) of SARS-CoV-2. 13-TP fully inhibits RdRp polymerase activity and obstructs the complete extension of some primer RNAs.</p>Fórmula:C12H19F2N6O12P3Forma y color:SolidPeso molecular:570.23RNA polymerase II-IN-2
<p>RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.</p>Fórmula:C41H58N10O12SForma y color:SolidPeso molecular:915.025-Methylcytidine 5′-triphosphate
CAS:<p>5-Methylcytidine 5′-triphosphate (5-Methyl-CTP), a modified nucleoside triphosphate, enhances translational properties and stability while reducing innate</p>Fórmula:C10H18N3O14P3Forma y color:SolidPeso molecular:497.182'-Deoxyguanosine 5'-monophosphate (sodium salt hydrate)
CAS:<p>dGMP is a substrate for DNA synthesis, phosphorylated to dGDP and dGTP, and linked to mitochondrial DNA depletion syndrome in humans.</p>Fórmula:C10H14N5Na2O8PForma y color:SolidPeso molecular:409.202wrwycr-NH2 TFA
<p>wrwycr-NH2 (TFA) is a peptide that exhibits cytotoxic properties against various cancer cells, inducing DNA damage and cell cycle arrest without causing endoplasmic reticulum stress. It possesses antitumor activity, and its efficacy is enhanced when used in combination with DNA-damaging agents.</p>Forma y color:Odour SolidGuanosine 5'-triphosphate trisodium salt hydrate
CAS:<p>5'-GTP trisodium salt hydrate activates G proteins and is a precursor for DNA/RNA synthesis.</p>Fórmula:C10H18N5NaO15P3Pureza:98%Forma y color:SolidPeso molecular:564.185IBU-DC Phosphoramidite
CAS:<p>IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.</p>Fórmula:C43H54N5O8PForma y color:SolidPeso molecular:799.906Ribonuclease T1
CAS:<p>Rnase T1, an endonuclease, degrades single-stranded RNA to yield 3'-GMP oligonucleotides.</p>Forma y color:SolidUridine triphosphate 13C9,15N2 sodium
CAS:<p>Uridine triphosphate 13C9,15N2 sodium is an isotopically labeled.UTP is a key in RNA synthesis molecule a substrate for RNA polymerase.</p>Fórmula:C9H1415N2NaO15P3Forma y color:SolidPeso molecular:517.04Thio-ITP
CAS:<p>Thio-ITP (6-Thioinosine 5'-triphosphate) inhibits RNA polymerases I & II with Ki of 40.9 & 38.0 μM.</p>Fórmula:C10H15N4O13P3SForma y color:SolidPeso molecular:524.23ONX 0801 trisodium
CAS:<p>ONX 0801 (BGC 945) trisodium is a targeted thymidylate synthase (TS) inhibitor specifically designed to act against tumors overexpressing the α-folate receptor.</p>Fórmula:C32H30N5Na3O10Forma y color:SolidPeso molecular:713.58(S)-DI-87
CAS:<p>(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor，reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.</p>Fórmula:C23H30N6O3S2Pureza:99.42%Forma y color:SoildPeso molecular:502.65Xanthosine-5'-Triphosphate
CAS:<p>Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.</p>Fórmula:C10H15N4O15P3Forma y color:SolidPeso molecular:524.164Pseudorabies virus-IN-1
<p>Pseudorabies virus-IN-1 is a potent inhibitor of pseudorabies virus (PRV) with an EC50 of 0.29 nM, acting by targeting PRV deoxyribonucleic acid polymerase (DNA pol) to suppress PRV replication. It effectively inhibits PRV replication even at low concentrations (MIC80: 1.6-8 nM) and is useful for research on PRV infections.</p>Fórmula:C27H23ClF2N4O2Forma y color:SolidPeso molecular:508.9477-TFA-ap-7-Deaza-ddA
CAS:<p>Compound 19c is a nucleotide derivative for DNA sequencing dye terminators.</p>Fórmula:C16H16F3N5O3Forma y color:SolidPeso molecular:383.331SR15006
CAS:<p>SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).</p>Fórmula:C16H20ClN3O4SPureza:99.87%Forma y color:SoildPeso molecular:385.87N6-Methyladenine
CAS:<p>N6-Methyladenine (6-(Methylamino)Purine) is a modified purine commonly found in genomes of prokaryotes, protists, and plants.</p>Fórmula:C6H7N5Pureza:99.78%Forma y color:SolidPeso molecular:149.15EFdA-TP
CAS:<p>EFdA-TP: potent HIV-1 RT inhibitor; acts via immediate/delayed chain termination (ICT/DCT) and multiple pathways.</p>Fórmula:C12H15FN5O12P3Forma y color:SolidPeso molecular:533.1955'-O-DMT-rU
CAS:<p>5’-O-DMT-rU is a modified nucleoside and can be used to synthesize RNA.</p>Fórmula:C30H30N2O8Forma y color:SolidPeso molecular:546.575'-O-TBDMS-dG
CAS:<p>5’-O-TBDMS-dG is a modified nucleoside. 5’-O-DMT-2’-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.</p>Fórmula:C16H27N5O4SiForma y color:SolidPeso molecular:381.505'-O-DMT-2'-O-TBDMS-Ac-rC
CAS:<p>5’-O-DMT-2’-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.</p>Fórmula:C38H47N3O8SiForma y color:SolidPeso molecular:701.892(+)-Glaucarubinone
<p>(+)-Glaucarubinone is a natural product that can be used as a reference standard.</p>Fórmula:C25H34O10Forma y color:SolidPeso molecular:494.537Cy5-dATP
<p>Cy5-dATP is a Cy5 -labeled dATP . Cy5-dATP can be incorporated into a DNA primer [1] [2] .</p>Fórmula:C47H58N7O19P3S2Forma y color:SolidPeso molecular:1182.055'-O-TBDMS-N2-ibu-dG
CAS:<p>5'-O-TBDMS-N2-ibu-dG: a nucleoside derivative with strong anti-BVDV activity, useful in lead compound synthesis.</p>Fórmula:C20H33N5O5SiForma y color:SolidPeso molecular:451.59Clofarabine-5'-diphosphate trisodium
<p>Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.</p>Fórmula:C10H10ClFN5Na3O9P2Forma y color:SolidPeso molecular:529.58
