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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • Methyl 2,5-dihydroxycinnamate
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    Methyl 2,5-dihydroxycinnamate

    CAS:
    <p>Methyl 2,5-dihydroxycinnamate is an EGF receptor-associated tyrosine kinases inhibitor.</p>
    Fórmula:C10H10O4
    Pureza:99.60%
    Forma y color:Crystalline
    Peso molecular:194.18

    Ref: TM-T22974

  • Allitinib tosylate
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    Allitinib tosylate

    CAS:
    <p>Allitinib tosylate (AST-1306) is a novel irreversible inhibitor of EGFR and ErbB2 with IC50 of 0.5 nM and 3 nM, respectively.</p>
    Fórmula:C31H26ClFN4O5S
    Pureza:98.46% - 98.68%
    Forma y color:Solid
    Peso molecular:621.08

    Ref: TM-T6331

  • Butein
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    Butein

    CAS:
    <p>Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.</p>
    Fórmula:C15H12O5
    Pureza:98.76% - >99.99%
    Forma y color:Solid
    Peso molecular:272.25

    Ref: TM-T6427

  • CL-387785
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    CL-387785

    CAS:
    <p>CL-387785 is an irreversible EGFR inhibitor with IC50 of 370 pM; overcomes T790M mutation resistance.</p>
    Fórmula:C18H13BrN4O
    Pureza:99.56% - 99.62%
    Forma y color:Solid
    Peso molecular:381.23

    Ref: TM-T2245

  • AMG319
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    AMG319

    CAS:
    <p>AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, &gt;47-fold selectivity over other PI3Ks. Phase 2.</p>
    Fórmula:C21H16FN7
    Pureza:98.9% - 99.24%
    Forma y color:Crystalline Solid
    Peso molecular:385.4

    Ref: TM-T6757

  • PI3K-IN-1
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    PI3K-IN-1

    CAS:
    <p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>
    Fórmula:C31H29N5O6S
    Pureza:97.03% - 98%
    Forma y color:Solid
    Peso molecular:599.66

    Ref: TM-T1826

  • Tuxobertinib
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    Tuxobertinib

    CAS:
    <p>Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations. BDTX-189 exhibits anticancer activity.</p>
    Fórmula:C29H29ClN6O4
    Pureza:99.22%
    Forma y color:Solid
    Peso molecular:561.03

    Ref: TM-T9072

  • AR-A014418
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    AR-A014418

    CAS:
    <p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>
    Fórmula:C12H12N4O4S
    Pureza:>99.99% - ≥95%
    Forma y color:Solid
    Peso molecular:308.31

    Ref: TM-T1881

  • WYE-687 dihydrochloride
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    WYE-687 dihydrochloride

    CAS:
    <p>WYE-687 dihydrochloride is an mTOR inhibitor with IC50 of 7 nM, also targeting PI3Kα (81 nM) and PI3Kγ (3.11 μM).</p>
    Fórmula:C28H34Cl2N8O3
    Forma y color:Solid
    Peso molecular:601.53

    Ref: TM-T72270

  • PKD-IN-1 dihydrochloride (956121-30-5 free base)
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    PKD-IN-1 dihydrochloride (956121-30-5 free base)

    CAS:
    <p>CRT0066101 dihydrochloride is an inhibitor of PKD.</p>
    Fórmula:C18H21Cl3N4O
    Pureza:99.5%
    Forma y color:Solid
    Peso molecular:415.75

    Ref: TM-T8957L

  • WHI-P154
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    WHI-P154

    CAS:
    <p>WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.</p>
    Fórmula:C16H14BrN3O3
    Pureza:98% - 99.67%
    Forma y color:Solid
    Peso molecular:376.2

    Ref: TM-T1985

  • ETP-46321
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    ETP-46321

    CAS:
    <p>ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).</p>
    Fórmula:C20H27N9O3S
    Pureza:99.8%
    Forma y color:Solid
    Peso molecular:473.55

    Ref: TM-TQ0229

  • RGB-286638 free base
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    RGB-286638 free base

    CAS:
    <p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>
    Fórmula:C29H35N7O4
    Pureza:98% - 99.91%
    Forma y color:Solid
    Peso molecular:545.63

    Ref: TM-T2378

  • Olmutinib
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    Olmutinib

    CAS:
    <p>Olmutinib (BI1482694) is a Novel Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor</p>
    Fórmula:C26H26N6O2S
    Pureza:99.14%
    Forma y color:Solid
    Peso molecular:486.59

    Ref: TM-T8460

  • Gallein
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    Gallein

    CAS:
    <p>Gallein (Mordant violet 25) is a small molecule inhibitor of Gβγ activity.</p>
    Fórmula:C20H12O7
    Pureza:85.50% - 95.94%
    Forma y color:Solid
    Peso molecular:364.31

    Ref: TM-T3040

  • GNF4877
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    GNF4877

    CAS:
    <p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>
    Fórmula:C25H27FN6O4
    Pureza:98.68% - 99.40%
    Forma y color:Solid
    Peso molecular:494.52

    Ref: TM-T11447

  • Selective PI3Kδ Inhibitor 1
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    Selective PI3Kδ Inhibitor 1

    CAS:
    <p>Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).</p>
    Fórmula:C23H20FN7O
    Pureza:97.96%
    Forma y color:Solid
    Peso molecular:429.45

    Ref: TM-T5831

  • (E)-AG 99
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    (E)-AG 99

    CAS:
    <p>(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).</p>
    Fórmula:C10H8N2O3
    Pureza:99.23%
    Forma y color:Solid
    Peso molecular:204.18

    Ref: TM-T5155

  • WS6
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    WS6

    CAS:
    <p>WS6, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway.</p>
    Fórmula:C29H31F3N6O3
    Pureza:97.65% - 99.95%
    Forma y color:Solid
    Peso molecular:568.59

    Ref: TM-T2106

  • Indirubin-3′-oxime
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    Indirubin-3′-oxime

    CAS:
    <p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>
    Fórmula:C16H11N3O2
    Pureza:98.34%
    Forma y color:Solid
    Peso molecular:277.28

    Ref: TM-T9138