Antibacteriano
Los inhibidores antibacterianos son compuestos que atacan las células bacterianas, inhibiendo su crecimiento o matándolas directamente. Estos inhibidores son esenciales en el desarrollo de tratamientos para infecciones bacterianas y se utilizan ampliamente en la investigación para estudiar la fisiología bacteriana, los mecanismos de resistencia y la eficacia de nuevos agentes antibacterianos. En CymitQuimica, ofrecemos una gama de inhibidores antibacterianos para apoyar su investigación en microbiología, enfermedades infecciosas y desarrollo de medicamentos.
Se han encontrado 3334 productos de "Antibacteriano"
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MsbA-IN-1
MsbA-IN-1: Potent MsbA inhibitor (IC50: 4 nM), anti-E. coli (MIC: 79 μM), penetrates Gram-negative bacteria.Fórmula:C23H18Cl2FNO3Forma y color:SolidPeso molecular:446.3HKI12134085
CAS:HKI12134085 (compound 3), an orally administered nitrobenzothiazinone (BTZ) derivative, demonstrates antibacterial efficacy against Mycobacterium tuberculosis. This compound exhibits significant in vivo inhibitory potency within a BALB/c mouse model of Mycobacterium tuberculosis infection [1].
Fórmula:C18H18F3N3O5SForma y color:SolidPeso molecular:445.41Antifungal agent 38
Antifungal agent 38, a heterocyclic disulfide, shrinks hyphae and damages cell membranes, causing leakage.Fórmula:C8H12N2S2Forma y color:SolidPeso molecular:200.32VEGFR-2/DHFR-IN-1
Compound 8b inhibits VEGFR-2/DHFR, combats various bacteria, and fights cancer cells.Fórmula:C20H18ClNO4Forma y color:SolidPeso molecular:371.81Antitubercular agent-11
Antitubercular agent-11 (Compound 1e) is an antitubercular agent with a bulkier electron-donating group (Bu-t) that shows the best MIC value of 0.060 μg/mL [1].Fórmula:C16H15N3O4Forma y color:SolidPeso molecular:313.31ZG297
CAS:ZG297 is an agonist of Staphylococcus aureus ClpP (SaClpP) with an EC50 of 0.26 μM. It degrades SaFtsZ and inhibits bacterial cell division, exhibiting antistaphylococcal activity by inhibiting S. aureus 8325-4 and MRSA strains, with a MIC range of 0.063-256 μg/mL. In mouse models, ZG297 demonstrates anti-infective properties.
Fórmula:C31H35F3N4O3Forma y color:SolidPeso molecular:568.63MtTMPK-IN-2
CAS:MtTMPK-IN-2 inhibits M. tuberculosis TMPK (IC50: 1.1 μM), Mtb H37Rv (MIC: 12.5 μM), and is cytotoxic in MRC-5 cells (EC50: 6.1 μM).Fórmula:C23H24ClN3O3Forma y color:SolidPeso molecular:425.91NFC nitro probe 1
CAS:NFC nitro probe 1 (compound 18) is a chemical probe designed for the detection of Mtb, exhibiting high potency against both R-Mtb and NR-Mtb.Fórmula:C19H19NO6Forma y color:SolidPeso molecular:357.357Probenecid sodium
CAS:Probenecid sodium is the sodium salt of Probenecid, a potent and selective agonist of transient receptor potential vanilloid 2 (TRPV2) channels. Additionally, Probenecid acts as an inhibitor of pannexin 1 channels.Fórmula:C13H18NNaO4SForma y color:SolidPeso molecular:307.341Anticaries agent-1
CAS:Anticaries agent-1 (Compound 21b) is utilized as an anticaries agent. It effectively inhibits biofilm formation with an IC50 of 77 μM and restricts the growth of S. mutans.Fórmula:C15H12O4Forma y color:SolidPeso molecular:256.253N-Cbz-L-Cysteine
CAS:N-Cbz-L-Cysteine (Cbz-cysteine) (compound 5) functions as a potent inhibitor of β-lactamase II, exhibiting a K i value of 97 µM [1].Fórmula:C11H13NO4SForma y color:SolidPeso molecular:255.29DC-159a
CAS:DC-159a, an 8-methoxy fluoroquinolone, possesses broad-spectrum antibacterial activity, with a particular efficacy against Gram-positive pathogens. The MIC90 values for DC-159a are 0.5 μg/mL against Streptococcus anginosus group, 4 μg/mL against Clostridium difficile, and 2 μg/mL against Bacteroides fragilis.Fórmula:C21H23F2N3O40·5H2OForma y color:SolidPeso molecular:428.42952-Bromo-2'-methoxyacetophenone
CAS:2-Bromo-2'-methoxyacetophenone acts as an irreversible inhibitor of MurA, effectively inhibiting MurA in E. coli with an IC50 of 0.38 μM. This compound helps inhibit bacterial cell wall synthesis, making it useful in antimicrobial research.Fórmula:C9H9BrO2Peso molecular:229.07D-CS319
CAS:D-CS319 is a potent inhibitor of metal-𝛽-lactamases (MBLs), exhibiting IC50 values of 2.0 μM for IMP-1 and 3.0 μM for IMP-78. RPX 7546 possesses antibacterial activity.Fórmula:C7H11NO2S3Forma y color:SolidPeso molecular:237.36Antitubercular agent-22
Antitubercular agent-22 combats Candida albicans (MIC: 2.34 μg/ml) and M. tuberculosis (MIC: 2 μg/ml).Fórmula:C24H28FN5O8Forma y color:SolidPeso molecular:533.51FtsZ-IN-4
FtsZ-IN-4 is an oral FtsZ inhibitor with strong antibacterial effects and good drug traits, low toxicity (CC50 >20μg/mL).Fórmula:C21H16ClF2NO2Forma y color:SolidPeso molecular:387.81BM635 mesylate
BM635 mesylate inhibits MmpL3; kills Divergent bacterium with 0.6 µM MIC50; boosts bioavailability.Fórmula:C26H33FN2O4SForma y color:SolidPeso molecular:488.61MBL-IN-5
CAS:MBL-IN-5 is an inhibitor of metallo-β-lactamase (MBL). It effectively suppresses three clinically significant B1 subfamily MBLs: NDM-1, VIM-1, and IMP-1 with IC50 values of 0.05 nM, 14 nM, and 21 nM respectively. MBL-IN-5 notably enhances the efficacy of carbapenem antibiotics against MBL-producing clinical strains and, when combined with IPM antibiotics, significantly reduces bacterial load in a thigh infection model.Fórmula:C20H16ClNO3Forma y color:SolidPeso molecular:353.80H052
CAS:H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla). It binds to the Hla monomer, disrupting its interaction with the host cell membrane, thereby blocking pore formation and inhibiting calcium influx, cytotoxicity, and inflammatory response. H052 exhibits inhibitory activity against Hla-induced calcium influx (EC50 = 30 nM in U937 cells) and holds potential for research into lung infections caused by S. aureus.
Fórmula:C21H15ClFN3O4SForma y color:SolidPeso molecular:459.88Urease-IN-1
Urease -IN-1 is a urease inhibitor (IC50: 2.21±0.45 μM).Fórmula:C17H12BrFN4O2SForma y color:SolidPeso molecular:435.27
