Antibacteriano

<p>Midecamycin acetate is a broad-spectrum antibiotic active against Gram-positive and some Gram-negative strains.</p>

<p>Cefozopran is a fourth-generation cephalosporin.</p>

<p>Maximin 3, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal</p>

<p>Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.</p>

<p>Amythiamicin C is an antimicrobial antibiotic effective against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and also exhibits activity against Plasmodium falciparum (the causative agent of malaria).</p>

<p>ANT3310 inhibits several Serine β-Lactamases (IC50: 1-175 nM); useful for bacterial infection research.</p>

<p>Tylosin lactate: a vet macrolide antibiotic; broad vs. Gram-positive, limited on Gram-negative; from Streptomyces fradiae.</p>

<p>Linearmycin B, a polyene antibiotic from Streptomyces, causes B. subtilis lysis in Streptomyces Mg1 extract.</p>

<p>Cefovecin Sodium(Convenia) is an antibiotic of the cephalosporin class, licensed for the treatment of skin infections in cats and dogs.</p>

<p>Rugulosin (RUG) is a bis-anthraquinoid pigment produced by fungi.</p>

<p>(R)-Eucomol, a flavonoid derivative, exhibits slight antibacterial properties and demonstrates cytotoxic activity against KB and P-388 cells [1].</p>

<p>Sulfamerazine sodium salt is a sulfonamide antibacterial.</p>

<p>'10'-Desmethoxystreptonigrin antibiotic derived from streptonigrin combats various bacteria and cancer cells, and inhibits p21ras farnesylation (IC50 = 21 nM).</p>

<p>Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.</p>

<p>Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics.</p>

<p>17-hydroxy Venturicidin A: Streptomyces-derived macrolide with antibiotic and antifungal properties.</p>

<p>Obtusalin, a triterpenoid initially identified in R. dauricum, exhibits UV absorption at 210 nm and possesses antibacterial properties.</p>

<p>Contezolid acefosamil sodium (MRX-4) is an oral antibiotic for drug-resistant Gram-positive cSSTIs, with low myelosuppression and MAOI risks.</p>

<p>Pazufloxacin (T-3761) is a broad-spectrum fluoroquinolone antibiotic effective against various infections, including strains resistant to other quinolones.</p>

<p>Arylomycin B6 is a lipoglycopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>6-C-Methylquercetin-3,4'-dimethyl ether is a flavonol derivative extracted from Bauhinia thonningii Schum leaves, displaying antibacterial effects on Gram-</p>

<p>Maximin H3, an antimicrobial peptide from Chinese red belly toad Bombina maxima skin secretions, exhibits antimicrobial properties against Escherichia coli</p>

<p>cis-11-Methyl-2-dodecenoic acid: a QS signal, aids microbial communication, regulates virulence, biofilm in pathogens.</p>

<p>15-acetoxyscirpenol: ASM that induces apoptosis, inhibits Jurkat T cell growth dose-dependently, and activates caspases other than caspase-3.</p>

<p>Tuberculosis inhibitor 9 (compound 3d), a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative, exhibits potent activity against Mycobacterium tuberculosis and</p>

<p>Cis-β-Terpineol, a monoterpene derived from the aerial parts of Anthemis turcomanica, exhibits antibacterial activity as evidenced by studies on the stems,</p>

<p>D13-9001, an antibiotic, inhibits AcrB and MexB with KDs of 1.15μM in E. coli and 3.57μM in P. aeruginosa.</p>

<p>Ro 09-1428, a parenteral cephalosporin, has high antipseudomonal activity.</p>

<p>Dicloxacillin, a β-Lactam antibiotic, targets beta-lactamase bacteria like Staphylococcus aureus, defeating penicillin resistance.</p>

<p>Sirpefenicol (ZTS-00007928), a phenicol antibacterial for treating animal bacterial infections.</p>

<p>Mycophenolate Mofetil: Non-competitive, selective inhibitor of IMP dehydrogenase I/II, IC50: 39/27 nM.</p>

<p>Flucloxacillin, an antibiotic, effectively combats both gram-positive and gram-negative bacteria [1] [2].</p>

<p>XT17 is an anthrone compound with broad-spectrum antibacterial activity, exerting its effects by disrupting the cell wall and inhibiting DNA synthesis. It demonstrates weak hemolytic activity, low cytotoxicity to mammalian cell lines, and a low rate of resistance development. Additionally, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies confirm that XT17 forms a stable complex with bacterial gyrase. XT17 is suitable for research in the field of anti-infective agents.</p>

<p>Thiomandelic acid is a simple, broad-spectrum and quite potent metallo-β-lactamase inhibitor, an antimicrobial compound.</p>

<p>Melimine, a hybrid antimicrobial peptide derived from Melittin and Protamine, exhibits broad-spectrum activity against various microorganisms, including</p>

<p>Arylomycin A1 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>ChlaDUB1-IN-2 (Compound 27a) serves as an inhibitor of the deubiquitinating enzyme ChlaDUB1 from Chlamydia trachomatis, with an IC50 of 0.97 μM. It also inhibits the formation of Chlamydia trachomatis inclusions, exhibiting an IIC50 of 25.6 μg/mL.</p>

<p>SCH 38519, a fungal metabolite, inhibits thrombin, serotonin in platelets, and bacteria growth.</p>

<p>Compd 3j (Antibacterial agent 149) is a laccase inhibitor that exhibits potent fungicidal activity, particularly useful in researching rice sheath blight [1].</p>

<p>Bryostatin 1, a marine macrolide, permeates CNS and modulates PKC, with strong affinity for Munc13-1 (Ki: 8.07 nM and 0.45 nM).</p>

<p>Psoracorylifol B is a natural product that can be used as a reference standard.</p>

<p>Quinaldopeptin: a quinomycin antibiotic, combats various bacteria, cytotoxic to cells, aids in P388 leukemia mouse survival, intercalates DNA.</p>

<p>Aurein 3.1 is an antibiotic antimicrobial peptide, whereas Aurein 2.6 demonstrates activity against Gram-positive bacteria, exhibiting minimum inhibitory</p>

<p>FtsZ-IN-6: strong FtsZ polymerization promoter, GTPase inhibitor, kills bacteria, low resistance and toxicity.</p>

<p>Spectinamide-1599 is a combination partner for anti-tuberculosis therapy.</p>

<p>Ledaborbactam etzadroxil (VNRX-7145) is an orally active inhibitor of Ambler class A, C, and D β-lactamase enzymes.</p>

<p>GSK299423: Antibiotic possibly effective against bacteria with New Delhi metal-β-lactamase, targeting topoisomerases.</p>

<p>RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] .</p>

<p>Chartreusin is an antibiotic. It also has anticancer activity.</p>

<p>Compound 7a: potent, selective MRSA growth inhibitor; MIC ≤ 0.26 µM; non-cytotoxic, non-hemolytic.</p>