gsk-3
Los inhibidores de GSK-3 son compuestos que inhiben la Glicógeno Sintasa Quinasa 3 (GSK-3), una enzima involucrada en numerosos procesos celulares, como el metabolismo del glucógeno, la transcripción génica y la proliferación celular. GSK-3 está implicada en diversas enfermedades, como la diabetes, los trastornos neurodegenerativos y el cáncer. Los inhibidores de GSK-3 son herramientas importantes para explorar estas vías y desarrollar posibles terapias. En CymitQuimica, ofrecemos inhibidores de GSK-3 para apoyar su investigación en enfermedades metabólicas, neurobiología y oncología.
Se han encontrado 112 productos de "gsk-3"
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Cromolyn sodium
CAS:<p>Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.</p>Fórmula:C23H14Na2O11Pureza:99.4% - 99.95%Forma y color:Colorless Crystals From Ethanol + Ether White Crystalline PowderPeso molecular:512.33Cyanoacetohydrazide
CAS:<p>Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.</p>Fórmula:C3H5N3OPureza:99.78%Forma y color:Stout Prisms From Alcohol Slightly Brown PowderPeso molecular:99.09BRD0705
CAS:<p>BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.</p>Fórmula:C20H23N3OPureza:99.01%Forma y color:SolidPeso molecular:321.42Indazole
CAS:<p>Indazole, a heterocyclic compound, offers diverse biological activities.</p>Fórmula:C7H6N2Pureza:99.59% - 99.85%Forma y color:White Or Beige Crystalline PowderPeso molecular:118.149-ING-41
CAS:<p>9-ING-41 is a glycogen synthase kinase-3 inhibitor.</p>Fórmula:C22H13FN2O5Pureza:99.32%Forma y color:SolidPeso molecular:404.35GSK-3 inhibitor 4
CAS:<p>Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.</p>Fórmula:C22H15F2N5OPureza:99.41%Forma y color:SoildPeso molecular:403.38MeBIO
CAS:MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.Fórmula:C17H12BrN3O2Pureza:99.64%Forma y color:SolidPeso molecular:370.2BMP agonist 1
<p>BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.</p>Fórmula:C21H16N2O6Forma y color:SolidPeso molecular:392.36GSK3-IN-1
CAS:<p>GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.</p>Fórmula:C14H10ClN3OSPureza:99.66%Forma y color:SolidPeso molecular:303.77FRATide
CAS:<p>FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein.</p>Fórmula:C55H102N2O2Forma y color:SolidPeso molecular:823.4336-Me-ATP
CAS:<p>6-Me-ATP, a modified ATP, binds well to GSK3 and donates phosphate for GSK3β phosphorylation.</p>Fórmula:C11H18N5O13P3Forma y color:SolidPeso molecular:521.21GSK-3β inhibitor 23
<p>GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.</p>Fórmula:C18H13Cl2N5O2SForma y color:SolidPeso molecular:434.299GSK-3 Inhibitor 5
CAS:<p>4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.</p>Fórmula:C9H6BrNOPureza:99.58%Forma y color:Off-White To Light Yellow Crystalline PowderPeso molecular:224.05GSK-3 inhibitor 3
CAS:<p>GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively</p>Fórmula:C23H15FN6OPureza:99.89%Forma y color:SoildPeso molecular:410.4CHIR-98023
CAS:<p>CHIR-98023 is a bio-active chemical.</p>Fórmula:C20H16Cl2N8O2Forma y color:SolidPeso molecular:471.30GSK3a-IN-38
CAS:<p>GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.</p>Fórmula:C18H20N4OPureza:99.75%Forma y color:SoildPeso molecular:308.38GSK-3β inhibitor 22
CAS:<p>GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.</p>Fórmula:C18H12F3N3O2S2Forma y color:SolidPeso molecular:423.432B-(SP)
CAS:<p>Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)</p>Fórmula:C71H123N26O29PPureza:98%Forma y color:SolidPeso molecular:1835.87GSK-3β inhibitor 24
<p>GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.</p>Fórmula:C26H18N4O3Forma y color:SolidPeso molecular:434.446GSK3β/mTOR modulator 1
<p>GSK3β/mTOR modulator 1 (derivative 2) is an agent that modulates the GSK3β/mTOR signaling pathway. It is applicable in research related to acute lung injury (ALI) and inflammation.</p>Fórmula:C19H28O5Forma y color:SolidPeso molecular:336.19367GSK3β inhibitor II
CAS:<p>GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).</p>Fórmula:C14H10IN3OSPureza:99.48%Forma y color:SolidPeso molecular:395.22Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Forma y color:Odour SolidGSK-3β inhibitor 21
<p>GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.</p>Forma y color:Odour SolidWnt/β-catenin agonist 2
CAS:<p>Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.</p>Fórmula:C13H12N4O3Pureza:99.35%Forma y color:SolidPeso molecular:272.26GSK-3β inhibitor 1
CAS:<p>GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.</p>Fórmula:C14H10N2OPureza:99.40%Forma y color:SolidPeso molecular:222.24GSK-3β inhibitor 14
CAS:<p>GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM.</p>Fórmula:C17H17NOSPureza:99.97%Forma y color:SolidPeso molecular:283.39GSK-3β inhibitor 19
<p>GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.</p>Fórmula:C15H12N4O2SForma y color:SolidPeso molecular:312.35GSK3-IN-4
CAS:<p>GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.</p>Fórmula:C18H20N4OPureza:98.33%Forma y color:SoildPeso molecular:308.38GSK3β Inhibitor XI
CAS:<p>GSK3β Inhibitor XI has GSK3β inhibitory effect.</p>Fórmula:C18H15N5O3Forma y color:SolidPeso molecular:349.35Phospho-Glycogen Synthase Peptide-2(substrate)
CAS:<p>Phospho-Glycogen Synthase Peptide-2 is a GSK-3 substrate, useful for serine kinase affinity purification.</p>Fórmula:C123H191N40O48PForma y color:SolidPeso molecular:3029.087Ceftriaxone Sodium
CAS:<p>Ceftriaxone Sodium is a sporotaxin antibiotic that inhibits GSK3β and Aurora B. It is used in the study of sepsis and infective endocarditis.</p>Fórmula:C18H17N8NaO7S3Forma y color:SolidPeso molecular:576.5627BIO
CAS:<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Fórmula:C16H10BrN3O2Pureza:99.67%Forma y color:SolidPeso molecular:356.17Tideglusib
CAS:<p>Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.</p>Fórmula:C19H14N2O2SPureza:98.40% - 99.35%Forma y color:SolidPeso molecular:334.39LY2090314
CAS:<p>LY2090314, a potent GSK-3α/β blocker (IC50: 1.5/0.9 nM), could boost platinum chemo. Tested in leukemia and advanced cancers.</p>Fórmula:C28H25FN6O3Pureza:99.21% - 99.91%Forma y color:SolidPeso molecular:512.53VP3.15 dihydrobromide
CAS:<p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Forma y color:SolidPeso molecular:528.3GNF4877
CAS:<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Fórmula:C25H27FN6O4Pureza:98.68% - 99.40%Forma y color:SolidPeso molecular:494.52Indirubin-3′-oxime
CAS:<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Fórmula:C16H11N3O2Pureza:98.34%Forma y color:SolidPeso molecular:277.28TDZD-8
CAS:<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Fórmula:C10H10N2O2SPureza:97.13% - 99.61%Forma y color:White SolidPeso molecular:222.26IM-12
CAS:<p>IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.</p>Fórmula:C22H20FN3O2Pureza:99.42% - >99.99%Forma y color:SolidPeso molecular:377.41(E/Z)-GSK-3β inhibitor 1
CAS:<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Fórmula:C14H10N2OPureza:98.60%Forma y color:SolidPeso molecular:222.24RGB-286638 free base
CAS:<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Fórmula:C29H35N7O4Pureza:98% - 99.91%Forma y color:SolidPeso molecular:545.63CP21R7
CAS:<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Fórmula:C19H15N3O2Pureza:96.14% - 99.16%Forma y color:SolidPeso molecular:317.34SB 415286
CAS:<p>SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.</p>Fórmula:C16H10ClN3O5Pureza:99.55%Forma y color:SolidPeso molecular:359.72CHIR-99021
CAS:<p>View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.</p>Fórmula:C22H18Cl2N8Pureza:97.94% - ≥95%Forma y color:SolidPeso molecular:465.34GSK-3β inhibitor 10
CAS:<p>GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.</p>Fórmula:C12H12N2O3SPureza:98.06%Forma y color:SolidPeso molecular:264.3SB 216763
CAS:<p>SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).</p>Fórmula:C19H12Cl2N2O2Pureza:98.9% - 99.13%Forma y color:SolidPeso molecular:371.22AZD2858
CAS:AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.Fórmula:C21H23N7O3SPureza:98% - 99.25%Forma y color:SolidPeso molecular:453.52BIO-acetoxime
CAS:<p>BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.</p>Fórmula:C18H12BrN3O3Pureza:97.15%Forma y color:SolidPeso molecular:398.21Indirubin-3'-monoxime
CAS:<p>Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/</p>Fórmula:C16H11N3O2Pureza:99.55%Forma y color:Dark Red SolidPeso molecular:277.28Bisindolylmaleimide I
CAS:<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Fórmula:C25H24N4O2Pureza:98.19% - 98.75%Forma y color:Orange SolidPeso molecular:412.48
