AMPK
Los inhibidores de AMPK son compuestos que inhiben la Proteína Quinasa Activada por AMP (AMPK), una enzima clave en la homeostasis energética celular. La AMPK se activa en respuesta a bajos niveles de energía en las células y regula procesos como la captación de glucosa, la oxidación de ácidos grasos y la biogénesis mitocondrial. Inhibir la AMPK es fundamental para estudiar su papel en enfermedades metabólicas, cáncer y envejecimiento. En CymitQuimica, ofrecemos una variedad de inhibidores de AMPK para apoyar su investigación en metabolismo, oncología y enfermedades relacionadas con la edad.
Se han encontrado 160 productos para "AMPK".
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PF-249
CAS:PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.Fórmula:C17H16ClN3O3Pureza:97.01%Forma y color:SolidPeso molecular:345.78Ref: TM-T24626
1mg46,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg236,00€50mg344,00€100mg482,00€200mg662,00€AMPK-IN-1
CAS:AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Fórmula:C24H18ClN3O3Forma y color:SolidPeso molecular:431.87MK-0626
CAS:MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Fórmula:C22H24F2N6O2Pureza:99.47% - >99.99%Forma y color:SolidPeso molecular:442.46AMPK activator 7
CAS:AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.Fórmula:C23H22F3N3O5Forma y color:SolidPeso molecular:477.43PF-06679142
CAS:PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.Fórmula:C20H17F2NO3Pureza:98%Forma y color:SolidPeso molecular:357.35MARK-IN-2
CAS:MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Fórmula:C18H18ClF2N5OSPureza:98%Forma y color:SolidPeso molecular:425.88Butylate
CAS:Butylate is a herbicide of thiocarbamate.Fórmula:C11H23NOSForma y color:SolidPeso molecular:217.37MARK-IN-1
CAS:MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Fórmula:C22H23F2N7OSPureza:98%Forma y color:SolidPeso molecular:471.53MRT199665
CAS:MRT199665, a selective MARK/SIK/AMPK inhibitor, blocks SIK CRTC3 S370 phosphorylation and triggers apoptosis in AML cells.Fórmula:C28H31N5O2Forma y color:SolidPeso molecular:469.58Ampkinone
CAS:Ampkinone is an indirect AMPK activator.Fórmula:C31H23NO6Pureza:98%Forma y color:SolidPeso molecular:505.52AMPK-α1β1γ1 activator 1
CAS:AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Fórmula:C25H24ClNO9Pureza:98%Forma y color:SolidPeso molecular:517.91ZLN024
CAS:ZLN024 is an activator of AMPK allosteric.Fórmula:C13H13BrN2OSPureza:99.75%Forma y color:SolidPeso molecular:325.22Ref: TM-T13411
1mg93,00€5mg177,00€1mL*10mM (DMSO)178,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€HDAC11-IN-2
CAS:HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.Fórmula:C25H35N3O3Forma y color:SolidPeso molecular:425.564Equisetin
CAS:Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria & HIV-1 integrase; not antibacterial to Gram-negative.Fórmula:C22H31NO4Pureza:98%Forma y color:SolidPeso molecular:373.49EGFR-IN-146
CAS:EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.Fórmula:C20H16N4Forma y color:SolidPeso molecular:312.368NPC26
CAS:NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.Fórmula:C19H23N3O5S2Forma y color:SolidPeso molecular:437.533Tezampanel etibutil
CAS:Tezampanel etibutil is an orally active AMPA/GluR antagonist. It is utilized in research related to pain, migraines, and neurological disorders.Fórmula:C19H33N5O2Peso molecular:363.50Galegine hemisulfate
CAS:Galegine hemisulfate, a guanidine derivative, aids in weight reduction in mice. It activates AMPK in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma cells, and HEK293 human renal cell lines. Galegine hemisulfate also exhibits antibacterial activity, with a minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains.Fórmula:C6H15N3O4SForma y color:SolidPeso molecular:225.27Aldometanib
CAS:Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.Fórmula:C27H43Cl2IN2Pureza:99.32% - 99.55%Forma y color:White SolidPeso molecular:593.46XMD-17-51 Trifluoroacetate
CAS:XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.Fórmula:C23H25F3N8O3Pureza:99.65%Forma y color:SolidPeso molecular:518.49
