Antibacteriano

Antibacterial agent 150 (compound 5g) exhibits potent activity against a wide range of bacteria, including both Gram-positive and Gram-negative species, with

Dodicin hydrochloride, an effective disinfectant, demonstrates broad antimicrobial activity [1].

Compound 1b, also known as Antibacterial agent 145, targets the bacterial iron uptake pathway to exert its effects.

Antibacterial 128, a siderophore-Ciprofloxacin blend with cleavable linker, targets P. aeruginosa and B. pseudomallei.

Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.

Antibiotic tan-592B is an antibiotic agent.

Antibacterial agent 49 (example 12) is a antibacterial agent.

Cis-2-dodecenoic acid, identified in Burkholderia cenocepacia, disrupts bacterial quorum sensing, thereby inhibiting biofilm formation and the production of

Cuprichydroxide exhibits inhibitory activity against Ralstonia solanacearum and A549 cells and has acute pulmonary toxicity.

Arylomycin A5 is a lipohexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.

Pleurocidin, an antibacterial peptide, originates from the skin secretions of the Winter Flounder (Pseudopleuronectes americanus) [1].

3-O-Methylellagic acid from Myrciaria cauliflora is anti-inflammatory, inhibits glucose transport, and kills Staph. Aureus at 32 μg/mL.

Aurein 5.2 is an antibiotic antimicrobial peptide [1].

LeuRS-IN-1 is a leucyl-tRNA synthetase inhibitor with anti-leukemic and anti-malarial activity that inhibits M.tb LeuRS.

Lysobactin (katanosin B) is an antibiotic effective against S. aureus, S. pneumoniae, and blocks PG biosynthesis.

Quinaldopeptin: a quinomycin antibiotic, combats various bacteria, cytotoxic to cells, aids in P388 leukemia mouse survival, intercalates DNA.

Flagelin 22, a bacterial flagellin fragment, serves as a potent elicitor for plants and algae.

T-91825 (PPI-0903M), an active N-phosphono cephalosporin, is potent against various bacteria and stems from TAK-599.

Cethromycin (ABT-773) is an antibiotic of ketolide.

Metallo-β-lactamase-IN-11 (compound 5f), a potent inhibitor of Metallo-β-lactamases (MBLs), demonstrates efficacy against the bacterial metallophyllactamase

Bicyclomycin is a broad spectrum antibiotic active against Gram-negative bacteria and the Gram-positive bacterium, Micrococcus luteusn.

Cyclacillin (Wy-4508), an oral aminopenicillin, fights many gram-positive/negative bacteria.

Spectinamide-1599 is a combination partner for anti-tuberculosis therapy.

Allolactose is a disaccharide used as an inducer of the lac operon in Escherichia coli and many other enteric bacteria.

Clostomycin B2 is a bioactive chemical.

Dienone B is a cytotoxic secondary metabolite from tyrosine as isolated from the sponges Verongia aerophoba & Aplysina aerophoba.

Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.

LEAP-2 (Human liver expressed antimicrobial peptide-2) is an antimicrobial peptide, a growth hormone-releasing peptide antagonist, and a GHS-R1a inverse agonist

<p>Melimine, a hybrid antimicrobial peptide derived from Melittin and Protamine, exhibits broad-spectrum activity against various microorganisms, including</p>

<p>Monogalactosyl diglyceride is a key lipid in photosynthesis and myelin, also boosting PKCα in oligodendrocytes.</p>

Renierone is an antimicrobial metabolite isolated from the marine sponge, Reniera sp.

<p>Tryptophanase, a bacterial enzyme, catalyzes the degradation of tryptophan into indole, pyruvate, and ammonia [1].</p>

MBL-IN-1 (compound 41), a β-Lactamase inhibitor, exhibits an IC50 range of 0.10 to 25.85 µM and is utilized in the study of bacterial infections [1].

FR-295389 is a cephalosporin. FR-295389 shows effective antibacterial activity against metallo-beta-lactamase (MBL)-producers in vitro.

Clorobiocin is an aminocoumarin antibacterial that suppresses the enzyme DNA gyrase.

Maximin 5, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal

<p>Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.Cost-effective and quality-assured.</p>

Thiotropocin is an antibiotic.

Maximin 1, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal

Racemomycin B is a beta-lysine-rich streptothricin antibiotic.

Aurein 2.5, an antimicrobial peptide with antibiotic properties, exhibits both antibacterial and antifungal activities [1] [2].

Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and

Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.

JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.

Amythiamicin A is an antibiotic effective against gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), and exhibits activity against Plasmodium falciparum.

Brilacidin tetrahydrochloride is a synthetic antibiotic effective against multiple bacteria with MIC90 values ranging from 1 to 8 μg/mL.

Methyl quinoline-2-carboxylate (Methyl 2-quinolinecarboxylate) inhibits the binding of Mycobacterium tuberculosis.

Colistin: polypeptide antibiotic for Gram-negative bacteria, including drug-resistant strains, but may cause nephrotoxicity.

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B.

Lipid X is a monosaccharide precursor of E coli lipid A.

<p>Dermaseptin is a peptide expressed by the frog skin glands with a potent antimicrobial activity against bacteria, fungi and protozoa.</p>

Ro-23-9424, a cephalosporin with fleroxacin at 3' and aminothiazolylmethoxyimino at 7, exhibits strong broad-spectrum antibacterial effects.

Flucloxacillin, an antibiotic, effectively combats both gram-positive and gram-negative bacteria [1] [2].

EATC, a tetracycline byproduct, combats Pseudomonas to E. coli with MIC50s of 0.75-16 mg/L.

SCH 38519, a fungal metabolite, inhibits thrombin, serotonin in platelets, and bacteria growth.

c-di-AMP sodium: STING agonist, activates TBK3-IRF3 pathway, boosts type I IFN/TNF, regulates bacterial growth/virulence, and stimulates immune responses.

<p>Polyunsaturated anacardic acid diene from cashew shells fights MRSA, S. mutans, and S. mansoni; inhibits soybean lipoxygenase-1.</p>

Calcimycin (A-23187) is an antibiotic calcium ionophore that raises intracellular Ca2+ to induce cell death.

Sedecamycin is a 17-membered macrolide antibiotic. It is used for treating swine dysentery.

Maximin 4, an antimicrobial peptide from Bombina maxima skin secretions, exhibits cytotoxic effects on tumor cells and spermicidal properties [1].

Psicofuranine: a nucleoside antibiotic inhibiting GMP synthase and P. falciparum growth with an IC50 of 0.3 mM.

Albocycline, a macrolide antibiotic from S. bruneogriseus MCRL-0129, targets staph including resistant strains.

Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.

Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative bacteria.

Sparsomycin is an antitumor antibiotic. It also inhibits protein synthesis in the 70S and 80S ribosomal systems.

Kitasamycin tartrate, a macrolide antibiotic produced by Streptomyces kitasatoensis, has a wide spectrum of antimicrobial activity.

Doxycycline hydrochloride (Hyclate) is a synthetic tetracycline derivative with similar antimicrobial activity.

Sperabillin A (free base) is a potent antibacterial antibiotic in vivo isolated from Pseudomonas fluorescens YK-437.

Compound 12: potent antimicrobial with 2-8 μg/mL MIC, effective against Gram-positive/negative bacteria; anti-inflammatory.

<p>Showdomycin is an antibiotic with antineoplastic activity.</p>

15-acetoxyscirpenol: ASM that induces apoptosis, inhibits Jurkat T cell growth dose-dependently, and activates caspases other than caspase-3.

<p>Bagougeramine B is an orally active nucleoside antibiotic with antibacterial properties, discovered in Bacillus circulans. It inhibits the growth of both Gram-positive and Gram-negative bacteria, as well as some fungi.</p>

Aurachin D, a cytotoxic quinolone targeting Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase, acts as an antibiotic against malaria, Plasmodium spp.

Paldimycin A is a semi-synthetic antibiotic from Streptomyces paulus.

Citrullinated LL-37 3cit is a host defense peptide with potent immunomodulatory and antimicrobial properties, demonstrating direct antiviral activity against

Antiangiogenic agent 8 (Compound 3m) functions as both an antibacterial agent and an antiangiogenic compound. It shows minimum inhibitory concentrations (MIC) of 16, 8, 4, 16, and 8 μg/mL against E. coli, P. aeruginosa, B. subtilis, S. aureus, and C. glabrata, respectively, with minimum bactericidal concentrations (MBC) ranging from 32 to 64 μg/mL. This compound holds potential for applications in infection control and cardiovascular disease research.

Kasugamycin is an antibiotic that acts by binding within the mRNA channel of the 30S subunit and inhibiting protein synthesis.

Rose Bengal is a photosensitizer effective against microbial cells. In the presence of light and oxygen, it inhibits the growth of yeast cells and other microorganisms, sometimes leading to their death. Rose Bengal can also limit bacterial growth, restrict the colony size of filamentous fungi, and suppress the growth of "spreading fungi" such as Rhizopus and Trichoderma.

Asperglaucid A: a phthalide-like compound with strong antibacterial effects against Pseudomonas syringae pv actinidae and Bacillus cereus; MIC: 6.25 μM.

Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus

Pectin, a plant cell wall derived heteropolysaccharide, forms nanoparticles for delivery and acts as an antimicrobial adsorbent.

Kapurimycin A3 is an antitumor antibiotics.

(±)-Heraclenol, a coumarin derivative isolated from the fruits of Angelica lucida, exhibits antibacterial properties [1].

Mram 8, a cyclotide isolated from Viola philippica of the Violaceae family [1], exhibits a characteristic cyclic peptide structure.

SF2312 ammonium is the ammonium salt of SF2312, a phosphonate antibiotic and enolase inhibitor derived from the actinomycete Micromonospora and active under

<p>Rabelomycin is an angucycline group antibiotic.</p>

Pirlimycin Hydrochloride, a Clindamycin analog, is a semi-synthetic lincosaminide antibiotic.

TP0586352 is a potent inhibitor of LpxC, exhibiting efficacy against carbapenem-resistant strains of Klebsiella pneumoniae without inducing cardiovascular risks

17-Hydroxyneomatrine, a compound derived from Sophora flavescens, exhibits multifaceted biological activities, including the inhibition of human cervical

α-Lipomycin is an acyclic polyene antibiotic isolated from the Gram-positive bacterium Streptomyces aureofaciens Tü117.

Chloramine-T (Chloralone) is a N-chlorinated, and N-deprotonated sulfonamide, used as a biocide and a mild disinfectant.

Compound 14, also known as Tuberculosis Inhibitor 11, enhances the antimycobacterial efficacy of antitubercular agent [1].

Compound 6 (Antibacterial agent 161, trifluoromethanesulfonate) exhibits antibacterial properties and demonstrates significant antiproliferative effects against

Amoxicillin + potassium clavulanate (4:1) is a broad-spectrum, well-absorbed oral antibiotic blocking cell wall synthesis.

Isepamicin (Sch 21420) is a strong aminoglycoside antibiotic, effective on Enterobacteriaceae and staphylococci, less so on other bacteria.

1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm^2, underscoring its potential in biotechnological applications.

Cefpirome: fourth-gen cephalosporin, broad-spectrum, inactivates penicillin-binding proteins in bacteria.

<p>Angolamycin is a macrolide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

Flomoxef is an antibiotic in oxacephem group and has excellent activity against various gram-positive bacteria.

<p>Ro 09-1428, a parenteral cephalosporin, has high antipseudomonal activity.</p>