Antibiótico

Adustin is an antifungal antibiotic characterized as a polypeptide that inhibits translation. It effectively suppresses translation in a cell-free rabbit reticulocyte lysate system, exhibiting an IC50 of 0.34 μM.

Chlortetracycline: a broad-spectrum antibiotic and anti-inflammatory by inhibiting neutrophils; includes epimer 4-epi-Chlortetracycline.

Distamycin A (NSC-82150), oligopeptide antibiotic, binds A/T rich DNA, affects cleavage sites, enhances apoptosis.

Erythromycin A enol ether is a degradation product of Erythromycin A which is a macrolide antibiotic.

Bleomycin B4 (Phleomycin F), an antibiotic with antitumor properties, is utilized in cancer research [1] [2] [3].

Anhydrotetracycline (hydrochloride) is a potent competitive inhibitor of broad-spectrum tetracycline destructase enzymes.

Bibrocathol is a well-established antiseptic drug used for the treatment of acute eyelid diseases like blepharitis.

Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.

DC 81: Streptomyces-derived antitumor antibiotic, potent nucleic acid synthesis inhibitor, binds DNA sequences, forms covalent adducts.

Polyoxin D (Polyoxorim), a polyoxin antibiotic fungicide, effectively inhibits chitin synthetase.

Protorubradirin is an antibiotic that can be isolated from the non-pigmented Streptomyces achromogenes var. rubradiris alongside Rubradirin. It exhibits inhibitory activity against HIV reverse transcriptase. In vitro studies show that Protorubradirin also inhibits strains of Staphylococcus aureus and Streptococcus. In infected mice, subcutaneous administration of Protorubradirin demonstrates in vivo efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may significantly reduce its activity compared to Rubradirin, possibly due to its C-nitroso sugar decomposing more rapidly in acidic gastric conditions.

Mandipropamid specifically induces complex formation between PYR1 and abscisic acid-insensitive hexameric mutants.

PD 116779 is a new antitumor antibiotic in the class os benz[a]anthraquinone.

Formycin B is a model nucleoside analog.

Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.

Harzianum A: a non-cytotoxic trichothecene from Trichoderma harzianum with modest antifungal properties at 100 μg/mL, inactive against bacteria.

Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity.

Farletuzumab (MORAb-003), a humanized antibody, inhibits FRα-expressing cell growth for cancer research.

Ascochlorin, an isoprenoid antibiotic, inhibits STAT3 to combat tumors, induces apoptosis, and reduces inflammation.