Proteasa del VIH
Los inhibidores de la proteasa del VIH son una clase de fármacos antirretrovirales que atacan específicamente la enzima proteasa del virus de la inmunodeficiencia humana (VIH). Al inhibir esta enzima, estos compuestos evitan que el virus procese sus poliproteínas en proteínas maduras y funcionales, bloqueando así la producción de nuevos viriones infecciosos. Los inhibidores de la proteasa del VIH son una piedra angular de la terapia antirretroviral altamente activa (TARGA) utilizada para manejar el VIH/SIDA. En CymitQuimica, ofrecemos una variedad de inhibidores de la proteasa del VIH para apoyar su investigación en el tratamiento del VIH, la resistencia a los medicamentos y la virología.
Se han encontrado 449 productos de "Proteasa del VIH"
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Lopinavir
CAS:<p>Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation.</p>Fórmula:C37H48N4O5Pureza:98% - 99.62%Forma y color:White Crystalline SolidPeso molecular:628.8RN-18
CAS:<p>RN-18 is an inhibitor of HIV-1 viral infectivity factor (IC50: 6 μM in nonpermissive H9 cells).</p>Fórmula:C20H16N2O4SPureza:97.21% - 98.39%Forma y color:SolidPeso molecular:380.42IMB-301
CAS:<p>IMB-301 is a small molecular inhibitor via virtual screening according to the hA3G model.</p>Fórmula:C19H17Cl2FN2OPureza:99.72%Forma y color:SolidPeso molecular:379.26I-XW-053 sodium
CAS:<p>I-XW-053 sodium inhibits the replication of a diverse panel of primary HIV-1 isolates in Peripheral blood mononuclear cell with no appreciable cytotoxicity.</p>Fórmula:C22H16N2NaO2Forma y color:SolidPeso molecular:363.372Lersivirine
CAS:<p>Lersivirine (UK-453061)(UK 453061) is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) under development for HIV infection therapy.</p>Fórmula:C17H18N4O2Pureza:98.01%Forma y color:SolidPeso molecular:310.35Raltegravir sodium
CAS:<p>Raltegravir (MK 0518) sodium is a potent, orally active HIV integrase (IN) inhibitor.</p>Fórmula:C20H20FN6NaO5Forma y color:SolidPeso molecular:466.405Peldesine dihydrochloride
CAS:<p>Peldesine (BCX 34) dihydrochloride is an inhibitor of PNP in humans, rats, and mice, also hindering T-cell proliferation, used in lymphoma and HIV research.</p>Fórmula:C12H13Cl2N5OForma y color:SolidPeso molecular:314.17PMEDAP
CAS:<p>PMEDAP is a potent inhibitor of Moloney murine sarcoma virus (MSV)-induced tumor formation and associated mortality and an inhibitor of human immunodeficiency</p>Fórmula:C8H13N6O4PPureza:99.77%Forma y color:SolidPeso molecular:288.2Amprenavir
CAS:<p>Amprenavir (KVX-478) is a synthetic derivative of hydroxyethylamine sulfonamide that selectively binds to and inhibits human immunodeficiency virus (HIV)</p>Fórmula:C25H35N3O6SPureza:99.60% - 99.87%Forma y color:Off-White To Pale YellowPeso molecular:505.63Tenofovir alafenamide
CAS:<p>Tenofovir alafenamide (GS-7340) is a nucleotide reverse transcriptase inhibitor (NRTI) and a novel ester prodrug of the antiretroviral tenofovir.</p>Fórmula:C21H29N6O5PPureza:99.68% - 99.81%Forma y color:SolidPeso molecular:476.47BMS-707035
CAS:<p>BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.</p>Fórmula:C17H19FN4O5SPureza:99.78%Forma y color:SolidPeso molecular:410.42Lamivudine 13C,15N2
CAS:<p>Lamivudine 13C,15N2, a BCH-189 impurity, blocks HIV/HBV reverse transcriptase as an NRTI.</p>Fórmula:C8H9N3O4SPureza:98%Forma y color:SolidPeso molecular:246.22Nelfinavir
CAS:<p>Nelfinavir (AG1341), with Ki=2 nM, is an HIV treatment and broad-spectrum anticancer drug.</p>Fórmula:C32H45N3O4SPureza:98.16% - 99.5%Forma y color:White To Off-White Crystalline PowderPeso molecular:567.78Elipovimab
CAS:<p>Elipovimab, a potent and broadly neutralizing antibody against HIV-1, targets and eliminates HIV-infected cells [1].</p>Forma y color:LiquidSemzuvolimab
CAS:<p>Semzuvolimab, a murine IgG1κ antibody, targets the p55 T-cell surface antigen T4/Leu-3 (CD4).</p>Forma y color:LiquidSuvizumab
CAS:<p>Suvizumab (KD-247) is a neutralizing anti-HIV-1 antibody with IC50 values of 0.1-1.0 µg/mL; it lowers viral load and prevents infection.</p>Forma y color:LiquidAntiviral agent 55
CAS:Antiviralagent 55 (Compound 95) is an inhibitor of human immunodeficiency viruses 1 and 2 (HIV1 and HIV2), demonstrating antiviral activity.Fórmula:C21H20N2O4Forma y color:SolidPeso molecular:364.39Nipamovir
CAS:<p>Nipamovir is a nitroimidazole prodrug that exhibits antiviral activity comparable to SAMT-247 and NS-1040 in cellular assays and a human ex vivo model of HIV infection, with low toxicity. Nipamovir has EC50 values of 3.64±3.28 and 3.23±2.81 μM for CEM-SS/HIV-1RF and hPBMC/HIV-192HT599, respectively [1].</p>Fórmula:C14H15N5O4SForma y color:SolidPeso molecular:349.37Benzalphthalide
CAS:<p>Benzalphthalide (NSC-2824) is a chemical compound with anti-HIV activity.</p>Fórmula:C15H10O2Pureza:99.94%Forma y color:Pale Yellow To Yellow Crystalline PowderPeso molecular:222.24Zinlirvimab
CAS:<p>Zinlirvimab is a humanized IgG1-λ2 monoclonal antibody that neutralizes HIV by targeting the HIV-1 gp120 envelope glycoprotein, specifically the IIIB gp120 V3</p>Forma y color:LiquidGCA-186
CAS:<p>GCA-186 is an effective non-nucleoside HIV-1 reverse transcriptase inhibitor.</p>Fórmula:C19H26N2O3Pureza:98%Forma y color:SolidPeso molecular:330.42APOBEC3G-IN-1
CAS:<p>APOBEC3G-IN-1 (MN136.0185) is a targeted APOBEC3G inhibitor with anti-HIV activity for the study of infectious diseases and cancer.</p>Fórmula:C15H11NO3Pureza:96.54%Forma y color:SolidPeso molecular:253.25HIV-IN-6
CAS:<p>HIV-IN-6, an anti-HIV agent, blocks replication by targeting SFKs like Hck involved with Nef protein.</p>Fórmula:C20H16N4O3SPureza:97.12%Forma y color:SolidPeso molecular:392.43HIV-1 inhibitor-49
<p>HIV-1 inhibitor-49, an oral HEPT analog, has strong pharmacokinetics, potent reverse transcriptase inhibition (IC50=30nM), and is safe in mice.</p>Fórmula:C21H18F2N2O3SForma y color:SolidPeso molecular:416.44MK-2048
CAS:<p>MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.</p>Fórmula:C21H21ClFN5O4Pureza:98%Forma y color:SolidPeso molecular:461.87HIV-1 inhibitor-22
CAS:<p>HIV-1 inhibitor-22 effectively blocks HIV-1 RT (IC50=3.63 μM) with low cytotoxicity (CC50 > 227 μM).</p>Fórmula:C30H26N6O3SForma y color:SolidPeso molecular:550.63HIV-1 integrase inhibitor 4
CAS:<p>HIV-1 integrase inhibitor 4 is an HIV-1 integrase strand transfer (INST) inhibitor (IC50: 3.7 nM).</p>Fórmula:C24H20F2N4O5SPureza:98%Forma y color:SolidPeso molecular:514.5HIV-1 inhibitor-29
CAS:<p>HIV-1 inhibitor-29: Blocks HIV-1 IIIB (EC50: 2.18μM), resists F227L/V106A (EC50: 0.974μM), low toxicity (CC50: 211μM), for AIDS research.</p>Fórmula:C30H36N6O5Forma y color:SolidPeso molecular:560.64D77
CAS:<p>D77 is anti-HIV-1 inhibitor. D77 inhibits HIV-1(IIIB) replication by EC50 value of 23.8 μg/ml in MT-4 cell (5.03 μg/ml for C8166 cells).</p>Fórmula:C28H22BrNO7SPureza:98%Forma y color:SolidPeso molecular:596.45HIV-1 inhibitor-34
CAS:<p>HIV-1 inhibitor-34 (5q): potent, selective; EC50: 6.4 nM; MT-4 CC50: 16 μM; useful in AIDS research.</p>Fórmula:C26H27N7OForma y color:SolidPeso molecular:453.54HIV-IN-4
CAS:<p>HIV-IN-4 (Compound 12) is a potent HIV inhibitor that exhibits promising anti-HIV activities [1].</p>Fórmula:C14H18N2O3Forma y color:SolidPeso molecular:262.3HIV-1 inhibitor-16
CAS:<p>HIV-1 inhibitor-16: potent with EC50 1.3 nM for wild-type; inhibits K103N, E138K, Y181C, L100I strains; good solubility; stable; low CYP impact; non-toxic.</p>Fórmula:C23H16F2N6Forma y color:SolidPeso molecular:414.41HIV-1 inhibitor-57
CAS:<p>HIV-1 Inhibitor-57 (Compound 12g) is an antiviral agent that potently inhibits both wild-type and five common NNRTI-resistant strains of HIV-1, exhibiting EC50</p>Fórmula:C25H24FN5O3SForma y color:SolidPeso molecular:493.55SARS-CoV-IN-3
CAS:SARS-CoV-IN-3 is an effective SARS-CoV replication inhibitor.Fórmula:C25H28ClFeN3OPureza:98%Forma y color:SolidPeso molecular:477.81Mesoxalic acid
CAS:<p>Mesoxalic acid is a dicarboxylic acid and a ketonic acid which blocks RT translocation.</p>Fórmula:C3H2O5Pureza:98%Forma y color:SolidPeso molecular:118.04SAMT-247
CAS:<p>SAMT-247 is an HIV inhibitor that acts by modifying the nucleocapsid NCp7 region of Gag in infected cells and blocking Gag processing and reducing infectivity.</p>Fórmula:C12H14N2O3SForma y color:SolidPeso molecular:266.32TMC310911
CAS:<p>TMC310911 is an oral HIV-1 protease inhibitor with an EC50 of 2.2-14.2 nM, effective against various HIV-1 strains.</p>Fórmula:C38H53N5O7S2Pureza:98%Forma y color:SolidPeso molecular:755.99Reverse transcriptase-IN-3
<p>Reverse transcriptase-IN-3, a pyrimidine carboxamide, inhibits HIV-1 including mutant strains.</p>Fórmula:C28H31N7O4SForma y color:SolidPeso molecular:561.66DQBS
CAS:<p>DQBS is an HIV-1 Nef function antagonist.</p>Fórmula:C22H17ClN4O4SPureza:98%Forma y color:SolidPeso molecular:468.91HIV-1 integrase inhibitor 7
CAS:<p>HIV-1 integrase inhibitor 7 is a potent HIV-1 integrase inhibitor (IC50: 33.3 nM).</p>Fórmula:C30H26O16Pureza:98%Forma y color:SolidPeso molecular:642.52β-L-D4A
CAS:<p>beta-L-D4A inhibits HIV-1 reverse transcriptase, stopping DNA synthesis.</p>Fórmula:C10H11N5O2Pureza:99.45%Forma y color:SolidPeso molecular:233.23MK-4965
CAS:<p>MK-4965 is a new type of non-nucleoside reverse transcriptase inhibitor with antiviral activity.</p>Fórmula:C20H13Cl2N5O2Forma y color:SolidPeso molecular:426.26gp120-IN-1
CAS:<p>gp120-IN-1 (4e) is a potent HIV-1 inhibitor, IC50 2.2 μM, CC50 100.90 μM, and blocks HIV entry.</p>Fórmula:C15H18N2O4SForma y color:SolidPeso molecular:322.38HIV-1 inhibitor-25
CAS:<p>Compound R-12a is a potent HIV-1 reverse transcriptase inhibitor (IC50: 0.1061 nM), with low cytotoxicity and effective against multiple mutants.</p>Fórmula:C26H19N5O2Forma y color:SolidPeso molecular:433.46LEDGIN6
CAS:<p>HIV-1 integrase inhibitor 2 is used for the treatment of human immunodeficiency virus (HIV) infection.</p>Fórmula:C21H20ClNO2Forma y color:SolidPeso molecular:353.84NIT
CAS:<p>NIT is an HIV-1 protease inhibitor.</p>Fórmula:C15H7N3O4S2Pureza:98%Forma y color:SolidPeso molecular:357.36HIV-1 inhibitor-36
CAS:<p>HIV-1 inhibitor-36 (Compound 2) is a potent HIV-1 inhibitor with significant potential as a novel latency reversing agent [1].</p>Fórmula:C14H14Cl2N2O2SForma y color:SolidPeso molecular:345.24HIV-1 inhibitor-24
CAS:<p>HIV-1 inhibitor-24 (S-12a) blocks HIV reverse transcription effectively (IC50: 9.5 nM), low toxicity, well-tolerated in mice, good heart safety.</p>Fórmula:C26H19N5O2Forma y color:SolidPeso molecular:433.46DPC-681
CAS:<p>DPC-681 is a potent and selective HIV protease inhibitor (IC90s: 4 to 40 nM for wild-type HIV-1).</p>Fórmula:C35H48FN5O5SForma y color:SolidPeso molecular:669.85HIV-1 inhibitor-19
CAS:<p>HIV-1 inhibitor-19 is a potent NNRTI targeting L100I, K103N, V106A/F227L mutants; EC50s: 7.3, 9.2, 21.0 nM respectively.</p>Fórmula:C24H22BClN2O5SForma y color:SolidPeso molecular:496.77
