Señalización PI3K / Akt / mTOR
Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.
Subcategorías de "Señalización PI3K / Akt / mTOR"
- AMPK(168 productos)
- ATM / ATR(72 productos)
- ADN-PK(49 productos)
- EGFR(595 productos)
- MELK(7 productos)
- PDK(9 productos)
- PI3K(236 productos)
- Quinasa S6(8 productos)
- gsk-3(110 productos)
- mTOR(162 productos)
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Se han encontrado 1026 productos de "Señalización PI3K / Akt / mTOR"
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Serabelisib
CAS:Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).Fórmula:C19H17N5O3Pureza:98.41% - 99.5%Forma y color:SolidPeso molecular:363.37CL-387785
CAS:CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.Fórmula:C18H13BrN4OPureza:99.56% - 99.62%Forma y color:SolidPeso molecular:381.23PS210
CAS:<p>PS210 selectively activates PDK1 (Kd: 3 μM), doesn't affect PDK1 downstream kinases. Prodrug PS423 inhibits PDK1-mediated S6K phosphorylation.</p>Fórmula:C19H15F3O5Pureza:99.78%Forma y color:SolidPeso molecular:380.31BpV(HOpic)
CAS:BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM).Fórmula:C6H4K2NO8VPureza:99.60%Forma y color:SolidPeso molecular:347.24WS3
CAS:WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.Fórmula:C28H30F3N7O3Pureza:97.93% - 99.94%Forma y color:SolidPeso molecular:569.58AS-605240
CAS:<p>AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).</p>Fórmula:C12H7N3O2SPureza:97% - 99.91%Forma y color:SolidPeso molecular:257.27PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Fórmula:C17H13BrN4OPureza:99.13% - 99.83%Forma y color:SolidPeso molecular:369.22Canertinib
CAS:Canertinib (CI-1033), a pan-erbB inhibitor, effectively targets esophageal cancer in vitro/vivo, altering metabolism and reducing growth and hypoxia.Fórmula:C24H25ClFN5O3Pureza:98% - >99.99%Forma y color:White Or Similar To White Crystalline PowderPeso molecular:485.94RG14620
CAS:<p>RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.</p>Fórmula:C14H8Cl2N2Pureza:99.82% - 99.87%Forma y color:SolidPeso molecular:275.13Tyrphostin 23
CAS:<p>Tyrphostin 23 (AG18) inhibits EGFR with IC50 of 35 μM.</p>Fórmula:C10H6N2O2Pureza:99.7% - 99.86%Forma y color:Yellow-Tan SolidPeso molecular:186.17MOMIPP
CAS:<p>MOMIPP: PIKfyve inhibitor, spurs macropinocytosis, crosses blood-brain barrier, curbs glioblastoma growth.</p>Fórmula:C18H16N2O2Pureza:99.66%Forma y color:SolidPeso molecular:292.33SU5204
CAS:SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) andFórmula:C17H15NO2Pureza:99.46%Forma y color:SolidPeso molecular:265.31Tyrphostin AG 879
CAS:<p>Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.</p>Fórmula:C18H24N2OSPureza:99.05%Forma y color:SolidPeso molecular:316.46EGFR-IN-12
CAS:<p>EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.</p>Fórmula:C21H18F3N5OPureza:98.3% - 99.76%Forma y color:SolidPeso molecular:413.4PD158780
CAS:PD 158780 blocks all ErbB receptors: EGFR, ErbB2-4, with IC50s: 8μM, 49-52 nM.Fórmula:C14H12BrN5Pureza:98.81%Forma y color:SolidPeso molecular:330.18PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Fórmula:C22H24N2O3Pureza:98.92%Forma y color:SolidPeso molecular:364.44AZD8186
CAS:AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).Fórmula:C24H25F2N3O4Pureza:99.89% - 99.91%Forma y color:SolidPeso molecular:457.47lavendustin C
CAS:lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.Fórmula:C14H13NO5Pureza:98.06%Forma y color:Yellow To Tan PowderPeso molecular:275.26TG100-115
CAS:TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.Fórmula:C18H14N6O2Pureza:99.22% - 99.26%Forma y color:SolidPeso molecular:346.34SB 415286
CAS:SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.Fórmula:C16H10ClN3O5Pureza:99.55%Forma y color:SolidPeso molecular:359.72PS 48
CAS:PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).Fórmula:C17H15ClO2Pureza:99.96% - ≥95%Forma y color:SolidPeso molecular:286.75NV-5138 hydrochloride
NV-5138 hydrochloride: a leucine analog, oral brain mTORC1 activator via Sestrin2, for antidepressant research.Fórmula:C7H14ClF2NO2Forma y color:SolidPeso molecular:217.64KY19382
CAS:KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.Fórmula:C17H11Cl2N3O2Pureza:98.06%Forma y color:SolidPeso molecular:360.19Epidermal Growth Factor
CAS:EGF binds EGFR, promotes cell growth & heals diabetic foot ulcers.Fórmula:C270H401N73O83S7Pureza:97.17%Forma y color:SolidPeso molecular:6222Bisindolylmaleimide I
CAS:<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Fórmula:C25H24N4O2Pureza:98.19% - 98.75%Forma y color:Orange SolidPeso molecular:412.48Alflutinib
CAS:<p>Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.</p>Fórmula:C28H31F3N8O2Pureza:99.87%Forma y color:SolidPeso molecular:568.59NS309
CAS:NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.Fórmula:C8H4Cl2N2O2Pureza:97.55%Forma y color:SolidPeso molecular:231.04NRC-2694 hydrochloride
CAS:NRC-2694 hydrochloride is an epidermal growth factor receptor (EGFR) antagonist potentially for the treatment of solid tumors.Fórmula:C24H27ClN4O3Forma y color:SolidPeso molecular:454.95Selective PI3Kδ Inhibitor 1
CAS:<p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>Fórmula:C23H20FN7OPureza:97.96%Forma y color:SolidPeso molecular:429.45WH-4-025
CAS:<p>WH-4-025 is a Salt-inducible kinase (SIK) inhibitor.</p>Fórmula:C39H38F3N7O5Pureza:99.41%Forma y color:SolidPeso molecular:741.76TMBIM6 antagonist-1
CAS:<p>TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor</p>Fórmula:C15H12N2O3Pureza:99.26%Forma y color:SolidPeso molecular:268.27RG13022
CAS:RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).Fórmula:C16H14N2O2Pureza:98.38%Forma y color:SolidPeso molecular:266.29NIBR-17
CAS:<p>NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.</p>Fórmula:C18H20N8O2Pureza:97.79%Forma y color:SolidPeso molecular:380.4PKI-166 hydrochloride
CAS:EGFR-kinase inhibitor, IC50 0.7 nM, >3000x selective, cuts metastasis and angiogenesis in mice, antihypertensive, oral use.Fórmula:C20H19ClN4OForma y color:SolidPeso molecular:366.85NU 7026
CAS:NU 7026 (DNA-PK Inhibitor II) is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibitionFórmula:C17H15NO3Pureza:99.51% - >99.99%Forma y color:SolidPeso molecular:281.31CZ415
CAS:<p>CZ415 is a potent and highly selective mTOR inhibitor.</p>Fórmula:C22H29N5O4SPureza:97.54% - 98.36%Forma y color:SolidPeso molecular:459.56Mutant EGFR inhibitor
CAS:<p>Selective, potent inhibitor for mutated EGFR: L858R, Exon19 deletion, T790M resistance mutants.</p>Fórmula:C27H30ClN7O2Pureza:98% - 99.75%Forma y color:SolidPeso molecular:520.03ZSTK474
CAS:<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Fórmula:C19H21F2N7O2Pureza:98.29% - 99.95%Forma y color:White PowderPeso molecular:417.41VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Forma y color:SolidPeso molecular:528.3GS87
CAS:GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.Fórmula:C16H11N5O2SPureza:98.86%Forma y color:SolidPeso molecular:337.36YU238259
CAS:YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.Fórmula:C22H22ClN3O4SPureza:99.28% - 99.56%Forma y color:SolidPeso molecular:459.95DMNB
CAS:DMNB (6-Nitroveratraldehyde) is DNA-dependent protein kinase (DNA-PK) inhibitor, an enzyme involved in the NHEJ pathway of DSB repair in human cells.Fórmula:C9H9NO5Pureza:97.87%Forma y color:Yellow SolidPeso molecular:211.17MHY-1685
CAS:<p>MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.</p>Fórmula:C11H8N2O4Pureza:99.76%Forma y color:SolidPeso molecular:232.19Allitinib tosylate
CAS:<p>Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.</p>Fórmula:C31H26ClFN4O5SPureza:98.46% - 98.68%Forma y color:SolidPeso molecular:621.08TWS119
CAS:<p>TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation</p>Fórmula:C18H14N4O2Pureza:98.14% - 99.63%Forma y color:SolidPeso molecular:318.33PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Fórmula:C26H35Cl2N7OPureza:99.92%Forma y color:SolidPeso molecular:532.51RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Fórmula:C29H35N7O4Pureza:98% - 99.91%Forma y color:SolidPeso molecular:545.63GDC-0326
CAS:GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).Fórmula:C19H22N6O3Pureza:99.35% - >99.99%Forma y color:SolidPeso molecular:382.42CC-115 hydrochloride
CAS:CC-115 hydrochloride: potent DNA-PK/mTOR inhibitor; IC50s: 13 nM and 21 nM; blocks mTORC1/C2 pathways.Fórmula:C16H17ClN8OForma y color:SolidPeso molecular:372.82PF-6274484
CAS:PF-6274484 is an EGFR inhibitor with Ki values of 0.14 and 0.18 nM for EGFR-L858R/T790M and WT-EGFR, respectively.Fórmula:C18H14ClFN4O2Pureza:97.71%Forma y color:SolidPeso molecular:372.78AZD-7648
CAS:<p>AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.</p>Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Forma y color:SolidPeso molecular:380.4TAS6417
CAS:Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor.Cost-effective and quality-assured.Fórmula:C23H20N6OPureza:99.71%Forma y color:SolidPeso molecular:396.44TDZD-8
CAS:<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Fórmula:C10H10N2O2SPureza:97.13% - 99.61%Forma y color:White SolidPeso molecular:222.26NRC-2694
CAS:NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.Fórmula:C24H26N4O3Pureza:99.90%Forma y color:SolidPeso molecular:418.49GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Fórmula:C19H22N6O3SPureza:98.42% - 99.54%Forma y color:SolidPeso molecular:414.48AZ7550
CAS:<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Fórmula:C27H31N7O2Pureza:97.07% - 99.75%Forma y color:SolidPeso molecular:485.58Trastuzumab
CAS:Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2.Pureza:97.1% (SDS-PAGE); 99.2% (SEC-HPLC) - SDS-PAGE: 97.1%；SEC-HPLC: 99.2%Forma y color:LiquidPeso molecular:Approximately 145.53 kDaLazertinib
CAS:Lazertinib (GNS-1480) is a potent, selective, irreversible EGFR-TKI; IC50: 1.7-76 nM for various EGFR mutations.Fórmula:C30H34N8O3Pureza:98.7% - 99.90%Forma y color:SolidPeso molecular:554.64GNE-477
CAS:<p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>Fórmula:C21H28N8O3S2Pureza:98.88% - 99.55%Forma y color:SolidPeso molecular:504.63KenPaullone
CAS:KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.Fórmula:C16H11BrN2OPureza:97.14% - 98.99%Forma y color:Tan SolidPeso molecular:327.18ZD-4190
CAS:<p>ZD-4190 blocks VEGFR2 and EGFR, aiding cancer treatment.</p>Fórmula:C19H16BrFN6O2Pureza:99.12%Forma y color:SolidPeso molecular:459.27VS-5584
CAS:<p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>Fórmula:C17H22N8OPureza:97.82% - 99.54%Forma y color:SolidPeso molecular:354.41CP21R7
CAS:<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Fórmula:C19H15N3O2Pureza:96.14% - 99.16%Forma y color:SolidPeso molecular:317.34TG 100713
CAS:<p>TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.</p>Fórmula:C12H10N6OPureza:98.17%Forma y color:SolidPeso molecular:254.25Chrysophanol
CAS:<p>Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.</p>Fórmula:C15H10O4Pureza:99.44% - 99.91%Forma y color:Physical Description Golden Yellow Plates Or Brown Powder Melting Point 196°CPeso molecular:254.24HTH-01-015
CAS:<p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>Fórmula:C26H28N8OPureza:98.38% - 99.70%Forma y color:SolidPeso molecular:468.55Neratinib
CAS:Neratinib (HKI-272) (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.Fórmula:C30H29ClN6O3Pureza:96.17% - 99.85%Forma y color:SolidPeso molecular:557.04Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Fórmula:C16H11N3O2Pureza:99.55%Forma y color:Dark Red SolidPeso molecular:277.28AG 1406
CAS:<p>AG 1406 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2.</p>Fórmula:C16H18N2OPureza:98.12%Forma y color:SolidPeso molecular:254.33AZD8931 diFuMaric acid
CAS:AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).Fórmula:C31H33ClFN5O11Pureza:99.92%Forma y color:SolidPeso molecular:706.1Poziotinib hydrochloride
CAS:<p>Oral poziotinib HCl targets EGFR/HER mutants, inhibiting cancer cell growth.</p>Fórmula:C23H22Cl3FN4O3Pureza:99.69% - 99.81%Forma y color:SolidPeso molecular:527.8Indirubin-3′-oxime
CAS:<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Fórmula:C16H11N3O2Pureza:98.34%Forma y color:SolidPeso molecular:277.28iMDK
CAS:iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.Fórmula:C21H13FN2O2SPureza:99.99%Forma y color:SolidPeso molecular:376.4SYR127063
CAS:<p>SYR127063 (BDBM-92454) (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.</p>Fórmula:C23H20ClF3N4O3Pureza:98.57%Forma y color:SolidPeso molecular:492.88Osimertinib mesylate
CAS:<p>Osimertinib mesylate (AZD-9291 mesylate) is an EGFR third-generation inhibitor. Osimertinib mesylate has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C29H37N7O5SPureza:99.46% - >99.99%Forma y color:SolidPeso molecular:595.71AG-494
CAS:AG-494 (Tyrphostin B48) is an inhibitor of epidermal growth factor receptor kinase.Fórmula:C16H12N2O3Pureza:98.69%Forma y color:SolidPeso molecular:280.28Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Fórmula:C21H25F3N6O2Pureza:99.88%Forma y color:SolidPeso molecular:450.46Derazantinib dihydrochloride
CAS:Derazantinib, a multi-kinase inhibitor targeting FGFR, benefits FGFR2-positive iCCA; its dihydrochloride form is a salt variant.Fórmula:C29H31Cl2FN4OForma y color:SolidPeso molecular:541.49WHI-P180
CAS:WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.Fórmula:C16H15N3O3Pureza:99.21%Forma y color:SolidPeso molecular:297.31Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Fórmula:C35H28F3N5O2Pureza:98.3% - 99.33%Forma y color:SolidPeso molecular:607.62AMG319
CAS:AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.Fórmula:C21H16FN7Pureza:98.9% - 99.24%Forma y color:Crystalline SolidPeso molecular:385.4(E)-AG 99
CAS:(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).Fórmula:C10H8N2O3Pureza:99.23%Forma y color:SolidPeso molecular:204.18CP-724714
CAS:<p>CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2</p>Fórmula:C27H27N5O3Pureza:97.1% - 98.82%Forma y color:SolidPeso molecular:469.54PP 3
CAS:<p>PP 3 is a Negative control for the Src kinase inhibitor PP 2</p>Fórmula:C11H9N5Pureza:98.61%Forma y color:Whit To Off-White SolidPeso molecular:211.22Almonertinib
CAS:Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.Fórmula:C30H35N7O2Pureza:99.99%Forma y color:SolidPeso molecular:525.64MOTS-c(Human) Acetate(1627580-64-6 free)
<p>MOTS-c(Human) Acetate is a mitochondrial-derived peptide.</p>Fórmula:C103H156N28O24S2Pureza:100%Forma y color:SolidPeso molecular:2234.64Torin 2
CAS:<p>Torin 2: mTOR inhibitor, IC50=0.25 nM, 800x more selective than PI3K, with EC50=28/35/118 nM for ATM/ATR/DNA-PK.</p>Fórmula:C24H15F3N4OPureza:98.31% - 99.32%Forma y color:SolidPeso molecular:432.4Dacomitinib
CAS:<p>Dacomitinib (PF299) is an oral selective inhibitor of EGFR, ERBB2, ERBB4 with IC50s: 6, 45.7, 73.7 nM.</p>Fórmula:C24H25ClFN5O2Pureza:99.4% - 99.72%Forma y color:SolidPeso molecular:469.944-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Fórmula:C8H6BrClOPureza:98.34% - 99.41%Forma y color:White To Beige SolidPeso molecular:233.49Theliatinib tartrate
CAS:Theliatinib: oral EGFR blocker, Ki 0.05 nM, IC50 3 nM (wild-type), 22 nM (T790M/L858R), >50x kinase selectivity.Fórmula:C29H32N6O8Forma y color:SolidPeso molecular:592.6Dacomitinib hydrate
CAS:Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family ofFórmula:C24H27ClFN5O3Pureza:99.52%Forma y color:SolidPeso molecular:487.96PKD-IN-1 dihydrochloride (956121-30-5 free base)
CAS:<p>CRT0066101 dihydrochloride is an inhibitor of PKD.</p>Fórmula:C18H21Cl3N4OPureza:99.5%Forma y color:SolidPeso molecular:415.75SU5214
CAS:SU5214 is a modulator of tyrosine kinase signal transduction.Fórmula:C16H13NO2Pureza:99.45% - 99.55%Forma y color:SolidPeso molecular:251.28TBB
CAS:<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Fórmula:C6HBr4N3Pureza:98.51% - 99.45%Forma y color:Off-White SolidPeso molecular:434.71ZM39923 hydrochloride
CAS:ZM39923 hydrochloride (JAK3 Inhibitor IV) is an JAK1/3 inhibitor, almost no activity to JAK2 and modestly potent to EGFR; also is sensitive to transglutaminase.Fórmula:C23H25NO·HClPureza:98.05%Forma y color:SolidPeso molecular:367.91Gefitinib-based PROTAC 3
CAS:Gefitinib-PROTAC 3 degrades EGFR in cancer cells; DC50s: 11.7 nM (HCC827) and 22.3 nM (H3255).Fórmula:C47H57ClFN7O8SPureza:97.29% - 98.25%Forma y color:SolidPeso molecular:934.51AMG 511
CAS:<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>Fórmula:C22H28FN9O3SPureza:≥98%Forma y color:SolidPeso molecular:517.58SB 216763
CAS:SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).Fórmula:C19H12Cl2N2O2Pureza:98.9% - 99.13%Forma y color:SolidPeso molecular:371.22Eganelisib
CAS:Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)Fórmula:C30H24N8O2Pureza:98.92% - 99.28%Forma y color:SolidPeso molecular:528.56WZ4003
CAS:<p>WZ4003, a highly selective NUAK kinase inhibitor, is with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively.</p>Fórmula:C25H29ClN6O3Pureza:99.65% - >99.99%Forma y color:SolidPeso molecular:496.99
